Month: November 2022

Wang, Fang; Qin, Jian; Zhu, Shengqing; Chu, Lingling published their research in RSC Advances in 2021. The article was titled 《Organic-photoredox-catalyzed three-component sulfonylative pyridylation of styrenes》.Application of 100-48-1 The article contains the following contents:

An efficient, metal-free protocol for the three-component sulfonylative pyridylation of alkenes via organic-photoredox catalysis was described. Metal-free process enabled the direct and selective installation of sulfonyl and heteroaryl motifs and tolerated a wide array of functional groups as well as complex mol. scaffolds, which complemented previous methods and was of great interest in pharmaceutical research. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mohan, Midhun; Essalhi, Mohamed; Zaye, Sarah; Rana, Love Karan; Maris, Thierry; Duong, Adam published an article in 2021. The article was titled 《Hydrogen Bond Patterns of Dipyridone and Bis(Hydroxypyridinium) Cations》, and you may find the article in ACS Omega.Application of 624-28-2 The information in the text is summarized as follows:

Dipyridonyl-substituted derivatives I,II,III ( 2,3,4, resp.) of benzene, pyridine, and pyrazine, resp., were synthesized to examine the ability of 2-pyridone and its protonated species to direct the self-assembly by hydrogen bonding. Structural anal. by single-crystal X-ray diffraction (SCXRD) of 2 and 4 in trifluoroacetic acid demonstrated that salts are formed as a result of the transfer of protons from the acid to the base (organic species) to generate a bis(hydroxypyridinium) dication. However, if no proton transfer takes place like in the case of crystals of 3 grown from DMSO/H2O, the self-assembly is mainly directed by the typical R22(8) hydrogen bond motif of 2-pyridone. These results indicate that the process of converting a neutral 2-pyridonyl group into a hydroxypyridinium cation makes structure prediction difficult. Consequently, examination of proton transfer and assembly of dipyridone and its protonated species are of interest. In combination with SCXRD, Hirshfeld surface anal. (HSA) was also used to have a better understanding on the nature of intermol. interactions within crystal structures of 2-4. The large number of F···H/H···F, H···O/O···H, H···H, and H···C/C···H contacts revealed by HSA indicates that hydrogen bonding and van der Waals interactions mainly contribute to crystal packing. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Application of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Soldin, Zeljka; Kukovec, Boris-Marko; Matkovic-Calogovic, Dubravka; Popovic, Zora published an article in 2021. The article was titled 《The Solvent Effect on Composition and Dimensionality of Mercury(II) Complexes with Picolinic Acid》, and you may find the article in Molecules.SDS of cas: 98-98-6 The information in the text is summarized as follows:

Three new mercury(II) coordination compounds, {[HgCl(pic)]}n (1), [HgCl(pic)(picH)] (2), and [HgBr(pic)(picH)] (3) (picH = pyridine-2-carboxylic acid, picolinic acid) were prepared by reactions of the corresponding mercury(II) halides and picolinic acid in an aqueous (1) or alc.-methanol or ethanol (2 and 3) solutions Two different types of coordination compounds were obtained depending on the solvent used. The crystal structures were determined by the single-crystal X-ray structural anal. Compound1 is a one-dimensional (1-D) coordination polymer with mercury(II) ions bridged by chelating and bridging N,O,O′-picolinate ions. Each mercury(II) ion is four-coordinated with a bidentate picolinate ion, a carboxylate O atom from the symmetry-related picolinate ion and with a chloride ion; the resulting coordination environment can be described as a highly distorted tetrahedron. Compounds 2 and 3 are isostructural mononuclear coordination compounds, each mercury(II) ion being coordinated with the resp. halide ion, N,O-bidentate picolinate ion, and N,O-bidentate picolinic acid in a highly distorted square-pyramidal coordination environment. Compounds 1-3 were characterized by IR spectroscopy, PXRD, and thermal methods (TGA/DSC) in the solid state and by 1H and 13C NMR spectroscopy in the DMSO solution In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,5-DibromopyridineIn 2021 ,《Synthesis and Steady State Photophysical Property Analysis of Beads on a Chain (BoC) Silsesquioxane Oligomers Containing Arene and Heteroarene Cross-linkers》 was published in Silicon. The article was written by Mahbub, Shahrea; Furgal, Joseph C.. The article contains the following contents:

Silsesquioxane-based materials are garnering considerable attention due to their unique structural and electronic properties which enable use in diverse fields of study. In this article, a series of hybrid oligomeric materials comprising a silsesquioxane (SQ) backbone linked by conjugated organic cross-linkers were investigated and their photophys. properties in the steady state absorption and emission realms were assessed. Silsesquioxanes improve the thermal and photo stabilities of the organic components, offer enhancements in the molar extinction coefficients of absorption, and have a significant influence on their emission properties. Heck cross-coupling reactions were used to build oligomers with a vinyl/phenylSQ cage backbone linked with a series of different cross-linkers including 2,7-dibromo-9-fluorenone, 2,7-dibromo-9,9-dimethylfluorene, 1,4-dibromo-2,5-dimethoxybenzene, 2,5-dibromopyridine, 2,6-dibromopyridine, 2,3-dibromothiophene, 2,5-dibromothiophene, and 2,5- dibromothieno [3,2-b]thiophene. Each of these linkers showed reasonable conversion to oligomers and exhibited a wide array of fluorescence quantum yield and shifts in the absorption and emission spectra dependent on the variations in substitution position. The study was confined to explore the overall steady state spectral properties of these synthesized hybrid materials in their solution phases. Understanding the basic photophys. processes in these materials will pave the way toward their use in photovoltaic or electroluminescence applications. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2Application In Synthesis of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 81376-84-3On March 31, 1982, Marsais, F.; Le Nard, G.; Queguiner, G. published an article in Synthesis. The article was 《Regioselective o-lithiation of 3-alkoxypyridines; a convenient route to new o-disubstituted pyridines》. The article mentions the following:

Lithiation of 3-alkoxypyridines occurred in the 2-position. The best yields were obtained by treating 3-ethoxypyridine with BuLi in THF in the presence of an equimolar amount of Me2NCH2CH2NMe2. Substitution reactions of the lithiated alkoxypyridines gave I (R = Et, CH2Ph, R1 = SiMe3; R = Et, Me, R1 = CHMeOH; R = Et, Bu, R1 = D; R = Et, R1 = AsMe2, CEt2OH, CH(OH)C6H4OMe-4, CHO). I (R = Et, R1 = CHMeOH) was oxidized to I (R = Et, R1 = Ac). In the experiment, the researchers used 3-Ethoxypicolinaldehyde(cas: 81376-84-3SDS of cas: 81376-84-3)

3-Ethoxypicolinaldehyde(cas: 81376-84-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 81376-84-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Ying, Jun; Fu, Lu-Yang; Zhong, Guoqiang; Wu, Xiao-Feng. Formula: C6H5NO2. The article was titled 《Cobalt-Catalyzed Direct Carbonylative Synthesis of Free (NH)-Benzo[cd]indol-2(1H)-ones from Naphthylamides》. The information in the text is summarized as follows:

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[cd]indol-2(1H)-one scaffolds was developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyl triormate as the CO source, affording various free (NH)-benzo[cd]indol-2(1H)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Metallomics included an article by Qin, Qi-Pin; Wang, Zhen-Feng; Tan, Ming-Xiong; Huang, Xiao-Ling; Zou, Hua-Hong; Zou, Bi-Qun; Shi, Bei-Bei; Zhang, Shu-Hua. Recommanded Product: 1134-35-6. The article was titled 《Complexes of lanthanides(III) with mixed 2,2′-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents》. The information in the text is summarized as follows:

Five novel lanthanides(III) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm) were synthesized in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as chelating ligands. The in vitro cytotoxic activities of five Ln(III) complexes have been studied with SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(III) complex with promising antitumor activity. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phenyldihydropyrazolones as Novel Lead Compounds Against Trypanosoma cruzi》 were Sijm, Maarten; Siciliano de Araujo, Julianna; Kunz, Stefan; Schroeder, Susanne; Edink, Ewald; Orrling, Kristina M.; Matheeussen, An; van de Meer, Tiffany; Sadek, Payman; Custers, Hans; Cotillo, Ignacio; Martin, Julio J.; Siderius, Marco; Maes, Louis; Brown, David G.; de Nazare Correia Soeiro, Maria; Sterk, GeertJan; de Esch, Iwan J. P.; Leurs, Rob. And the article was published in ACS Omega in 2019. HPLC of Formula: 1692-25-7 The author mentioned the following in the article:

As over 6 million people are infected with Chagas disease and only limited therapeutic options are available, there is an urgent need for novel drugs. The involvement of cyclic nucleotide phosphodiesterases (PDE) in the life cycle and biol. fitness of a number of protozoan parasites has been described and several of these enzymes are thought to be viable drug targets. Within this context, a PDE-focused library was screened for its ability to affect the viability of Trypanosoma cruzi parasites. Previously reported human PDE4 inhibitor, 5-(3-(benzyloxy)-4-methoxyphenyl)-2-isopropyl-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one, was identified as a hit. Upon optimization on three positions of the phenylpyrazolone scaffold, 2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (I) proved to be the most active compound against intracellular forms of T. cruzi (pIC50 = 6.4) with a 100-fold selectivity with respect to toxicity towards human MRC-5 cells. Evaluation on different life stages and clin. relevant T. cruzi strains revealed that the phenylpyrazolones are not active against the bloodstream form of the Y strain but show submicromolar activity against the intracellular form of the Y- and Tulahuen strains as well as against the nitro-drug resistant Colombiana strain. In vitro screening of phenylpyrazolones against TcrPDEB1, TcrPDEC and TcrCYP51 showed that there was a poor correlation between enzyme inhibition and the observed phenotypic effect. Amongst the most potent compounds both TcrCYP51 and non-TcrCYP51 inhibitors are identified, which were both equally able to inhibit T. cruzi in vitro. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and physical properties of (trans-TTF-py2)1.5(PF6)·EtOH: a molecular conductor with weak CH···N hydrogen bondings》 was published in Crystals in 2020. These research results belong to Koyama, Shohei; Kawai, Morio; Takaishi, Shinya; Yamashita, Masahiro; Hoshino, Norihisa; Akutagawa, Tomoyuki; Kanno, Manabu; Iguchi, Hiroaki. Related Products of 1122-54-9 The article mentions the following:

The studies of crystal structures with hydrogen bonds have been actively pursued because of their moderate stabilization energy for constructing unique structures. In this study, we synthesized a mol. conductor based on 2,6-bis(4-pyridyl)-1,4,5,8-tetrathiafulvalene (trans-TTF-py2). Two pyridyl groups were introduced into the TTF skeleton toward the structural exploration in TTF-based mol. conductors involved by hydrogen bonds. In the obtained mol. conductor, (trans-TTF-py2)1.5(PF6)·EtOH, short contacts between the pyridyl group and the hydrogen atom of the TTF skeleton were observed, indicating that hydrogen bonding interactions were introduced in the crystal structure. Spectroscopic measurements and conductivity measurement revealed semiconducting behavior derived from p-stacked trans-TTF-py2 radical in the crystal structure. Finally, these results are discussed with the quantified hydrogen bonding stabilization energy, and the band calculation of the crystal obtained from d. functional theory calculation4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-pot synthesis of 2,2′ -dipicolylamine derived highly photoluminescent nitrogen-doped carbon quantum dots for Fe3+ detection and fingermark detection》 was published in Nanotechnology in 2020. These research results belong to Li, Quan; Guo, Zhiwei; Zhao, Xiaoyan; Zhang, Taoyi; Chen, Jing; Wei, Yun. Related Products of 1539-42-0 The article mentions the following:

The novel nitrogen-doped carbon quantum dots (N-CQDs) with high fluorescence quantum yield of 23.2% were successfully prepared via a simple hydrothermal reaction with citric acid and 2,2′ -dipicolylamine. The as-prepared blue fluorescent N-CQDs had excellent water dispersibility, and showed pH and excitation-dependent emission behaviors. Noticeably, owing to the strong interaction between the residual 2,2′ -dipicolylamine group on the surface of N-CQDs and Fe3+, the N-CQDs could be used as a turn off fluorescence probe for Fe3+ sensing through an electron transfer process. Moreover, the photoluminescent N-CQDs/poly(vinyl alc.) film was further applied for latent fingermark imaging. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem