Month: November 2022

The author of 《Iridium Single-Atom Catalyst Performing a Quasi-homogeneous Hydrogenation Transformation of CO2 to Formate》 were Shao, Xianzhao; Yang, Xiaofeng; Xu, Jinming; Liu, Song; Miao, Shu; Liu, Xiaoyan; Su, Xiong; Duan, Hongmin; Huang, Yanqiang; Zhang, Tao. And the article was published in Chem in 2019. Application In Synthesis of 2,6-Diaminopyridine The author mentioned the following in the article:

Heterogeneous single-atom catalysts (SACs) with atomically dispersed active metal centers represent an intermediary between heterogeneous and homogeneous catalysis. In this work, a porous organic polymer with aminopyridine functionalities was designed to fabricate a stable, atomically dispersed Ir catalyst. This Ir-based SAC exhibits excellent catalytic activity during the liquid-phase hydrogenation of CO2 to formate. The associated turnover number is as high as 25,135, representing the best performance yet for a heterogeneous conversion of CO2 to formate. Spectral characterization and d. functional theory modeling demonstrate that the chem. structure of the Ir single-atom active site is analogous to that of a homogeneous mononuclear Ir pincer complex catalyst. As a result, a catalytic mechanism similar to that over a homogeneous Ir catalyst occurs during CO2 hydrogenation with this quasi-homogeneous Ir-based SAC. This work suggests a promising basis for the design of efficient SACs for the once-dominant homogeneous catalytic processes. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis》 were Fan, Yu; Zhang, Jiulong; Shi, Menghan; Li, Dan; Lu, Chunhua; Cao, Xueyan; Peng, Chen; Mignani, Serge; Majoral, Jean-Pierre; Shi, Xiangyang. And the article was published in Nano Letters in 2019. Product Details of 98-98-6 The author mentioned the following in the article:

The development of a powerful nanoplatform to realize the simultaneous therapy and diagnosis of cancer using a similar element for theranostics remains a critical challenge. Herein, we report such a theranostic nanoplatform based on pyridine (Pyr)-functionalized generation 5 (G5) poly(amidoamine) dendrimers complexed with copper(II) (Cu(II)) for radiotherapy-enhanced T1-weighted magnetic resonance (MR) imaging and the synergistic radio-chemotherapy of both tumors and tumor metastasis. In this study, amine-terminated G5 dendrimers were covalently linked with 2-pyridinecarboxylic acid, acetylated to neutralize their remaining terminal amines, and complexed with Cu(II) through both the internal tertiary amines and the surface Pyr groups to form the G5.NHAc-Pyr/Cu(II) complexes. We show that the complexes are able to inhibit the proliferation of different cancer cell lines with half-maximal inhibitory concentrations ranging from 4 to 10μM and induce significant cancer cell apoptosis. Due to the presence of Cu(II), the G5.NHAc-Pyr/Cu(II) complexes display an r1 relaxivity of 0.7024 mM-1 s-1, enabling effective in vivo MR imaging of tumor xenografts and lung metastatic nodules. Further, under radiotherapy (RT) conditions, the tumor MR imaging sensitivity can be significantly enhanced, and the G5.NHAc-Pyr/Cu(II) complexes enable the enhanced chemotherapy of both a xenografted tumor model and a blood-vessel metastasis model. With the demonstrated theranostic potential of the dendrimer-Cu(II) nanocomplexes without addnl. agents or elements for RT-enhanced MR imaging and chemotherapy of tumor and tumor metastasis, this novel Cu(II)-based nanohybrids may hold great promise for the theranostics of different cancer types and metastases. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sheng, Min; Fujita, Shu; Yamaguchi, Sho; Yamasaki, Jun; Nakajima, Kiyotaka; Yamazoe, Seiji; Mizugaki, Tomoo; Mitsudome, Takato published their research in JACS Au in 2021. The article was titled 《Single-Crystal Cobalt Phosphide Nanorods as a High-Performance Catalyst for Reductive Amination of Carbonyl Compounds》.Related Products of 1122-54-9 The article contains the following contents:

Herein, the successful synthesis of single-crystal cobalt phosphide nanorods (Co2P NRs) containing coordinatively unsaturated Co-Co active sites, which serve as a new class of air-stable, highly active, and reusable heterogeneous catalysts for the reductive amination of carbonyl compounds was reported. The Co2P NR catalyst showed high activity for the transformation of a broad range of carbonyl compounds to their corresponding primary amines using an aqueous ammonia solution or ammonium acetate as a green amination reagent at 1 bar of H2 pressure; these conditions were far milder than previously reported. The air stability and high activity of the Co2P NRs was noteworthy, as conventional Co catalysts were air-sensitive (pyrophorous) and show no activity for this transformation under mild conditions. P-alloying was therefore of considerable importance for nanoengineering air-stable and highly active non-noble-metal catalysts for organic synthesis. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Han, Ming; Liu, Yuwei; Qian, Dong-Jin; Lee, Yong-Ill; Liu, Hong-Guo published an article in 2021. The article was titled 《Large-Area Assembly of Metal-Organic Layered Ultrathin Films at the Liquid/Liquid Interface》, and you may find the article in Langmuir.Electric Literature of C12H12N2 The information in the text is summarized as follows:

Two-dimensional functional metal-organic frameworks and coordination polymers have attracted much attention and have been successfully prepared in solutions and at interfaces through the coordination of ligands to metal ions. However, the preparation of large-area ultrathin ordered films is still a challenge. Here, a modified liquid/liquid interfacial epitaxial growth method has been developed. A planar liquid/liquid interface between a chloroform solution of bipyridine derivatives and pure water was constructed first, and then an aqueous solution of Eu3+ or Cu2+ ions was added dropwise into the water phase. A layered ultrathin film with the size of several hundreds of square micrometers appeared at the liquid/liquid interface after a certain time. The monitoring results showed that the formation of ultrathin films was a result of continuous epitaxial growth of the adsorbed species due to the synergistic effects of hydrophobic effects of the alkyl chains, coordination bonds between the ligands and metal ions, π-π interactions between the ligands, and the restriction of the interface on the vertical growth. This offers a way to fabricate more large-area thin films of amphiphilic mols. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Gupta, G.; Iqbal, P.; Yin, F.; Liu, J.; Palmer, R. E.; Sharma, S.; Leung, K. Cham-Fai; Mendes, P. M. published 《Pt Diffusion Dynamics for the Formation Cr-Pt Core-Shell Nanoparticles》.Langmuir published the findings.HPLC of Formula: 13534-97-9 The information in the text is summarized as follows:

Layered core-shell bimetallic Cr-Pt nanoparticles were prepared by the formation and later reduction of an intermediate Pt-ion-containing supramol. complex onto preformed Cr nanoparticles. The resultant nanoparticles were characterized by x-ray diffraction anal., TEM, XPS, and aberration-corrected scanning TEM. The results are consistent with the presence of Pt diffusion during or after bimetallic nanoparticle formation, which resulted in a Pt/Cr-alloyed core and shell. The authors postulate that such Pt diffusion occurs by an elec.-field-assisted process according to Cabrera-Mott theory and that it originates from the low work function of the preformed oxygen-defective Cr nanoparticles and the rather large electron affinity of Pt. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Talanta included an article by Xu, Shaomei; Che, Songtian; Ma, Pinyi; Zhang, Fangmei; Xu, Longbin; Liu, Xin; Wang, Xinghua; Song, Daqian; Sun, Ying. Application of 1692-25-7. The article was titled 《One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid》. The information in the text is summarized as follows:

Typically, sialic acids (SA) with a nine-carbon backbone are found at the glycan chain termini on the cell membranes, which play crucial roles in various physiol. and pathol. processes. The expression level of SA in the blood serum has been reported to correlate with various disease states among cancer. A novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source. The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 μM with a detection limit of 54 μM. The as-developed boronic-acid nanoprobe was successfully applied for the detection of SA in human serum samples with satisfactory results. In addition, this method afforded results within 4 min. Compared to other methods, this new proposed approach was simpler and exhibited excellent sensitivity and selectivity, demonstrating immense potential as an alternative for SA detection. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hydrogen Bond-Accelerated meta-Selective C-H Borylation of Aromatic Compounds and Expression of Functional Group and Substrate Specificities》 were Lu, Xu; Yoshigoe, Yusuke; Ida, Haruka; Nishi, Mitsumi; Kanai, Motomu; Kuninobu, Yoichiro. And the article was published in ACS Catalysis in 2019. Computed Properties of C5H3Br2N The author mentioned the following in the article:

Meta-selective C-H borylation of aromatic compounds was accelerated when using urea moiety-containing bipyridine-type ligands unlike in cases involving a bipyridine-type ligand without the urea moiety. The acceleration was due to the recognition and capture of the aromatic substrates by the urea moiety of the ligand by H bonding. The acceleration was further enhanced by modifying the electronic and steric properties of the ligand. The functional group and substrate specificities were also observed using the urea moiety-containing ligands. In the experiment, the researchers used many compounds, for example, 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Yinfu; Wang, Jinglan; Wu, Yaqian; Xu, Shengxian; Zhao, Feng; He, Haifeng; Wang, Yibo published their research in Polyhedron in 2021. The article was titled 《Yellow-green luminescence of four-coordinate copper(I) complexes bearing N-heterocyclic carbene (NHC) ligands: Synthesis, photophysical and computational studies》.Related Products of 3510-66-5 The article contains the following contents:

The synthesis and photophys. investigation of a series of six copper(I) complexes [(1,2-Ph2PC6H4OC6H4PPh2)(1-PhCH2BimMe2-3-PyR1R2)Cu][PF6] (1-6; BimMe2 = 5,6-dimethylbenzimidazol-2-ylidene; PyR1R2 = 6-R1-5-R2-2-pyridyl) bearing benzimidazolylidene-type N-heterocyclic carbene (NHC) ligands with different groups are reported. Their photophys. properties can be tuned by adjusting the groups at the R1/R2 positions of the pyridine ring. The lowest-lying metal-to-ligand (MLCT) absorption bands at 325-437 nm can be observed for all the complexes. Upon excitation with UV light all the complexes emit bright yellow-green light (λem = 540-573 nm) with higher emission quantum yields of 21.1-55.6% and excited state lifetimes on the microsecond scale (τ = 30.6-62.1μs) in PMMA films. The substituents (R2 = COMe, F, Br, Me, or OMe) on R2-position of the pyridine ring were shown to have effects on the emission wavelengths of these complexes, while the introduction of R1 substituents (R1 = CH3) shows negligible effects on the emission wavelength but allow the enhancement of photoluminescence quantum yield (Φ) of the complexes. Addnl., the electronic properties, absorption and emission profiles of these complexes were further explored using DFT/TDDFT methods. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Du, Yun; Sun, Chenglong; Shen, Yuru; Liu, Luyao; Chen, Mingjian; Xie, Qingji; Xiao, Hongbo published an article in 2022. The article was titled 《Anodic Stripping Voltammetric Analysis of Trace Arsenic(III) on a Au-Stained Au Nanoparticles/Pyridine/Carboxylated Multiwalled Carbon Nanotubes/Glassy Carbon Electrode》, and you may find the article in Nanomaterials.Safety of 4-Cyanopyridine The information in the text is summarized as follows:

A Au-stained Au nanoparticle (Aus)/pyridine (Py)/carboxylated multiwalled carbon nanotubes (C-MWCNTs)/glassy carbon electrode (GCE) was prepared for the sensitive anal. of As(III) by cast-coating of C-MWCNTs on a GCE, electroreduction of 4-cyanopyridine (cPy) to Py, adsorption of gold nanoparticles (AuNPs), and gold staining. The Py/C-MWCNTs/GCE can provide abundant active surface sites for the stable loading of AuNPs and then the AuNPs-initiated Au staining in HAuCl4 + NH2OH solution, giving a large surface area of Au on the Aus/Py/C-MWCNTs/GCE for the linear sweep anodic stripping voltammetry (LSASV) anal. of As(III). At a high potential-sweep rate of 5 V s-1, sharp two-step oxidation peaks of As(0) to As(III) and As(III) to As(V) were obtained to realize the sensitive dual-signal detection of As(III). Under optimal conditions, the ASLSV peak currents for oxidation of As(0) to As(III) and of As(III) to As(V) are linear with a concentration of As(III) from 0.01 to 8μM with a sensitivity of 0.741 mA μM-1 and a limit of detection (LOD) of 3.3 nM (0.25 ppb) (S/N = 3), and from 0.01 to 8.0μM with a sensitivity of 0.175 mA μM-1 and an LOD of 16.7 nM (1.20 ppb) (S/N = 3), resp. Determination of As(III) in real water samples yielded satisfactory results. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 53939-30-3In 2019 ,《Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines》 appeared in ACS Omega. The author of the article were Sun, Chao; Yao, Wubing; Chen, Xu; Zhao, Yiwen; Wei, Qiqi; Chen, Zishuang; Wu, Jiashou; Hao, Feiyue; Xie, Huiping. The article conveys some information:

An environmental, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides, to 2- aminopyridine derivatives I (X = 5-Br, 3-Br, 4-Cl, etc.; R = H, Me; R1 = Me, n-Bu, n-hexyl, Bn, etc.) using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N,N-dimethylformamide to generate the dimethylamine is likely. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem