Day: December 1, 2022

Kuriyama, Shogo published the artcileCatalytic Formation of Ammonia from Molecular Dinitrogen by Use of Dinitrogen-Bridged Dimolybdenum-Dinitrogen Complexes Bearing PNP-Pincer Ligands: Remarkable Effect of Substituent at PNP-Pincer Ligand, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Journal of the American Chemical Society (2014), 136(27), 9719-9731, database is CAplus and MEDLINE.

A series of dinitrogen-bridged dimolybdenum-dinitrogen complexes bearing 4-substituted PNP-pincer ligands are synthesized by the reduction of the corresponding molybdenum trichloride complexes under 1 atm of mol. dinitrogen. In accordance with a theor. study, the catalytic activity is enhanced by the introduction of an electron-donating group to the pyridine ring of PNP-pincer ligand, and the complex bearing 4-methoxy-substituted PNP-pincer ligands is found to work as the most effective catalyst, where 52 equiv of ammonia are produced based on the catalyst (26 equiv of ammonia based on each molybdenum atom of the catalyst), together with mol. dihydrogen as a side-product. Time profiles for the catalytic reactions indicate that the rates of the formation of ammonia and mol. dihydrogen depend on the nature of the substituent on the PNP-pincer ligand of the complexes. The formation of ammonia and mol. dihydrogen is complementary in the reaction system.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kinoshita, Eriko published the artcileSynthesis and Catalytic Activity of Molybdenum-Nitride Complexes Bearing Pincer Ligands, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is European Journal of Inorganic Chemistry (2015), 2015(10), 1789-1794, database is CAplus.

Mo-nitride complexes, e.g., [Mo(N)(Cl)(L)][OTf] (L = N,N’-bis(di-tert-butylphosphino)-2,6-diaminopyridine), bearing pincer ligands were designed, prepared, and characterized spectroscopically. The synthetic method described in this paper provides a convenient and useful approach to the preparation of cationic Mo(V)-nitride complexes that may act as catalysts for the formation of NH₃ from mol. dinitrogen under ambient reaction conditions.

European Journal of Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vasbinder, Melissa M. published the artcileDiscovery and Optimization of a Novel Series of Potent Mutant B-Raf^V600E Selective Kinase Inhibitors, SDS of cas: 1008506-24-8, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1996-2015, database is CAplus and MEDLINE.

B-Raf represents an attractive target for anticancer therapy, and the development of small mol. B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. The authors have discovered a novel class of small mols. that inhibit mutant B-Raf^V600E kinase activity both in vitro and in vivo. Investigations into the structure-activity relationships of the series are presented along with efforts to improve upon the cellular potency, solubility, and pharmacokinetic profile. Compounds selectively inhibited B-Raf^V600E in vitro and showed preferential antiproliferative activity in mutant B-Raf^V600E cell lines and exhibited selectivity in a kinase panel against other kinases. Examples from this series inhibit growth of a B-Raf^V600E A375 xenograft in vivo at a well-tolerated dose. In addition, aminoquinazolines described herein were shown to display pERK elevation in nonmutant B-Raf cell lines in vitro.

Journal of Medicinal Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C11H8O3, SDS of cas: 1008506-24-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shigehisa, Hiroki published the artcileHydroalkoxylation of Unactivated Olefins with Carbon Radicals and Carbocation Species as Key Intermediates, Application In Synthesis of 107263-95-6, the publication is Journal of the American Chemical Society (2013), 135(28), 10306-10309, database is CAplus and MEDLINE.

A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alc. solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alc. in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Exptl. results suggest that catalysis involves both carbon radical and carbocation intermediates.

Journal of the American Chemical Society published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C8H17Br, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oliveira Araujo, Vinicius published the artcileLead(II) compounds with neutral coordination of semicarbazones: Synthesis and characterization, Related Products of pyridine-derivatives, the publication is Inorganica Chimica Acta (2022), 120785, database is CAplus.

2-Benzoylpyridine semicarbazide/4-phenylsemicarbazide derived ligands as hydrochloride salts, [H₂L]Cl and [H₂L^Ph]Cl·2H₂O, react with Pb²⁺ ions in aqueous and organic milieus. The compounds [Pb₂(HL)₂Cl₄]·2DMF (1a), [Pb₂(HL)₂Cl₄]·5H₂O (1b), [Pb₂(HL)₂Cl₂(NO₃)₂]·4H₂O (2), [Pb₂(HL)₂(SCN)₄] (3), [Pb₄(HL^Ph)₄Cl₈] (4), [Pb(HL^Ph)₂(NO₃)₂] (5) and [Pb(HL^Ph)₂(SCN)₂] (6) were obtained and characterized by powder x-ray diffraction and by IR and UV-visible spectroscopies. Compounds 1–5 were analyzed by single-crystal x-ray diffraction. Tetrel and hydrogen bonds dominate the solid-state arrangements. The aqueous synthetic approach makes the pre-ligands of this work promising for further studies in aqueous coordination chem. with p-block metal ions. [H₂L]Cl and [H₂L^Ph]Cl·2H₂O are suitable for coordination as neutral HL or HL^Ph species.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dotson, Jordan J. published the artcileA data-driven approach to the development and understanding of chiroptical sensors for alcohols with remote γ-stereocenters, Quality Control of 1420830-61-0, the publication is Journal of the American Chemical Society (2021), 143(45), 19187-19198, database is CAplus and MEDLINE.

Dynamic covalent chem.-based sensors have recently emerged as powerful tools to rapidly determine the enantiomeric excess of organic small mols. While a bevy of sensors have been developed, those for flexible mols. with stereocenters remote to the functional group that binds the chiroptical sensor remain scarce. In this study, we develop an iterative, data-driven workflow to design and analyze a chiroptical sensor capable of assessing challenging acyclic γ-stereogenic alcs. Following sensor optimization, the mechanism of sensing was probed with a combination of computational parametrization of the sensor mols., statistical modeling, and high-level d. functional theory (DFT) calculations These were used to elucidate the mechanism of stereochem. recognition and revealed that competing attractive noncovalent interactions (NCIs) determine the overall performance of the sensor. It is anticipated that the data-driven workflows developed herein will be generally applicable to the development and understanding of dynamic covalent and supramol. sensors. Dynamic covalent chem.-based sensors have recently emerged as powerful tools to rapidly determine the enantiomeric excess of organic small mols. While a bevy of sensors have been developed, those for flexible mols. with stereocenters remote to the functional group that binds the chiroptical sensor remain scarce. In this study, we develop an iterative, data-driven workflow to design and analyze a chiroptical sensor capable of assessing challenging acyclic γ-stereogenic alcs. Following sensor optimization, the mechanism of sensing was probed with a combination of computational parameterization of the sensor mols., statistical modeling, and high-level d. functional theory (DFT) calculations These were used to elucidate the mechanism of stereochem. recognition and revealed that competing attractive non-covalent interactions (NCIs) determine the overall performance of the sensor. It is anticipated that the data-driven workflows developed herein will be generally applicable to the development and understanding of dynamic covalent and supramol. sensors.

Journal of the American Chemical Society published new progress about 1420830-61-0. 1420830-61-0 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester,, name is [6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]boronic acid, and the molecular formula is C7H7BF3NO3, Quality Control of 1420830-61-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hollingworth, Samantha A published the artcileAntihypertensive medicine use differs between Ghana and Nigeria., Quality Control of 21829-25-4, the publication is BMC cardiovascular disorders (2022), 22(1), 368, database is MEDLINE.

BACKGROUND: Non-communicable diseases are a growing burden in many African countries; cardiovascular disease is the main disease. Antihypertensive medicines (AHM) are a common treatment option but we know little about community use in most low- and medium-income countries (LMIC). We aimed to describe the use of antihypertensive medicines (AHM) in Ghana and Nigeria using a novel data source. METHODS: We used data from mPharma-a health and pharmaceutical company which distributes pharmaceuticals to hospital and retail pharmacies. We extracted data using the anatomical therapeutic chemical (ATC) classification codes and calculated use in defined daily doses and explored patterns by class, medicines, dose, and originator or generic product. RESULTS: AHM use differed between Ghana and Nigeria. The most used classes in Ghana were angiotensin receptor blockers (ARB) followed by calcium channel blockers (CCB) and angiotensin-converting-enzyme inhibitors (ACEi). The five most used products were 16 mg candesartan, 30 mg nifedipine, 10 mg lisinopril, 5 mg amlodipine and 50 mg losartan. In Nigeria ARB, CCB and diuretics were widely used; the top five products were 50 mg losartan, 10 mg lisinopril, 30 mg nifedipine, 40 mg furosemide, and 5 mg amlodipine. More originator products were used in Ghana than Nigeria. CONCLUSION: The differences between Ghana and Nigeria may result from a combination of medical, contextual and policy evidence and reflect factors related to clinical guidance (e.g. standard treatment guidelines), accessibility to prescribers and the role of community pharmacies, and structure of the health system and universal health coverage including funding for medicines. We show the feasibility of using novel data sources to gain insights on medicines use in the community.

BMC cardiovascular disorders published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Quality Control of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Konda, Yesuraju published the artcileSynthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates, Formula: C5H6BNO2, the publication is Russian Journal of General Chemistry (2022), 92(5), 898-907, database is CAplus.

A new class of 3,3′-disubstituted chiral (R)-BINOL-derived phosphoric acid derivatives has been prepared The synthetic method has been optimized by involving Pd/C as a catalyst in the Suzuki-Miyaura cross coupling using a non-protected BINOL derivative The target compounds have been characterized and tested for their α-glucosidase inhibitory and antibacterial activities.

Russian Journal of General Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rombouts, Frederik J. R. published the artcileDiscovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease, Recommanded Product: 4-Amino-2-picoline, the publication is Journal of Medicinal Chemistry (2017), 60(4), 1272-1291, database is CAplus and MEDLINE.

A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggregated tau with modest selectivity vs. aggregated β-amyloid (Aβ). Initial medicinal chem. efforts identified key elements for potency and selectivity, as well as suitable positions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline tau binding ligands with suboptimal physicochem. properties. Further optimization toward a more optimal pharmacokinetic profile led to the discovery of 1,5-naphthyridine 75, a potent and selective tau aggregate binder with potential as a tau PET tracer.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Billingsley, Kelvin L. published the artcileA highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds, SDS of cas: 612845-44-0, the publication is Angewandte Chemie, International Edition (2006), 45(21), 3484-3488, database is CAplus and MEDLINE.

Catalysts derived from Pd and bulky dialkylphosphinobiaryl ligands are shown to be highly stable and active in Suzuki-Miyaura reactions of heteroaryl halides and heteroaryl boronic acids/esters (e.g., 3- or 4-pyridine, indole, and N-protected pyrrole derivatives). Furthermore, this catalyst system is not inhibited by the presence of highly basic aminopyridines or aminopyrimidines.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, SDS of cas: 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem