Day: December 7, 2022

Tan, Jing published the artcileMetal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes, Category: pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2018), 16(23), 4227-4230, database is CAplus and MEDLINE.

Arylacetaldehydes and aliphatic aldehydes underwent oxidative cyclocondensation reactions with aminopyridines mediated by S₈ in cyclohexane/DMSO to yield imidazopyridines without added metal or base.

Organic & Biomolecular Chemistry published new progress about 1174626-28-8. 1174626-28-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Benzene,Ether, name is 2-Amino-6-benzyloxypyridine, and the molecular formula is C20H17FO4S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ettel, Viktor published the artcileLocal anesthetics derived from acylaminoacridine, Product Details of C23H20BN, the publication is Chemicke Listy pro Vedu a Prumysl (1957), 1906-8, database is CAplus.

Preparing Xylocaine analogs of the type RNHCOCH₂NEt₂ (I) where R is acridine or its derivatives gave compounds with biol. activity approximating that of Procaine but with considerably lower toxicity. Adding 3 g. ClCH₂COCl to 9.7 g. 9-aminoacridine in 400 ml. Me₂CO, boiling the mixture shortly under reflux, filtering while hot, and evaporating Me₂CO gave 13.3 g. crude 9-(chloroacetylamino)acridine (II), m. 212° (decomposition, from EtOH). Adding 4 g. NHEt₂ to suspension of 5.4 g. II in 250 ml. PhMe, refluxing the mixture 8 hrs., separating the precipitated HCl-salt, evaporating the solution, extracting the base with dilute HCl, and precipitating with aqueous NH₄OH gave 5.5 g. I (R = 9-acridyl), m. 132° (C₆H₆); dihydrochloride, m. 220° (decomposition). Adding MeONa solution from 8 g. Na and 200 ml. MeOH to suspension of 22.6 g. tetrahydroacridine-9-carboxylamide in 45 ml. MeOH, dropping into the mixture with stirring at 20° 28.5 g. Br in 1 hr., raising the temperature to boiling in 1 hr., boiling shortly, cooling down, neutralizing with AcOH, distilling the MeOH, diluting with an equal volume of H₂O, separating the precipitated urethan, decomposing by heating with excess 30% H₂SO₄ 1 hr. on an H₂O-bath, filtering, and precipitating the base with NaOH gave 15 g. 9-amino-1,2,3,4-tetrahydroacridine (III), m. 178° (EtOH). III (20 g.) heated in a sealed tube with 17 g. ClCH₂COCl 4 hrs. to 130-5°, the reaction mixture dissolved in H₂O, the solution filtered with C, and the product precipitated with NH₄OH gave 25 g. 9-(chloroacetylamino)-1,2,3,4-tetrahydroacridine (IV), m. 207° (EtOH). IV (5.5 g.) allowed to react with 4.0 g. NHEt₂ in 250 ml. PhMe gave 6.6 g. I [R = 9-(1,2,3,4-tetrahydroacridyl)], m. 80° (aqueous EtOH); dihydrochloride, m. 235°. Reducing the preceding base (7.7 g.) in boiling EtOH by adding portionwise 200 g. 4% Na-Hg in the presence of NaHCO₃ in a stream of CO₂, cooling the mixture, separating Hg, and distilling EtOH in vacuo gave 7.2 g. I [R = 9-(1,2,3,4,9,10,11,12-octahydroacridyl)], m. 50°.

Chemicke Listy pro Vedu a Prumysl published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Product Details of C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Lei published the artcileChiral Bifunctional Phosphine-Carboxylate Ligands for Palladium(0)-Catalyzed Enantioselective C-H Arylation, Product Details of C5H5BrN2, the publication is Angewandte Chemie, International Edition (2018), 57(5), 1394-1398, database is CAplus and MEDLINE.

Previous enantioselective Pd⁰-catalyzed C-H activation reactions proceeding via the concerted metalation-deprotonation mechanism employed either a chiral ancillary ligand, a chiral base, or a bimol. mixture thereof. This study describes the development of new chiral bifunctional ligands based on a binaphthyl scaffold which incorporates both a phosphine and a carboxylic acid moiety. The optimal ligand provided high yields and enantioselectivities for a desymmetrizing C(sp²)-H arylation leading to 5,6-dihydrophenanthridines, whereas the corresponding monofunctional ligands showed low enantioselectivities. The bifunctional system proved applicable to a range of substituted dihydrophenanthridines, and allowed the parallel kinetic resolution of racemic substrates.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C14H10O4S2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vogt, Matthias published the artcileActivation of Nitriles by Metal Ligand Cooperation. Reversible Formation of Ketimido- and Enamido-Rhenium PNP Pincer Complexes and Relevance to Catalytic Design, HPLC of Formula: 338800-13-8, the publication is Journal of the American Chemical Society (2013), 135(45), 17004-17018, database is CAplus and MEDLINE.

The dearomatized complex cis-[Re-(PNP^tBu*)-(CO)₂] (4) undergoes cooperative activation of CN triple bonds of nitriles via [1,3]-addition Reversible C-C and Re-N bond formation in 4 was investigated in a combined exptl. and computational study. The reversible formation of the ketimido complexes (5-7) was observed When nitriles bearing an alpha methylene group are used, reversible formation of the enamido complexes (8 and 9) takes place. The reversibility of the activation of the nitriles in the resulting ketimido compounds was demonstrated by the displacement of p-CF₃-benzonitrile from cis-[Re-(PNP^tBu-N=CPh^pCF3)-(CO)₂] (6) upon addition of an excess of benzonitrile and by the temperature-dependent [1,3]-addition of pivalonitrile to complex 4. The reversible binding of the nitrile in the enamido compound cis-[Re-(PNP^tBu-HNC=CHPh)-(CO)₂] (9) was demonstrated via the displacement of benzyl cyanide from 9 by CO. Computational studies suggest a stepwise activation of the nitriles by 4, with remarkably low activation barriers, involving precoordination of the nitrile group to the Re-(I) center. The enamido complex 9 reacts via β-carbon methylation to give the primary imino complex cis-[Re-(PNP^tBu-HN=CC-(Me)-Ph)-(CO)₂]-OTf 11. Upon deprotonation of 11 and subsequent addition of benzyl cyanide, complex 9 is regenerated and the monomethylation product 2-phenylpropanenitrile is released. Complexes 4 and 9 were found to catalyze the Michael addition of benzyl cyanide derivatives to α,β-unsaturated esters and carbonyls.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C14H12N2S, HPLC of Formula: 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mukherjee, Arup published the artcileManganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H₂: A Catalytic and Mechanistic Study, Related Products of pyridine-derivatives, the publication is Journal of the American Chemical Society (2016), 138(13), 4298-4301, database is CAplus and MEDLINE.

The catalytic dehydrogenative coupling of alcs. and amines to form aldimines represents an environmentally benign methodol. in organic chem. This has been accomplished in recent years mainly with precious-metal-based catalysts. We present the dehydrogenative coupling of alcs. and amines to form imines and H₂ that is catalyzed, for the first time, by a complex of the earth-abundant Mn. Detailed mechanistic study was carried out with the aid of NMR spectroscopy, intermediate isolation, and X-ray anal.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Benyettou, Farah published the artcileViologen-Templated Arrays of Cucurbit[7]uril-Modified Iron-Oxide Nanoparticles, Application In Synthesis of 47369-00-6, the publication is Chemistry – A European Journal (2015), 21(12), 4607-4613, database is CAplus and MEDLINE.

Magnetic and fluorescent assemblies of iron-oxide nanoparticles (NPs) were constructed by threading a viologen-based ditopic ligand, DPV²⁺, into the cavity of cucurbituril (CB[7]) macrocycles adsorbed on the surface of the NPs. Evidence for the formation of 1:2 inclusion complexes that involve DPV²⁺ and two CB[7] macrocycles was first obtained in solution by ¹H NMR and emission spectroscopy. DPV²⁺ was found to induce self-assembly of nanoparticle arrays (DPV²⁺⊂CB[7]NPs) by bridging CB[7] mols. on different NPs. The resulting viologen-crosslinked iron-oxide nanoparticles exhibited increased saturation magnetization and emission properties. This facile supramol. approach to NP self-assembly provides a platform for the synthesis of smart and innovative materials that can achieve a high degree of functionality and complexity and that are needed for a wide range of applications.

Chemistry – A European Journal published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Application In Synthesis of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sazonova, V. A. published the artcileReaction of tetraphenylborocopper with oxo compounds, SDS of cas: 971-66-4, the publication is Zhurnal Obshchei Khimii (1956), 3440-5, database is CAplus.

cf. C.A. 50, 1644d. To 2.25 g. Et benzalacetoacetate in MePh was added at 80° 5 g. pyridine salt of PH₄BCu (I); after filtration, treatment with 10% AcOH, then 10% NaOH and H₂O, there was formed on evaporation 70% Et α-benzhydrylacetoacetate, m. 83-4°, also formed under N in 70% yield. The precipitate formed in the reaction was 96% Cu. Similarly benzalacetylacetone gave 61% α-benzhydryl-α-acetylacetone, m. 115.5°, Et benzalbenzoylacetate gave 98% Et benzhydrylbenzoylacetate, m. 135°, Et α-ethylideneacetoacetate gave over 100% Et α-phenethylacetoacetate, b_4.5 125.5-6°, n_D²⁰ 1.4990; benzalacetophenone gave 29% β,β-diphenylpropiophenone, m. 96-6.5°, and dibenzalacetone and I heated to 160° gave 42% α-benzhydryl-α-benzalacetone, m. 136-6.5°. To 1.14 g. BzH in MePh was added at 80° 5 g. I yielding 0.71 g. Ph₂; a similar failure to add was noted for Ph₂CO and dibenzoylethylene. Addition of 7.5 g. I at 75° under N in CCl₄ gave a brown precipitate containing Ph₃B pyridine salt and Cu salts; evaporation of the filtrate and heating with H₂O 2 hrs. with Ca(OH)₂ and powd. Fe gave BzOH. The brown precipitate extracted with Me₂CO gave on extraction with Me₂CO and treatment of the insoluble part with aqueous KI, a precipitate of CuI and iodine; the filtrate gave triphenylboron pyridine salt, m. 212-18° (decomposition).

Zhurnal Obshchei Khimii published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hong, Junting published the artcileCarboxylation of Alkenyl Boronic Acids and Alkenyl Boronic Acid Pinacol Esters with CO₂ Catalyzed by Cuprous Halide, HPLC of Formula: 844501-00-4, the publication is European Journal of Organic Chemistry (2020), 2020(19), 2813-2818, database is CAplus.

A cuprous halide catalyzed carboxylation of alkenyl boronic acids and alkenyl boronic acid pinacol esters under CO₂, affording the corresponding α,β-unsaturated carboxylic acids in good yield, has been developed. The potassium (E)-trifluoro(styryl)borate is also compatible with this reaction. This simple and efficient copper(I) catalytic system showed good functional group tolerance.

European Journal of Organic Chemistry published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C10H18BNO4, HPLC of Formula: 844501-00-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Garcia Sanchez, F. published the artcileCoupled redox and complex formation processes as a kinetic fluorometric method for the determination of cobalt, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1983), 315(6), 491-5, database is CAplus.

A sensitive and relatively interference-free method for the kinetic determination of Co is described. The method is based on the slow oxidation of 2-pyridinealdehyde 2-pyridylhydrazone (PAPH) by BrO₃^– to a fluorescent product. Complexation of PAPH with Co causes a decrease in the rate of oxidation, which is related to the concentration of Co and also to the stability constant of the complex. The influence of reaction variables and the effect of foreign ions are discussed. Co 20-150 ng mL^-1 can be determined with a relative standard deviation of 4%. The absorption of the 1:2 Co PAPH complex was measured at 440 nm.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shapiro, Anna published the artcileIn vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei, Product Details of C11H10N4, the publication is Journal of Protozoology (1982), 29(1), 85-90, database is CAplus and MEDLINE.

A system of prescreens and a screen was developed to select chelators as potential drugs against T. brucei brucei EATRO 110. The chelators tested were nearly all com. available, low mol., and had a moderate to high affinity for Fe(III). Seventy compounds showing heme-sparing or inhibitory activity in a Crithidia fasciculata growth system having excess Fe and minimal hemin were prescreened. Of these, 45 were highly trypanocidal for suspensions of bloodstream T. brucei brucei; criteria of activity here were immobilization, lysis, and loss of infectivity. Eighteen of the chelators highly active in the suspension prescreen were tried in T. brucei brucei-infected mice. Thirteen of these chelators were curative in mice with 24-h infections, i.e., they allowed survival >30 days beyond the untreated controls, caffeic acid  [331-39-5], neocuproine  [484-11-7], and 2-pyridinecarboxaldehyde-2-pyridylhydrazone  [2215-33-0] cure 5 out of 5 mice after an i.v. dose of 100 mg/kg. salicylaldehyde thiosemicarbazone  [5351-90-6] Cured 5 of 5 mice at an i.p. dose of 500 mg/kg. Lesser activity was shown by several other chelators.

Journal of Protozoology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H18BFO2, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem