Month: December 2022

Spring Walsh, Breeanna published the artcileA Cohort Comparison Study on Women in Threatened Preterm Labor Given Nifedipine or Nifedipine and Salbutamol Tocolysis in Air Medical Retrieval., HPLC of Formula: 21829-25-4, the publication is Air medical journal (2022), 41(3), 298-302, database is MEDLINE.

OBJECTIVE: Women with threatened preterm labor in remote Australia often require tocolysis in the prevention of in-flight birth during air medical retrieval. However, debate exists over the tocolytic choice. METHODS: A retrospective analysis was undertaken on data containing women who required air medical retrieval for threatened preterm labor within Western Australia between the years 2013 and 2018. RESULTS: A total number of 236 air medical retrievals were deemed suitable for inclusion; 141 received nifedipine, and 95 women received salbutamol + nifedipine. Tocolytic efficaciousness was reported in 151 cases, proportionally more (P < .05) from the women who received salbutamol + nifedipine (n = 68, 71.6%) compared with the women who received nifedipine only (n = 83, 58.9%). Those receiving salbutamol + nifedipine were more likely to suffer maternal tachycardia (n = 87 [91.6%] vs. n = 62 [44.0%]), fetal tachycardia (n = 26 [27.4%] vs. n = 13 [9.2%]), nausea (n = 17 [17.9] vs. n = 5 [3.55%]), and vomiting (n = 12 [12.6%] vs. n = 2 [1.4%]). Three women who received salbutamol + nifedipine had serious side effects including echocardiographic changes, chest pain, and metabolic and lactic acidosis. CONCLUSION: Salbutamol + nifedipine tocolysis was proven to be more effective than nifedipine only. Although salbutamol + nifedipine had increased temporary side effects, most were nonsevere and managed in-flight.

Air medical journal published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C9H5FO2, HPLC of Formula: 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileSpectrofluorometric kinetic determination of copper based on the autoxidation of 2,2′-dipyridyl ketone azine or hydrazone or phenyl-2-pyridyl ketone hydrazone, SDS of cas: 2215-33-0, the publication is Analytica Chimica Acta (1981), 21-8, database is CAplus.

Kinetic methods for determination of ppm levels of Cu are based on its catalytic effect on the autoxidation of the hydrazone and the azine of 2,2′-dipyridyl ketone and the hydrazone of phenyl-2-pyridyl ketone. The reactions are followed by measuring the rate of appearance of fluorescence. The methods suffer very few interferences.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileFluorimetric determination of copper and mercury based on their catalytic effects on the autoxidation of 2,2′-dipyridylketone hydrazone, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1980), 119(2), 359-65, database is CAplus.

Fluorometric methods for the determination of Hg(II) (80-320 ppb) and Cu(II) (0.4-1 ppb) are described. These ions catalyze the autoxidation of 2,2′-dipyridyl ketone hydrazone, which yields a product exhibiting an intense blue fluorescence in acidic solution This product was investigated and the exptl. variables and interferences in each determination were studied.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcile2,2′-Dipyridyl ketone hydrazone as photometric reagent. Critical study of colorimetric and fluorimetric reaction ability of hydrazones, azines and phenylhydrazones of various ketones, Product Details of C11H10N4, the publication is Afinidad (1982), 39(377), 30-2, database is CAplus.

2,2′-Dipyridyl ketone hydrazone in EtOH reacts with Pd(II) to form a complex with absorption peak at 500 nm. The development of the color takes 30 min and is then stable for at least 2 h. Optimum conditions are pH 13.4 and 80% EtOH solvent. Beer’s law is followed for 0.5-4.0 ppm Pd. Tolerance levels for 21 ions are given. The colorimetric and fluorometric reactions of hydrazones, azine, and phenylhydrazones of various ketones are briefly reviewed.

Afinidad published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Perez-Gomez, Marta published the artcileTrapping σ-Alkyl-Palladium(II) Intermediates with Arynes Encompassing Intramolecular C-H Activation: Spirobiaryls through Pd-Catalyzed Cascade Reactions, Formula: C5H5BrN2, the publication is Angewandte Chemie, International Edition (2016), 55(46), 14389-14393, database is CAplus and MEDLINE.

A palladium-catalyzed cascade reaction based on the trapping of transient alkyl-Pd^II intermediates with arynes encompassing a C-H activation step has been developed. This synthetic pathway gives rise to hetero-spirocyclic scaffolds containing a biaryl motif, and opens up new synthetic strategies in the design of cascade reactions since it gathers several aspects of Pd chem., i.e., intra- and intermol. carbopalladation of unsaturated species, C-H activation and C-C coupling processes.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pan, Huaqiang published the artcileInfluencing factors and evaluation of CaCO₃ modified with three coupling agents, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Wuhan Keji Daxue Xuebao (2013), 36(1), 64-68, database is CAplus.

KH101, KH151 and KH570 were used to modify the surface of CaCO₃, resp., to improve the surface properties, and the optimum modification conditions were determined by analyzing the factors that influenced the activation grade of modified CaCO₃. The modification effects of three coupling agents were compared by means of SEM anal. and settling volume test. The results show that, the optimum conditions for KH101 modification of CaCO₃ are the reaction temperature at 80°C, the reaction time at 70 min, the coupling agent content at 3%, and the amount of cyclohexanone five times that of CaCO₃, and the optimum conditions for KH570 and KH151 modification of CaCO₃ are the reaction temperature at 70°C, the reaction time at 70 min, the coupling agent content at 3%, and the amount of cyclohexanone five times that of CaCO₃. It is also found that modification with KH151 and KH570 is characterized by severe reunion phenomenon, while modification with KH101 can remarkably ameliorate the reunion phenomenon of CaCO₃.

Wuhan Keji Daxue Xuebao published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jiao, Mingdong published the artcileEnantioselective Synthesis of 4-Cyanotetrahydroquinolines via Ni-Catalyzed Hydrocyanation of 1,2-Dihydroquinolines, Formula: C5H6BNO2, the publication is Organic Letters (2020), 22(21), 8566-8571, database is CAplus and MEDLINE.

A Ni-catalyzed asym. hydrocyanation that enables the formation of 4-cyanotetrahydroquinolines in good yields with excellent enantioselectivities is presented herein. A variety of functional groups are well-tolerated, and a gram-scale reaction supports the synthetic potential of the transformation. Addnl., several crucial intermediates for pharmaceutically active agents, including a PGD2 receptor antagonist, are now accessible through asym. synthesis using this new protocol.

Organic Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jing published the artcileIron(II) complexes based on electron-rich, bulky PNN- and PNP-type ligands, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Inorganica Chimica Acta (2006), 359(6), 1955-1960, database is CAplus.

Reaction of the PNN ligand ((2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine) with 1 equiv of anhydrous FeCl₂ in THF gave (PNN)FeCl₂ (1). The cationic complex [(PNN)Fe(THF)Cl](PF₆) (2) was obtained by chloride abstraction from 1 with 1 equiv of TlPF₆. Similarly, the PNP-type complexes, (t-Bu-PNP)FeCl₂ (3) and (i-Pr-PNP)FeCl₂ (4) were obtained from FeCl₂ with 1 equiv of t-Bu-PNP (2,6-bis(di-tert-butylphosphinomethyl)pyridine) and i-Pr-PNP (2,6-bis(di-iso-propylphosphinomethyl)pyridine), resp. Complexes 1 and 3 were characterized by x-ray diffraction and elemental analyses. In both structures the Fe(II) centers exhibit a distorted square pyramidal geometry comprising two chloride ligands and one tridentate PNN or PNP ligand. The magnetic properties of the paramagnetic complexes 1–4 are discussed.

Inorganica Chimica Acta published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C14H10N2O, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jing published the artcileElectron-Rich, Bulky Ruthenium PNP-Type Complexes. Acceptorless Catalytic Alcohol Dehydrogenation, Formula: C23H43NP2, the publication is Organometallics (2004), 23(17), 4026-4033, database is CAplus.

Reaction of the electron-rich, bulky tridentate PNP ligand (2,6-bis-(di-tert-butylphosphinomethyl)pyridine) with Ru(PPh₃)₃Cl₂ at 65° gave a solution containing the dinitrogen monomeric Ru(II) complex, Ru(PNP)(N₂)Cl₂ (1a), and the N₂-bridged dinuclear Ru(II) complex, [Ru(PNP)Cl₂]₂(μ-N₂) (1b), which can be interconverted. Passing Ar through the solution gave pure 1b. The Ru(II) hydride dinitrogen complex, [Ru(PNP)N₂(Cl)(H)] (2), was obtained by the reaction of complex 1b with 2 equiv of NaBEt₃H. Complex 1b reacted with 4 equiv of AgOCOCF₃ to yield [Ru(PNP)(CF₃COO)₂], 3. The Ru(II) carbonyl hydride complex, [Ru(PNP)H(OAc)₂] (4) was obtained by the reaction of PNP and Ru₂(OAc)₄ in MeOH as a result of O-H activation and decarbonylation of MeOH. Complexes 1b, 2, and 4 were structurally characterized by x-ray crystallog. Complexes 1b and 2 catalyze the dehydrogenation of secondary alcs. to the corresponding ketones with good yields and high selectivity accompanied with the evolution of dihydrogen in a homogeneous system without a need for a H acceptor. The presumed intermediate Ru dihydride complex is generated in situ by reaction 1b or 2 with a base (1 equiv for each Ru-Cl bond), and the reaction can proceed in the absence of excess base or acid.

Organometallics published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C8H16O2, Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jing published the artcileStable Carbene and Diazoalkane Complexes of the Same Complex System. Synthesis, Structure, and Reactivity of PNP-Ru(II) Fluorenylidene and Diazofluorene Complexes, Product Details of C23H43NP2, the publication is Organometallics (2008), 27(14), 3526-3533, database is CAplus.

The choice of synthetic methodol. leads to either carbene or diazoalkane complexes of the same system. Thus, treatment of RuCl₂(PPh₃)₃ with 9-diazofluorene followed ^tBu-PNP (^tBu-PNP = 2,6-bis(di-tert-butylphosphinomethyl)pyridine) resulted in loss of dinitrogen and formation of the Ru(II) fluorenylidene complex 1. On the other hand, treatment of the ^tBu-PNP Ru(II) dinitrogen complex 4 with 9-diazofluorene resulted in the formation of η¹-dizaofluorene Ru(II) complex 5, in which the diazo unit remains intact. The cationic Ru(II) carbene complex 2 was obtained by the reaction of 1 with 1 equivalent of AgBF₄ or HBF₄. Chloride dissociation to form a 16-e cationic carbene complex 3 took place also upon refluxing of 1 in toluene. The five-coordinated, unsaturated, charge-neutral diiodide Ru(II) complex 6 was obtained by reaction of 4 with NaI. Complex 6 is stabilized by a C-H agostic interaction, as observed by x-ray crystallog. Reaction of 4 with NaBEt₃H followed by 9-dizaofluorene resulted in a novel η¹-diazenofluorene Ru(II) complex 7, accompanied by the migration of one hydrogen atom from the metal center to the coordinated nitrogen atom of the diazenofluorene unit. Heating complex 7 at 65° resulted in sp² C-H activation followed by elimination of dihydrogen to form the chelated, β-carbon coordinated diazenofluorene ruthenium complex 8. Complexes 1, 2, 5, 6, and 8 were structurally characterized by x-ray crystallog.

Organometallics published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C7H7ClN2S, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem