Month: December 2022

Georgescu, Florentina C. published the artcilePyrimidinium ylides. V. Reactions of some 4-phenylpyrimidinium monosubstituted-carbanion ylides with nitromethane, Application of 5-Nitro-2-phenylpyridine, the publication is Revue Roumaine de Chimie (1983), 28(6), 653-7, database is CAplus.

Ylides I (R = Ph, O₂NC₆H₄, BrC₆H₄, anisyl, OEt) were treated with MeNO₂ and base to yield a pyridine II. I (R = Ph) (obtained from 4-phenyl-1-phenacylpyrimidinium bromide and base) was treated with Na₂CO₃ to give II.

Revue Roumaine de Chimie published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileEffect of surfactants on the fluorescence intensity of organic reagents, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Microchemical Journal (1985), 31(1), 44-9, database is CAplus.

The effect of 45 surfactants on the fluorescence intensity of 12 organic reagents was studied and is discussed. There is a marked enhancement in the fluorescence intensity of organic reagents with nonrigid structures and with Ph groups closely located.

Microchemical Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileIndirect spectrofluorometric kinetic determination of palladium and nickel based on the oxidation of 2,2′-dipyridylketone hydrazone and dipyridylglyoxal hydrazone, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1984), 359-64, database is CAplus.

Kinetic methods for Pd (0.1-0.8 mg L^-1) and Ni (0.1-0.7 mg L^-1) are based, resp., on the uncatalyzed bromate oxidation of 2,2′-dipyridylketone hydrazone (DPKH) in acidic media and of dipyridylglyoxal hydrazone (DPDKH) in basic media, to yield fluorescent products. Complexation of DPKH and DPDKH by Pd(II) and Ni(II), resp., causes a decrease in ligand concentration and thus in reaction rate, which can be related to the concentration of metal. The method for Pd is relatively free from interferences.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhao published the artcileAqueous Suzuki Coupling Reactions of Basic Nitrogen-Containing Substrates in the Absence of Added Base and Ligand: Observation of High Yields under Acidic Conditions, Product Details of C5H5BrN2, the publication is Journal of Organic Chemistry (2016), 81(18), 8520-8529, database is CAplus and MEDLINE.

A series of aqueous heterogeneous Suzuki coupling reactions of substrates containing basic nitrogen centers with phenylboronic acid in the absence of added base and ligand is presented. High yields of products were obtained by employing aryl bromides containing aliphatic 1°, 2°, and 3° amine substituents, and good to high yields were obtained by employing a variety of substituted bromopyridines. In the former series, the pH of the aqueous phase changed from basic to acidic during the course of the reaction, while in the latter series the aqueous phase was on the acidic side of the pH scale throughout the entire course of reaction. A mechanistic interpretation for these observations, which generally preserves the oxo palladium catalytic cycle widely accepted in the literature, is presented.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhao published the artcilePd-Catalyzed Suzuki coupling reactions of aryl halides containing basic nitrogen centers with arylboronic acids in water in the absence of added base, Category: pyridine-derivatives, the publication is New Journal of Chemistry (2017), 41(24), 15420-15432, database is CAplus.

The Pd-catalyzed Suzuki coupling reactions of a series of aryl chlorides and aryl bromides containing basic nitrogen centers with arylboronic acids in water in the absence of added base were reported. The reactions proceeded either partially or entirely under acidic conditions. After surveying twenty-two phosphorus ligands, high yields of products were obtained with aryl chlorides only when a bulky ligand, 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole (cataCXiumPtB) was used. In contrast, aryl bromides produced high yields of products in the absence of both added base and added ligand. In order to explore the Suzuki coupling process entirely under acidic conditions, a series of reactions were conducted in buffered acidic media using several model substrates. 4-Chlorobenzylamine, in the presence of cataCXiumPtB, produced high yields of product at buffered pH 6.0; the yields dropped off precipitously at buffered pH 5.0 and lower. The fall-off in yield was attributed to the decomposition of the Pd-ligand complex due to the protonation of the ligand in the more acidic aqueous media. In contrast, in the absence of an added ligand, 4-amino-2-chloropyridine produced quant. yields at buffered pH 3.5 and 4.5 while 4-amino-2-bromopyridine produced quant. yields in a series of buffered media ranging from pH 4.5 to 1.5. These substrates were only partially protonated in acidic media and could behave as active Pd ligands in the Suzuki catalytic cycle.

New Journal of Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mathis, Cheryl L. published the artcileThermodynamic Analysis of Metal-Ligand Cooperativity of PNP Ru Complexes: Implications for CO₂ Hydrogenation to Methanol and Catalyst Inhibition, Application In Synthesis of 338800-13-8, the publication is Journal of the American Chemical Society (2019), 141(36), 14317-14328, database is CAplus and MEDLINE.

The hydrogenation of CO₂ in the presence of amines to formate, formamides, and methanol (MeOH) is a promising approach to streamlining carbon capture and recycling. To achieve this, understanding how catalyst design impacts selectivity and performance is critical Herein we describe a thorough thermochem. anal. of the (de)hydrogenation catalyst, (PNP)Ru-Cl (PNP = 2,6-bis(di-tert-butylphosphinomethyl)pyridine; Ru = Ru(CO)(H)) and correlate our findings to catalyst performance. Although this catalyst is known to hydrogenate CO₂ to formate with a mild base, we show that MeOH is produced when using a strong base. Consistent with pK_a measurements, the requirement for a strong base suggests that the deprotonation of a six-coordinate Ru species is integral to the catalytic cycle that produces MeOH. Our studies also indicate that the concentration of MeOH produced is independent of catalyst concentration, consistent with a deactivation pathway that is dependent on methanol concentration, not equivalency. Our temperature-dependent equilibrium studies of the dearomatized congener, (*PNP)Ru, with various H-X species (to give (PNP)Ru-X; X = H, OH, OMe, OCHO, OC(O)NMe₂) reveal that formic acid equilibrium is approx. temperature-independent; relative to H₂, it is more favored at elevated temperatures We also measure the hydricity of (PNP)Ru-H in THF and show how subsequent coordination of the substrate can impact the apparent hydricity. The implications of this work are broadly applicable to hydrogenation and dehydrogenation catalysis and, in particular, to those that can undergo metal-ligand cooperativity (MLC) at the catalyst. These results serve to benchmark future studies by allowing comparisons to be made among catalysts and will pos. impact rational catalyst design.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Application In Synthesis of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sarkate, A. P. published the artcileMicrowave-Assisted Copper Slag-Catalyzed Green S-Arylation of Arenethiols with Arylboronic Acids, Synthetic Route of 197958-29-5, the publication is Russian Journal of Organic Chemistry, database is CAplus.

Diaryl sulfides have been synthesized in moderate to excellent yield by S-arylation of arenethiols with arylboronic acids using copper slag as a catalyst. Copper slag is a byproduct obtained from smelting and refining of copper. Conventional heating method has been compared with the microwave-assisted technique. The proposed microwave-assisted synthesis provides excellent yields of diaryl sulfides ArSAr¹ (Ar = Ph, 4-HOC₆H₄, 2-pyridyl, etc.; Ar¹ = Ph, 4-MeOC₆H₄) in a short time (10 min) and is ligand-free, green, and cost-effective.

Russian Journal of Organic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Synthetic Route of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shukla, Satyendra Nath published the artcileNovel NNO pincer type Schiff base ligand and its complexes of Fe(IIl), Co(II) and Ni(II): Synthesis, spectroscopic characterization, DFT, antibacterial and anticorrosion study, Product Details of C12H9NO, the publication is Journal of Molecular Structure (2021), 130582, database is CAplus.

A novel NNO pincer type ligand (E)-N’-(phenyl(pyridin-2-yl)methylene)isonicotinohydrazide, PPMINH, was synthesized by condensation of 2-benzoyl pyridine and isonicotinylhydrazide. The ligand PPMINH on reaction with metal ions Fe(III), Co(II) and Ni(II) yielded six metal derivatives Different anal. tools like; Elemental analyses, ESI-MS, FTIR, molar conductivity, UV-spectra, magnetic susceptibility, NMR and EPR measurement were used. Theor. FTIR, ¹H NMR and ¹³C NMR of ligand and complex 6 exhibits quite a good correlation coefficient EPR spectrum of complex 6 at LNT suggests octahedral geometry around Ni(II). The ligand and complexes were screened for antibacterial activity. DFT was carried out to optimize the geometry of the ligand and complexes. The properties most relevant to their potential action as corrosion inhibitors was calculated all parameters of DFT from the inhibitor mol. to the metal atom. The corrosion inhibition effect of compounds on mild steel in an acidic medium was studied for 24, 48, 72 h using weight loss measurement.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C18H17NO8, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Blake, James F. published the artcileDiscovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2, Computed Properties of 18437-58-6, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(12), 2635-2639, database is CAplus and MEDLINE.

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts. Proliferation of HCT116 (K-RasG12D) and A375 (BRafV600E) cell lines was inhibited by compound (I) with EC50s of 0.74 and 0.39 μM, resp. Pharmacokinetic parameters of I are given.

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ball, Nicholas D. published the artcileMechanistic and Computational Studies of Oxidatively-Induced Aryl-CF₃ Bond-Formation at Pd: Rational Design of Room Temperature Aryl Trifluoromethylation, Related Products of pyridine-derivatives, the publication is Journal of the American Chemical Society (2011), 133(19), 7577-7584, database is CAplus and MEDLINE.

This article describes the rational design of first generation systems for oxidatively induced Aryl-CF₃ bond-forming reductive elimination from Pd^II. Treatment of (dtbpy)Pd^II(Aryl)(CF₃) (dtbpy = di-tert-butylbipyridine) with NFTPT (N-fluoro-1,3,5-trimethylpyridinium triflate) afforded the isolable Pd^IV intermediate (dtbpy)Pd^IV(Aryl)(CF₃)(F)(OTf). Thermolysis of this complex at 80° resulted in Aryl-CF₃ bond-formation. Detailed exptl. and computational mechanistic studies have been conducted to gain insights into the key reductive elimination step. Reductive elimination from this Pd^IV species proceeds via pre-equilibrium dissociation of TfO^– followed by Aryl-CF₃ coupling. DFT calculations reveal that the transition state for Aryl-CF₃ bond formation involves the CF₃ acting as an electrophile with the Aryl ligand serving as a nucleophilic coupling partner. These mechanistic considerations along with DFT calculations have facilitated the design of a second generation system utilizing the tmeda (N,N,N’,N’-tetramethylethylenediamine) ligand in place of dtbpy. The tmeda complexes undergo oxidative trifluoromethylation at room temperature

Journal of the American Chemical Society published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem