Day: December 8, 2022

Wang, Qiang published the artcileIntroducing electrostatic interaction into Ru(bda) complexes for promoting water-oxidation catalysis, Related Products of pyridine-derivatives, the publication is Journal of Molecular Structure (2021), 130745, database is CAplus.

Ru(bda) (H₂bda = 2,2â€?bipyridine-6,6â€?dicarboxylic acid) complex is a kind of well-known water oxidation catalyst, which goes through the bimol. I2M mechanism with an inter-catalyst O-O coupling step. Recently, we developed two facile strategies to accelerate O-O coupling via introducing the electrostatic interaction into Ru(bda)-catalyzed systems. In this work, a series of Ru(bda) complexes with different charged groups on different positions were synthesized to demonstrate the general applicability of these design strategies. It found these catalytic systems with attractive electrostatic interaction display much better activity, and the position of the charged substituents also has a significant influence on the catalytic activity.

Journal of Molecular Structure published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C8H6ClN, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ban, Yan published the artcileThioamide directed iridium(I)-catalyzed C-H arylation of ferrocenes with aryl boronic acids, Computed Properties of 612845-44-0, the publication is Organic & Biomolecular Chemistry (2022), 20(29), 5759-5763, database is CAplus and MEDLINE.

The first Ir(I)-catalyzed thioamide-assisted C-H arylation of ferrocenes with aryl boronic acids under base-free mild reaction conditions in the presence of Ag₂CO₃ as an oxidant with eco-friendly 2-MeTHF as a solvent was developed. This reaction has a wide range of substrates (37 examples) and functional group tolerance (18-94% yields), and provides promising access to aryl thioamide-ferrocene compounds with good yields and regioselectivity.

Organic & Biomolecular Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Computed Properties of 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Handa, Sachin published the artcileSustainable Fe-ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water, Application In Synthesis of 844501-00-4, the publication is Science (Washington, DC, United States) (2015), 349(6252), 1087-1091, database is CAplus and MEDLINE.

Iron nanoparticles containing ppm quantities of palladium were effective for Suzuki-Miyaura coupling reactions of boronic acids, trifluoroborates, and N-methyliminodiacetic acid boronates with aryl and heteroaryl bromides and iodides in aqueous solutions containing the com. available surfactant TPGS-750-M. Treatment of FeCl₃ (naturally containing 320 ppm Pd) with a phosphine ligand, particularly SPhos {dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine} or XPhos, in THF with a Grignard reagent in THF yielded Fe nanoparticles which were used as Suzuki-Miyaura coupling reaction catalysts with K₃PO₄ as base. The activity of the nanoparticles depended strongly on the iron source and the ligand used. The nanoparticles were recycled after extraction of product; for every two cycles, roughly 160 ppm Pd(OAc)₂ was added to replace leached palladium.

Science (Washington, DC, United States) published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C10H18BNO4, Application In Synthesis of 844501-00-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Leng, Faqiang published the artcileFacile synthesis of trifluoroethyl compounds by the Suzuki cross-coupling reactions of CF₃CH₂OTs with arylboronic acids, Synthetic Route of 774170-15-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(91), 10697-10699, database is CAplus and MEDLINE.

This research provides a novel approach for introducing a CF₃CH₂ group onto aromatic rings using Pd(OAc)₂/palladacycle as a catalyst for the Suzuki cross-coupling reaction of CF₃CH₂OTs (OTs = 4-methylbenzene sulfonate) with arylboronic acids.

Chemical Communications (Cambridge, United Kingdom) published new progress about 774170-15-9. 774170-15-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amine,Boronic Acids, name is (6-(Methylamino)pyridin-3-yl)boronic acid, and the molecular formula is C6H9BN2O2, Synthetic Route of 774170-15-9.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nan, Xiao-Lei published the artcileSite-selective D₂O-mediated deuteration of diaryl alcohols via quantum dots photocatalysis, COA of Formula: C12H9NO, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(55), 6768-6771, database is CAplus and MEDLINE.

Owing to the high synthetic value of deuteration in the pharmaceutical industry, the conversion of a range of aromatic ketones to deuterium-labeled products such as RR¹CD(OH) [R = Ph, 4-ClC₆H₄, 4-BrC₆H₄, 4-CNC₆H₄, 4-PhC₆H₄; R¹ = Ph, 2-thienyl, 2-naphthyl, etc.] in good to excellent yields was described. Efficient and site-selective deuteration of benzyl alcs. by D₂O with visible light irradiation of quantum dots (QDs), together with gram-scale synthesis and photocatalyst recycling experiments indicated the potential of the developed method in practical organic synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Tianshu published the artcileNitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Particle and Fibre Toxicology (2022), 19(1), 22, database is CAplus and MEDLINE.

Along with the wild applications of nitrogen-doped graphene quantum dots (N-GQDs) in the fields of biomedicine and neuroscience, their increasing exposure to the public and potential biosafety problem has gained more and more attention. Unfortunately, the understanding of adverse effects of N-GQDs in the central nervous system (CNS), considered as an important target of nanomaterials, is still limited. After we found that N-GQDs caused cell death, neuroinflammation and microglial activation in the hippocampus of mice through the ferroptosis pathway, microglia was used to assess the mol. mechanisms of N-GQDs inducing ferroptosis because it could be the primary target damaged by N-GQDs in the CNS. The microarray data suggested the participation of calcium signaling pathway in the ferroptosis induced by N-GQDs. In microglial BV2 cells, when the calcium content above the homeostatic level caused by N-GQDs was reversed, the number of cell death, ferroptosis alternations and excessive inflammatory cytokines release were all alleviated. Two calcium channels of L-type voltage-gated calcium channels (L-VGCCs) in plasma membrane and ryanodine receptor (RyR) in endoplasmic reticulum (ER) took part in N-GQDs inducing cytosolic calcium overload. L-VGCCs and RyR calcium channels were also involved in promoting the excess iron influx and triggering ER stress response, resp., which both exert excessive ROS generation and result in the ferroptosis and inflammation in BV2 cells. N-GQDs exposure caused ferroptosis and inflammatory responses in hippocampus of mice and cultured microglia through activating two calcium channels to disrupt intracellular calcium homeostasis. The findings not only posted an alert for biomedical applications of N-GQDs, but also highlighted an insight into mechanism researches of GQDs inducing multiple types of cell death in brain tumor therapy in the future.

Particle and Fibre Toxicology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C11H7ClFNO3, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Qiao, Jun published the artcileMagnetically Reusable Fe3O4@NC@Pt Catalyst for Selective Reduction of Nitroarenes, Related Products of pyridine-derivatives, the publication is Catalysts (2021), 11(10), 1219, database is CAplus.

A novel reusable Fe3O4@NC@Pt heterogeneous catalyst was synthesized by immobilizing platinum on nitrogen-doped carbon magnetic nanostructures. It was characterized by IR anal. (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The catalytic efficiency of Fe3O4@NC@Pt was investigated by reduction of nitro aromatic compounds The catalyst showed good catalytic activity, wide range of substrates, and good chem. selectivity, especially for the substrates of compounds containing halide and carbonyl groups. The magnetically catalyst can readily be reused up to ten cycles without loss of catalytic activity. Moreover, the key pharmaceutical intermediate Lorlatini can be facilely achieved through this strategy.

Catalysts published new progress about 1454848-00-0. 1454848-00-0 belongs to pyridine-derivatives, auxiliary class Aromatic Fluorinated Building Blocks, name is (R)-Methyl 2-(1-((2-amino-5-bromopyridin-3-yl)oxy)ethyl)-4-fluorobenzoate, and the molecular formula is C15H14BrFN2O3, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhu, Tong-Hao published the artcileCo(acac)₂/O₂-Mediated Oxidative Isocyanide Insertion with 2-Aryl Anilines: Efficient Synthesis of 6-Amino Phenanthridine Derivatives, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Organic Letters (2014), 16(4), 1260-1263, database is CAplus and MEDLINE.

A novel and efficient protocol for the creation of 6-amino phenanthridine derivatives, e.g., I, by Co(acac)₂-catalyzed isocyanide insertion with 2-aryl anilines under an O₂ atmosphere via homolytic aromatic substitution (HAS) type C-H functionalization has been developed. This reaction not only proceeds smoothly utilizing O₂ as the oxidant but also provides a new approach to construct phenanthridine derivatives utilizing readily available 2-aryl anilines with isocyanides instead of 2-isocyanobiaryls with different radical precursors.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C7H12ClNO, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Xiaoyu published the artcileRedox-triggered switchable synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives via hydride transfer/N-dealkylation/N-acylation, Computed Properties of 197958-29-5, the publication is Organic Letters (2021), 23(2), 358-364, database is CAplus and MEDLINE.

The switchable synthesis of 3-non, 3-mono, 3,3′-disubstituted 3,4-dihydroquinolin-2(1H)-ones was developed through a redox-neutral hydride-transfer/N-dealkylation/N-acylation strategy from o-aminobenzaldehyde with 4-hydroxycoumarin, and Meldrum’s acid, resp. The unprecedented strategy for the synthesis of 3,3′-highly functionalized 3,4-dihydroquinolin-2(1H)-one has been realized with the in situ utilization of the released HCHO via the o-QM involved Michael addition In addition, the synthetic utility of this protocol has been well illustrated via concise synthesis of CYP11B2 inhibitor.

Organic Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H11NO2S, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Duan, Lele published the artcileInsights into Ru-Based Molecular Water Oxidation Catalysts: Electronic and Noncovalent-Interaction Effects on Their Catalytic Activities, Safety of Pyridine-3-sulfonic acid, the publication is Inorganic Chemistry (2013), 52(14), 7844-7852, database is CAplus and MEDLINE.

A series of Ru-bda water oxidation catalysts [Ru(bda)L₂] (H₂bda = 2,2′-bipyridine-6,6′-dicarboxylic acid; L = [HNEt₃][3-SO₃-pyridine], 1; 4-(EtOOC)-pyridine, 2; 4-bromopyridine, 3; pyridine, 4; 4-methoxypyridine, 5; 4-(Me₂N)-pyridine, 6; 4-[Ph(CH₂)₃]-pyridine, 7) were synthesized with electron-donating/-withdrawing groups and hydrophilic/hydrophobic groups in the axial ligands. These complexes were characterized by ¹H NMR spectroscopy, high-resolution mass spectrometry, elemental anal., and electrochem. In addition, complexes 1 and 6 were further identified by single crystal X-ray crystallog., revealing a highly distorted octahedral configuration of the Ru coordination sphere. All of these complexes are highly active toward Ce^IV-driven (Ce^IV = Ce(NH₄)₂(NO₃)₆) water oxidation with oxygen evolution rates up to 119 mols of O₂ per mol of catalyst per s. Their structure-activity relationship was investigated. Electron-withdrawing and noncovalent interactions (attraction) exhibit pos. effect on the catalytic activity of Ru-bda catalysts.

Inorganic Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Safety of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem