Month: November 2022

In 2022,Li, Jia-Yi; Wang, Li; Yin, Li-Ping; Jiang, Xin-Meng; Guo, Kai; Zhang, Chun; Yu, Shan-Shan; Yu, Xiao-Qi; Wang, Qin published an article in ChemistryOpen. The title of the article was 《A Racemic Naphthyl-Coumarin-Based Probe for Quantitative Enantiomeric Excess Analysis of Amino Acids and Enantioselective Sensing of Amines and Amino Alcohols》.Product Details of 31106-82-8 The author mentioned the following in the article:

A new racemic naphthyl-coumarin-based probe was found to bind covalently with amino acids in MeOH-KOH system and thereby generates distinct CD responses. The induced strong CD signals allowed quant. enantiomeric excess anal. of amino acids and enantioselective sensing of amines and amino alcs. The mechanism for the reaction of the coumarin-aldehyde probe with an amino acid was investigated by CD, UV-Vis, NMR, ESI-MS analyses and ECD calculation2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C12H13N3In 2021 ,《Electronic effects on polypyridyl Co complex-based water reduction catalysts》 appeared in RSC Advances. The author of the article were Guo, Xusheng; Li, Chao; Wang, Weibo; Zhang, Baowen; Hou, Yuanjun; Wang, Xuesong; Zhou, Qianxiong. The article conveys some information:

Three new isomeric cobalt complexes of TPA (tris(2-pyridylmethyl)amine) based on methoxy substitution at the ortho, meta and para positions, resp., were constructed and their photocatalytic proton reduction efficiencies were compared. It was found that there are good linear correlations with the Hammett constants of the substituents for the computed Co-N bond lengths, redox potentials of CoII/I and CoI/0 events, and the photocatalytic activities of the complexes. The ortho-substituted Co complex distinguished itself from the others remarkably in all these comparisons, demonstrating the presence of a steric effect besides the electronic effect. For other examined complexes, a stronger electron-donating substituent may lead to a higher hydrogen evolution efficiency, suggesting that the formation of a Co(III) hydride intermediate is the rate-limiting step. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-AcetylpyridineIn 2021 ,《Chiral Iron(II)-Catalysts within Valinol-Grafted Metal-Organic Frameworks for Enantioselective Reduction of Ketones》 appeared in ACS Catalysis. The author of the article were Antil, Neha; Akhtar, Naved; Newar, Rajashree; Begum, Wahida; Kumar, Ajay; Chauhan, Manav; Manna, Kuntal. The article conveys some information:

The development of highly efficient and enantioselective heterogeneous catalysts based on earth-abundant elements and inexpensive chiral ligands is essential for environment-friendly and economical production of optically active compounds The authors report a strategy of synthesizing chiral amino alc.-functionalized metal-organic frameworks (MOFs) to afford highly enantioselective single-site base-metal catalysts for asym. organic transformations. The chiral MOFs (vol-UiO) were prepared by grafting of chiral amino alc. such as L-valinol within the pores of aldehyde-functionalized UiO-MOFs via formation of imine linkages. The metalation of vol-UiO with FeCl2 in THF gives amino alc. coordinated octahedral FeII species of vol-FeCl(THF)3 within the MOFs as determined by x-ray absorption spectroscopy. Upon activation with LiCH2SiMe3, vol-UiO-Fe catalyzed hydrosilylation and hydroboration of a range of aliphatic and aromatic carbonyls to afford the corresponding chiral alcs. with enantiomeric excesses up to 99%. Vol-UiO-Fe catalysts have high turnover numbers of up to 15,000 and could be reused at least 10 times without any loss of activity and enantioselectivity. The spectroscopic, kinetic, and computational studies suggest iron-hydride as the catalytic species, which undergoes enantioselective 1,2-insertion of carbonyl to give an iron-alkoxide intermediate. The subsequent σ-bond metathesis between Fe-O bond and Si-H bond of silane produces chiral silyl ether. This work highlights the importance of MOFs as the tunable mol. material for designing chiral solid catalysts based on inexpensive natural feedstocks such as chiral amino acids and base-metals for asym. organic transformations. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2019 ,《Nitrogen-Doped Carbon-Supported Nickel Nanoparticles: A Robust Catalyst to Bridge the Hydrogenation of Nitriles and the Reductive Amination of Carbonyl Compounds for the Synthesis of Primary Amines》 appeared in ChemSusChem. The author of the article were Zhang, Yangmin; Yang, Hanmin; Chi, Quan; Zhang, Zehui. The article conveys some information:

An efficient method was developed for the synthesis of primary amines either from the hydrogenation of nitriles or reductive amination of carbonyl compounds The reactions were catalyzed by nitrogen-doped mesoporous carbon (MC)-supported nickel nanoparticles (abbreviated as MC/Ni). The MC/Ni catalyst demonstrated high catalytic activity for the hydrogenation of nitriles into primary amines in high yields (81.9-99 %) under mild reaction conditions (80° and 2.5 bar H2). The MC/Ni catalyst also promoted the reductive amination of carbonyl compounds for the synthesis of primary amines at 80° and 1 bar H2. The hydrogenation of nitriles and the reductive amination proceeded through the same intermediates for the generation of the primary amines. To the best of knowledge, no other heterogeneous non-noble metal catalysts have been reported for the synthesis of primary amines under mild conditions, both from the hydrogenation of nitriles and reductive amination. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2In 2019 ,《Lewis Acid-Catalyzed Selective Reductive Decarboxylative Pyridylation of N-Hydroxyphthalimide Esters: Synthesis of Congested Pyridine-Substituted Quaternary Carbons》 appeared in ACS Catalysis. The author of the article were Gao, Liuzhou; Wang, Guoqiang; Cao, Jia; Chen, Hui; Gu, Yuming; Liu, Xueting; Cheng, Xu; Ma, Jing; Li, Shuhua. The article conveys some information:

A practical and efficient Lewis acid-catalyzed radical-radical coupling reaction of N-hydroxyphthalimide esters and 4-cyanopyridines with inexpensive bis(pinacolato)diboron as reductant has been developed. With ZnCl2 as the catalyst, a wide range of quaternary 4-substituted pyridines, including highly congested diarylmethyl and triarylmethyl substituents, could be selectively obtained in moderate to good yields with broad functional group tolerance. Combined theor. calculations and exptl. studies indicate that the Lewis acid could coordinate with the cyano group of the pyridine-boryl radical to lower the activation barrier of the C-C coupling pathway, leading to the formation of 4-substituted pyridines. Moreover, it could also facilitate the decyanation/aromatization of the radical-radical coupling intermediate. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1134-35-6In 2020 ,《Effect of fluoro-substituted acceptor-based ancillary ligands on the photocurrent and photovoltage in dye-sensitized solar cells》 was published in Solar Energy. The article was written by Ashraf, Saba; Su, Rui; Akhtar, Javeed; Siddiqi, Humaira M.; Shuja, Ahmed; El-Shafei, Ahmed. The article contains the following contents:

Herein, we report four novel heteroleptic ruthenium (II) complexes, namely SD-7 to SD-10, containing fluoro- and trifluoro- Me antennas as substituents on the ancillary ligands for dye-sensitized solar cells, and were compared to the benchmark dye N719. Photosensitizers (dyes) SD-7 to SD-10 were synthesized according to a typical one-pot three-step procedure with the corresponding ancillary ligands (LS-7 to LS-10). All the dyes were characterized by ATR-FTIR, 1H NMR and mass spectrometry. Furthermore, the photophys., electrochem. and photovoltaic performances were compared with N719. The band gaps, ground and excited state oxidation potentials were measured. The photovoltaic performance of the dyes showed that SD-7 with five fluorine atoms and SD-8 with -CF3 at the -ortho position of the Ph moiety outperformed the benchmark dye N719 with the efficiencies of 8.03% and 8.17%, resp., with c.d. of 19.57 and 19.46 mA•cm-2, resp., and open-circuit voltages of 0.65 V and 0.69 V, resp., under optimized conditions. The fabricated solar devices at lab-scale showed a systematic trend of decreasing JSC when the fluoro-substituted dyes were sensitized on TiO2: SD-7 (with five -F) > SD-8 (with one -CF3 at ortho position) > SD-9 (with one -CF3 at para position) > SD-10 (with two -CF3, one at ortho and one at para position). This can be attributed to the greater number of fluorine atoms directly attached to sp2 hybridized carbon atoms, which greatly enhanced the dipole moment and intimate electronic coupling of SD-7 with TiO2 nanoparticles leading to better photocurrent d. In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Pyridin-3-ylboronic acidIn 2020 ,《Sequential C-S and S-N Coupling Approach to Sulfonamides》 was published in Organic Letters. The article was written by Chen, Kai; Chen, Wei; Han, Bing; Chen, Wanzhi; Liu, Miaochang; Wu, Huayue. The article contains the following contents:

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides RNHS(O)2R1 [R = Ph, 3-pyridyl, 1-naphthyl, etc.; R1 = Ph, 2-thienyl, 2-naphthyl, etc.] was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts. In the experiment, the researchers used Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Jun; Ji, Shun-Jun; Teo, Yong-Chua; Loh, Teck-Peng published an article on January 6 ,2005. The article was titled 《Highly Enantioselective Allylation of Aldehydes Catalyzed by Indium(III)-PYBOX Complex》, and you may find the article in Organic Letters.Safety of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine The information in the text is summarized as follows:

A chiral indium(III)-PYBOX complex prepared from indium triflate and chiral PYBOX has been discovered to effect high enantioselectivities in the addition of allyltributylstannane to aldehydes. The allylation of a variety of aromatic, α,β-unsaturated, and aliphatic aldehydes resulted in good yields and high enantioselectivities (up to 94% ee). After reading the article, we found that the author used 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7Safety of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Lei; Liu, Fu-Yue; Zhang, Qi; Chang, Wei-Jun; Liu, Zhong-Lin; Lv, Ying; Yu, Hai-Zhu; Xu, Jun; Dai, Jian-Jun; Xu, Hua-Jian published an article on January 31 ,2021. The article was titled 《The amine-catalysed Suzuki-Miyaura-type coupling of aryl halides and arylboronic acids》, and you may find the article in Nature Catalysis.Product Details of 39856-58-1 The information in the text is summarized as follows:

A robust and chemoselective organocatalytic Suzuki-Miyaura-type coupling of aryl halides viz. Me 2-(4-bromophenyl)propanoate, Me 2-(4-chlorophenyl)propanoate, 5-bromopyrimidine, etc. with arylboronic acids viz. phenylboronic acid, naphthalen-2-ylboronic acid, furan-3-ylboronic acid, etc. catalyzed by amines, e.g. 2-methyl-N1,N3-di-o-tolylbenzene-1,3-diamine was reported. The utility and scope of this reaction were demonstrated by the synthesis of several com. relevant small mols. viz. Me 2-([1,1′-biphenyl]-4-yl)propanoate, Me 2-(4-(naphthalen-2-yl) phenyl)propanoate, 5-(furan-3-yl)pyrimidine, etc. and a selection of derivatives of pharmaceutical drugs e.g., Boscalid. The experimental process involved the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Product Details of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Product Details of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Luo, Kui; Cao, Tongxiang; Jiang, Huanfeng; Chen, Lianfen; Zhu, Shifa published 《Gold-Catalyzed Ring Expansion of Enyne-Lactone: Generation and Transformation of 2-Oxoninonium》.Organic Letters published the findings.Name: 2-Bromonicotinaldehyde The information in the text is summarized as follows:

An efficient gold-catalyzed ring-expansion reaction of enyne-lactones to form 2-oxoninonium intermediates is reported. The 2-oxoninonium generated in this work could undergo further 6π electrocyclization and aromatization reaction to produce different aromatic compounds In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Name: 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem