Month: December 2022

Lu, Xiao published the artcileAcid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly of Imidazo[4,5-c]quinolin-2-ones, Recommanded Product: (6-Hydroxypyridin-3-yl)boronic acid, the publication is European Journal of Organic Chemistry (2018), 2018(13), 1572-1580, database is CAplus and MEDLINE.

An acid-promoted cascade reaction of N-(4-chloroquinolin-3-yl)carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermol. amination/intramol. cyclization reaction sequence. In combination with a subsequent Suzuki coupling reaction, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives

European Journal of Organic Chemistry published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C5H6BNO3, Recommanded Product: (6-Hydroxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dau, Phuong V. published the artcileSingle-Atom Ligand Changes Affect Breathing in an Extended Metal-Organic Framework, Product Details of C13H13N, the publication is Inorganic Chemistry (2012), 51(10), 5671-5676, database is CAplus and MEDLINE.

2-Phenylpyridine-5,4′-dicarboxylic acid (1, dcppy), a derivative of 4,4′-biphenyldicarboxylic (2, bpdc) was used as the organic linking component for several metal-organic frameworks (MOFs). The pyridine component of 1 does not interfere with the solvothermal synthetic procedure, and hence both 1 and 2 form similar isoreticular MOFs. Zr⁴⁺-based UiO-67-dcppy, Al³⁺-based DUT-5-dcppy, Zn²⁺-based DMOF-1-dcppy, and interpenetrated Zn²⁺-based BMOF-1-dcppy were readily synthesized from 1. Similarly, isostructural frameworks from 2 were prepared (UiO-67, DUT-5, DMOF-1-bpdc, and interpenetrated BMOF-1-bpdc). The structures and phys. properties of these frameworks were characterized by powder x-ray diffraction (PXRD), single XRD, TGA, and gas sorption anal. Generally, frameworks prepared from 1 or 2 displayed similar properties; however, gas sorption data showed that BMOF-1-dcppy displayed a very large hysteresis with N₂ and CO₂ suggestive of possible framework flexibility. In contrast, the analogous framework prepared from 2 (BMOF-1-bpdc) showed low uptake of N₂ and CO₂. The substantial difference in the gas sorption behavior of these MOFs is attributed to the pyridine nature of 1 that results in weakened π-π interactions between the interpenetrated nets.

Inorganic Chemistry published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hong, Seunghee published the artcileDiscovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Including the T315I Mutant, COA of Formula: C6H8BNO3, the publication is Journal of Medicinal Chemistry (2013), 56(9), 3531-3545, database is CAplus and MEDLINE.

The existence of drug resistance caused by mutations in the break-point cluster region-Abelson tyrosine kinase (Bcr-Abl) kinase domain remains a clin. challenge due to limited effective treatment options for chronic myeloid leukemia. Herein the authors report a novel series of benzothiazole-based inhibitors that are effective against wild-type and T315I mutant Bcr-Abl kinases. The original hit compound, nocodazole, was extensively modified through a structure-based drug design strategy, especially by varying the groups at the C2 and C6 positions of the scaffold. In addition, the introduction of water-solubilizing groups at the terminal Et group resulted in enhanced physicochem. properties and potency in cellular inhibition. Several compounds inhibited the kinase activity of both wild-type Bcr-Abl and the T315I mutant with IC₅₀ values in the picomolar range and exhibited good antiproliferative effects on Ba/F3 cell lines transformed with either wild-type or T315I mutant Bcr-Abl.

Journal of Medicinal Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, COA of Formula: C6H8BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oh, In-Chan published the artcileCharacterization of palladium electrodeposition in ammonia-free electrolyte with additives, Product Details of C5H5NO3S, the publication is Surface and Interface Analysis (2021), 53(12), 1035-1042, database is CAplus.

Electrodeposition of Pd provides excellent chem. and low-contact resistance with good elec. properties, such as different types of elec. contacts in the electronics industry. The conventional Pd plating process utilizes ammonia-based electrolytes. Ammonia was added continuously to maintain the optimum pH range in Pd electrolyte. In addition, the harmful and strong odor of the evaporating ammonia necessitates the use of a ventilator. A further disadvantage is that the brass substrate is corroded by ammonia vapor, and the corrosion products can contaminate the electrolytes, thereby changing the technol. properties of the deposited plating for the worse. Ethylenediamine has been proposed as an alternative to ammonia; however, Pd electrodeposition occurs as microcracks via hydrogen evolution. In this study, the effects of Pd electrolyte on ethylenediamine as a complexing agent and the properties of various additives are investigated to improve c.d. and internal stress in Pd electrodeposition that occurs on a brass substrate. Therefore, complexing agents such as 3-pyridine sulfonic acid, sodium nicotinate, butyne 1-4 diol, and sodium allylsulfonate are selected as additives, to serve as an alternative to ammonia in Pd electrolyte. In this study, the properties of electrodeposited Pd with various additives were examined The effect of additives on Pd electrolytes can be classified as dense surfaces without defects such as microcracks and pinholes, which improved surface roughness and corrosion resistance. Particularly, Pd electrolyte using sodium nicotinate has relatively improved surface roughness and properties. Pd electrolyte was optimized under ammonia-free conditions by the addition of sodium nicotinate.

Surface and Interface Analysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schneider, D. published the artcileInfluence of 3 antivertiginous medications on the vigilance of healthy volunteers, Product Details of C10H20N2O6S2, the publication is International Journal of Clinical Pharmacology and Therapeutics (2003), 41(4), 171-181, database is CAplus and MEDLINE.

In the present randomized, comparative, double-blind, 3-way crossover study, possible effects of 3 antivertiginous medications on vigilance were investigated. Thirty healthy volunteers received single doses of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg (Arlevert, ARL), dimenhydrinate 50 mg, or betahistine dimesylate 12 mg, in randomized order at 1-wk intervals. Spontaneous brain elec. activity (EEG), acoustic late evoked potentials (ALEP) with P300, and reaction time were measured before and 90 (t₉₀) and 180 min (t₁₈₀) after drug intake. All 3 medications led to a delay of P300 (primary criterion) and a decrease of its amplitude. The maximum delay at t₁₈₀ was found for dimenhydrinate (16.42 ms) and the lowest for betahistine (6.33 ms). The differences in ARL vs. dimenhydrinate and ARL vs. betahistine were not statistically significant (p > 0.05). Spectral anal. of spontaneous EEG showed slight and similar decreases in the power in the α-band under dimenhydrinate and ARL (p = 0.07 and p = 0.03 with respect to baseline, resp.), but basically no change under betahistine. There was no effect on reaction time by either medication. None of the subjects reported drowsiness or any other adverse event. The findings confirm the reported suitability of P300 latency for measurement of drug effects on brain activity, but provide no indication of concomitant impairment of performance capacity by the tested drugs. Global assessment of the results suggests that the fixed combination cinnarizine 20 mg/dimenhydrinate 40 mg exerts only a minor effect on vigilance, not significantly different from betahistine, which is commonly regarded as a non-sedating antivertiginous drug.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Product Details of C10H20N2O6S2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saha, Debasmita published the artcileIntramolecular cyclization of imidazo[1,2-a]pyridines via a silver mediated/palladium catalyzed C-H activation strategy, HPLC of Formula: 1174626-28-8, the publication is Organic Chemistry Frontiers (2019), 6(13), 2234-2239, database is CAplus.

A C-H activation reaction was developed using imidazo[1,2-a]pyridine adducts via an AgOAc-mediated, Pd catalyzed intramol. cyclization for the preparation of tetrazolylpyridoimidazo[4,5-c]quinoline derivatives I (R¹ = H, 9-Me, 9-Br, etc.; R² = t-Bu, Bn, cyclohexyl, etc.). The reaction was optimized and extensively explored using the Ugi/azide MCR as a tool to rapidly broaden substrate scope. Title compounds were screened against a cancer cell panel, and I (R¹ = H; R² = 1-phenylethyl) exhibited selective, antiproliferative activity against the MCF-7 (breast cancer) cell line. This C-H activation methodol. can be utilized to rapidly reach new chem.-space for drug discovery.

Organic Chemistry Frontiers published new progress about 1174626-28-8. 1174626-28-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Benzene,Ether, name is 2-Amino-6-benzyloxypyridine, and the molecular formula is C12H12N2O, HPLC of Formula: 1174626-28-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zafar, Sana published the artcileLinear and non linear optical properties of electron donor and acceptor pyridine moiety: a study by ab initio and DFT methods, COA of Formula: C11H8N2O2, the publication is Canadian Journal of Pure & Applied Sciences (2012), 6(1), 1827-1835, database is CAplus.

The Donor-Acceptor type conjugated mol. structures containing pyridine as a bridge were explored for non linear optical properties. The ab-initio Hartree Fock calculations and D. Functional Theory with B3LYP method were carried out employing 6-31 G basis set. The dipole moments (μ), polarizability (α), 1st hyperpolarizability (β), and HOMO-LUMO energy gap are calculated using the same level of theory. The dependence of the hyperpolarizability of different mol. structure on the nature of donor and acceptor on the pyridine is discussed from MO picture. Of all the mol. systems studied, the mol. system containing nitro as an acceptor and dimethylaniline as a donor has largest value of hyperpolarizability; 49.92 × 10^-30 esu and 164.61 × 10^-30 esu with ab-initio/HF and DFT/B3LYP, resp. The large value of β for the Donor-Acceptor pyridine derivative suggests the potential applications of these mol. systems in the development of non linear materials.

Canadian Journal of Pure & Applied Sciences published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C9H6BrNO, COA of Formula: C11H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pham, Duc T. published the artcileAnion/cation layers at electrified interfaces: a comprehensive STM, XRD and XPS case study, Quality Control of 47369-00-6, the publication is Chimia (2009), 63(3), 115-121, database is CAplus.

Charged organic adsorbates play an important role in a number of electrochem. reactions, e.g. as additives for metal plating relevant for device fabrication in the semiconductor industry. Fundamental investigations are mandatory in order to acquire profound knowledge of the structural and electronic properties of these layers parallel and perpendicular to the surface, and to finally achieve a deeper mechanistic understanding of the kinetics of involved charge transfer reactions taking place at these complex metal/organic/electrolyte interfaces. A key structural motif of these interfaces consists in ‘paired’ (inorganic)anion/(organic)cation layers that can have an enormous stability even during an ongoing charge transfer reaction. In this contribution we present and discuss a selected case study on the co-adsorption of halide anions and cationic organic mols. that exhibit a pronounced redox activity. It will be demonstrated that their phase behavior at the interface crucially depends on both their particular redox-state and the surface concentration of the halide counter ions. The subtle balance between adsorbate-adsorbate and adsorbate-substrate interaction of the poly-cationic organic layer can be carefully controlled by potential dependent anion adsorption and desorption processes through the organic layer. This process can be followed by in situ high-resolution scanning tunnelling microscopy, while addnl. information about the structural and chem. state of the resp. phase is obtained from in situ X-ray diffraction and ex situ photoelectron spectroscopy.

Chimia published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Quality Control of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guha, Somraj published the artcileIodine-promoted controlled and selective oxidation of (aryl)(heteroaryl)methanes, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2022), 87(8), 5424-5429, database is CAplus and MEDLINE.

Herein, an iodine-catalyzed controlled oxidation of (aryl)(heteroaryl)methanes to (aryl)(heteroaryl)methanols ArCH(O)Ar¹ [Ar = Ph, 2-MeC₆H₄, 4-ClC₆H₄, etc.; Ar¹ = pyridin-2-yl, benzothiazol-2-yl] was disclosed under metal-free reaction conditions. A catalytic system comprised of iodine/silyl chloride with HI as an additive in the presence of DMSO selectively oxidize the C(sp³)-H bonds without being over oxidized to corresponding ketones. Therapeutically important aryl heteroaryl methanol derivatives were obtained in good yields. The preliminary mechanistic investigation proved that the primary source of oxygen was DMSO.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Perlovich, German L. published the artcileSolubility and Transfer Processes of Some Hydrazones in Biologically Relevant Solvents, Category: pyridine-derivatives, the publication is Journal of Chemical & Engineering Data (2013), 58(9), 2659-2667, database is CAplus.

Solubility values of 20 hydrazones in water, 1-octanol and hexane were determined by the isothermal saturation method. Thermophys. characteristics of fusion processes (m.ps. and fusion enthalpies) of the selected substances were measured by DSC method. The impact of structural modification of the mols. on solubility processes in the solvents was analyzed. Transfer processes from water to 1-octanol and from water to hexane were analyzed. Correlation equations connecting the transfer coefficients with physicochem. descriptors were obtained.

Journal of Chemical & Engineering Data published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem