Month: December 2022

Gueye, Mbosse Ndiaye published the artcileSynthesis, physical studies and crystal structure determination of Y(III) and Er(III) complexes of 1-(pyridin-2-yl)-2-(pyridine-2-yl-methylene)hydrazine, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is European Journal of Chemistry (2017), 8(2), 137-143, database is CAplus.

Two isotype mononuclear yttrium(III) and erbium(III) complexes, {[Y(HL)(OAc)₂(H₂O)₂]. (H₂O)·(NO₃)} (1) and {[Er(HL)(OAc)₂(H₂O)₂].(H₂O)·(NO₃)} (2), where HL is the neutral Schiff base ligand 1-(pyridin-2-yl)-2-(pyridine-2-yl-methylene)hydrazine, and OAc is the acetate anion, were synthesized and characterized by physicochem. methods and single crystal x-ray determination Both complexes crystallize in the triclinic space group P-1 with unit cell dimensions for complex of Y(III) a 7.909(2), b 11.718(4), c 12.497(3) Å, α 78.907(3), β 73.840(3), γ 72.074(3)°, Z = 2, R₁ = 0.051 and wR₂ = 0.112 and for complex of Er(III) a 7.913(1), b 11.719(2), c 12.487(2) Å, α 78.832(1), α 73.674(1), γ 72.012(1)°, Z = 2, R₁ = 0.028, and wR₂ = 0.062. In both complexes, the coordination polyhedra around Ln(III) atoms are best described as a distorted tricapped trigonal prism. Antioxidant activities of the ligand and its Y(III) and Er(III) complexes were studied.

European Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gueye, Mbosse Ndiaye published the artcileLanthanide(III) complexes with tridentate schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes, Application In Synthesis of 2215-33-0, the publication is South African Journal of Chemistry (2017), 70(1), 8-15, S1-S6, database is CAplus.

The tridentate N4-type Schiff base was synthesized from the condensation reaction of 2-hydrazinopyridine and pyridine-2-carbaldehyde. Neodymium and samarium complexes were isolated when the corresponding nitrate salt was added to the solution of the ligand. The isolated compounds were characterized by elemental analyses, IR study, room temperature magnetic measurements and single x-ray crystal diffraction of the two crystals. Both complexes crystallize in the monoclinic system with space group P21/c. The cell parameters of the Nd complex are a 11.0927(8), b 17.9926(13) Å, c 11.9395(9) Åand β 115.274(5)° while the Sm complex shows parameters cell of a 11.0477(8), b 17.9254(13), c 11.9149(8) Å and β 115.489(5)°. The x-ray study reveals isotopic Nd/Sm binuclear structures were each metal ion is nine-coordinated in the same fashion. Both metal centers have distorted tricapped trigonal prism geometry, with the Schiff base acting as tridentate ligand. The DPPH• radical scavenging effects of the Schiff base ligand and its Ln(III) complexes were screened. The Ln(III) complexes were significantly more efficient in quenching DPPH• than the free Schiff base ligand.

South African Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rao, Maddali L. N. published the artcileCross-coupling study of iodo/chloropyridines and 2-chloroquinoline with atom-economic triarylbismuth reagents under Pd-catalysis, Application In Synthesis of 89076-64-2, the publication is Tetrahedron (2015), 71(2), 338-349, database is CAplus.

This study describes the palladium-catalyzed couplings of iodopyridines, chloropyridines, and chloroquinoline with atom-economic BiAr₃ reagents in sub-stoichiometric loadings. Mono-arylations of iodo and chloropyridines produced arylpyridines in high yields. The couplings addressed with dihalopyridines have afforded chemo- and regioselective coupling products. Arylations of 2-chloroquinoline with different triarylbismuth reagents demonstrated fruitful coupling reactivity under the established conditions. This sumptuous study demonstrates the remarkable cross-coupling reactivity of iodo/chloropyridines and chloroquinoline with triarylbismuth reagents.

Tetrahedron published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application In Synthesis of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rao, Maddali L. N. published the artcileTriarylbismuthanes as Threefold Aryl-Transfer Reagents in Regioselective Cross-Coupling Reactions with Bromopyridines and Quinolines, Related Products of pyridine-derivatives, the publication is European Journal of Organic Chemistry (2014), 2014(24), 5214-5228, database is CAplus.

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalyzed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both sym. and unsym. diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalyzed conditions.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sarthou, Manon C. M. published the artcileCalcium-permeable cation channels are involved in uranium uptake in Arabidopsis thaliana, Category: pyridine-derivatives, the publication is Journal of Hazardous Materials (2022), 424(Part_B), 127436, database is CAplus and MEDLINE.

Uranium (U) is a non-essential and toxic element that is taken up by plants from the environment. The assimilation pathway of U is still unknown in plants. In this study, we provide several evidences that U is taken up by the roots of Arabidopsis thaliana through Ca²⁺-permeable cation channels. First, we showed that deprivation of Arabidopsis plants with calcium induces a 1.5-fold increase in the capacity of roots to accumulate U, suggesting that calcium deficiency promotes the radionuclide import pathway. Second, we showed that external calcium inhibits U accumulation in roots, suggesting a common route for the uptake of both cations. Third, we found that gadolinium, nifedipine and verapamil inhibit the absorption of U, suggesting that different types of Ca²⁺-permeable channels serve as a route for U uptake. Last, we showed that U bioaccumulation in Arabidopsis mutants deficient for the Ca²⁺-permeable channels MCA1 and ANN1 is decreased by 40%. This suggests that MCA1 and ANN1 contribute to the absorption of U in different zones and cell layers of the root. Together, our results describe for the first time the involvement of Ca²⁺-permeable cation channels in the cellular uptake of U.

Journal of Hazardous Materials published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Maidich, Luca published the artcileElectronic and Steric Effects in Rollover C-H Bond Activation, Application In Synthesis of 197958-29-5, the publication is Organometallics (2015), 34(5), 817-828, database is CAplus.

Steric and electronic factors in rollover C-H bond activation of substituted 2,2′-bipyridines, mediated by Pt(II), were studied by comparing the influence of two substituents, CH₃ and CF₃, on the progress of the reaction. The substituents were chosen to have similar steric hindrance but different electronic effects and were placed in position 6 (i.e., near one of the N atoms) or in position 5, which allows, in part, electronic and steric influence to be distinguished. The ligands studied, 6-methyl-2,2′-bipyridine, 5-methyl-2,2′-bipyridine, 6-trifluoromethyl-2,2′-bipyridine, and 5-trifluoromethyl-2,2′-bipyridine, were compared to unsubstituted 2,2′-bipyridine in the reaction with the electron-rich complex [Pt(Me)₂(DMSO)₂]. The electron-withdrawing CF₃ group has a significant effect in accelerating the cyclometalation reaction. The substituent in position 6 influences the stability of the intermediate adduct [Pt(N,N)(Me)₂] (N,N = chelated bipyridine), as indicated by d. functional theory calculations The steric hindrance of substituted bipyridines was also evaluated by defining and measuring the angle ζ in [Pt(N,N)(Me)₂] adducts. The presence of a substituent in position 6 causes destabilization of the adduct, acceleration of the cyclometalation reaction, and regioselectivity of C-H bond activation.

Organometallics published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Koovits, Paul J. published the artcileStructure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi, Name: 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(1), 126779, database is CAplus and MEDLINE.

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “Chagas box” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhong, Shuai published the artcileVisible-light-induced 4CzIPN/LiBr system: a tireless electron shuttle to enable reductive deoxygenation of N-heteroaryl carbonyls, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Organic Chemistry Frontiers (2021), 8(16), 4419-4425, database is CAplus.

A visible-light-induced photoredox system that enabled efficient reductive deoxygenation of N-heteroaryl ketones and alcs. under mild conditions was reported. The combinational use of 4CzIPN as photocatalyst and LiBr as additive in acidic media constituted a tireless electron shuttle to transfer electrons from benzaldehyde to N-heteroaryl carbonyls. Mechanistically, the reduction course involved two-round sequential cascade of proton-coupled electron transfer, spin-center shift and single-electron-transfer processes. The presented reductive deoxygenation protocol provides a mild route to pharmaceutically valuable alkyl and benzyl N-containing heteroarenes.

Organic Chemistry Frontiers published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C3H3Br2ClO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Van der Does, L. published the artcileDidehydrohetarenes. XXV. Amination of alkyl substituted halopyridines with potassium amide in liquid ammonia, HPLC of Formula: 39919-70-5, the publication is Recueil des Travaux Chimiques des Pays-Bas (1972), 91(12), 1403-13, database is CAplus.

The action of KNH2 in liquid NH3 on Me substituted 3- and 4-bromo(or chloro)pyridines, of 5-bromo-2-tert-butylpyridine and of 3-bromo(or chloro) and 4-bromo(or chloro)-2,6-dimethylpyridine was studied. The results of the reactions indicate the occurrence of derivatives of 3,4-didehydropyridine as intermediates. An interpretation is given of the influence of the substituent and the hetero atom on the course of the aminations.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 39919-70-5. 39919-70-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 6-(tert-Butyl)pyridin-3-amine, and the molecular formula is C6H12N2O, HPLC of Formula: 39919-70-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vrijdag, Johannes L. published the artcilePractical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions, Related Products of pyridine-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(95), 15094-15097, database is CAplus and MEDLINE.

A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, giving amides in-line from haloarenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C18H10, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem