Month: December 2022

Raghu, M. S. published the artcileSynthesis, characterization, antimicrobial and interaction studies of pteridines with human serum albumin: A combined multi-spectroscopic and computational study, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Molecular Structure (2022), 1250(Part_3), 131857, database is CAplus.

A novel series of pteridine derivatives I [R = H, F, Cl, F₃C, Br] was synthesized, and the structures of these mols. were established using elemental anal. and numerous spectroscopic methods. The disk diffusion technique was used to examine the antimicrobial potential of the newly synthesized mols. Among the compounds examined, I [R = F, F₃C] compounds had the highest impact against the examined bacterial and fungal strains. The compounds min. inhibitory concentration (MIC) was observed to be in the line of 0.41-6.83μM. UV-vis absorption, fluorescence quenching, FT-IR spectroscopy and CD (CD) along with mol. docking methods, were studies to assess the binding behavior of efficient pteridine derivatives I [R = F, F₃C] with human serum albumin (HSA). Formation of HSA-test compounds complex indicated the static quenching phenomena during fluorescence quenching of HSA by test compounds Synthesized I [R = F, F₃C] were further evaluated for three basic binding sites of HSA including subdomains IIA, IIIA, and IB, using mol. docking studies. Hydrophobic and interaction through hydrogen bonding influenced the binding pathway of HSA with test mols., according to the mol. docking data. Furthermore, the DFT technique was used to optimize the mol. geometry of potent I [R = F, F₃C] compounds using the B3LYP hybrid functional and the 6-311 + G(d, p) basis set. The optimized structure closely aligned with the test findings. The electrostatic potential framework was produced to visualize the mol.’s energy distribution and chem. reactive areas.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kobayashi, Yoshiro published the artcileStudies on the reaction of heterocyclic compounds. XV. N-Alkylation of 1,2,3,4-tetrahydro-5-methyl-1,6-naphthyridine, Application In Synthesis of 18437-58-6, the publication is Chemical & Pharmaceutical Bulletin (1976), 24(8), 1704-7, database is CAplus.

Alkylation of the 1-position of 5-methyl-1,2,3,4-tetrahydro-1,6-naphthyridine (I) does not proceed by ordinary methods. The UV absorption maximum of I shows a bathochromic shift on protonation. Considering this, alkylation was successfully carried out in the presence of NaNH2.

Chemical & Pharmaceutical Bulletin published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Yiwen published the artcileConvenient synthesis of 2-aryl-1-haloindolizines from pyridinium salts and 2-aryl-1,1-dihaloalk-1-enes, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Synthesis (2011), 3447-3452, database is CAplus.

2-Aryl-1-haloindolizines were synthesized from pyridinium salts and 2-aryl-1,1-dihaloalk-1-enes using a DBU/THF system. 2-Aryl-1,1-dihaloalk-1-enes containing electron-withdrawing or -donating groups were efficiently converted into the corresponding 2-aryl-1-haloindolizines in moderate to excellent yields.

Synthesis published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C8H19NO2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Das, Sabuj Kanti published the artcileCuO grafted triazine functionalized covalent organic framework as an efficient catalyst for C-C homo coupling reaction, Formula: C5H6BNO2, the publication is Molecular Catalysis (2020), 110650, database is CAplus.

A new copper oxide immobilized covalent organic framework (COF) material Cu^II-TRIPTA by grafting of CuO nanoparticles at the surface of a nitrogen rich porous COF material TRIPTA was reported. TRIPTA was synthesized through the extended Schiff base reaction between 2,4,6-triformylphloroglucinol and 1,3,5-tris-(4-aminophenyl)triazine. The COF as well as CuO loaded materials were characterized by powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), XPS, N₂ adsorption-desorption, Fourier transform IR spectroscopy (FT-IR), thermogravimetry (TG) and EPR spectroscopic analyses. Cu^II-TRIPTA material was successfully applied as heterogeneous nanocatalyst for the C-C homo-coupling reaction of phenylboronic acids to synthesize wide range of biaryl compounds under mild and eco-friendly conditions (60°, methanol solvent). Remarkably high sp. surface area of Cu^II-TRIPTA (583 m² g^-1) and highly accessible catalytic sites in the 2D-hexagonal COF nano-architecture potentially makes it excellent catalyst in the C-C bond formation reaction, which was evident from the high TON of the catalyst in this reaction. The catalyst was recollected and reused till 6th cycles without any noticeable change of its catalytic activity, suggesting its high catalytic efficiency in this C-C bond formation reaction.

Molecular Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Stamm, T. published the artcileZeolite-catalyzed isomerization of aromatic amines to methyl-aza-aromatics, Synthetic Route of 18437-58-6, the publication is Journal of Catalysis (1995), 155(2), 268-82, database is CAplus.

The scope and mechanism of the isomerization of arylamines to methyl-substituted aromatic heterocycles have been studied. Aniline, toluidines, naphthylamines and m-phenylenediamine all reacted to the corresponding ortho-methyl-substituted aza-aromatics when exposed to high NH₃ pressure and elevated temperature in the presence of acid catalysts. Zeolites with a three-dimensional pore structure, especially H-ZSM-5, showed the best performance. Optimum reaction conditions are around 600 K and 10 MPa. Two mechanisms which had been proposed earlier for this apparent N-ortho C exchange reaction proved untenable. Neither incorporation of the N atom into the aromatic ring nor a mechanism based on an intramol. Ritter reaction could explain the required high NH₃ pressure or the product distribution. Two new mechanisms are proposed which can explain all observations. In both mechanisms, reaction starts with addition of NH₃ to the arylamine, followed by ring opening. In one mechanisms an alkyno-imine intermediate is formed; in the other mechanisms an enamino-imine intermediate is formed through a reverse aldol reaction. In both cases ring closure and NH₃ elimination lead to the required aromatic heterocycles. The high NH₃ presure is explained by the need to add NH₃ to the aromatic ring, and the high temperature by the need to desorb NH₃ from the acid sites.

Journal of Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C15H24O2, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Novotny, Miroslav published the artcileFixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Meniere’s disease: a randomized, double-blind, parallel group clinical study, Synthetic Route of 54856-23-4, the publication is International Tinnitus Journal (2002), 8(2), 115-123, database is CAplus.

In a randomized, double-blind clin. study, we evaluated the efficacy and tolerability of the fixed combination of cinnarizine, 20 mg, and dimenhydrinate, 40 mg (Arlevert [ARL]) in comparison to betahistine dimesylate (12 mg) in 82 patients suffering from Meniere’s disease for at least 3 mo and showing the characteristic triad of symptoms (paroxysmal vertigo attacks, cochlear hearing loss, and tinnitus). The treatment (one tablet three times daily) extended to 12 wk, with control visits at 1, 3, 6, and 12 wk after drug intake. The study demonstrated for both the fixed-combination ARL and for betahistine a highly efficient reduction of vertigo symptoms in the course of the 12 wk of treatment; however, no statistically significant difference between the two treatment groups could be established. Similar results were found for tinnitus (approx. 60% reduction) and for the associated vegetative symptoms (almost complete disappearance). Vestibulospinal reactions, recorded by craniocorpog., also improved distinctly, with a statistically significant superiority of ARL vs. betahistine (p <.042) for the parameter of lateral sway (Unterberger’s test). The caloric tests (electronystagmog.) showed only minor changes for both treatment groups in the course of the study. A statistically significant improvement of hearing function of the affected ear (p =.042) was found for the combination preparation after 12 wk of treatment. The tolerability was judged by the vast majority of patients (97.5%) in both groups to be very good. Only one patient (betahistine group) reported a nonserious adverse event, and two betahistine patients did not complete the study. In conclusion, the combination preparation proved to be a highly efficient and safe treatment option for Meniere’s disease and may be used both in the management of acute episodes and in long-term treatment. Efficacy and safety were similar to the widely used standard therapy with betahistine.

International Tinnitus Journal published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Synthetic Route of 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Stambirskyi, Maksym V. published the artcilePhosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications, HPLC of Formula: 39856-58-1, the publication is Journal of Organic Chemistry (2021), 86(18), 12783-12801, database is CAplus and MEDLINE.

A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C13H18N2, HPLC of Formula: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deady, Leslie W. published the artcileSubstituent effects on the isomer ratios in the rearrangement of some 2- and 4-nitraminopyridines, SDS of cas: 18437-58-6, the publication is Australian Journal of Chemistry (1982), 35(10), 2025-34, database is CAplus.

The preparation and rearrangement in 92% H₂SO₄ of I–III (R = H, Me, MeO, Br, Cl, CO₂H) were investigated. The product isomer ratios can be explained by differential electronic stabilization of the appropriate σ complexes for aromatic nitration and steric effects seem relatively unimportant. Deuteration [3-D in I, R = Me] had no effect on the product distribution.

Australian Journal of Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, SDS of cas: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Han, Zhiji published the artcileCO₂ Reduction Selective for C_â‰? Products on Polycrystalline Copper with N-Substituted Pyridinium Additives, Product Details of C22H18Cl2N2, the publication is ACS Central Science (2017), 3(8), 853-859, database is CAplus and MEDLINE.

Electrocatalytic CO₂ reduction to generate multicarbon products is of interest for applications in artificial photosynthetic schemes. This is a particularly attractive goal for CO₂ reduction by Cu electrodes, where a broad range of hydrocarbon products can be generated but where selectivity for C-C coupled products relative to CH₄ and H₂ remains an impediment. Herein the authors report a simple yet highly selective catalytic system for CO₂ reduction to C_â‰? hydrocarbons on a polycrystalline Cu electrode in bicarbonate aqueous solution that uses N-substituted pyridinium additives. Selectivities of 70-80% for C₂ and C₃ products with a hydrocarbon ratio of C_â‰?/CH₄ significantly >100 were observed with several additives. ¹³C-labeling studies verify CO₂ to be the sole C source in the C_â‰? hydrocarbons produced. Upon electroreduction, the N-substituted pyridinium additives lead to film deposition on the Cu electrode, identified in one case as the reductive coupling product of N-arylpyridinium. Product selectivity can also be tuned from C_â‰? species to H₂ (âˆ?0%) while suppressing methane with certain N-heterocyclic additives.

ACS Central Science published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Product Details of C22H18Cl2N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuzuya, Masayuki published the artcileA novel single electron transfer in solid-state organic compounds: mechanically induced reduction of dipyridinium salts, Related Products of pyridine-derivatives, the publication is Journal of Physical Chemistry (1993), 97(30), 7800-2, database is CAplus.

When mech. vibration (56 Hz) of dipyridinium dications I (R = Me, R¹ = cyano, X = Br; R = Ph, R¹ = H, X = Cl; R = Me, R¹ = H, X = Cl), II (n = 2, 3, 4), and III (100 mg each) was conducted with a stainless steel ball (6.0-mm diameter, 890 mg) in a stainless steel twin-shell blender (7.8-mm diameter, 24 mm long) for 30 min at room temperature under strictly anaerobic conditions, the powder surfaces of all I and of II (n = 2) turned deep blue-purple, and nearly isotropic broad single-line ESR spectra were observed in the resulting powders, which can be ascribed to the formation of the corresponding monocation radicals via solid-state single electron transfer (SSET). Facile intermol. SSET also occurred from the monocation radical of I (R = Me, R¹ = H, X = Cl) to I (R = Ph, R¹ = H, X = Cl) and to II (n = 4). The mech. induced SSET reported herein seems to be a general phenomenon with broad implications for many organic compounds with relatively low redox potentials and is of special significance in connection with manufacturing a variety of solid materials in pulverized form in a metallic vessel.

Journal of Physical Chemistry published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem