Month: December 2022

Sokolova, Ekaterina A. published the artcileHighly Fluorescent Pyrido[2,3-b]indolizine-10-Carbonitriles through Pseudo Three-Component Reactions of N-(Cyanomethyl)pyridinium Salts, Related Products of pyridine-derivatives, the publication is European Journal of Organic Chemistry (2019), 2019(40), 6770-6775, database is CAplus.

An interaction of N-(cyanomethyl)pyridinium salts with vinamidinium perchlorates or enaminones proceeds as a pseudo-three component process and results in the formation of 3- or 2-substituted pyrido[2,3-b]indolizine-10-carbonitriles, resp. Optical properties of these compounds have been evaluated, revealing effective green light emission with fluorescence quantum yields of up to 0.81.

European Journal of Organic Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C6H6N2O, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Carballo, Rosa published the artcileSupramolecular networks through second-sphere coordination based on 1D metal-4,4′-dipyridyldisulfide coordination polymers and hydrogenfumarate or sulfonate anions, Computed Properties of 636-73-7, the publication is Polyhedron (2012), 31(1), 118-127, database is CAplus.

Four H-bonded assemblies [M(dpds)₂(OH₂)₂]A₂·nH₂O (A = anion) are described. These assemblies result from the 2nd-sphere coordination interactions between the 1-dimensional coordination polymers [M(dpds)₂(OH₂)₂]²⁺, M = Zn(II), and Cu(II), dpds = 4,4′-dipyridyldisulfide, and the pyridine-3-sulfonate (3pySO₃^–) or hydrogenfumarate (Hfum^–) anions. Significantly, supramol. structural variations are observed depending on the presence of H₂O lattice mols., which formed discrete aggregates when the Hfum^– anion was used. The effects of geometrical variations in the building blocks are also evident on using Jahn-Teller-distorted divalent Cu(II) ions or regular octahedral species based on Zn(II) ions. The 2nd-sphere effects on the stabilization of the compounds are illustrated by TGA experiments

Polyhedron published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Salameh, Nihad published the artcileWaste-Minimized Continuous-Flow Synthesis of Oxindoles Exploiting a Polymer-Supported N Heterocyclic Palladium Carbene Complex in a CPME/Water Azeotrope, Computed Properties of 39856-58-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(11), 3766-3776, database is CAplus.

The development of an effective synthetic protocol for the synthesis of oxindoles in flow based on a C(sp³)-H activation process promoted by a supported N-heterocyclic carbene palladium heterogeneous catalytic system using cyclopentyl Me ether (CPME) as the reaction medium was reported. The design of the catalyst, the selection of the solvent medium, and the definition of a tailored continuous flow reactor have been all designed to establish an efficient waste-minimized process for the intramol. cyclization of N-methyl-2-halo-acetanilides. The use of CPME in its aqueous azeotropic mixture has allowed to reach high yields of products with a simplified precipitation workup that includes the downstream process separation and recycling of the solvent. An assessment of the environmental and safety hazard features has also been made in order to better clarify the implications in terms of sustainability of the newly developed process.

ACS Sustainable Chemistry & Engineering published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Computed Properties of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Barlaam, Bernard published the artcileNew heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors, COA of Formula: C6H7ClN2O, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(24), 5446-5449, database is CAplus and MEDLINE.

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthesized and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and phys. properties suitable for oral dosing were achieved within this series: I [X = CH, N] were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.

Bioorganic & Medicinal Chemistry Letters published new progress about 742070-73-1. 742070-73-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Amine,Ether, name is 2-Amino-3-chloro-6-methoxypyridine, and the molecular formula is C6H7ClN2O, COA of Formula: C6H7ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xitao published the artcileTransition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions, Recommanded Product: 5-Nitro-2-phenylpyridine, the publication is Organic Letters (2018), 20(22), 7095-7099, database is CAplus and MEDLINE.

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Organic Letters published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C7H6FNO3, Recommanded Product: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhou, Su published the artcileOptimization for the coating prescription of porosity osmotic pump-controlled release tablets of betahistine mesilate, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Zhongguo Yaofang (2011), 22(21), 1970-1972, database is CAplus.

The aim of this paper is to prepare porosity osmotic pump-controlled release tablets of betahistine mesilate, and optimize the coating prescription. Main influencing factors for drug release of porosity osmotic pump-controlled release tablets were investigated with single factor experiment The coating prescription was optimized by orthogonal test with the amount of PEG and DBP as factors and drug release indicator L as index. Similar factor was less than 50 which indicated that the amount of PEG, DBP and coating level affected the in vitro drug release significantly. The optimized coating prescription was as follows: PEG 30%, DBP 20% and the weight increment of coating material 4%. The drug release indicators of 3 batches of samples in validation test were 13.99, 11.15 and 8.37. Accumulative drug release rate was more than 90% within 12 h, and the drug release model showed zero-level drug release characteristics. Porosity osmotic pump-controlled release tablets of betahistine mesilate with optimized prescription can achieve constant complete release in 12 h.

Zhongguo Yaofang published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C9H8O4, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bornholdt, Jan published the artcileRing Opening of Pymisyl-Protected Aziridines with Organocuprates, Application In Synthesis of 636-73-7, the publication is Chemistry – A European Journal (2010), 16(41), 12474-12480, S12474/1-S12474/100, database is CAplus and MEDLINE.

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methylaziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson’s disease.

Chemistry – A European Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Ying-Chu published the artcileC-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis, Recommanded Product: 4-Amino-2-picoline, the publication is Bioconjugate Chemistry (2020), 31(3), 770-780, database is CAplus and MEDLINE.

DNA-encoded chem. library (DECL) screens are a rapid and economical tool to identify chem. starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chem. matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.

Bioconjugate Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shahzadi, Hafiza Tayyaba published the artcileIridium-Catalyzed C-H Borylation of CF₃-Substituted Pyridines, Application In Synthesis of 741709-67-1, the publication is ACS Omega (2022), 7(13), 11460-11472, database is CAplus and MEDLINE.

Iridium-catalyzed C-H borylation of CF₃-substituted pyridines is described in this paper. The boronic ester group can be installed on the α, β, or γ position of pyridine by an appropriate substitution pattern. Sterically governed regioselectivity provides convenient access to a variety of CF₃-substituted pyridylboronic esters. These catalytic C-H borylation reactions were carried out neatly without the use of any solvent. Several functional groups, such as halo, ester, alkoxy, amino, etc., are compatible with this methodol. These pyridylboronic esters are amenable to column chromatog. and the products were isolated in good to excellent yields. α-Borylated pyridines, although isolated in good yields, do not have a long shelf life. The boronic ester derivatives of these CF₃-substituted pyridines can serve as useful precursors in the synthesis regime.

ACS Omega published new progress about 741709-67-1. 741709-67-1 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Chloride,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine, and the molecular formula is C12H16BBrO2, Application In Synthesis of 741709-67-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shahzadi, Hafiza Tayyaba published the artcileIridium-Catalyzed C-H Borylation of CF₃-Substituted Pyridines, Related Products of pyridine-derivatives, the publication is ACS Omega (2022), 7(13), 11460-11472, database is CAplus and MEDLINE.

Iridium-catalyzed C-H borylation of CF₃-substituted pyridines is described in this paper. The boronic ester group can be installed on the α, β, or γ position of pyridine by an appropriate substitution pattern. Sterically governed regioselectivity provides convenient access to a variety of CF₃-substituted pyridylboronic esters. These catalytic C-H borylation reactions were carried out neatly without the use of any solvent. Several functional groups, such as halo, ester, alkoxy, amino, etc., are compatible with this methodol. These pyridylboronic esters are amenable to column chromatog. and the products were isolated in good to excellent yields. α-Borylated pyridines, although isolated in good yields, do not have a long shelf life. The boronic ester derivatives of these CF₃-substituted pyridines can serve as useful precursors in the synthesis regime.

ACS Omega published new progress about 1256360-49-2. 1256360-49-2 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Bromide,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine, and the molecular formula is C8H8BNO2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem