Month: November 2022

Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridineIn 2021 ,《Reversible Stimuli-Dependent Aggregation-Induced Emission from a “”Nonfluorescent”” Amphiphilic PVDF Graft Copolymer》 was published in Langmuir. The article was written by Pakhira, Mahuya; Chatterjee, Dhruba P.; Mallick, Dibyendu; Ghosh, Radhakanta; Nandi, Arun K.. The article contains the following contents:

A poly(vinylidine fluoride) graft random copolymer of t-Bu aminoethyl methacrylate (tBAEMA) and oligo(ethylene glycol) Me ether methacrylate (OEGMA, Mn = 300) [PVDF-g-P(tBAEMA-ran-OEGMA), PVBO] is synthesized by atom transfer radical polymerization (ATRP), and PVBO is fractionated to get a highly water-soluble fraction (PVBO-1) showing a reversible on/off fluorescence behavior with gradual increase and decrease in pH, resp., achieving a maximum quantum yield of 0.18 at pH = 12. PVBO-1 dissolved in water shows large multimicellar aggregates (MMcA), but at pH 12, crumbling of larger aggregates to much smaller micelles occurs, forming nonconjugated polymer dots (NCPDs), as supported by transmission electron microscopy and dynamic light scattering study. The reversible fluorescence on/off behavior also occurs with the decrease and increase of temperature Theor. study indicates that, at high pH, most of the amino groups become neutral and exhibit a strong tendency to form aggregates from crowding of a large number of carbonyl and amine groups, minimizing the HOMO-LUMO gap, showing an absorption peak at the visible region, and generating aggregation-induced emission.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H7N3In 2022 ,《Ruthenium Complexes Bearing α-Diimine Ligands and Their Catalytic Applications in N-Alkylation of Amines, α-Alkylation of Ketones, and β-Alkylation of Secondary Alcohols》 was published in ACS Omega. The article was written by Gayathri, Sekar; Viswanathamurthi, Periasamy; Bertani, Roberta; Sgarbossa, Paolo. The article contains the following contents:

New Ru(II) complexes encompassing α-diimine ligands were synthesized by reacting ruthenium precursors with α-diimine hydrazones. The new ligands and Ru(II) complexes were analyzed by anal. and various spectroscopic methods. The mol. structures of L1 and complexes 1, 3, and 4 were determined by single-crystal XRD studies. The results reveal a distorted octahedral geometry around the Ru(II) ion for all complexes. Also, the new ruthenium complexes show efficient catalytic activity toward the C-N and C-C coupling reaction involving alcs. Particularly, complex 3 demonstrates effective conversion in N-alkylation of aromatic amines, α-alkylation of ketones, and β-alkylation of alcs. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Abel, Anton S.; Averin, Alexei D.; Buryak, Alexei K.; Savelyev, Evgenii N.; Orlinson, Boris S.; Novakov, Ivan A.; Beletskaya, Irina P. published 《The Palladium-Catalyzed Heteroarylation of Adamantylalkyl Amines with Dihalogenopyridines: Scope and Limitations》.Synthesis published the findings.SDS of cas: 53939-30-3 The information in the text is summarized as follows:

Palladium-catalyzed heteroarylation of adamantylalkyl amines characterized by different steric hindrances at the amino group was carried out using 2,3-, 2,5-, 2,6-, and 3,5-dihalogenopyridines. The dependence of the results of the coupling on the nature of the halogen atoms (bromine, chlorine), their position in the pyridine ring, and on the structure of adamantylalkyl amines was investigated. The application of dichloropyridines or bromochloropyridines was shown to be advantageous over the use of dibromopyridines in many cases. Selective substitution of bromine atom in positions 3 and 5 in the presence of chlorine atom in position 2 of the pyridine ring was observed The possibility of N,N-diheteroarylation of adamantane-containing amines with 2,5-dihalogenopyridines was shown, and diamination of 2,6- and 3,5-dihalogenopyridines was demonstrated.5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Odingo, Joshua; Bailey, Mai A.; Files, Megan; Early, Julie V.; Alling, Torey; Dennison, Devon; Bowman, Julie; Dalai, Suryakanta; Kumar, Naresh; Cramer, Jeffrey; Masquelin, Thierry; Hipskind, Philip A.; Parish, Tanya published 《In Vitro Evaluation of Novel Nitazoxanide Derivatives against Mycobacterium tuberculosis》.ACS Omega published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:

Nitazoxanide has antiparasitic and antibiotic activities including activity against Mycobacterium tuberculosis. We prepared and evaluated a set of its analogs to determine the structure-activity relationship, and identified several amide- and urea-based analogs with low micromolar activity against M. tuberculosis in vitro. Pharmacokinetics in the rat suggested a path forward to obtain bioavailable compounds The series had a good microbiol. profile with bactericidal activity in vitro against replicating and nonreplicating M. tuberculosis. Analogs had limited activity against other Gram-pos. bacteria but no activity against Gram-neg. bacteria. Our studies identified the key liability in this series as cytotoxicity. Future work concentrating on identifying the target(s) could assist in removing activity against eukaryotic cells. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Gao, Jie; Bhunia, Subhajit; Wang, Kailiang; Gan, Lu; Xia, Shanghua; Ma, Dawei published 《Discovery of N-(Naphthalen-1-yl)-N’-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers》.Organic Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

In the presence of Cu2O and the oxalamide I, aryl- and heteroaryl bromides and iodides were aminated chemoselectively with primary amines (alkyl favored over aryl), ammonium hydroxide, and secondary cyclic amines and N-methylbenzylamine using KOH in EtOH at 50-80° to yield aryl- and heteroarylamines such as N-benzyl-p-anisidine in 35-98% yields using 0.1-0.5 mol% of Cu2O. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Science included an article by Jin, Bo; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Safety of 5-Bromo-2-chloropyridine. The article was titled 《ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors》. The information in the text is summarized as follows:

A new catalyst was developed for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions. Both the palladium pre-catalyst and ligand are com. available, bench stable, and highly cost-effective. The catalyst is applicable to reactions of both aryl- and heteroaryl bromides. A wide range of functional groups are tolerated and the aqueous reaction medium can be recycled. An application of this procedure to the synthesis of a key intermediate to an active pharmaceutical ingredient (ponatinib) is discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Food Chemistry included an article by Wu, Xiaoming; Wang, Hao; Yang, Shaoxiang; Tian, Hongyu; Liu, Yongguo; Sun, Baoguo. Product Details of 98-98-6. The article was titled 《A novel coumarin-based fluorescent probe for sensitive detection of copper(II) in wine》. The information in the text is summarized as follows:

A novel coumarin-based fluorescent probe (probe 1) for the detection of copper(II) was developed. The fluorescence intensity of probe 1 showed a linear relationship with the concentration of copper(II) in the range 0-16μM (0-1.02 mg/L) and the limit of detection was 62 nM (3.94μg/L). The luminescence of probe 1 at the maximum allowable amounts of copper(II) in wine and water could be observed with the naked eye under a 365-nm UV lamp. Moreover, probe 1 was successfully used for the qual. and quant. detection of copper(II) in wine. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《General synthesis of primary amines via reductive amination employing a reusable nickel catalyst》 were Hahn, G.; Kunnas, P.; de Jonge, N.; Kempe, R.. And the article was published in Nature Catalysis in 2019. Application of 1122-54-9 The author mentioned the following in the article:

A nanostructured nickel catalyst was reported for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. The catalyst, which operated at low temperature and pressure, was highly active, reusable and easy to handle. The synthesis from a specific nickel complex and γ-Al2O3 was straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones could all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products was demonstrated. Many functional groups-including hydrogenation-sensitive examples-were tolerated. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer》 were Zhao, Zhicong; Shang, Dongsheng; Qiu, Lipeng; Guo, Chang; Li, Yanyan; Liu, Hanqing; Yuan, Guoyue; Tu, Zhigang. And the article was published in Life Sciences in 2019. Synthetic Route of C6H5NO2 The author mentioned the following in the article:

Gastric cancer (GC) is a common cancer with a relatively low survival rate. Cellular senescence, a potent anti-cancer mechanism, is naturally occurred, and can be induced by chemotherapeutic agents. We sought to explore new compounds against GC cells by inducing cellular senescence. Primary screening of a library of N-heterocyclic compounds identified some with potent inhibitory effects on GC cells. Furthermore, in vitro effects of the most potent candidate compound on the proliferation and senescence of GC cells were studied by classical assays, including senescence-associated (SA)-beta-galactosidase staining, and immunofluorescence; and in vivo effects of this compound was evaluated in a xenograft tumor mouse model. Among 43 tested compounds, 4,5-diphenyl-2-Me picolinate (DMP) showed the highest inhibition effects on the growth of GC cells. In vitro experiments showed that DMP inhibited the proliferation by inducing senescence and DNA-damage associated protein markers and signaling pathways. In vivo experiment confirmed that DMP treatment inhibited tumor growth by promoting DNA-damage signaling. This study set up a platform to identify senescence-inducing anti-cancer compounds, and uncovers that DMP exerted anticancer effects by inducing cellular senescence through targeting DNA damage and associated signaling pathways in GC cancer. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Synthetic Route of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Synthetic Route of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic Dehydrosulfurization of Thioamides to Nitriles by Gold Nanoparticles Supported on Carbon Nanotubes》 were Gopi, Elumalai; Geertsen, Valerie; Gravel, Edmond; Doris, Eric. And the article was published in ChemCatChem in 2019. Application of 100-48-1 The author mentioned the following in the article:

A gold-carbon nanotube nanohybrid was shown to act as an efficient heterogeneous catalyst in the smooth and selective conversion of thioamides to the corresponding nitriles. The reaction was performed under mild conditions (room temperature, atm. pressure of oxygen) using only a gold loading of 0.35 mol %. Substituted aromatic or aliphatic nitriles were produced in very good to excellent yields and the catalyst could be easily recycled and reused over several consecutive cycles with no loss in dehydrosulfurization performances. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem