Month: December 2022

Cabalin, L. M. published the artcileSample illumination configurations for spatially resolved Raman spectrometry using a charge-coupled device detector, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1995), 42(10), 1379-83, database is CAplus and MEDLINE.

Two simple configurations for sample illumination using a CCD detectors are shown. The choice of an appropriate sample illumination can be crucial to obtain spatial and spectral information of complex samples. Simultaneous Raman spectra of a heterogeneous sample of 3 compounds can be obtained using a vertical sample illumination. Spatially resolved resonant Raman and surface-enhanced resonant Raman spectra of Ni 2-pyridinecarboxaldehyde 2-pyridylhydrazone complex were observed with a low integration time. Dividing the CCD in 2 regions and with horizontal multiline sample illumination (Ar-ion laser at 488 nm and He-Ne laser at 632.8 nm) spatially resolved fluorescence of a homogeneous mixture of dyes were obtained. The total image was acquired in only 1 s.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Beng, Timothy K. published the artcileRegiocontrolled synthesis of (hetero)aryl and alkenyl dehydropyrrolidines, dehydropiperidines and azepenes by Ru-catalyzed, heteroatom-directed α-C-H activation/cross-coupling of cyclic enamides with boronic acids, Recommanded Product: 2-Pyridinylboronic acid, the publication is Organic & Biomolecular Chemistry (2016), 14(3), 830-834, database is CAplus and MEDLINE.

The synthesis of α-aryl and alkenyl pyrrolidine-, piperidine-, and azepane derivatives, through the intermediacy of cyclic enamides is described. The desired outcome is achieved through ruthenium-catalyzed, site-selective sp² C-H activation/cross-coupling with aryl and alkenyl boronic acids. The regioselectivity (α-sp²vs. α-sp³vs. β-sp² C-H functionalization) is governed by the rate differences between sp² and sp³ C-H activation and the necessity for chelation between the ruthenium metal and the carbonyl directing group.

Organic & Biomolecular Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wikaira, Jan L. published the artcileTetrahalocuprate salts of substituted 4-aminopyridines: Synthesis, structure and magnetic properties, Related Products of pyridine-derivatives, the publication is Polyhedron (2013), 770-780, database is CAplus.

The reaction of CuX₂ (X = Br or Cl) with 4-amino-2-chloropyridine or 4-amino-2-methylpyridine in aqueous acids (HX; X = Br or Cl) yields bis(4-amino-2-chloropyridinium) tetrachlorocuprate(II) 3, bis(4-amino-2-chloropyridinium) tetrabromocuprate(II) 4, bis(4-amino-2-methylpyridinium) tetrachlorocuprate(II) monohydrate 5, and bis(4-amino-2-methylpyridinium) tetrabromocuprate(II) monohydrate 6. These compounds were characterized by IR, powder x-ray diffraction, single crystal X-ray diffraction, combustion anal., and temperature dependent magnetic susceptibility. Compounds 3 and 4 both crystallize in the monoclinic space group C2/c, compounds 5 crystallizes in the monoclinic space group P2₁/c and compound 3 crystallizes in the triclinic space group P-1. Magnetic data were collected for the four synthesized compounds and their previously reported parent compounds of 4-aminopyridinium tetrachlorocuprate 1, or tetrabromocuprate 2. All compounds exhibit antiferromagnetic exchange via the two-halide exchange, with strongest exchange observed for compound 6. A number of potential magnetic exchange pathways are seen in these compounds, but fitting of the data to available anal. models suggests that the magnetic exchange constants are 2J/k_B approx. -0.14(2) K in 1, âˆ?0.812(5) K in 2, âˆ?0.173(6) K in 3, âˆ?0.82(1) K in 4, âˆ?2.123(6) K in 5, and âˆ?30.9(1) K in 6.

Polyhedron published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C4Br2N2O4S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Appa, Rama Moorthy published the artcilePd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions, Recommanded Product: 2-Pyridinylboronic acid, the publication is Molecular Catalysis (2021), 111366, database is CAplus.

A quick and eco-friendly protocol for the synthesis of biaryls, e.g., I by an oxidative (aerobic) homocoupling of arylboronic acids RB(OH)₂ (R = C₆H₅, pyridin-2-yl, 2-thienyl, etc.) using Pd(OAc)₂ in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media is described. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result sym. biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.

Molecular Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Abdallah el hadj, A. published the artcileAI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters, Product Details of C17H18N2O6, the publication is Fluid Phase Equilibria (2022), 113297, database is CAplus.

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state.

Fluid Phase Equilibria published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Peng, De-wei published the artcileConnexin 43 participates in atrial electrical remodelling through colocalization with calcium channels in atrial myocytes, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Clinical and Experimental Pharmacology and Physiology (2022), 49(1), 25-34, database is CAplus and MEDLINE.

Atrial fibrillation (AF) is associated with atrial conduction disturbances caused by elec. and/or structural remodelling. In the present study, author hypothesized that connexin might interact with the calcium channel through forming a protein complex and, then, participates in the pathogenesis of AF. Western blot and whole-cell patch clamp showed that protein levels of Cav1.2 and connexin 43 (Cx43) and basal ICa,L were decreased in AF subjects compared to sinus rhythm (SR) controls. In cultured atrium-derived myocytes (HL-1 cells), knocking-down of Cx43 or incubation with 30 mmol/L glycyrrhetinic acid significantly inhibited protein levels of Cav1.2 and Cav3.1 and the c.d. of I_Ca,L and I_Ca,T. Incubation with nifedipine or mibefradil decreased the protein level of Cx43 in HL-1 cells. Moreover, Cx43 was colocalized with Cav1.2 and Cav3.1 in atrial myocytes. Therefore, Cx43 might regulate the I_Ca,L and I_Ca,T through colocalization with calcium channel subunits in atrial myocytes, representing a potential pathogenic mechanism in AF.

Clinical and Experimental Pharmacology and Physiology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kadassery, Karthika J. published the artcilePentacarbonylmethylmanganese(I) as a synthon for Mn(I) pincer catalysts, Formula: C23H43NP2, the publication is Dalton Transactions (2019), 48(14), 4467-4470, database is CAplus and MEDLINE.

Mn(I) complexes that enable metal-ligand cooperative substrate activation catalyze a range of transformations. Use of MeMn(CO)₅ as a synthon in place of typical Mn(CO)₅Br was explored and found to be quite versatile, generating catalytically active species in situ by activation of O-H, N-H, and even C-H bonds.

Dalton Transactions published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Albrizio, Maria published the artcileThe role of bicarbonate in the modulation of capacitation, spontaneous acrosome reaction and motility of equine fresh and frozen spermatozoa, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Theriogenology (2022), 112-118, database is CAplus and MEDLINE.

In this study, we defined the composition of the culture medium that yield a significant percentage of alive and functional equine spermatozoa during enough time before artificial insemination. The effects of sodium bicarbonate were analyzed in fresh and frozen semen in respect to sperm viability, capacitation, spontaneous acrosome reaction and several kinetic parameters such as total motility, progressive motility, VCL, VSL, ALH, BCF, LIN. Moreover, employing Bayk-6844 and Nifedipine, the involvement of L-type voltage-gated calcium channels in the modulation of intracellular calcium concentrations was investigated. Results evidenced an immediate effect of sodium bicarbonate in reducing fresh sperm viability and in increasing capacitation and spontaneous acrosome reaction of fresh and frozen spermatozoa. Furthermore, it affected total and progressive motility of fresh and frozen semen. Because of the sudden effects of the compound, we think that a buffer lacking sodium bicarbonate is more suitable to preserve the viability and the functional state of equine spermatozoa required to undergo at the right time those modifications necessary for fertilization. We also demonstrated that intracellular calcium modifications induced by Bayk-8644 and Nifedipine are not involved in signals related to vitality, capacitation, spontaneous acrosome reaction and motility.

Theriogenology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Junwon published the artcileSerendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors, Safety of (6-Hydroxypyridin-3-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(23), 5473-5477, database is CAplus and MEDLINE.

The authors identified a novel class of 2-[(phenylsulfonyl)methyl]thieno[3,2-d]pyrimidine compounds as potent HIV-1 replication inhibitors serendipitously during the process of evaluation of triazolothienopyrimidine (TTPM) compounds Herein, the authors report a synthesis and biol. evaluation of 2-[(phenylsulfonyl)methyl]thieno[3,2-d]pyrimidine compounds using a cell-based full replication assay to identify thienopyrimidine derivatives which could be further utilized as viable lead compounds The synthesis of the target compounds was achieved by a reaction of (chloro)[[(aryl)sulfonyl]methyl]thieno[3,2-d]pyrimidine with boronic acids, amines, phenol derivative

Bioorganic & Medicinal Chemistry Letters published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C5H6BNO3, Safety of (6-Hydroxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oh, Sangmi published the artcileIdentification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities, Category: pyridine-derivatives, the publication is ACS Medicinal Chemistry Letters (2021), 12(4), 563-571, database is CAplus and MEDLINE.

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

ACS Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem