Month: December 2022

Ijuin, Kazushige published the artcileClassification of drugs according to drug supply stochastic properties at a pharmacy, Safety of N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Iryo Yakugaku (2006), 32(6), 489-496, database is CAplus.

Eighty-one prescription drugs were divided into three groups according to the strength of the auto-correlation (strong, weak or none) of daily variations in the drug supply amounts at a pharmacy. The power spectral d. and autocorrelation function were used as an indicator for the classification. Sixty-four drugs fell into the no auto-correlation group, 15 drugs into the weak auto-correlation group and 2 drugs into the strong auto-correlation group. Interestingly, our grouping using auto-correlation as a criterion was consistent with the target-oriented classification (standard commodity classification of Japan).

Iryo Yakugaku published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Safety of N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mangalam, Neema Ani published the artcileDiversities in the chelation of aroylhydrazones towards cobalt(II) salts: Synthesis, spectral characterization, crystal structure and some theoretical studies, COA of Formula: C12H9NO, the publication is Journal of Molecular Structure (2021), 129978, database is CAplus.

Five Co complexes synthesized from two aroylhydrazones were characterized by elemental analyses, TGA, molar conductivity, magnetic susceptibility measurements, IR and electronic spectra. Single crystal x-ray structure of one of the complex is also reported and it got crystallized in triclinic space group P1̅ and the crystal structure shows a distorted octahedral geometry around the metal center. Spectral data reveal that both the aroylhydrazones are tridentate and coordinate through the azomethine N, hydrazonic O, and pyridyl N. Magnetic susceptibility measurements confirm the paramagnetic nature of the Co(II) complexes and one of the complex is diamagnetic in nature. Addnl., HF/6-311G(d,p)/LANL2DZ calculations were performed to predict the possible intramol. interactions contributing to the lowering of the stabilization energy. Accordingly, πâ†?π^* transitions are responsible for the stabilization energy for the ligands and their Co complexes. To describe and discuss the chem. reactivity and stability of synthesized complexes, quantum chem. parameters like frontier orbital energies, hardness, softness, energy gap, electronegativity, chem. potential, electrophilicity, polarizability and dipole moment were calculated Also, the main electronic structure principles such as maximum hardness, min. polarizability, and min. electrophilicity principles were considered to evaluate the stability of the complexes.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wilson, Jonathan E. published the artcileDiscovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes, SDS of cas: 1008506-24-8, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(12), 2947-2951, database is CAplus and MEDLINE.

A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides that were identified from a high-throughput screen of the Merck compound collection for GPR142 agonists. This work led to the discovery of 3-phenoxy-benzo-[1,2,4]-triazolo-[1,4]-oxazepine I, a potent GPR142 agonist with an off-target and PK profile suitable for in vivo studies. This compound and a related analog II were shown to be active in mouse oral glucose tolerance tests (OGTTs). Furthermore, a GPR142 knock-out mouse OGTT study with compound II provides evidence that its glucose-lowering effect is mediated by GPR142.

Bioorganic & Medicinal Chemistry Letters published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C9H13NO2, SDS of cas: 1008506-24-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Meng, Fanqiang published the artcileAmmonia Formation Catalyzed by a Dinitrogen-Bridged Dirhenium Complex Bearing PNP-Pincer Ligands under Mild Reaction Conditions, Quality Control of 338800-13-8, the publication is Angewandte Chemie, International Edition (2021), 60(25), 13906-13912, database is CAplus and MEDLINE.

A series of rhenium complexes bearing a pyridine-based PNP-type pincer ligand are synthesized from rhenium phosphine complexes as precursors. A dinitrogen-bridged dirhenium complex bearing the PNP-type pincer ligands catalytically converts dinitrogen into ammonia during the reaction with KC8 as a reductant and [HPCy₃]BArF₄ (Cy=cyclohexyl, ArF=3,5-(CF₃)₂C₆H₃) as a proton source at -78 °C to afford 8.4 equiv of ammonia based on the rhenium atom of the catalyst. The rhenium-dinitrogen complex also catalyzes silylation of dinitrogen in the reaction with KC8 as a reductant and Me₃SiCl as a silylating reagent under ambient reaction conditions to afford 11.7 equiv of tris(trimethylsilyl)amine based on the rhenium atom of the catalyst. These results demonstrate the first successful example of catalytic nitrogen fixation under mild reaction conditions using rhenium-dinitrogen complexes as catalysts.

Angewandte Chemie, International Edition published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Quality Control of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hu, Essa published the artcileDiscovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors, Application In Synthesis of 1366482-40-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(6), 2262-2265, database is CAplus and MEDLINE.

Aminopyridinyl-substituted dimethoxycinnolines such as piperidinylpyridinyl dimethoxycinnolines I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) were prepared as selective inhibitors of phosphodiesterase 10A (PDE10A) for potential use in the treatment of schizophrenia. Bromodimethoxycinnoline II was prepared in two steps from 2-amino-4,5-dimethoxyacetophenone; Suzuki coupling of II with fluoropyridinyl boronic acids followed by aryl substitution reactions with amines and nitrogen heterocycles yielded aminopyridinyl-substituted dimethoxycinnolines. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) inhibited PDE10A with IC₅₀ values of 1.3-13.2 nM and were selective for PDE10A over phosphodiesterases 1-9 and 11 (particularly PDE3) by greater than 350-fold. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl), in which the piperidinyl moiety was hydroxy- or hydroxyalkyl-substituted, showed reduced clearance in rats [0.15-2.15 L/(h × kg)] relative to methoxyethyl- and methoxyazetidinyl-substituted pyridinyl cinnolines. I (R = Me; R¹ = HO; R² = 2-pyridinyl) suppressed the conditioned avoidance response in rats (a model of schizophrenia) at a dosage of 5.6 mg/kg. The structure of I (R = Me; R¹ = HOCMe₂; R² = H) bound to the catalytic domain of human PDE10A was determined by X-ray crystallog.

Bioorganic & Medicinal Chemistry Letters published new progress about 1366482-40-7. 1366482-40-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (5,6-Difluoropyridin-3-yl)boronic acid, and the molecular formula is C5H4BF2NO2, Application In Synthesis of 1366482-40-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hu, Essa published the artcileDiscovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors, HPLC of Formula: 1366482-32-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(6), 2262-2265, database is CAplus and MEDLINE.

Aminopyridinyl-substituted dimethoxycinnolines such as piperidinylpyridinyl dimethoxycinnolines I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) were prepared as selective inhibitors of phosphodiesterase 10A (PDE10A) for potential use in the treatment of schizophrenia. Bromodimethoxycinnoline II was prepared in two steps from 2-amino-4,5-dimethoxyacetophenone; Suzuki coupling of II with fluoropyridinyl boronic acids followed by aryl substitution reactions with amines and nitrogen heterocycles yielded aminopyridinyl-substituted dimethoxycinnolines. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) inhibited PDE10A with IC₅₀ values of 1.3-13.2 nM and were selective for PDE10A over phosphodiesterases 1-9 and 11 (particularly PDE3) by greater than 350-fold. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl), in which the piperidinyl moiety was hydroxy- or hydroxyalkyl-substituted, showed reduced clearance in rats [0.15-2.15 L/(h × kg)] relative to methoxyethyl- and methoxyazetidinyl-substituted pyridinyl cinnolines. I (R = Me; R¹ = HO; R² = 2-pyridinyl) suppressed the conditioned avoidance response in rats (a model of schizophrenia) at a dosage of 5.6 mg/kg. The structure of I (R = Me; R¹ = HOCMe₂; R² = H) bound to the catalytic domain of human PDE10A was determined by X-ray crystallog.

Bioorganic & Medicinal Chemistry Letters published new progress about 1366482-32-7. 1366482-32-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Chloride,Boronic acid and ester,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-6-fluoropyridin-3-yl)boronic acid, and the molecular formula is C5H4BClFNO2, HPLC of Formula: 1366482-32-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Matsuo, Yutaka published the artcileSynthesis of Metal Fullerene Complexes by the Use of Fullerene Halides, Recommanded Product: 1-Fluoropyridiniumtriflate, the publication is Organometallics (2008), 27(14), 3403-3409, database is CAplus.

K(C₆₀R₅) (1, R = Me, Ph) was generated by deprotonation of C₆₀R₅H (2) and allowed to react with N-fluoropyridinium triflate and N-chloro- and N-bromosuccinimide in benzene at 25° for 10 min to obtain halogenated fullerenes C₆₀R₅X (3a: R = Me, X = F; 3b: R = Me, X = Cl; 3c: R = Me, X = Br; 4a: R = Ph, X = F; 4b: R = Ph, X = Cl, 4c: R = Ph, X = Br) in good yield. The pentamethyl[60]fullerene halides are useful for the synthesis of a variety of η⁵-fullerene metal complexes. The reaction of the fullerene bromide 3c with the low-valent transition metal complexes Na[Re(CO)₄], Fe(CO)₅, Ru₃(CO)₁₂, and Na[Co(CO)₄] gave Re(η⁵-C₆₀Me₅)(CO)₃ (5), Fe(η⁵-C₆₀Me₅)Br(CO)₂ (6), Ru(η⁵-C₆₀Me₅)Br(CO)₂ (7), and Co(η⁵-C₆₀Me₅)(CO)₂ (8), resp. The structures of halide 3c and rhenium complex 5 were determined by x-ray crystallog. Electrochem. measurements on 3b and 3c were also performed. The iron complex 6 was converted into Fe(η⁵-C₆₀Me₅)Cp (9), Fe(η⁵-C₆₀Me₅)Me(CO)₂ (10), Fe(η⁵-C₆₀Me₅)(CO)₂(CCH) (11), and Fe(η⁵-C₆₀Me₅)(CO)₂(CCPh) (12), by ligand exchange reactions.

Organometallics published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Recommanded Product: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liang, Ling published the artcileComparative peripheral edema for dihydropyridines calcium channel blockers treatment: A systematic review and network meta-analysis, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Journal of Clinical Hypertension (Hoboken, NJ, United States) (2022), 24(5), 536-554, database is CAplus and MEDLINE.

Dihydropyridine calcium channel blockers (DHPCCBs) are widely used to treat hypertension and chronic coronary artery disease. One common adverse effect of DHPCCBs is peripheral edema, particularly of the lower limbs. The side effect could lead to dose reduction or discontinuation of the medication. The combination of DHPCCBs and renin-angiotensin system blockers has shown to reduce the risk of DHPCCBs-associated peripheral edema compared with DHPCCBs monotherapy. Author performed the current systematic review and network meta-anal. of randomized controlled trials (RCTs) to estimate the rate of peripheral edema with DHPCCBs as a class and with individual DHPCCBs and the ranking of the reduction of peripheral edema. The effects of renin-angiotensin system blockers on DHPCCBs network meta-anal. were created to analyze the ranking of the reduction of peripheral edema. A total of 3312 publications were identified and 71 studies with 56,283 patients were included. Nifedipine ranked highest in inducing peripheral edema (SUCRA 81.8%) and lacidipine (SUCRA 12.8%) ranked the least. All DHPCCBs except lacidipine resulted in higher relative risk (RR) of peripheral edema compared with placebo. Nifedipine plus angiotensin receptor blocker (SUCRA: 92.3%) did not mitigate peripheral edema and amlodipine plus angiotensin-converting enzyme inhibitors (SUCRA: 16%) reduced peripheral edema the most. Nifedipine ranked the highest and lacidipine ranked the lowest amongst DHPCCBs for developing peripheral edema when used for cardiovascular indications. The second or higher generation of DHPCCBs combination with ACEIs or ARBs or diuretics lowered the chance of peripheral edema development compared to single DHPCCB treatment.

Journal of Clinical Hypertension (Hoboken, NJ, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kao, Sheng-Yuan published the artcileAn electrochromic device based on all-in-one polymer gel through in-situ thermal polymerization, Recommanded Product: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Solar Energy Materials & Solar Cells (2016), 145(Part_1), 61-68, database is CAplus.

A self-standing all-in-one electrochromic gel utilizing Ph viologen (PV) and N,N,N’,N’-tetramethyl-1,4-phenylenediamine (TMPD) as the electrochromic materials is prepared by incorporating a thermo-cured cross-linked polymer matrix. The thermal-cured polymer matrix can prevent the agglomeration of PV happening on the electrode surface, resulting in the excellent write-erase ability of the obtained gelated ECD. Moreover, the cross-linker which possesses the long propoxylated arms leads to the easier diffusion for both PV and TMPD in the obtained polymer network. As a result, the obtained ECD exhibits a large transmittance change (ΔT>67% at 620 nm) within a short response time (<3.5 s) under an extremely low driving voltage (0.5 V). Besides, this device remains over 55% of ΔT after 10,000 cycles of switching.

Solar Energy Materials & Solar Cells published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Recommanded Product: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Yong published the artcileCopper-Catalyzed, One-Pot, Three-Component Synthesis of Benzimidazoles by Condensation and C-N Bond Formation, Quality Control of 39856-58-1, the publication is Journal of Organic Chemistry (2011), 76(23), 9577-9583, database is CAplus and MEDLINE.

Benzimidazoles, e.g., I, were synthesized by the copper-catalyzed, one-pot, three-component reaction of 2-haloanilines, aldehydes, and NaN₃. The reaction was optimized when 2-iodo- or 2-bromoanilines (1.0 equiv), aldehydes (1.2 equiv), NaN₃ (2.0 equiv), 5 mol% of CuCl, and 5 mol % of TMEDA were reacted in DMSO at 120 °C for 12 h. Good yields were obtained and the reaction showed tolerance toward functional groups such as ester, nitro, and chloro. Aliphatic and heteroaromatic aldehydes also afforded the desired products in moderate to good yields.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Quality Control of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem