Month: December 2022

Asuero, Agustin G. published the artcileSpectrophotometric evaluation of acidity constants of two-step overlapping equilibria from the inflexion points of the absorbance versus pH graphs with application to the dipyridylglyoxal mono-(2-pyridyl)hydrazone system, Product Details of C11H10N4, the publication is Acta Pharmaceutica Technologica (1988), 34(3), 164-8, database is CAplus.

Some pyridylhydrazone type derivatives are being currently studied from a pharmacol. point of view. In this respect, the knowledge of acidity constants of a drug is of great worth in solving fundamental problems of pharmaceutical interest. Thus, an extension of the method of Irving, Rossotti and Harris (1955) for the evaluation of acidity constants of diprotic acids is presented. A simple method of developing the final equations given by those authors in a more usual anal. form is also presented, thus providing a rapid and convenient desk method of calculation The methods devised were applied to the evaluation of acidity constants of dipyridylglyoxal mono-(2-pyridyl)-hydrazone (DMPH). Results obtained agree well with those obtained by applying a three equation procedure.

Acta Pharmaceutica Technologica published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lixia published the artcileCross coupling of arylboronic acids with imidazoles by sulfonatocopper(II)(salen) complex in water, HPLC of Formula: 197958-29-5, the publication is Chemistry Letters (2010), 39(7), 764-765, database is CAplus.

A mild and clean protocol for the cross coupling reactions between imidazoles and arylboronic acids has been developed in good to excellent yields up to 98% in the presence of sulfonatocopper(II)(salen) catalyst in water without addition of other additives and bases.

Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C8H11BO2, HPLC of Formula: 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Bing published the artcileSelf-Assembled Amphiphilic Water Oxidation Catalysts: Control of O-O Bond Formation Pathways by Different Aggregation Patterns, Name: Pyridine-3-sulfonic acid, the publication is Angewandte Chemie, International Edition (2016), 55(21), 6229-6234, database is CAplus and MEDLINE.

The oxidation of water to mol. oxygen is the key step to realize water splitting from both biol. and chem. perspective. In an effort to understand how water oxidation occurs on a mol. level, a large number of mol. catalysts have been synthesized to find an easy access to higher oxidation states as well as their capacity to make O-O bond. However, most of them function in a mixture of organic solvent and water and the O-O bond formation pathway is still a subject of intense debate. Herein, we design the first amphiphilic Ru-bda (H₂bda=2,2′-bipyridine-6,6′-dicarboxylic acid) water oxidation catalysts (WOCs) of formula [Ru^II(bda)(4-OTEG-pyridine)₂] (1, OTEG=OCH₂CH₂OCH₂CH₂OCH₃) and [Ru^II(bda)(PySO₃Na)₂] (2, PySO₃^–=pyridine-3-sulfonate), which possess good solubility in water. Dynamic light scattering (DLS), scanning electron microscope (SEM), critical aggregation concentration (CAC) experiments and product anal. demonstrate that they enable to self-assemble in water and form the O-O bond through different routes even though they have the same bda^2- backbone. This work illustrates for the first time that the O-O bond formation pathway can be regulated by the interaction of ancillary ligands at supramol. level.

Angewandte Chemie, International Edition published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C8H11NO, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vantomme, Ghislaine published the artcileAdaptation in Constitutional Dynamic Libraries and Networks, Switching between Orthogonal Metalloselection and Photoselection Processes, Formula: C11H10N4, the publication is Journal of the American Chemical Society (2014), 136(26), 9509-9518, database is CAplus and MEDLINE.

Constitutional dynamic libraries of hydrazones ^aA^bB and acylhydrazones ^aA^cC undergo reorganization and adaptation in response to a chem. effector (metal cations) or a phys. stimulus (light). The set of hydrazones [¹A¹B, ¹A²B, ²A¹B, ²A²B] undergoes metalloselection on addition of zinc cations which drive the amplification of Zn(¹A²B)₂ by selection of the fittest component ¹A²B. The set of acylhydrazones [E-¹A¹C, ¹A²C, ²A¹C, ²A²C] undergoes photoselection by irradiation of the system, which causes photoisomerization of E-¹A¹C into Z-¹A¹C with amplification of the latter. The set of acyl hydrazones [E-¹A¹C, ¹A³C, ²A¹C, ²A³C] undergoes a dual adaptation via component exchange and selection in response to two orthogonal external agents: a chem. effector, metal cations, and a phys. stimulus, light irradiation Metalloselection takes place on addition of zinc cations which drive the amplification of Zn(¹A³C)₂ by selection of the fittest constituent ¹A³C. Photoselection is obtained on irradiation of the acylhydrazones that leads to photoisomerization from E-¹A¹C to Z-¹A¹C configuration with amplification of the latter. These changes may be represented by square constitutional dynamic networks that display up-regulation of the pairs of agonists (¹A²B, ²A¹B), (Z-¹A¹C, ²A²C), (¹A³C, ²A¹C), (Z-¹A¹C, ²A³C) and the simultaneous down-regulation of the pairs of antagonists (¹A¹B, ²A²B), (¹A²C, ²A¹C), (E-¹A¹C,²A³C), (¹A³C, ²A¹C). The orthogonal dual adaptation undergone by the set of acylhydrazones amounts to a network switching process.

Journal of the American Chemical Society published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C15H21BO3, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Jinghu published the artcileFacile synthesis of highly porous hyper-cross-linked polymer for light hydrocarbon separation, HPLC of Formula: 971-66-4, the publication is Polymer Engineering & Science (2021), 61(3), 662-668, database is CAplus.

Light hydrocarbon separation is a crucial process associated with high energy expenditure in the petrochem. industry. The utilization of porous organic materials as solid porous adsorbents for light hydrocarbon separation has found widespread attention because of the advantages of low cost, excellent stability, and good recyclability. Here, we present the facile synthesis of a porous organic material, constructed from pyridine-triphenylborane by using a Friedel-Crafts alkylation coupling reaction, affording the hyper-crosslinked polymer, HCP-B. HCP-B features significant thermal stability, and high surface area. Gas adsorption experiments show that this material adsorbs much larger amounts of ethane, ethylene, and acetylene than that of methane. Ideal adsorbed solution theory (IAST) calculations also predict that HCP-B selectively adsorbs ethane, ethylene, and acetylene over methane. Both are indicative of the great potential of HCP-B in light hydrocarbon separation

Polymer Engineering & Science published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, HPLC of Formula: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Fang-tao published the artcileSynthesis of aldehyde-amines type sulfide 808 and DHP, Safety of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Yingyong Huagong (2013), 42(4), 765-767, database is CAplus.

Aniline reacted with n-butyraldehyde under different conditions afforded condensation products 808 and DHP (808HP). By using gas chromatog., products were verified by compared to standard samples, and purity was decent. This process achieved improved yield and simplified operations, reduced costs, and provided a new approach in industrial production

Yingyong Huagong published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Safety of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hu, Gongfang published the artcileSurprisingly big linker-dependence of activity and selectivity in CO₂ reduction by an iridium(I) pincer complex, Formula: C23H43NP2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(64), 9126-9129, database is CAplus and MEDLINE.

Here, we report the quant. electroreduction of CO₂ to CO by a PNP-pincer iridium(I) complex bearing amino linkers in DMF/water. The electrocatalytic properties greatly depend on the choice of linker within the ligand. The complex 3-N is far superior to the analogs with methylene and oxygen linkers, showing higher activity and better selectivity for CO₂ over proton reduction

Chemical Communications (Cambridge, United Kingdom) published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xin, Zhijun published the artcileStudy on N-(pyridin-4-yl) salicylamides as antimycobacterial agents, HPLC of Formula: 18437-58-6, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2013), 1371-1375, 6 pp., database is CAplus.

A series of N-(pyridin-4-yl) salicylamides derivatives were prepared through acylation of the corresponding acetylsalicyloyl chlorides with substituted 4-amino-pyridines. These compounds were evaluated in vitro for antimycobacterial activities against Mycobacterium tuberculosis (TB) and Mycobacterium avium (A) by the min. inhibitory concentrations (MIC) values. Eight of the compounds exhibited lower MIC against A than isoniazide (INH). Meanwhile, four of the compounds exhibited good anti-TB activity, when they were compared with INH. Antimycobacterial activities of N-(pyridin-4-yl) salicylamides were influenced by the balance between hydrophobicity and electron-withdrawing substituent effect on the Ph and pyridine ring. These studies show that these compounds might serve as prospective wide-spectrum antimycobacterial substances.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C24H12, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gou, Yi published the artcileDithiocarbazate-Fe^III, -Co^III, -Ni^II, and -Zn^II Complexes: Design, Synthesis, Structure, and Anticancer Evaluation, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Medicinal Chemistry (2022), 65(9), 6677-6689, database is CAplus and MEDLINE.

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe^III(L)₂]·Cl·2H₂O 1, [Co^III(L)₂]·NO₃·2.5H₂O 2, [Ni^II(L)₂] 3, and [Zn^II(L)₂] 4, have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex 2 exhibited higher anticancer efficacy than complexes 1, 3, 4, and cisplatin against several cancer cell lines. Hemolysis assays revealed that complex 2 showed comparable hemolysis with cisplatin. In vivo anticancer evaluations showed that complex 2 could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex 2 suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.

Journal of Medicinal Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Qian, Yingjie published the artcileA palladium complex confined in a thiadiazole-functionalized porous conjugated polymer for the Suzuki-Miyaura coupling reaction, Application In Synthesis of 39856-58-1, the publication is RSC Advances (2019), 9(58), 33563-33571, database is CAplus and MEDLINE.

Porous organic polymers (POPs) with well-distributed and tunable functional groups acting as ligands for specific reactions are promising supports for confining useful novel metals such as Pd, Au, and Pd. Herein, a thiadiazole-containing POP has been successfully synthesized and used for immobilizing Pd species. Pd immobilized inside the micropores (2.3 nm) of the POP material is easily prepared owing to a large amount of the strong anchoring group, thiadiazole, which is intrinsically distributed in the as-prepared POP. The rigid thiadiazole-containing polymer can stabilize the central metal rather than poisoning it. The as-prepared catalyst shows excellent catalytic activity in Suzuki-Miyaura coupling reactions under mild reaction conditions and low catalyst loading. Importantly, the intrinsically distributed thiadiazole ligands can stabilize the Pd moiety, preventing aggregation and leaching, and afford excellent catalytic lifetimes. Consequently, the catalyst can be reused 10 times without a significant loss of its catalytic activity.

RSC Advances published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem