Month: December 2022

Kobayashi, Yuka published the artcileTailored cell sheet engineering using microstereolithography and electrochemical cell transfer, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Scientific Reports (2019), 9(1), 1-8, database is CAplus and MEDLINE.

Postoperative adhesion and occlusion remain a serious issue associated with various surgeries, including endoscopic surgery, in which proliferated fibrous tissues stick to adjacent tissues and often cause severe complications. Cell sheet engineering has emerged as an effective approach not only for cell transplantation but also for the treatment of postoperative adhesion and occlusion. However, as the tissues in the body, such as middle ear and small intestine, and typical operative sites are non-flat and spatially complicated, tailored cell sheets with three-dimensional (3D) configurations may lead to widespread use of this approach. In the present study, we used microstereolithog., biocompatible gold plating, and electrochem. cell detachment to achieve this purpose. Various objects with dimensions ranging from millimeter- to micrometer-scale were fabricated with photocurable resin using lab-made equipment for microstereolithog. To coat the fabricated objects with a thin gold layer, conventional cyanide-based gold plating was unusable because it severely damaged almost all cells. Electroless non-cyanide gold plating we prepared was cytocompatible and suitable for electrochem. cell detachment. Cell sheets on the gold-plated substrate could be directly transplanted into a mouse i.p. using electrochem. cell detachment. We further demonstrated that cell sheets grown on gold-coated 3D objects were rapidly detached along with the desorption of electroactive-oligopeptide monolayer and transferred to a surrounding hydrogel. This approach may provide a promising strategy to prepare and directly transplant tailor-made cell sheets with suitable configurations.

Scientific Reports published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gezerman, Ahmet Ozan published the artcileAnalysis of the characteristics of nickel-plating baths, Category: pyridine-derivatives, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2010), 2(2), 124-137, database is CAplus.

Ni plating processes, popularly used in Europe since 1950s, were increasingly employed in Turkey in recent years. As a result, industrial usage has developed rapidly. Ni plating is the preferred process for this study because of the uniformity of the plating thickness on the plated surface and the ease with which complex components can be plated. It is also resistant to corrosion and has good levels of hardness. In this experiment, the following parameters were studied: the effect of varying the amount of Ni, the thickness of the plating, and sheen (whether shiny or dull). Brightening and carrying agents were used to determine the best operational parameters for the Kale Kilit Factory. The compositions of the brightening and carrying agents used in the experiment are included in this text. Addnl., studies were conducted on how the plating color changed when compared to the original bath as a result of using Fe²⁺ complex concentration in Ni plating baths, as a brightening agent and for analyzing the color of the plated sample, under a visible region spectrophotometer at 350 nm and 6500 K light power and D65 (Average North Sky Daylight) light. In the authors’ research, the most important feature of anal. is that the desired color effect was obtained by using brightening agents containing Fe²⁺ complex concentration without any interference from any colorant after Ni plating by electrolysis. In this study where Ni plating bath characteristics are researched, phys. tests such as brittle test are applied to the plated materials, which provide the authors important ideas about the accuracy of the choices made according to standards

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gezerman, A. O. published the artcileIron(II) acetylacetonate containing brightener and sulphur containing carrier in nickel plating, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Surface Engineering (2013), 29(7), 516-521, database is CAplus.

The effects of an Fe(II) acetylacetonate containing brightening agent and a carrier on color and mech. properties of Ni plating were studied to determine optimal electroplating process parameters. The brightening agent contained metasulfobenzaldehyde, pyridine-3-sulfonic acid, p-vinylbenzenesulfonic acid, o-benzoylsulfonamide, Na saccharine and Fe(II) acetylacetonate. The carrier comprised Na saccharine and Na allyl sulfonate in H₂O. Plating color was analyzed by visible region spectrophotometry at 350 nm under 6500 K illumination (CIE Standard Illuminant D65). Electron microscopy confirmed that carrier facilitated Ni deposition onto the surface and increased cohesion, thus allowing complete coverage. Also, brightening agent increased the bath pH, while carrier did not. In bending experiments on a coated plate, brightening agent increased H embrittlement, although desired decorative appearance was obtained. Finally, the optimum concentrations of carrier and brightening agent are 12 and 0·4 g L-1, resp.

Surface Engineering published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bruce, R. St. L. published the artcileLinkage isomers of molybdenum and the chelate ligand pyridine-2-carboxaldehyde-2′-pyridylhydrazone (paphy), Application In Synthesis of 2215-33-0, the publication is Journal of the Chemical Society [Section] D: Chemical Communications (1970), 69-70, database is CAplus.

Direct reaction of paphy with Mo(CO)6 in diglyme at 128° gave orange-red air-stable I, while reaction of tetraethylammonium chloropentacarbonylmolybdenum(0) with paphy in diglyme at room temperature gave II.

Journal of the Chemical Society [Section] D: Chemical Communications published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Egbertson, Melissa S. published the artcileNon-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation. [Erratum to document cited in CA131:179285], Synthetic Route of 636-73-7, the publication is Journal of Medicinal Chemistry (1999), 42(19), 4014, database is CAplus.

On page 2409, in the Abstract, line 8, mg/kg should be μg/kg. On page 2412, in Table 3, the correct values are flow cytometry K_D = 2.2 nM and fold difference K_D/ED₅₀ = 5.7. On page 2413, under Single-Dose I.v. and Oral Administration of 4 to Conscious Dogs, lines 11, 16, 18, and 22, mg/kg should be μg/kg. On page 2414, in line 1 and under Once-Daily Oral Administration of 4 for 6 days to Conscious Dogs by Gastric Lavage, line 13, mg/kg should be μg/kg. On page 2419, under Single-Dose I.v. and Oral Administration of 4 to Conscious Dogs, line 12, μ/kg should be μg/kg. On page 2421, in reference 16, last line, 1,000,000 should be 100,000: “20,000 to 100,000 receptors/platelet”.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Egbertson, Melissa S. published the artcileNon-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Journal of Medicinal Chemistry (1999), 42(13), 2409-2421, database is CAplus and MEDLINE.

The synthesis and pharmacol. of a potent thienothiophene non-peptide fibrinogen receptor antagonist (I) are reported. Compound I inhibited the aggregation of human gel-filtered platelets with an IC₅₀ of 8 nM and demonstrated an 8-fold improvement in affinity for isolated GPIIb/IIIa receptors over analogs possessing an isoindolinone backbone. Flow cytometry studies revealed that the binding of I to resting platelets is a diffusion-controlled process (k_on = 3.3 × 10⁶ M^-1 s^-1) and that I binds to dog and human platelets with comparable affinity (K_d = 0.04 and 0.07 nM, resp.). Ex vivo platelet aggregation in dogs was completely inhibited by an i.v. dose of 5 mg/kg, and an oral dose of 50-90 mg/kg followed by low daily doses of 10 mg/kg was sufficient to maintain ∼80% inhibition of ex vivo platelet aggregation over several days. Inhibition of ADP-induced platelet aggregation in anesthetized dogs at 77 ± 7% resulted in a moderate 2.5-fold increase in bleeding time, while complete inhibition (100%) resulted in an approx. 10-min bleeding time. Addnl. doses were required to increase the bleeding time to the maximum time allowed in the protocol (15 min), thus indicating a potentially useful and safe separation of efficacy and bleeding time.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Farfan, Norberto published the artcileCarbon-13 nuclear magnetic resonance spectroscopy as a method to determine relative acidity of boron Lewis acids in pyridine complexes, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1987), 771-3, database is CAplus.

Complexes of pyridine and 2-ethylpyridine with a series of boron Lewis acids have been studied using ¹H, ¹¹B, and ¹³C NMR. The difference in chem. shifts (Δδ_c-4) between the boron complex and the free pyridine were correlated with calorimetric data. The ¹³C data show that Δδ_c-4 of pyridines provides a measure of the strength of the N → B bond, thus allowing a scale of acidity for boron compounds to be derived.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Whitlock, Gavin A. published the artcileNovel 2-imidazoles as potent and selective α_1A adrenoceptor partial agonists, Safety of 2-Pyridinylboronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(9), 2930-2934, database is CAplus and MEDLINE.

Novel 2-imidazoles have been identified as potent partial agonists of the α_1A adrenergic receptor, with good selectivity over the α_1B, α_1D and α_2A receptor sub-types. Sulfonamide 23 (I) possessed attractive drug-like properties with respect to physicochem. and ADME properties and wide ligand selectivity.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C17H14N2O2, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mori-Quiroz, Luis M. published the artcileExploiting Iminoquinones as Electrophilic at Nitrogen “N+” Synthons for C-N Bond Construction, HPLC of Formula: 39856-58-1, the publication is Organic Letters (2021), 23(18), 7008-7013, database is CAplus and MEDLINE.

New methods for C-N bond construction exploiting the N-centered electrophilic character of iminoquinones were reported. Iminoquinones, generated in situ via the condensation of o-vinylanilines with benzoquinones, underwent acid-catalyzed cyclization to afford N-arylindoles I [R = H, F; R¹ = H, Me, Ph, etc.; R² = H, Me; R³ = H, Cl, CO₂Me, etc.; Ar = 3,5-di-(t-Bu)-4-OHC₆H₂, 3,5-di-Me-4-OHC₆H₂, 3,5-di-(t-Bu)-2-OHC₆H₂, 10-hydroxy-9-phenanthryl] in excellent yields. Under similar reaction conditions, homoallylic amines reacted analogously to afford N-arylpyrroles II [R⁴ = Ph, 3-MeOC₆H₄, 4-FC₆H₄, 2,6-di-FC₆H₃, 2,3-dihydrobenzofuran-5-yl; R⁵ = H, 4-MeC₆H₄; Ar = 3,5-di-(t-Bu)-4-OHC₆H₂]. Addnl., organometallic nucleophiles were shown to add to the nitrogen atom of N-alkyliminoquinones to provide amine products. Finally, iminoquinones were shown to be competent electrophiles for copper-catalyzed hydroamination.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, HPLC of Formula: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Manz, Kevin M. published the artcileCocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Neuropsychopharmacology (2022), 47(3), 652-663, database is CAplus and MEDLINE.

Parvalbumin-expressing fast-spiking interneurons (PV-INs) within feedforward microcircuits in the nucleus accumbens (NAc) coordinate goal-directed motivational behavior. Feedforward inhibition of medium spiny projection neurons (MSNs) is initiated by glutamatergic input from corticolimbic brain structures. While corticolimbic synapses onto MSNs are targeted by the psychostimulant, cocaine, it remains unknown whether cocaine also exerts acute neuromodulatory actions at collateralizing synapses onto PV-INs. Using whole-cell patch-clamp electrophysiol., optogenetics, and pharmacol. tools in transgenic reporter mice, we found that cocaine decreases thalamocortical glutamatergic drive onto PV-INs by engaging a monoamine-independent mechanism. This mechanism relies on postsynaptic sigma-1 (σ1) activity, leading to the mobilization of intracellular Ca2+ stores that trigger retrograde endocannabinoid signaling at presynaptic type-1 cannabinoid receptors (CB1R). Cocaine-evoked CB1R activity occludes the expression of CB1R-dependent long-term depression (LTD) at this synaptic locus. These findings provide evidence that acute cocaine exposure targets feedforward microcircuits in the NAc and extend existing models of cocaine action on mesolimbic reward circuits.

Neuropsychopharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem