Month: December 2022

Sano, Tomoharu published the artcileSynthesis of N-(1-Nitropyren-6-yl and 8-yl)-2′-deoxyribonucleosides, HPLC of Formula: 107263-95-6, the publication is Chemical Research in Toxicology (1995), 8(5), 699-702, database is CAplus and MEDLINE.

A new type of 1-nitropyrene-DNA adduct via addition-elimination reaction was synthesized. Treatment of fluorinated 1-nitropyrene with 3′- and 5′-O-protected 2′-deoxyribonucleoside in DMSO at 140 °C afforded N-(1-nitropyren-6-yl or 8-yl)-2′-deoxyribonucleoside, I (R = H, R¹ = NO₂; R =NO₂, R¹ = H). These DNA adducts resulted from addition of the exocyclic amino group of deoxynucleosides to the fluorinated carbon of the fluoro-1-nitropyrene following elimination of fluoride anion. This is the first report that describes the 1-nitropyrene-DNA adducts in which aromatic ring moiety of 1-nitropyrene is covalently linked to the exocyclic amino group of the deoxyribonucleoside. From our findings, we suggest that the addition-elimination reaction may be responsible for the formation mechanism of the putative 1-nitropyrene-DNA adducts in vivo.

Chemical Research in Toxicology published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, HPLC of Formula: 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Engin, Seckin published the artcileThe inhibitory effect of trimetazidine on detrusor contractility – a potential repositioning of trimetazidine for the treatment of overactive bladder., Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is The Journal of pharmacy and pharmacology (2022), 74(1), 94-102, database is MEDLINE.

OBJECTIVES: This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action. METHODS: We performed in-vitro contractility studies on isolated mouse DSM strips and investigated the effect of TMZ on Ca2+ levels in fura-2-loaded A7r5 cells. KEY FINDINGS: TMZ (300 or 1000 µM) inhibited carbachol (CCh)- and KCl-induced contractions and produced a concentration-dependent (10-1000 µM) relaxation in KCl-precontracted DSM strips. TMZ-induced relaxation was markedly decreased by BaCl2, an inward-rectifying K+ channel blocker, but was not altered by preincubation with tetraethylammonium, glibenclamide, 4-aminopyridine, propranolol, L-NAME or methylene blue. TMZ (300 or 1000 µM) reduced both the CaCl2-induced contraction of depolarized DSM strips under Ca2+-free conditions and the CCh-induced contraction of DSM strips preincubated with nifedipine in Ca2+-containing Krebs solution. Furthermore, TMZ (1000 µM) significantly decreased the Ca2+ levels in fura-2-loaded A7r5 cells. CONCLUSIONS: TMZ decreased DSM contractility and caused a concentration-dependent relaxation of the tissue possibly through its actions on Ca2+ transients and K+ channels. Our results provide preclinical evidence that TMZ would be a potential candidate to treat disorders related to the overactivity of the bladder.

The Journal of pharmacy and pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Higashi, Tomohiro published the artcileTwo Sharp Phase Change Processes of Diphenyl Viologen at a Au(111) Electrode Surface: Non-Faradaic Transition with Interplay of Ionic Adsorption of Chloride and Bromide and Faradaic One, Synthetic Route of 47369-00-6, the publication is Journal of Physical Chemistry C (2015), 119(3), 1320-1329, database is CAplus.

Two phase change processes of di-Ph viologen (dPhV) on a Au(111) electrode in KCl and KBr aqueous solutions were described using the results of voltammetric, electroreflectance (ER), and electrochem. scanning tunneling microscopic (EC-STM) measurements. Both processes exhibited sharp spikelike voltammetric responses. In KCl solution, the phase change at 0.30 V vs. Ag/AgCl/saturated KCl is a nonfaradaic order-disorder phase transition, from an ordered adlayer of dPhV dication (dPhV²⁺) with coadsorbed Cl^– at more pos. potentials than 0.30 V to a gas-like phase at less pos. potentials. The faradaic reaction at -0.09 V is the transition from the gaslike phase to a condensed monolayer of dPhV^â€?. The EC-STM images of the condensed monolayer showed stripe patterns of rows of π-π stacked dPhV^â€?. Almost the same set of two processes was observed in KBr solution but not in KF solution In KF solution, although two voltammetric responses were observed, the peaks were small and broad, indicative of sluggish adsorption state changes of individual dPhV cations. Taken together, specific adsorption of coexistent anions is of critical importance for the occurrence of the sharp nonfaradaic phase transition.

Journal of Physical Chemistry C published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Synthetic Route of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tius, Marcus A. published the artcileSelectivity in aromatic fluorination. Introduction of fluorine probes into nabilone, Computed Properties of 107263-95-6, the publication is Chemical Communications (Cambridge) (1996), 2085-2086, database is CAplus.

Selective fluorination of the aromatic ring of nabilone leads to functional analogs with diminished affinity for the CB1 receptor, thereby confirming the hypothesis that the phenolic hydroxy group is engaged in a hydrogen bonding interaction with the receptor.

Chemical Communications (Cambridge) published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C10H11N3O3S, Computed Properties of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kao, Sheng-Yuan published the artcileAchieving a large contrast, low driving voltage, and high stability electrochromic device with a viologen chromophore, Name: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2015), 3(14), 3266-3272, database is CAplus.

The viologen radical salt (VRS), consisting of Ph viologen (PV) dications and 2,2,6,6-tetramethyl-1-piperidinyloxy derivative (TEMPOD) anions, was successfully synthesized. The VRS was combined with N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD) to form an electrochromic device (ECD). This ECD offers significant transmittance changes (>60% at both 580 and 620 nm), but only requires 0.4 V for switching, the lowest driving voltage ever reported. Such a low driving voltage further strengthens the energy-saving capability of the ECD. The incorporation of TEMPOD in the ECD greatly improved its write-erase ability while insufficient bleaching was clearly observed within only 5 cycles in the case of its counterpart without adding TEMPOD anions. No significant decay in the transmittance change was noticed in the proposed ECD after subjecting to 100 cycles. Even better cycling stability would be expected if counter anions with multiple TEMPO units were utilized.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Name: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Umemoto, Teruo published the artcileN-Fluoropyridinium triflate and its derivatives: useful fluorinating agents, Computed Properties of 107263-95-6, the publication is Tetrahedron Letters (1986), 27(37), 4465-8, database is CAplus.

N-Fluoropyridinum triflate and its derivatives, stable and nonhygroscopic crystals, were found to be widely applicable reagents for mild and selective fluorination of a variety of organic compounds, including aromatics, enol ethers or acetates, active methylene compounds, and organometallics.

Tetrahedron Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H3ClFNO2, Computed Properties of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bodke, Yadav D. published the artcileApplication of Suzuki coupling in the synthesis of some novel coumarin derivatives as potent antibacterial agents, COA of Formula: C5H6BNO2, the publication is Pharma Chemica (2017), 9(21), 29-34, database is CAplus.

The synthesis of some novel coumarin derivatives by palladium catalyzed Suzuki cross-coupling and evaluation of their antibacterial potency was reported. Most of the compounds exhibited exceptional antibacterial activity as compared with the resp. standard, Ciprofloxacin.

Pharma Chemica published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chatterjee, Arnab published the artcilepH dependent catecholase activity of Fe(II) complexes of type [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)]: Role of counter anion on turnover number, SDS of cas: 91-02-1, the publication is Inorganica Chimica Acta (2020), 119933, database is CAplus.

Two mononuclear Fe(II) complexes having same ligand framework, coordination geometry but different counter anions [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)] have been synthesized and crystallog. characterized. Both the complexes catalyzed catechol-quinone oxidation pH dependently. In the pH range 8.3-8.5 the suitable activity of both the complexes were found. Counter anions in the complexes played a significant role in controlling the turn over numbers of the catalytic reactions. In acetonitrile (MeCN), the turn over number for 1 was 4.99 h^-1 and for 2, it was 42.75 h^-1.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Graphakos, Basil J. published the artcileHeterocycles in organic synthesis. Part 13. The reaction of 2,4-diphenylthiopyrylium perchlorate with amines, Application In Synthesis of 18437-58-6, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1980), 1345-6, database is CAplus.

2,4-Diphenylthiopyrylium perchlorate (I) [30235-02-0], prepared by sequential treatment of 4,6-diphenylthiopyran-2-thione [842-62-6] with 30% H₂O₂ (AcOH, 40°, 2 h) and 70% HClO₄, reacted with aromatic amines and aminopyridines (EtOH, 40-4°, 2 h, 20°) to give the thiopyrylium dyes II (R = aminoaryl, aminopyridyl). Thus, 52% II (R = C₆H₄NH₂-4) [75076-63-0] was obtained from PhNH₂ [62-53-3] and I. Analogous treatment of I with MeNH₂ [74-89-5] (EtOH, reflux, 2 h) gave 12% 1-methyl-2,4-diphenylpyridinium perchlorate [75076-60-7] and 45% 4,6-diphenyl-2H-thiopyran [75076-61-8].

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sankar, Velayudham published the artcileZinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach, Category: pyridine-derivatives, the publication is Advanced Synthesis & Catalysis (2020), 362(20), 4409-4414, database is CAplus.

An efficient zinc-catalyzed N-alkylation reaction of aromatic amines was achieved using aliphatic, aromatic and heteroaromatic alcs. as the alkylating reagent. A variety of aniline derivatives, including heteroaromatic amines, underwent the N-alkylation reaction and furnished N-alkyl amines in good to excellent yields. The application of reaction was also further demonstrated by the synthesis of 2-phenylquinoline from acetophenone and 2-aminobenzyl alc. Deuterium labeling experiments showed that the reaction proceeded via a borrowing hydrogen process.

Advanced Synthesis & Catalysis published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem