Day: December 7, 2022

Hamukwaya, Eunike published the artcileA multi-colorimetric probe to discriminate between heavy metal cations and anions in DMSO-H₂O with high selectivity for Cu²⁺ and CN^–: study of logic functions and its application in real samples, Quality Control of 91-02-1, the publication is RSC Advances (2021), 11(47), 29466-29485, database is CAplus and MEDLINE.

A ditopic multi-colorimetric probe based on the phenylpridyl-thioic moiety (EN) was synthesized via a Schiff base reaction mechanism and characterized using ¹H NMR and UV-vis spectroscopy. The colorimetric analyses carried out revealed that EN was capable of discriminating between a number of heavy metal cations via coordination induced charge transfer, as well as between anions through hydrogen bonding induced charge transfer, in DMSO-H₂O (9 : 1). In particular, the ditopic probe could spectrally and colorimetrically recognize the most toxic heavy metal cations of Cd²⁺, Pb²⁺ and Hg²⁺, among others, in DMSO-H₂O. Addnl., EN was selective and sensitive to the presence of CN^–, F^–, AcO^– and H₂PO₄^– in the same solvent system as cations. The reversibility and reproducibility studies showed that EN exhibited complementary IMP/INH logic functions, based on color and spectral switching (ON/OFF), modulated by F^–/Al³⁺. The real time application of the probe was tested on food grade products to detect the presence of F^– in toothpastes and mouthwash dissolved in water, as well as cations in underground water (normally saline), which displayed substantial responses. Thus, EN displayed an excellent scope of response and can thus be developed for real time sensing kits, which could be used instantly in on-field anal. Theor. studies were conducted to complement the exptl. work.

RSC Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Jong-Woo published the artcileFlexible and transparent electrochromic displays with simultaneously implementable subpixelated ion gel-based viologens by multiple patterning, HPLC of Formula: 47369-00-6, the publication is Advanced Functional Materials (2019), 29(13), n/a, database is CAplus.

Electrochromic materials reversibly change colors by redox reactions depending on the oxidation states. To utilize electrochromic materials for active-matrix display applications, an electrochromic display (ECD) requires simultaneous implementation of various colors and a fine-pixelation process. Herein, flexible and transparent ECDs with simultaneously implementable subpixelated EC gels by sequential multiple patterning are successfully demonstrated. Ionic liquid-based EC gels of monoheptyl-viologen, diheptyl-viologen (DHV), and diphenyl-viologen (DPV) are used to create the colors of ECDs: magenta, blue, and green, resp. Especially, to realize an improved green color, DHV-DPV composite gels are synthesized. Three EC gels exhibit stable properties without degradation during repetitive operation. Moreover, a transmittance greater than 90% is maintained in a bleached state, which is sufficient for application as a transparent display. The subpixelation process for multicolored-flexible ECDs is designed to facilitate both easy fabrication and rapid operation with various patterns at low cost. The subpixelated EC gels using a film mask can be implemented to a min. size of 200 μm. Furthermore, the subpixelated flexible ECDs exhibit high durability even after 1000 cycles of mech. bending tests at a bending radius of 10 mm. Therefore, these EC materials can be used directly for flexible and transparent active-matrix displays.

Advanced Functional Materials published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, HPLC of Formula: 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nirmalram, Jeyaraman Selvaraj published the artcileHydrogen-bonding patterns in pyrimethaminium pyridine-3-sulfonate, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Acta Crystallographica, Section E: Structure Reports Online (2010), 66(8), o2121-o2122, database is CAplus and MEDLINE.

In the asym. unit of the title salt [systematic name: 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidin-1-ium pyridine-3-sulfonate], C₁₂H₁₄N₄Cl⁺·C₅H₄NSO₃^–, there are two independent pyrimethaminium cations and two 3-pyridine sulfonate anions. Each sulfonate group interacts with the corresponding protonated pyrimidine ring through two N-H…O hydrogen bonds, forming a cyclic hydrogen-bonded bimol. R₂²(8) motif. Even though the primary mode of association is the same, the next higher level of supramol. architectures are different due to different hydrogen-bonded networks. In one of the independent mols. in the asym. unit, the pyrimethamine cation is paired centrosym. through N-H…N hydrogen bonds, generating an R₂²(8) ring motif. In the other mol., the pyrimethamine cation does not form any base pairs; instead it forms hydrogen bonds with the 3-pyridine sulfonate anion. The structure is further stabilized by C-H…O, C-H…N and π-π stacking [centroid-centroid distance = 3.9465 (13) Å] interactions. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Yiding published the artcileDirect Copper-Catalyzed Three-Component Synthesis of Sulfonamides, Formula: C5H6BNO2, the publication is Journal of the American Chemical Society (2018), 140(28), 8781-8787, database is CAplus and MEDLINE.

Sulfonamides such as N-(phenylsulfonyl)morpholine were prepared in one step by coupling of aryl-, heteroaryl-, and alkenylboronic acids such as phenylboronic acid with cyclic and acyclic alkyl secondary amines such as morpholine and primary anilines and the bis(sulfur dioxide) complex of DABCO (DABSO) in the presence of Cu(OTf)₂ and 4,4′-dimethoxy-2,2′-bipyridine in DMSO. The method was used on gram scale and was used to prepare sulfonamides from drugs and drug fragments.

Journal of the American Chemical Society published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Prakash, Sekar published the artcileCobalt-Catalyzed Oxidative Annulation of Nitrogen-Containing Arenes with Alkynes: An Atom-Economical Route to Heterocyclic Quaternary Ammonium Salts, Quality Control of 85237-71-4, the publication is Angewandte Chemie, International Edition (2016), 55(5), 1844-1848, database is CAplus and MEDLINE.

Four cobalt-catalyzed oxidative annulation reactions of nitrogen-containing arenes with alkynes proceeds by C-H activation, thus leading to biol. useful quaternary ammonium salts, including pyridoisoquinolinium, cinnolinium, isoquinolinium, and quinolizinium salts, in high yields. The results are comparable to those reactions catalyzed by rhodium and ruthenium complexes. The transformation of the salts into various N-heterocycles has also been demonstrated.

Angewandte Chemie, International Edition published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nogawa, Hisashi published the artcilePharmacological characterisation of electrocardiogram J-T_peak interval in conscious Guinea pigs, Product Details of C17H18N2O6, the publication is European Journal of Pharmacology (2022), 175065, database is CAplus and MEDLINE.

Drug-induced human ether-a-́go-go-related gene (hERG) channel block and QT interval prolongation increase torsade de pointes (TdP) risk. However, some drugs block hERG channels and prolong QT interval with low TdP risk, likely because they block addnl. inward currents. We investigated the utility of J-T_peak interval, a novel biomarker of inward current block and TdP risk, in conscious telemetered guinea pigs. ECG parameters were analyzed in Hartley guinea pigs orally administered one of eight test compounds (dofetilide, flecainide, nifedipine, quinidine, quinine, ranolazine, sotalol, verapamil) or vehicle alone as controls. Heart rate-corrected QT (QTcX) and J-T_peak (J-T_peakcX) were calculated to evaluate the relations of QT-RR and J-T_peak-RR. Dofetilide and sotalol significantly increased ΔQTcX and ΔJ-T_peakcX intervals to similar degrees. Quinidine, quinine and flecainide also increased ΔQTcX and ΔJ-T_peakcX intervals, but the degrees of ΔJ-T_peakcX interval prolongation were shorter than those of ΔQTcX interval prolongation. Ranolazine showed slight increasing trends in ΔQTcX and ΔJ-T_peakcX intervals, but the differences were not significant. Verapamil and nifedipine did not increase the ΔQTcX or ΔJ-T_peakcX intervals. Based on the relations of ΔΔJ-T_peakcX and ΔΔQTcX intervals, dofetilide, sotalol and quinidine were classified as high risk for TdP, quinine, flecainide and ranolazine were classified as intermediate risk and verapamil and nifedipine were classified as low risk. These results supported the usefulness of J-T_peak interval assessment in conscious guinea pigs for predicting drug-induced balanced block of inward currents and TdP risk in early-stage preclin. studies.

European Journal of Pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileComplexation behavior of heterocyclic hydrazones. II. Effects of steric factors on formation constants for nickel(II) complexes with heterocyclic hydrazones, Related Products of pyridine-derivatives, the publication is Bulletin of the Chemical Society of Japan (1994), 67(3), 710-19, database is CAplus.

The equilibrium of nickel(II) ion with thirteen nitrogen-heterocyclic hydrazones (neutral form: HL) with and without blocking group(s) have been investigated spectrophotometrically in 28% aqueous dioxane solution at 25°C and an ionic strength of 0.2 (KCl). For a series of 2-pyridinecarbaldehyde 5-substituted-2-pyridylhydrazones, the following linear free energy relationships (LFER) were derived between the overall formation constants, β₁, β₁‘, and β₂, of Ni(HL)²⁺, NiL⁺, and Ni(HL)₂²⁺ complexes, resp., and the dissociation constants, K_a1 and K_a2, of H₃L²⁺ and H₂L⁺, resp.: log β₁ = 0.95 (pK_a1 + pK_a2)/2 + 4.60, 1/2 log β₂ = 0.95 × (pK_a1 + pK_a2)/2 + 4.82, and log β₁‘ = 1.40 (pK_a1 + pK_a2)/2 + 9.73. The steric effects of the 6-Me group in pyridine and the quinolyl ring in place of pyridyl group on the complex formation were evaluated on the basis of LFER. The complex stabilization effect of the pyridyl group substituted for formyl hydrogen was also evaluated for Ni(HL)₂²⁺, Ni(HL)²⁺, and NiL⁺ complexes. These results together with LFER were discussed in conjunction with the thermodn. parameters for the formation of Ni(HL)²⁺ complex and the ligand field parameters, D_q, for Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes.

Bulletin of the Chemical Society of Japan published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C7H8BBrO3, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Safarudin published the artcileEvaluation of lipid profile in patients with cardiovascular diseases receiving simvastatin in Palu Indonesia, Related Products of pyridine-derivatives, the publication is Journal of Pharmacy and Nutrition Sciences (2018), 8(4), 199-204, database is CAplus.

Cardiovascular diseases (CVDs) are the leading cause of death worldwide which results from the impaired function of the heart and blood vessels. The most common CVDs are coronary heart and stroke. The main clin. manifestation of these diseases is the formation of atherosclerosis which is associated with the change of blood lipid levels. Simvastatin is widely used in patients with impaired lipid levels in the blood. The study was a descriptive research with a retrospective approach on medical record data (n = 64) taken from Palu City, Central Sulawesi, Indonesia. The variables included in this study were gender, age, diagnosis, co-medication, lipid profile including total cholesterol, LDL, triglycerides, and HDL in patients with CVDs receiving simvastatin. In the study, sixty-four patients of CVDs met the inclusion and exclusion criteria. This study suggested that simvastatin achieved to normalize the blood lipid levels, including total cholesterol in forty-four patients (68.75%), LDL in forty-nine patients (80.3%), triglycerides in fifty-nine patients (92.19%), and HDL in fifty-two patients (81.25%). The use of simvastatin in patients with CVDs managed to lower total cholesterol, LDL, and triglycerides, as well as increase the HDL level.

Journal of Pharmacy and Nutrition Sciences published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lessing, Timo published the artcileActivation-free one-pot alkynylation-cyclization synthesis of 2-substituted 4-azaindoles and indoles, Application In Synthesis of 39856-58-1, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2018), 54(3), 334-338, database is CAplus.

2-Substituted 4-azaindoles and indoles were rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation-cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hartung, Jane E. published the artcileVoltage-gated calcium currents in human dorsal root ganglion neurons, Quality Control of 21829-25-4, the publication is Pain (2022), 163(6), e774-e785, database is CAplus and MEDLINE.

Voltage-gated calcium channels in sensory neurons underlie processes ranging from neurotransmitter release to gene expression and remain a therapeutic target for the treatment of pain. Yet virtually all we know about voltage-gated calcium channels has been obtained through the study of rodent sensory neurons and heterologously expressed channels. To address this, high voltage-activated (HVA) Ca²⁺ currents in dissociated human and rat dorsal root ganglion neurons were characterized with whole-cell patch clamp techniques. The HVA currents from both species shared basic biophys. and pharmacol. properties. However, HVA currents in human neurons differed from those in the rat in at least 3 potentially important ways: (1) Ca²⁺ c.d. was significantly smaller, (2) the proportion of nifedipine-sensitive currents was far greater, and (3) a subpopulation of human neurons displayed relatively large constitutive current inhibition. These results highlight the need to for the study of native proteins in their native environment before initiating costly clin. trials.

Pain published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Quality Control of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem