Day: December 5, 2022

Tung, Ying-Chang published the artcileComparative effectiveness of generic nifedipine versus Adalat long-acting nifedipine for hypertension treatment: A multi-institutional cohort study, Product Details of C17H18N2O6, the publication is Journal of Clinical Hypertension (Hoboken, NJ, United States) (2022), 24(5), 621-629, database is CAplus and MEDLINE.

This retrospective multi-institutional database anal. aimed to evaluate the blood-pressure-lowering efficacy and clin. outcomes of a generic vs. brand-name nifedipine for hypertension management. A total of 12 693 patients who were prescribed a generic or brand-name nifedipine between Jan. 1, 2011, and Dec. 31, 2018, were identified from the Chang Gung Research Database of Chang Gung Memorial Hospitals, Taiwan. Among them, 2112 (21.4%) were prescribed generic nifedipine. After propensity score matching, both the generic and brand-name groups consisted of 2102 patients. At a mean follow-up of 3 years, the changes in office systolic (p for interaction = .791) and diastolic blood pressure (p for interaction = .689) did not differ significantly between the patients who received the generic and the brand-name nifedipine. There was no significant difference between the two study groups regarding the composite of all-cause mortality, acute myocardial infarction, stroke, coronary revascularization, or hospitalization for heart failure (hazard ratio 0.98, 95% confidence interval 0.85-1.13; p = .774). In conclusion, the generic nifedipine was comparable to its brand-name counterpart regarding office blood pressure reduction and the composite cardiovascular outcome for the treatment of patients with hypertension.

Journal of Clinical Hypertension (Hoboken, NJ, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C6H6BClO3, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lian, Lingxiang published the artcilePhosphine oxide-directed palladium-catalyzed B(3)-H arylation of o-carboranes, Safety of 2-Pyridinylboronic acid, the publication is Tetrahedron Letters (2020), 61(51), 152625, database is CAplus.

The selective functionalization of carboranes has received increasing research interests due to their wild applications in chem., life, and material sciences. Among various structurally diverse carboranes, the development of selective functionalization of the com. available o-carborane (1,2-C₂B₁₀H₁₂) has largely focused on the two acidic C-H bonds. By contrast, research on the activation of the other ten hydridic cage B-H vertexes is relatively less explored. Of particularly challenging, the most electron-deficient nature of B(3,6)-H bonds render very few synthetic methods available for their functionalization. Herein, the authors develop a phosphine oxide-directed Pd-catalyzed highly B(3)-H selective arylation of o-carboranes under very mild reaction conditions in short reaction time.

Tetrahedron Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Popov, V. I. published the artcileNovel syntheses of fluoroferrocene and pentafluoroanisole, Application of 1-Fluoropyridiniumtriflate, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1990), 56(10), 1115-16, database is CAplus.

Treating mercurated ferrocene (I; R = HgOAc) (II) or (CF₃CO₂Hg)₅C₆OMe with AcOF in CFCl₃/HOAc gave 42, 29% I (R = F) or C₆F₅OMe, resp. II was also fluorinated in 37% yield by using N-fluoropyridinium trifluoromethanesulfonate.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Application of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yakun published the artcileSuper-structural 2D ultrathin carbon nitride/acrylate boron silane polymer with multi-function for enhancing antifouling performance, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Coatings Technology and Research (2021), 18(4), 1051-1064, database is CAplus.

Haunted by marine biofouling and the ecol. crisis caused by toxic antifouling paints, the demand for environmental coatings has become more and more pressing. In this work, a series of super-structural 2D ultrathin carbon nitride/acrylate boron silane polymers (CNPs) was prepared by incorporating C₃N₄ into a self-polishing acrylate boron silane polymer (ABSP). The antifouling, environmental performances were evaluated, and the antifouling mechanism was investigated. The results showed that when the content of C₃N₄ was 3-7 wt%, the coatings showed the best resistance to diatoms, Staphylococcus aureus and Escherichia coli in visible light. It was noted that the coatings showed weak antibacterial properties in the dark. In addition, the CNPs and ABSP were shown to expel mussels by photocatalytic active species, self-renewal and amphiphilic surfaces. The COD (COD) values showed that the addition of C₃N₄ made the CNPs become environmental coatings.

Journal of Coatings Technology and Research published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Qingqing published the artcilePreparation of 2-pyridylboronic acid, Computed Properties of 197958-29-5, the publication is Bengbu Yixueyuan Xuebao (2010), 35(10), 1043-1045, database is CAplus.

The means of preparing 2-pyridylboronic acid was investigated. The product was synthesized with 2-bromopyridine, tris-trimethylsilylborate and iPrMgCl as Grignard reagents under N₂, and identified by 1H-NMR. 2-Pyridylboronic acid was synthesized with the yield of 67.7% on conditions of n(tris-trimethylsilylborate): n(2-bromopyridine)=2:1; the reaction temperature was 0 degree, the reaction time 3 h and the hydrolysis temperature 0 degree. 2-Pyridylboronic acid can be synthesized by Grignard reaction on moderate conditions with high yield, which may contribute to the study of pyridine drugs.

Bengbu Yixueyuan Xuebao published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C19H14Cl2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jiang, Lin published the artcileCRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Molecular Therapy (2022), 30(1), 54-74, database is CAplus and MEDLINE.

Fibroblasts can be reprogrammed into cardiovascular progenitor cells (CPCs) using transgenic approaches, although the underlying mechanism remains unclear. We determined whether activation of endogenous genes such as Gata4, Nkx2.5, and Tbx5 can rapidly establish autoregulatory loops and initiate CPC generation in adult extracardiac fibroblasts using a CRISPR activation system. The induced fibroblasts (>80%) showed phenotypic changes as indicated by an Nkx2.5 cardiac enhancer reporter. The progenitor characteristics were confirmed by colony formation and expression of cardiovascular genes. Cardiac sphere induction segregated the early and late reprogrammed cells that can generate functional cardiomyocytes and vascular cells in vitro. Therefore, they were termed CRISPR-induced CPCs (ciCPCs). Transcriptomic anal. showed that cell cycle and heart development pathways were important to accelerate CPC formation during the early reprogramming stage. The CRISPR system opened the silenced chromatin locus, thereby allowing transcriptional factors to access their own promoters and eventually forming a pos. feedback loop. The regenerative potential of ciCPCs was assessed after implantation in mouse myocardial infarction models. The engrafted ciCPCs differentiated into cardiovascular cells in vivo but also significantly improved contractile function and scar formation. In conclusion, multiplex gene activation was sufficient to drive CPC reprogramming, providing a new cell source for regenerative therapeutics.

Molecular Therapy published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Qiu, Zhi-Hui published the artcilecatena-Poly[[diaquamanganese(II)]-di-μ-pyridine-3-sulfonato-κ²N:O;κ²O:N], Quality Control of 636-73-7, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(6), m765, m765/1-m765/7, database is CAplus and MEDLINE.

In the title polymeric complex, [Mn(C₅H₄NO₃S)₂(H₂O)₂]_n, the Mn atom is located on a center of inversion and is coordinated by two O atoms and two N atoms derived from four different pyridine-3-sulfonate (pySO₃) ligands, and two O atoms derived from two H₂O mols. in a distorted trans-N₂O₄ octahedral geometry. The metal atoms are bridged by the pySO₃ ligands to form a 1-dimensional chain. The chains are further connected into a three-dimensional architecture via H bonds. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Biao published the artcileA conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair, Product Details of C17H18N2O6, the publication is Bioactive Materials (2022), 103-119, database is CAplus and MEDLINE.

The current effective method for treatment of spinal cord injury (SCI) is to reconstruct the biol. microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells (NSCs) to repair SCI. However, the method is characterized by several challenges including irregular wounds, and mech. and elec. mismatch of the material-tissue interface. In the current study, a unique and facile agarose/gelatin/polypyrrole (Aga/Gel/PPy, AGP3) hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and PPy. The gelation occurred through non-covalent interactions, and the phys. crosslinked features made the AGP3 hydrogels injectable. In vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility, and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of astrocytes. The in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity areas. In vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation, resulting in significant functional recovery. RNA sequencing anal. further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+ signaling cascades. Overall, this supramol. strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiol. properties of the spinal cord.

Bioactive Materials published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C9H11BO4, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Shikai published the artcileInhibition of Sympathetic Activation by Delivering Calcium Channel Blockers from a 3D Printed Scaffold to Promote Bone Defect Repair, Related Products of pyridine-derivatives, the publication is Advanced Healthcare Materials (2022), 11(16), 2200785, database is CAplus and MEDLINE.

Enhancing osteogenesis by promoting neural network reconstruction and neuropeptide release is considered to be an attractive strategy for repairing of critical size bone defects. However, traumatic bone defects often activate the damaged sympathetic nervous system (SNS) in the defect area and release excessive catecholamine to hinder bone defect repair. Herein, a 3D printed scaffold loaded with the calcium channel blocker-nifedipine is proposed to reduce the concentration of catecholamine present in the bone defect region and to accelerate bone healing. To this end, nifedipine-loaded ethosome and laponite are added into a mixed solution containing sodium alginate, methacrylated gelatin, and bone mesenchymal stem cells (BMSCs) to prepare a cell-laden scaffold using 3D bioprinting. The released nifedipine is able to close the calcium channels of nerve cells, thereby blocking sympathetic activation and ultimately inhibiting the release of catecholamine by sympathetic nerve cells, which further promotes the osteogenic differentiation and migration of BMSCs, inhibits osteoclastogenesis in vitro, and effectively improves bone regeneration in a rat critical-size calvarial defect model. Therefore, the results suggest that sustained release of nifedipine from the scaffold can effectively block SNS activation, providing promising strategies for future treatment of bone defects.

Advanced Healthcare Materials published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Li published the artcileRegioselective synthesis of polysubstituted N2-alkyl/aryl-1,2,3-triazoles via 4-bromo-5-iodo-1,2,3-triazole, Category: pyridine-derivatives, the publication is Synlett (2012), 23(7), 1052-1056, database is CAplus.

The regioselective N(2)-substitution of 4-bromo-5-iodo-1,2,3-triazole with alkyl/aryl halides in the presence of K₂CO₃ in DMF produced the desired 2-substituted 4-bromo-5-iodo-1,2,3-triazoles as major products in good to excellent regioselectivity. Subsequent chemoselective Suzuki-Miyaura cross-coupling of N(2)-substituted 4-bromo-5-iodo-1,2,3-triazoles provided polysubstituted 1,2,3-triazoles efficiently.

Synlett published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C13H10N2S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem