Month: November 2022

《Synthesis of pyridine-bridged bisferrocene and its pH value adjustable photoelectric properties》 was written by Ma, Jingjing; Zhai, Yali; Chen, Jiahui; Zhou, Xiang; Shi, Weimin; Zhang, Jianye; Li, Gaiping; Hou, Hong wei. Application In Synthesis of 2,6-Dibromopyridine And the article was included in Tetrahedron in 2020. The article conveys some information:

Four bisferrocenyl pyridine derivatives 2, 6-bis(ferrocenylethynyl) pyridine (3), 2, 6-bis (ferrocenylbutadiynyl) pyridine (8), 2, 6-bis (ferrocenylhexyltriynyl) pyridine (9), 2, 5-bis (ferrocenylbutadiynyl) pyridine (14) were synthesized and photoelec. properties of these compounds were studied. UV-visible spectroscopic, 3rd-order nonlinear optical property and electrochem. studies revealed that the photoelec. properties of these compounds would change significantly by adjusting pH. Compared with neutral conditions, lower-energy metal-to-ligand charge transfer (MLCT) transition was stronger, the oxidation potential shift neg., a luminescence increase and 3rd-order nonlinear optical properties were stronger under acidic conditions. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Effect of Substitution at Amine Functionality of 2,6-Diaminopyridine-Coupled Rhodamine on Metal-Ion Interaction and Self-Assembly》 was written by Panja, Santanu; Mondal, Subhendu; Ghosh, Sourav; Ghosh, Utpal; Ghosh, Kumaresh. Product Details of 141-86-6 And the article was included in ACS Omega in 2020. The article conveys some information:

2,6-Diaminopyridine-coupled rhodamines I and II have been synthesized, and the effect of substitution on amine functionality toward metal-ion interactions and self-assembly is thoroughly investigated. Both the compounds effectively recognize different metal ions of biol. significance fluorimetrically and colorimetrically with a high degree of selectivity and sensitivities. While compound I is sensitive to Fe3+ ions, compound II is responsive to both Fe3+ and Al3+ ions in aqueous CH3CN (4/1, volume/volume; 10 mM tris HCl buffer, pH 6.8). The sensing mechanism involves the metal-ion chelation-induced spirolactam ring opening of the rhodamine scaffold that results in both color and fluorescence changes, while the extent of interactions with the metal ions is truly governed by the chem. structure of the compounds Both I and II are proficient in detecting Fe3+ and Al3+ ions in human lung cancer cells (A549). As new findings, unlike I, compound II formed a faint pink gel in the toluene-hexane mixture solvent (1:1, volume/volume), and the gel state of II selectively recognizes Ag+ ions by exhibiting a phase change from gel to purple soluble Exptl. findings establish the role of the formamide moiety in forming the self-assembly. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xue; Bai, Fang; Liu, Chaogan; Ma, Xiaowei; Gu, Chengzhi; Dai, Bin published their research in Organic Letters in 2021. The article was titled 《Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls》.Safety of 4-Acetylpyridine The article contains the following contents:

An efficient electrochem. method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, e.g., p-chlorotoluene, methylheteroarenes, e.g., 6-methylquinoline and benzylic (hetero)methylenes, e.g., p-ethyltoluene could be converted into the desired aryl aldehydes, e.g., 4-chlorobenzaldehyde/e.g., quinoline-6-carbaldehyde and aryl ketones, e.g., 1-(p-tolyl)ethan-1-one in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Jiale; Yuan, Tao; Zheng, Meifang; Wang, Xinchen published their research in ACS Catalysis in 2021. The article was titled 《Metal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids》.COA of Formula: C6H4N2 The article contains the following contents:

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Liu, Wenbo; Tao, Ouyang; Chen, Li; Ling, Yun; Zeng, Ming; Jin, Hongguang; Jiang, Dengzhao published an article in RSC Advances. The title of the article was 《Synthesis and characterization of a Cu(II) coordination-containing TAM radical as a nitroxyl probe》.Related Products of 1539-42-0 The author mentioned the following in the article:

Nitroxyl (HNO) has been identified as an important signaling mol. in biol. systems, and it plays critical roles in many physiol. processes. However, its detection remains challenging because of the limited sensitivity and/or specificity of existing detection methods. Low-frequency ESR (EPR) spectroscopy and imaging, coupled with the use of exogenous paramagnetic probes, have been indispensable techniques for the in vivo measurement of various physiol. parameters owing to their specificity, noninvasiveness and good depth of magnetic field penetration in animal tissues. However, the in vivo detection of HNO levels by EPR spectroscopy and imaging is limited due to the need for improved probes. We report the first “”turn on-response”” EPR probe for HNO utilizing a Cu(II) coordination-containing TAM radical (denoted as CuII[TD1]). Upon reaction with HNO, CuII[TD1] shows a 16.1-fold turn-on in EPR signal with a low detection limit of 1.95 μM. Moreover, low-temperature EPR spectroscopic and ESI-MS studies showed that the sensing mechanism relies on the reduction of Cu(II) by HNO. Lastly, CuII[TD1] is selective for HNO over other reactive nitrogen and oxygen species except for some reductants (Cys and Asc). This new Cu(II) coordination-containing TAM radical shows great potential for in vivo EPR HNO applications in the absence of reducing agents and provides insights into developing improved and targeted EPR HNO probes for biomedical applications. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Fan, Weibin; Zhang, Yuan; Li, Yinghua; Zhang, Wei; Huang, Deguang published an article in ChemSusChem. The title of the article was 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》.Computed Properties of C7H7NO The author mentioned the following in the article:

A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,He, Tao; Kong, Xiang-Jing; Bian, Zhen-Xing; Zhang, Yong-Zheng; Si, Guang-Rui; Xie, Lin-Hua; Wu, Xue-Qian; Huang, Hongliang; Chang, Ze; Bu, Xian-He; Zaworotko, Michael J.; Nie, Zuo-Ren; Li, Jian-Rong published an article in Nature Materials. The title of the article was 《Trace removal of benzene vapour using double-walled metal-dipyrazolate frameworks》.Product Details of 624-28-2 The author mentioned the following in the article:

In principle, porous physisorbents are attractive candidates for the removal of volatile organic compounds such as benzene by virtue of their low energy for the capture and release of this pollutant. Unfortunately, many physisorbents exhibit weak sorbate-sorbent interactions, resulting in poor selectivity and low uptake when volatile organic compounds are present at trace concentrations Herein, we report that a family of double-walled metal-dipyrazolate frameworks, BUT-53 to BUT-58, exhibit benzene uptakes at 298 K of 2.47-3.28 mmol g-1 at <10 Pa. Breakthrough experiments revealed that BUT-55, a supramol. isomer of the metal-organic framework Co(BDP) (H2BDP = 1,4-di(1H-pyrazol-4-yl)benzene), captures trace levels of benzene, producing an air stream with benzene content below acceptable limits. Furthermore, BUT-55 can be regenerated with mild heating. Insight into the performance of BUT-55 comes from the crystal structure of the benzene-loaded phase (C6H6@BUT-55) and d. functional theory calculations, which reveal that C-H···X interactions drive the tight binding of benzene. Our results demonstrate that BUT-55 is a recyclable physisorbent that exhibits high affinity and adsorption capacity towards benzene, making it a candidate for environmental remediation of benzene-contaminated gas mixtures In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Xia, Jianshe; Lee, Margaret; Santos, Peter J.; Horst, Nathan; Macfarlane, Robert J.; Guo, Hongxia; Travesset, Alex published an article in Soft Matter. The title of the article was 《Nanocomposite tectons as unifying systems for nanoparticle assembly》.Related Products of 141-86-6 The author mentioned the following in the article:

Nanocomposite tectons (NCTs) are nanocomposite building blocks consisting of nanoparticle cores functionalized with a polymer brush, where each polymer chain terminates in a supramol. recognition group capable of driving particle assembly. Like other ligand-driven nanoparticle assembly schemes (for example those using DNA-hybridization or solvent evaporation), NCTs are able to make colloidal crystal structures with precise particle organization in three dimensions. However, despite the similarity of NCT assembly to other methods of engineering ordered particle arrays, the crystallog. symmetries of assembled NCTs are significantly different. In this study, we provide a detailed characterization of the dynamics of hybridizations through universal (independent of microscopic details) parameters. We perform rigorous free energy calculations and identify the persistence length of the ligand as the critical parameter accounting for the differences in the phase diagrams of NCTs and other assembly methods driven by hydrogen bond hybridizations. We also report new experiments to provide direct verification for the predictions. We conclude by discussing the role of non-equilibrium effects and illustrating how NCTs provide a unification of the two most successful strategies for nanoparticle assembly: solvent evaporation and DNA programmable assembly. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DiaminopyridineIn 2020 ,《New Pyridine-Bridged Ferrocene-Rhodamine Receptor for the Multifeature Detection of Hg2+ in Water and Living Cells》 appeared in ACS Omega. The author of the article were Guo, Yu-Shuang; Zhao, Mei; Wang, Qiong; Chen, Yu-Qin; Guo, Dian-Shun. The article conveys some information:

A challenge in the design of optical and redox-active receptors is how to combine a specific recognition center with an efficient responsive system to facilely achieve multifeature detection in biol. and environmental analyses. Herein, a novel ferrocene-rhodamine receptor conjugated with a pyridine bridge was designed and synthesized. This receptor can sensitively sense Hg2+ in aqueous media via chromogenic, fluorogenic, and electrochem. multisignal outputs with a low detection limit and fast response time. Moreover, it can be qualified as a fluorescent probe for effectively monitoring Hg2+ in living cells. A plausible recognition mode was proposed and rationalized with theor. calculations In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2019 ,《Synthesis of Secondary Aldimines from the Hydrogenative Cross-Coupling of Nitriles and Amines over Al2O3-Supported Ni Catalysts》 was published in ACS Catalysis. The article was written by Zhou, Peng; Jiang, Liang; Wang, Shuguo; Hu, Xun; Wang, Hongming; Yuan, Ziliang; Zhang, Zehui. The article contains the following contents:

A heterogeneous Ni catalyst was discovered to be active in the synthesis of secondary cross-imines via hydrogenative coupling of nitriles and amines. The mesoporous Al2O3-supported Ni nanoparticles (abbreviated as Ni/m-Al2O3-600, where 600 represents the reduction temperature) were active in hydrogenative coupling of nitriles and amines reaction at 80 °C and 1 bar H2, affording corresponding cross-imines with yields in the range 64.1-98.1%. D. functional theory calculations reveal the hydrogenation of benzonitrile (PhCN) to benzylamine (PhCH2NH2) has higher activation energy than that for hydrogenative cross-coupling of PhCN and RNH2 on the Ni/m-Al2O3-600 catalyst, suggesting the latter reaction is more favorable. The theor. calculations are in good agreement with our exptl. results. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem