Month: December 2022

Zhao, Chongjian published the artcileSyntheses, structures and photoluminescence of Cd(II) coordination polymers based on in situ synthesized bifunctional ligands, Name: Pyridine-3-sulfonic acid, the publication is Inorganic Chemistry Communications (2014), 30-35, database is CAplus.

By employing Cd(II) salt, NaN₃, and CN-(CH₂)_n-NC (n = 1, 2) and with the absence or presence of secondary ligands, four new cadmium coordination frameworks, named, {[Cd₄(btm)₄(H₂O)₂]·3H₂O}_n (1); [Cd₂(btm)₂(H₂O)]_n (2); [Cd₂(bte)(PMA)_0.5(H₂O)]_n (3); and [Cd(tzp)(2,2′-bipy)]_n (4) (H₂btm = bis(tetrazole) methane: H₂bte = 1,2-bis(tetrazole-5-yl)ethane; H₂tzp = 1H-tetrazolate-5-propionic acid; bipy = bipyridine; PMA = 1,2,4,5-benzenetetracarboxylic acid) were synthesized via in situ hydrothermal reaction. Single crystal x-ray diffraction reveals that compounds 1–3 are all three-dimensional (3D) frameworks. Compound 1 is constructed by Cd1- and Cd3-btm^2- layers and large bridging metalloligands. Compound 2 exhibits a 3D framework with two-dimensional (2D) Cd-btm^2- (adopting μ₆:κN1, N1′: κN2: κN3: κN4: κN3′: κN4’coordination mode) layers pillared by μ₃:κN1, N1′: κN2: κN4′ btm^2-. Compound 3 is built up by the Cd-bte^2- layers and the linker PMA, with left- and right-handed helical chains arranged alternately. It is notable that btm^2- takes on six different coordination modes in 1 and 2. Compound 4 represents a 2D layered framework, which can be simplified into a Shubnikov plane net (4.82̂) topol. network with 3-connected T shape linker tzp^2- ligands. In addition, the research results show that compounds 1–4 exhibit different fluorescent behaviors and thermal stabilities.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C18H12FN, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dai, Xi-Jie published the artcileEn Route to a Practical Primary Alcohol Deoxygenation, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Journal of the American Chemical Society (2016), 138(16), 5433-5440, database is CAplus and MEDLINE.

A long-standing scientific challenge in the field of alc. deoxygenation has been direct catalytic sp³ C-O defunctionalization with high selectivity and efficiency, in the presence of other functionalities, such as free hydroxyl groups and amines widely present in biol. mols. Previously, the selectivity issue had been only addressed by classic multistep deoxygenation strategies with stoichiometric reagents. Herein, we propose a catalytic late-transition-metal-catalyzed redox design, on the basis of dehydrogenation/Wolff-Kishner (WK) reduction, to simultaneously tackle the challenges regarding step economy and selectivity. The early development of our hypothesis focuses on an iridium-catalyzed process efficient mainly with activated alcs., which dictates harsh reaction conditions and thus limits its synthetic utility. Later, a significant advancement has been made on aliphatic primary alc. deoxygenation by employing a ruthenium complex, with good functional group tolerance and exclusive selectivity under practical reaction conditions. Its synthetic utility is further illustrated by excellent efficiency as well as complete chemo- and regioselectivity in both simple and complex mol. settings. Mechanistic discussion is also included with exptl. supports. Overall, our current method successfully addresses the aforementioned challenges in the pertinent field, providing a practical redox-based approach to the direct sp³ C-O defunctionalization of aliphatic primary alcs.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Steinig, Arno G. published the artcileNovel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases, Application In Synthesis of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(15), 4381-4387, database is CAplus and MEDLINE.

A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296. We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacol. activity against cMET and RON in cellular assays. OSI-296 is a potent and selective inhibitor of cMET and RON kinases that shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C10H9NO, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bertagna, Federico published the artcileThapsigargin blocks electromagnetic field-elicited intracellular Ca²⁺ increase in HEK 293 cells, Computed Properties of 21829-25-4, the publication is Physiological Reports (2022), 10(9), e15189, database is CAplus and MEDLINE.

Biol. effects of electromagnetic fields (EMFs) have previously been identified for cellular proliferation and changes in expression and conduction of diverse types of ion channels. The major effect elicited by EMFs seems to be directed toward Ca2+ homeostasis. This is particularly remarkable since Ca2+ acts as a central modulator in various signaling pathways, including, but not limited to, cell differentiation and survival. Despite this, the mechanisms underlying this modulation have yet to be unraveled. Here, we assessed the effect of EMFs on intracellular [Ca2+], by exposing HEK 293 cells to both radio-frequency electromagnetic fields (RF-EMFs) and static magnetic fields (SMFs). We detected a constant and significant increase in [Ca2+] subsequent to exposure to both types of fields. Strikingly, the increase was nulled by administration of 10 μM Thapsigargin, a blocker of sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs), indicating the involvement of the endoplasmic reticulum (ER) in EMF-related modulation of Ca2+ homeostasis.

Physiological Reports published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Computed Properties of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Constable, Edwin C. published the artcileThe preparation and coordination chemistry of 2,2′:6′,2″-terpyridine macrocycles – 1, Product Details of C7H7ClN2, the publication is Polyhedron (1982), 1(3), 303-6, database is CAplus.

Derivatives of 2,2′:6′,2”-terpyridine were prepared with the intention of forming macrocycles incorporating the 2,2′:6′,2”-terpyridyl moiety. Bis(methylhydrazino)phenylterpyridine I (R = MeNNH₂) and a number of metal complexes of this novel pentadentate ligand were prepared Thus, Ortoleva-King reaction of 2-acetyl-6-bromopyridine with iodine and pyridine gave pyridinium iodide II. Cyclocondensation of II and 2-bromo-6-cinnamoylpyridine in refluxing HOAc containing NH₄OAc gave I (R = Br). Reaction of the latter with MeNHNH₂ gave I (R = MeNNH₂) which formed colored complexes with Cr, Mn, Fe, Co, and Ni.

Polyhedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Product Details of C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

An, Peng published the artcileSterically Shielded, Stabilized Nitrile Imine for Rapid Bioorthogonal Protein Labeling in Live Cells, Application of 2-Pyridinylboronic acid, the publication is Journal of the American Chemical Society (2018), 140(14), 4860-4868, database is CAplus and MEDLINE.

In pursuit of fast bioorthogonal reactions, reactive moieties have been increasingly employed for selective labeling of biomols. in living systems, posing a challenge in attaining reactivity without sacrificing selectivity. To address this challenge, here the authors report a bioinspired strategy in which mol. shape controls the selectivity of a transient, highly reactive nitrile imine dipole. By tuning the shape of structural pendants attached to the ortho position of the N-aryl ring of diaryltetrazoles, precursors of nitrile imines, the authors discovered a sterically shielded nitrile imine that favors the 1,3-dipolar cycloaddition over the competing nucleophilic addition The photogenerated nitrile imine exhibits an extraordinarily long half-life of 102 s in aqueous medium, owing to its unique mol. shape that hinders the approach of a nucleophile as shown by DFT calculations The utility of this sterically shielded nitrile imine in rapid (� min) bioorthogonal labeling of glucagon receptor in live mammalian cells was demonstrated.

Journal of the American Chemical Society published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Xisheng published the artcilePd(II)-catalyzed para-selective C-H arylation of monosubstituted arenes, Formula: C6H5F4NO3S, the publication is Journal of the American Chemical Society (2011), 133(35), 13864-13867, database is CAplus and MEDLINE.

Pd-catalyzed highly para-selective C-H arylation of monosubstituted arenes (including toluene) is developed for the first time using an F⁺ reagent as a bystanding oxidant. This finding provides a new retrosynthetic disconnection for para-substituted biaryl synthesis e. g., I via C-H/C-H cross-coupling.

Journal of the American Chemical Society published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C3H5BN2O2, Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Raboisson, Pierre published the artcileEvaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors, Synthetic Route of 18437-58-6, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(7), 1843-1849, database is CAplus and MEDLINE.

Screening of a focused library of TGF beta kinase inhibitors in the cellular HCV replicon model with luciferase read out yielded a number of low micromolar HCV inhibitors. Medicinal chem. driven optimization resulted in the discovery of 4-[2-(5-bromo-2-fluoro-phenyl)pteridin-4-ylamino]-N-[3-(2- oxopyrrolidin-1-yl)propyl]nicotinamide 36 with a replicon EC₅₀ of 64 nM, associated with a selective kinase inhibitory profile for human JNK kinases 2 and 3 as well as VEGFR-1, 2, and 3 kinases. Moreover, 36 showed an advantageous PK profile in mice. Experiments performed using different replicon constructs suggest that this series of kinase inhibitors might mediate their effect through the HCV non-structural protein 5A (NS5A).

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vekariya, Rakesh H. published the artcileSynthesis and Structure-Activity Relationships of 5′-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects, Product Details of C5H6BNO2, the publication is Journal of Medicinal Chemistry (2020), 63(14), 7663-7694, database is CAplus and MEDLINE.

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed μ opioid receptor (MOR) agonist and δ/κ opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this mol. gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20(I) (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression vs. morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects.

Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C9H5ClO4S, Product Details of C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hood, Thomas M. published the artcileSynthesis and Structural Dynamics of Five-Coordinate Rh(III) and Ir(III) PNP and PONOP Pincer Complexes, COA of Formula: C23H43NP2, the publication is Inorganic Chemistry (2019), 58(11), 7593-7601, database is CAplus and MEDLINE.

The synthesis and characterization of a homologous series of five-coordinate Rh(III) and Ir(III) complexes of PNP (2,6-(tBu₂PCH₂)₂C₅H₃N) and PONOP (2,6-(tBu₂PO)₂C₅H₃N) pincer ligands are described: [M(PNP)(biph)][BAr^F₄] (M = Rh, 1a; Ir, 1b; biph = 2,2′-biphenyl; Ar^F = 3,5-(CF₃)₂C₆H₃) and [M(PONOP)(biph)][BAr^F₄] (M = Rh, 2a; Ir, 2b). These complexes are structurally dynamic in solution, exhibiting pseudorotation of the biph ligand on the ¹H NMR time scale (ΔG^{îŒ?/sup> âˆ?0 kJ mol-1) and, in the case of the flexible PNP complexes, undergoing interconversion between helical and puckered pincer ligand conformations (ΔGîŒ?/sup> âˆ?0 kJ mol-1). Remarkably, the latter is sufficiently facile that it persists in the solid state, leading to temperature-dependent disorder in the associated x-ray crystal structures. Reaction of 1 and 2 with CO occurs for the Ir congeners 1b and 2b, giving sterically congested carbonyl derivatives}

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, COA of Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem