Month: December 2022

Fatemi, Mohammad H. published the artcileCytotoxicity estimation of ionic liquids based on their effective structural features, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Chemosphere (2011), 84(5), 553-563, database is CAplus and MEDLINE.

Cytotoxicity of a diverse set of 227 ionic liquids (taken from UFT/Merck Ionic Liquids Biol. Effects Database) containing 94 imidazolium, 53 pyridinium, 23 pyrrolidinium, 22 ammonium, 15 piperidinium, 10 morpholinium, 5 phosphanium, and 5 quinolinium cations in combination with 25 different types of anions to Leukemia Rat Cell Line (IPC-81) was estimated from their structural parameters using quant. structure – toxicity relationship “QSTR” methodol. Linear and nonlinear models were developed using genetic algorithm (GA), multiple linear regressions (MLR) and multilayer perceptron neural network (MLP NN) approaches. Robustness and reliability of the constructed models were evaluated through internal and external validation methods. Furthermore, chem. applicability domain was determined via leverage approach. In this work, it was revealed that the cationic moieties make the major contribution to cytotoxicity and the anionic parts play a secondary role in cytotoxicity of the ionic liquids studied here. Structural information represented in this work, can be used for a rational design of safer ILs.

Chemosphere published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kakehi, Akikazu published the artcilePreparation of new nitrogen-bridged heterocycles. 42. Synthesis and the reaction of pyridinium N-ylides using bifunctional ethyl thiocyanatoacetates, COA of Formula: C7H7ClN2, the publication is Bulletin of the Chemical Society of Japan (1996), 69(6), 1769-1776, database is CAplus.

Various pyridinium (monosubstituted methylide)s I (R², R³, R⁴ = H, Me; R⁵ = cyano, CO₂Et, COMe, COPh) were smoothly attached to the cyano group in Et thiocyanatoacetate or Et 2-thiocyanatopropionate to afford the corresponding pyridinium (substituted cyanomethylide)s II in low-to-moderate yields, while pyridinium (unsubstituted amidate)s III (R¹, R², R³ = H, Me) reacted with the ester carbonyl group in the same reagents to give pyridinium (thiocyanatoacetato)- or (2-thiocyanatopropiono)amidates IV in considerable yields. The 1,3-dipolar cycloadditions of some pyridinium (unsym. substituted cyanomethylide)s with di-Me acetylenedicarboxylate (DMAD) in various solvents afforded only di-Me 3-cyanoindolizine-1,2-dicarboxylate, except for a few examples. On the other hand, the treatment of pyridinium (thiocyanatoaceto)- or (2-thiocyanatopropiono)amidates with a strong base, such as potassium tert-butoxide, gave new bicyclic mesoionic compounds, N-[2-(1,3,4-thiadiazolo[3,2-a]pyridinio)]acetamidate derivatives V, in moderate yields. The intermediacy of N-[1-(2-thiocyanatopyridinio)]acetamidates in the formation reactions of the latter compounds was also proven by independent syntheses.

Bulletin of the Chemical Society of Japan published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, COA of Formula: C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saku, Osamu published the artcileDiscovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3436-3451, database is CAplus and MEDLINE.

We have developed a novel and potent chem. series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the Ph ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b (I), which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mech. allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.

Journal of Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fogler, Eran published the artcileRu(0) and Ru(II) Nitrosyl Pincer Complexes: Structure, Reactivity, and Catalytic Activity, Product Details of C23H43NP2, the publication is Inorganic Chemistry (2013), 52(19), 11469-11479, database is CAplus and MEDLINE.

Despite considerable interest in ruthenium carbonyl pincer complexes and their substantial catalytic activity, there has been relatively little study of the isoelectronic ruthenium nitrosyl complexes. Here the authors describe the synthesis and reactivity of several complexes of this type as well as the catalytic activity of complex 6. Reaction of the PNP ligand (PNP = 2,6-bis(^tBu₂PCH₂)pyridine) with RuCl₃(NO)(PPh₃)₂ yielded the Ru(II) complex 3. Chloride displacement by BAr^F- (BAr^F- = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate) gave the crystallog. characterized, linear NO Ru(II) complex 4, which upon treatment with NaBEt₃H yielded the Ru(0) complexes 5. The crystallog. characterized Ru(0) square planar complex 5·BF₄ bears a linear NO ligand located trans to the pyridyl nitrogen. Further treatment of 5·BF₄ with excess LiOH gave the crystallog. characterized Ru(0) square planar, linear NO complex 6. Complex 6 catalyzes the dehydrogenative coupling of alcs. to esters, reaching full conversion under air or under argon. Reaction of the PNN ligand (PNN = 2-(^tBu₂PCH₂)-6-(Et₂NCH₂)pyridine) with RuCl₃(NO)(H₂O)₂ in ethanol gave an equilibrium mixture of isomers 7a and 7b. Further treatment of 7a + 7b with 2 equiv of sodium isopropoxide gave the crystallog. characterized, bent-nitrosyl, square pyramidal Ru(II) complex 8. Complex 8 was also synthesized by reaction of PNN with RuCl₃(NO)(H₂O)₂ and Et₃N in ethanol. Reaction of the “long arm” PN²N ligand (PN²N = 2-(^tBu₂PCH₂)-6-(Me₂NCH₂CH₂)pyridine) with RuCl₃(NO)(H₂O)₂ in ethanol gave complex 9, which upon treatment with 2 equiv of sodium isopropoxide gave complex 10. Complex 10 was also synthesized directly by reaction of PN²N with RuCl₃(NO)(H₂O)₂ and a base in ethanol. A noteworthy aspect of these nitrosyl complexes is their preference for the Ru(0) oxidation state over Ru(II). This preference is observed with both aromatized and dearomatized pincer ligands, in contrast to the Ru(II) oxidation state which is preferred by the analogous carbonyl complexes.

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zheng, Ke published the artcileDesign and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives, Product Details of C6H8N2, the publication is Journal of Medicinal Chemistry (2014), 57(23), 10013-10030, database is CAplus and MEDLINE.

The c-jun N-terminal kinase 3 (JNK3) is expressed primarily in the brain. Numerous reports have shown that inhibition of JNK3 is a promising strategy for treatment of neurodegeneration. The optimization of aminopyrazole-based JNK3 inhibitors with improved potency, isoform selectivity, and pharmacol. properties by structure-activity relationship (SAR) studies utilizing biochem. and cell-based assays, and structure-based drug design is reported. These inhibitors had high selectivity over JNK1 and p38α, minimal cytotoxicity, potent inhibition of 6-OHDA-induced mitochondrial membrane potential dissipation and ROS generation, and good drug metabolism and pharmacokinetic (DMPK) properties for iv dosing. 26n was profiled against 464 kinases and was found to be highly selective hitting only seven kinases with >80% inhibition at 10 μM. Moreover, 26n showed good solubility, good brain penetration, and good DMPK properties. Finally, the crystal structure of 26k in complex with JNK3 was solved at 1.8 Å to explore the binding mode of aminopyrazole based JNK3 inhibitors.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C15H24S, Product Details of C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yonova, P. A. published the artcileSynthesis of 1,1′-polymethylenebis-(3-substituted) ureas and related compounds of potential biological interest, Quality Control of 18437-58-6, the publication is Dokladi na Bulgarskata Akademiya na Naukite (1999), 52(3-4), 53-56, database is CAplus.

RNHCONH(CH₂)_nNHCONHR [I, R = Ph, 3-FC₆H₄, 4-FC₆H₄, 3-ClC₆H₄, 4-ClC₆H₄, n = 2-6; R = 2-thiazolyl, 4-pyridyl, 4-picolyl, 3,5-dichloro-4-pyridyl, n = 6] were pred. from RNCO and H₂N(CH₂)_nNH₂ or from RNH₂ and H₂N(CH₂)₆NH₂. I have antisenescence activity comparable to that of PhNHCONHPh and putrescine.

Dokladi na Bulgarskata Akademiya na Naukite published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H11BF3KO, Quality Control of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jung, Ju young published the artcileEnhanced Solubility Through Particle Size Control, Modification of Crystal Behavior, and Crystalline Form Changes in Solid Dispersion of Nifedipine, Related Products of pyridine-derivatives, the publication is Biotechnology and Bioprocess Engineering (2022), 27(1), 105-110, database is CAplus.

The purpose of this study was to investigate the selectivity of polymers and the suitability of spray drying to enhance nifedipine solubility Nifedipine alone or in combination with polymers was dissolved in a mixed solvent of methylene chloride and ethanol. The hydrophilic polymers used were PVP K-30, HPMC, HPMCP, Eudragit, and HPMCAS. Each solid dispersion was prepared using a laboratory spray dryer. The spray-dried solid dispersants were characterized by SEM, DSC, and XRPD anal., and dissolution tests compared the dissolution rates of nifedipine solid dispersants and nifedipine. The results showed that all spray-dried solid dispersions were in an amorphous form. Dissolution tests were performed at pH 1.2 (artificial gastric juice) and pH 6.8 (artificial intestinal juice) to evaluate solid dispersion solubility The solid dispersion containing HPMC showed a notably enhanced dissolution rate under both pH conditions. Interestingly, HPMCP and HPMCAS showed almost no enhancement of dissolution behavior at pH 1.2, but a significant increase (10 times or higher) over that of the pure polymer at pH 6.8. Solubility enhancement of poorly soluble drugs differs markedly among the polymers used for spray drying. From the results, HPMCP and HPMCAS are suitable as carriers for drugs with poor solubility that require acid resistance.

Biotechnology and Bioprocess Engineering published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Katagiri, Takayuki published the artcileVisible light-induced reduction properties of diphenylviologen with water-soluble porphyrin, Related Products of pyridine-derivatives, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2018), 368-373, database is CAplus.

Mol. conversion reaction system containing a dye and a biocatalyst catalyzing a reaction of a carbon-carbon bond formation from CO₂ as a feedstock were constructed. For example, NADP-malic enzyme (ME, EC1.1.1.40) catalyzes the reaction of introducing CO₂ as a carboxy group to pyruvate (C3 compound) to form malate (C4 compound) via oxaloacetate in the presence of natural co-enzyme NADPH. In a recent study, visible light-induced oxaloacetate production from pyruvate and CO₂ with the system consisting an electron donor, a photosensitizer, diphenylviologen (PV²⁺) derivative as an electron mediator and ME was reported. However, the visible light-induced reduction properties of PV²⁺ with water-soluble Zn porphyrin have not been clarified. In this study, chem. and photo-redox properties of PV²⁺ were studied. In addition, to produce malate, CO₂ saturated reaction solution containing triethanolamine, tetraphenylporphine tetrasulfonate (H₂TPPS), pyruvate, PV²⁺ and ME in the presence of Mg²⁺, co-factor for ME was irradiated with visible-light, the oxaloacetate and malate were produced.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishida, Naoki published the artcileSynthesis of Pyridine-N-oxide-Borane Intramolecular Complexes by Palladium-Catalyzed Reaction of 2-Bromopyridine-N-oxides with Alkynyltriarylborates, Application In Synthesis of 971-66-4, the publication is Organic Letters (2011), 13(12), 3008-3011, database is CAplus and MEDLINE.

Pyridine-N-oxide-borane intramol. complexes, e.g., I, having an aza-stilbene π-framework were synthesized by the Pd-catalyzed coupling reactions of 2-bromopyridine-N-oxides with alkynyltriarylborates. E.g., reaction of 2-bromo-5-methoxypyridine-N-oxide and HN(ⁱPr)₂ in toluene at room temperature with [Me₄N][HCCBPh₃] in the presence of [PdCl(π-allyl)]₂/DPEPhos catalyst to give I in 79% yield.

Organic Letters published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application In Synthesis of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Maeda, Hideko published the artcileCharacterization of inclusion complexes of betahistine with β-cyclodextrin and evaluation of their anti-humidity properties, Name: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2016), 86(3-4), 337-342, database is CAplus.

The formation of inclusion complexes between betahistine (BTH) and the β-CD derivatives were investigated. The binding constant (K_c) of the BTH/β-cyclodextrin (β-CD) inclusion complex was determined to be 1400 L/mol based on UV data. The structure of the BTH/β-CD complex in aqueous solution was examined by ¹H-¹H rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR, and the pyridine ring and side chain moiety of the BTH mol. were found to be inserted from the secondary hydroxyl face of the β-CD. The thermal properties of the solid BTH/β-CD inclusion complexes prepared by kneading and freeze-drying methods were studied by differential scanning calorimetry, and for comparison, solid betahistine mesilate (BTHm)/β-CD inclusion complexes were similarly prepared Humidity tests showed that the solid BTH/β-CD complexes exhibited less moisture absorption compared to the BTHm alone and BTHm/β-CD complexes.

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Name: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem