Month: November 2022

In 2022,Dahiya, Amit; Schoenebeck, Franziska published an article in Organic Letters. The title of the article was 《Direct C-H Dehydrogenative Germylation of Terminal Alkynes with Hydrogermanesã€?Computed Properties of C7H5N The author mentioned the following in the article:

A direct C(sp)-H germylation of terminal alkynes with tri-Et Ge hydride is reported. The method is operationally simple and makes use of B(C6F5)3 catalysis in combination with 2,6-lutidine as an organic base. Exclusive selectivity for dehydrogenative germylation of the alkyne over the competing hydrogermylation is observed The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-CyanopyridineIn 2021 ,《Transition metal-free NaOH-catalyzed hydration of nitriles to primary amides in NH3·H2O-DMSO mixtureã€?appeared in Molecular Diversity. The author of the article were Wang, Nan; Ma, Peilong; Xie, Jianwei; Zhang, Jie. The article conveys some information:

An efficient protocol for hydration of aryl(hetero)/alkyl nitriles RCN (R = Bu, cyclohexyl, thiophen-2-yl, 4-chlorophenyl, etc.) toward primary amides RC(O)NH2 with 0.1 equivalent was reported. NaOH in NH3·H2O-DMSO under mild conditions is used. Various substituted nitriles are smoothly converted to the corresponding amides with good to excellent isolated yields. Gram-scale reactions were also performed to produce the desired products in high yields. In addition, the excessive hydrolysis of the benzonitrile to form benzoic acid was also achieved with increasing the amount of NaOH and prolonging the reaction time. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-Bromo-5-methylpyridineIn 2019 ,《Systematic investigation of hydrogen-bond propensities for informing co-crystal design and assemblyã€?appeared in CrystEngComm. The author of the article were Sarkar, Nandini; Sinha, Abhijeet S.; Aakeroy, Christer B.. The article conveys some information:

Co-crystallizations can be utilized for generating new solid forms of a target substance in order to alter or enhance some specific bulk phys. property. Generally, selection of the co-former (the necessary partner for the target mol.) is based on existing structural information about mol. recognition events involving complementary functional groups, and extensive exptl. screening methods. In this study, we utilize structure-informatics in an attempt to predict if two different mols. will form a co-crystal or not. Our study is based on hydrogen-bond propensity (HBP), and the key premise of our approach rests on whether target-co-former interactions are more likely to take place than either target-target or co-former-co-former hydrogen bonds. We examined six different target mols. in combination with 25 possible co-formers each and used the HBP protocol for predicting if a co-crystal would form or not. The predictions were then compared with results from an exptl. co-crystal screen of the 150 different combinations. The correct outcome was successfully predicted 92-95% of the time which shows that for this series of small mols., HBP is a very reliable indicator for determining if a co-crystal will form between a target mol. and a particular co-former. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of Methyl 5-bromopicolinateIn 2005 ,《Ligand creation via linking – a rapid and convenient method for construction of novel supported PyOX-ligandsã€?appeared in Tetrahedron. The author of the article were Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M. P.. The article conveys some information:

A novel, tyrosine-derived, supported amino alc. linker was synthesized and used for attachment of picolinic acid derivatives onto different supports. When the resin bound mol. was further activated, the PyOX-moiety could be constructed reliably in enantiopure form. Furthermore, an efficient Pd-catalyzed modification of a picolinic acid derivative is presented. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100-48-1In 2021 ,《Electroreductive C3 Pyridylation of Quinoxalin-2(1H)-ones: An Effective Way to Access Bidentate Nitrogen Ligandsã€?appeared in Organic Letters. The author of the article were Wen, Jiangwei; Yang, Xiaoting; Yan, Kelu; Qin, Hongyun; Ma, Jing; Sun, Xuejun; Yang, Jianjing; Wang, Hua. The article conveys some information:

A simple and practical electroreductive-induced C3 pyridylation of quinoxalin-2(1H)-ones with readily available cyanopyridines was reported. More than 36 examples were supplied, and the reaction performed in >95% yield. The present protocol provided a convenient, efficient and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands I [R = H, Me, F, etc.; R1 = H, Me, Cl; R2 = H, Me, Ph, etc.; R3 = H, Me; R4 = 4-pyridyl, 2-chloro-4-pyridyl, 1-isoquinolyl, etc.; RR1 = CH=CH-CH=CH]. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 3510-66-5In 2019 ,《Palladium-Catalyzed Hydrocarbonylative Cyclization Enabled by Formal Insertion of Aromatic C=N Bonds into Pd-Acyl Bondsã€?appeared in Organic Letters. The author of the article were Zhou, Xibing; Chen, Anrong; Du, Wei; Wang, Yawen; Peng, Yu; Huang, Hanmin. The article conveys some information:

An efficient new formal insertion strategy via combination of reductive elimination and oxidative addition sequence was reported, in which the transient N-acyliminium ions formed via hydrocarbonylation function as key intermediates. This strategy has enabled a novel palladium-catalyzed hydrocarbonylative cyclization of azaarene-tethered alkenes or dienes via sequential insertion of a C=C bond, CO, and a C=N bond into palladium-hydride bonds. This method provides a new and highly efficient synthetic approach to quinolizinones and its derivatives with extended π-conjugated systems, possessing tunable emission wavelengths and good photoluminescence capabilities.2-Bromo-5-methylpyridine(cas: 3510-66-5SDS of cas: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. SDS of cas: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 6-Bromopyridin-3-amineIn 2018 ,《Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductionsã€?was published in Green Chemistry. The article was written by Pang, Haobo; Gallou, Fabrice; Sohn, Hyuntae; Camacho-Bunquin, Jeffrey; Delferro, Massimiliano; Lipshutz, Bruce H.. The article contains the following contents:

A remarkable synergistic effect was uncovered between ppm levels of Pd and Ni embedded within Fe nanoparticles that leads to mild and selective catalytic reductions of nitroarenes in water using TPGS-750-M as surfactant at room temperature NaBH4 serves as an inexpensive source of hydride. Broad substrate scope is documented, along with several other features including: low catalyst loading, low residual metal in the products, and recycling of the catalyst and reaction medium, highlight the green nature of this new technol. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2020 ,《A convenient method for synthesis of terpyridines via a cooperative vinylogous anomeric based oxidationã€?was published in RSC Advances. The article was written by Karimi, Fatemeh; Yarie, Meysam; Zolfigol, Mohammad Ali. The article contains the following contents:

The presented study is the first report of the synthesis of terpyridines I (R = pyridin-4-yl, pyridin-3-yl, pyridin-2-yl; R1 = Ph, thiophen-2-yl, pyridin-4-yl, etc.) in the presence of a nanomagnetic catalyst instead of harmful reagents. Herein, Fe3O4@O2PO2(CH2)2NH3+CF3CO2- as a retrievable nanocatalyst with magnetic properties was applied for the multi-component reaction between acetylpyridine derivatives RC(O)Me (2 or 3 or 4-isomer), aryl aldehydes R1CHO and ammonium acetate under conventional heating conditions in the absence of any solvent. The derived terpyridines I were obtained with acceptable yields and brief reaction times via a cooperative vinylogous anomeric based oxidation route. Fe3O4@O2PO2(CH2)2NH3+CF3CO2- showed a high capability for recovery and reuse in the mentioned reaction. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2,6-DibromopyridineIn 2022 ,《Multi-resonant thermally activated delayed fluorescence emitters based on tetracoordinate boron-containing PAHs: colour tuning based on the nature of chelatesã€?was published in Chemical Science. The article was written by Meng, Guoyun; Liu, Lijie; He, Zhechang; Hall, David; Wang, Xiang; Peng, Tai; Yin, Xiaodong; Chen, Pangkuan; Beljonne, David; Olivier, Yoann; Zysman-Colman, Eli; Wang, Nan; Wang, Suning. The article contains the following contents:

Multi-resonant thermally activated delayed fluorescence (MR-TADF) materials have attracted considerable attention recently. The mol. design frequently incorporates cycloboration. However, to the best of our knowledge MR-TADF compounds containing nitrogen chelated to boron are still unknown. Reported herein is a new class of tetracoordinate boron-containing MR-TADF emitters bearing CNC- and NNN-chelating ligands. We demonstrate that the replacement of the B-C covalent bond in the CNC-chelating ligand by the B-N covalent bond affords an isomer, which dramatically influences the optoelectronic properties of the mol. The resulting NNN-chelating compounds show bathochromically shifted absorption and emission spectra relative to CNC-chelating compounds The incorporation of a tert-butylcarbazole group at the 4-position of the pyridine significantly enhances both the thermal stability and the reverse intersystem crossing rate, yet has a negligible effect on emission properties. Consequently, high-performance hyperfluorescent organic light-emitting diodes (HF-OLEDs) that utilize these mols. as green and yellow-green emitters show a maximum external quantum efficiency (ηext) of 11.5% and 25.1%, and a suppressed efficiency roll-off with an ηext of 10.2% and 18.7% at a luminance of 1000 cd m-2, resp. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Reference of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Reference of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Libraryã€?was written by Bao, Yapeng; Deng, Zongfa; Feng, Jing; Zhu, Weiwei; Li, Jin; Wan, Jinqiao; Liu, Guansai. COA of Formula: C6H4N2O4 And the article was included in Organic Letters on August 21 ,2020. The article conveys some information:

Indazolone cores are among the most common structural components in medicinal chem. and can be found in many biol. active mols. In this report, a mild and efficient approach to 2-substituted indazolones via B2(OH)4-mediated reductive N-N bond formation is developed. This strategy features mild conditions, no request for a metal catalyst, and a wide scope for both aliphatic and aromatic amines. Meanwhile, this method was further successfully applied on DNA to construct indazolone cores for a DNA-encoded library. This will enable the production of a very attractive indazolone-cored library from simple amines and scaffolds, which will provide considerable diversity. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3COA of Formula: C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem