Month: December 2022

Yan, Qiao published the artcileA Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts, Safety of 4-Amino-2-picoline, the publication is Journal of Organic Chemistry (2017), 82(8), 4328-4335, database is CAplus and MEDLINE.

α-, β-, γ-, And δ-carboline and the β-carboline alkaloid harman were prepared using the Ullman coupling of 2-iodo-2-cyclohexenone with nitropyridinyl halides followed by reductive cyclization and palladium-catalyzed aromatization as the key steps. The structures of α-, β-, γ-, and δ-carboline and harman were determined by X-ray crystallog.

Journal of Organic Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C10H13BrN2O2, Safety of 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Scott, Georgia published the artcileGuidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is American Journal of Obstetrics and Gynecology (2022), 226(2_Suppl.), S1222-S1236, database is CAplus and MEDLINE.

A review. This study aimed to review pregnancy hypertension clin. practice guidelines to inform international clin. practice and research priorities. Relevant national and international clin. practice guidelines, 2009-19, published in English, French, Dutch or German. Following published methods and prospective registration (CRD42019123787), a literature search was updated. CPGs were identified by 2 authors independently who scored quality and usefulness for practice (Appraisal of Guidelines for Research and Evaluation II instrument), abstracted data, and resolved any disagreement by consensus. Of note, 15 of 17 identified clin. practice guidelines (4 international) were deemed “clin. useful” and had recommendations abstracted. The highest Appraisal of Guidelines for Research and Evaluation II scores were from government organizations, and scores have improved over time. The following were consistently recommended: (1) automated blood pressure measurement with devices validated for pregnancy and preeclampsia, reflecting increasing recognition of the prevalence of white-coat hypertension and the potential usefulness of home blood pressure monitoring; (2) use of dipstick proteinuria testing for screening followed by quant. testing by urinary protein-to-creatinine ratio or 24-h urine collection; (3) key definitions and most aspects of classification, including a broad definition of preeclampsia (which includes proteinuria and maternal end-organ dysfunction, including headache and visual symptoms and laboratory abnormalities of platelets, creatinine, or liver enzymes) and a recognition that it can worsen after delivery; (4) preeclampsia prevention with aspirin; (5) treatment of severe hypertension, most commonly with i.v. labetalol, oral nifedipine, or i.v. hydralazine; (6) treatment for nonsevere hypertension when undertaken, with oral labetalol (in particular), methyldopa, or nifedipine, with recommendations against the use of renin-angiotensin-aldosterone inhibitors; (7) magnesium sulfate for eclampsia treatment and prevention among women with “severe” preeclampsia; (8) antenatal corticosteroids for preterm birth but not hemolysis, elevated liver enzymes, and low platelet count syndrome; (9) delivery at term for preeclampsia; (10) a focus on usual labor and delivery care but avoidance of ergometrine; and (11) an apprecia. Lack of uniformity was seen in the following areas: (1) the components of a broad preeclampsia definition (specifically respiratory and gastrointestinal symptoms, fetal manifestations, and biomarkers), what constitutes severe preeclampsia, and whether the definition has utility because at present what constitutes severe preeclampsia by some guidelines that mandate proteinuria now defines any preeclampsia for most other clin. practice guidelines; (2) how preeclampsia risk should be identified early in pregnancy, and aspirin administered for preeclampsia prevention, because multivariable models (with biomarkers and ultrasonog. added to clin. risk markers) used in this way to guide aspirin therapy can substantially reduce the incidence of preterm preeclampsia; (3) the value of calcium added to aspirin for preeclampsia prevention, particularly for women with low intake and at increased risk of preeclampsia; (4) emerging recommendations to normalize blood pressure with antihypertensive agents even in the absence of comorbidities; (5) fetal neuroprotection as an indication for magnesium sulfate in the absence of “severe” preeclampsia; and (6) timing of birth for chronic and gestational hypertension and preterm preeclampsia. Consistent recommendations should be implemented and audited. Inconsistencies should be the focus of research.

American Journal of Obstetrics and Gynecology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C13H18BBrO3, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan John published the artcileMetal-pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes as visual acid-base indicators. II. Extractive end point titrations and pH of extraction, Product Details of C11H10N4, the publication is Analytica Chimica Acta (1970), 51(2), 257-63, database is CAplus.

The pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes of Cu(II), Fe(II), and Ni(II) are very good indicators for extractive end points in acid-base titrations The pH ranges for extraction of the complexes have been established, and their relevance to the extractive end points is discussed.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan John published the artcileMetal-pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes as visual acid-base indicators. I. Indicator constants, color changes, and titrations, Formula: C11H10N4, the publication is Analytica Chimica Acta (1970), 51(2), 249-56, database is CAplus.

The pyridine-2-carboxaldehyde 2-pyridylhydrazone complexes of certain metals are suggested as acid-base indicators. The color change intervals of aqueous solutions of the complexes of Cu(II), Fe(II), Ni(II), Zn(II), and Cd(II) have been studied. Apparent indicator constants have been determined The performance of the indicators in titrns of weak and strong acids and bases is excellent.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan J. published the artcileColorimetric determination of palladium with pyridine-2-carboxaldehyde 2′-pyridylhydrazone, Related Products of pyridine-derivatives, the publication is Analytica Chimica Acta (1968), 40(3), 413-19, database is CAplus.

Pd can be determined colorimetrically by extraction of the 1:1:1 Pd(II)-chlorine-pyridine-2-carboxaldehyde 2′-pyridylhydrazone complex from an acidic aqueous solution into σ-dichlorobenzene and measurement of the absorbance of the extract solution The method is suitable for the determination of 10-110 μg. of Pd. Tolerance amounts for many metals have been determined and compare very favorably with those of other methods.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mishra, Sanket J. published the artcileTransformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold, Application of 2-Pyridinylboronic acid, the publication is ACS Chemical Biology (2017), 12(1), 244-253, database is CAplus and MEDLINE.

Glucose regulated protein 94 kDa, Grp94, is the endoplasmic reticulum (ER) localized isoform of heat shock protein 90 (Hsp90) that is responsible for the trafficking and maturation of toll-like receptors, Igs, and integrins. As a result, Grp94 has emerged as a therapeutic target to disrupt cellular communication, adhesion, and tumor proliferation, potentially with fewer side effects compared to pan-inhibitors of all Hsp90 isoforms. Although, the N-terminal ATP binding site is highly conserved among all four Hsp90 isoforms, recent cocrystal structures of Grp94 have revealed subtle differences between Grp94 and other Hsp90 isoforms that has been exploited for the development of Grp94-selective inhibitors. In the current study, a structure-based approach has been applied to a Grp94 nonselective compound, SNX 2112, which led to the development of 8j (ACO1), a Grp94-selective inhibitor that manifests ∼440 nM affinity and >200-fold selectivity against cytosolic Hsp90 isoforms.

ACS Chemical Biology published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Moise, Iuliana-Monica published the artcileSwitching the reactivity of cyanomethylpyridinium salts in the 1,3-cycloaddition conditions with alkyl propiolates to cyanoindolizines or cyanoazaindolizinyl-indolizines, Related Products of pyridine-derivatives, the publication is Tetrahedron (2020), 76(41), 131502, database is CAplus.

A particular reactivity of 1-cyanomethylpyridinium salts was revealed in the [3 + 2] cycloaddition conditions with alkyl propiolates. Cyanoindolizines I [R = H, 7-Me, 7-OMe, etc.] were obtained in reactions carried out at room temperature while refluxing in CH₃CN provided unexpected Et or Me 3-(3-cyanoimidazo[1,2-a]pyridin-2-yl)indolizine-1-carboxylates II. The structure of the new 2:1 azaindolizine-indolizine adducts was secured by X-ray anal. Methodol. efforts had enabled the adjustment of the reactivity towards the formation of 3-cyanoindolizines I or cyanoazaindolizine-indolizines II. A mechanism for the formation of azaindolizine-indolizines was proposed.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hohmann, Urszula published the artcileNimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures, Computed Properties of 21829-25-4, the publication is International Journal of Molecular Sciences (2022), 23(6), 3331, database is CAplus and MEDLINE.

During injuries in the central nervous system, intrinsic protective processes become activated. However, cellular reactions, especially those of glia cells, are frequently unsatisfactory, and further exogenous protective mechanisms are necessary. Nimodipine, a lipophilic L-type calcium channel blocking agent is clin. used in the treatment of aneurysmal subarachnoid hemorrhage with neuroprotective effects in different models. Direct effects of nimodipine on neurons amongst others were observed in the hippocampus as well as its influence on both microglia and astrocytes. Earlier studies proposed that nimodipine protective actions occur not only via calcium channel-mediated vasodilatation but also via further time-dependent mechanisms. In this study, the effect of nimodipine application was investigated in different time frames on neuronal damage in excitotoxically lesioned organotypic hippocampal slice cultures. Nimodipine, but not nifedipine if pre-incubated for 4 h or co-applied with NMDA, was protective, indicating time dependency. Since blood vessels play no significant role in our model, intrinsic brain cell-dependent mechanisms seems to strongly be involved. We also examined the effect of nimodipine and nifedipine on microglia survival. Nimodipine seem to be a promising agent to reduce secondary damage and reduce excitotoxic damage.

International Journal of Molecular Sciences published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Computed Properties of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zahn, Helmut published the artcileA derivative of O-(2,4-dinitrophenyl)-DL-serine, Computed Properties of 971-66-4, the publication is Biochemische Zeitschrift (1955), 209-12, database is CAplus.

The N content of carefully purified cotton after exhaustive treatment with 2,4-(O₂N)₂C₆H₃F (Ia) (cf. C.A. 46, 7144i) increases from 0.09 to 0.22% indicating that the hydroxyl in serine has not reacted. α-N-Benzoylamino-β-hydroxyethyl propionate (I) (1.5 g.) and 1.1 g. Ia in 30 ml. dry C₆H₆, refluxed 6 hrs., evaporated in vacuo, and the residue treated with 15 ml. 2N HCl gave 5% EtCO₂CH(NHBz)CH₂OC₆H₃(NO₂)₂-2,4 (II), m. 122° (from EtOH). I (0.7 g.) was treated with 1.5 g. PhN:NC₆H₄COCl-p in 30 ml. C₅H₅N, and after 2 days H₂O added and the mass evaporated in vacuo. The residue dissolved in 50 ml. CHCl₃, extracted with aqueous KHSO₄, and chromatographed on Al₂O₃ yielded EtCO₂CH(NHBz)CH₂O₂CC₆H₄N:NPh-p, m. 154°.

Biochemische Zeitschrift published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is 0, Computed Properties of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zapf, Christoph W. published the artcileCovalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay, HPLC of Formula: 774170-15-9, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10047-10063, database is CAplus and MEDLINE.

We wish to report a strategy that targets interleukin-2 inducible T cell kinase (Itk) with covalent inhibitors. Thus far, covalent inhibition of Itk has not been disclosed in the literature. Structure-based drug design was utilized to achieve low nanomolar potency of the disclosed series even at high ATP concentrations Kinetic measurements confirmed an irreversible binding mode with off-rate half-lives exceeding 24 h and moderate on-rates. The analogs are highly potent in a cellular IP1 assay as well as in a human whole-blood (hWB) assay. Despite a half-life of approx. 2 h in resting primary T cells, the covalent inhibition of Itk resulted in functional silencing of the TCR pathway for more than 24 h. This prolonged effect indicates that covalent inhibition is a viable strategy to target the inactivation of Itk.

Journal of Medicinal Chemistry published new progress about 774170-15-9. 774170-15-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amine,Boronic Acids, name is (6-(Methylamino)pyridin-3-yl)boronic acid, and the molecular formula is C15H21BO2, HPLC of Formula: 774170-15-9.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem