Month: December 2022

Synthesis and roperties of seven ionic liquids containing 1-methyl-3-octylimidazolium or 1-butyl-4-methylpyridinium cations was written by Papaiconomou, Nicolas;Yakelis, Neal;Salminen, Justin;Bergman, Robert;Prausnitz, John M.. And the article was included in Journal of Chemical & Engineering Data in 2006.Category: pyridine-derivatives This article mentions the following:

Syntheses are reported for ionic liquids containing 1-methyl-3-octylimidazolium or 1-butyl-4-methylpyridinium cations and trifluoromethyl sulfonate, dicyanamide, bis(trifluoromethylsulfonyl)imide, or nonafluorobutyl sulfonate anions. Densities, m.ps., glass-transition temperatures, solubilities in water, and polarities have been measured. Ionic liquids containing pyridinium cations exhibit higher m.ps., lower solubility in water, and higher polarity than those containing imidazolium cations. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Category: pyridine-derivatives).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4-[5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl]pyridinium benzoate was written by Han, Meng Ting;Zhang, Yuan. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2011.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

In the title compound, C₁₂H₉N₄O⁺·C₇H₅O₂^–, π-π stacking interactions [centroid-centroid distance = 3.6275(14) Å] stabilize the crystal structure. The dihedral angles between the central ring and the terminal rings are 3.27(12) and 10.30(13)°. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives was written by Hagishita, Sanji;Yamada, Masaaki;Shirahase, Kazuhiro;Okada, Toshihiko;Murakami, Yasushi;Ito, Yuji;Matsuura, Takaharu;Wada, Masaaki;Kato, Toshiyuki. And the article was included in Journal of Medicinal Chemistry in 1996.Category: pyridine-derivatives This article mentions the following:

Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biol. active products. As human nonpancreatic secretory phospholipase A2 (sPLA2) is present in high levels in the blood of patients in several pathol. conditions, the potent sPLA2 inhibitors have been suggested to be useful drugs. Here the authors describe the synthesis, structure-activity relationship, and inhibitory activities of indolizine and indene derivatives 1-(Carbamoylmethyl)indolizine derivatives and 1-oxamoylindolizine derivatives exhibited very potent inhibitory activity. The former was unstable to air oxidation, but the latter exhibited an improvement both in stability and in potency. Some compounds approached the stoichiometric limit of the chromogenic assay. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Category: pyridine-derivatives).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses with aromatic nitramines. VI. Substituent effect in the photolytic rearrangement of nitraminopyridines was written by Sepiol, Jadwiga;Tomasik, Piotr. And the article was included in Acta Chimica Hungarica in 1986.Synthetic Route of C5H3Br2NO This article mentions the following:

Isomeric 2-nitraminopyridines I (R = 3-Me, 4-Me, 5-Me, 6-Me, 3-NO₂, 5-NO₂, 5-Cl, 3-CO₂H) as well as 3,5-dibromo-2-nitraminopyridine (II, R¹ = NO₂) rearranged on irradiation with a low pressure Hg lamp (253.7 nm) in MeOH. Preference was generally noted for the migration of the side-chain NO₂ group to the vicinal β-position. II (R¹ = NO₂) gave both II (R¹ = H) and the pyridone III. The ratio of the preparative and quantum yields of the two products were 2.5 and 3.0, resp. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Synthetic Route of C5H3Br2NO).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C₂-Symmetric Bispyrrolidinoindoline Manifold was written by Taniguchi, Tomoaki;Tsubouchi, Akira;Imai, Yuki;Yuasa, Junpei;Oguri, Hiroki. And the article was included in Journal of Organic Chemistry in 2018.HPLC of Formula: 122637-39-2 This article mentions the following:

As an effort to integrate natural products chem. and coordination chem., a diastereomeric pair of chiral alkaloidal manifolds composed of a bispyrrolidinoindoline (BPI) framework was designed and synthesized to generate luminescent Eu^III complexes with switchable chiroptical properties. The C₂-sym. alkaloidal manifolds were linked with bis(benzimidazolyl)pyridine (BBIPy) as an achiral metal-binding component through substituents installed at the stereogenic 2/2′ positions of the BPI manifolds. The resulting diastereomeric pair of ligands, syn-L1 and anti-L2, allow pseudomirror sym. presentation of the metal-binding BBIPy units due to the stereogenic centers on the alkaloidal manifold. The ligand syn-L1 induces intramol. coordination to form the 1:1 complex Eu^III(syn-L1) composed of a single stranded metal helicate which exhibits a neg. split Cotton effect. In contrast, the ligand anti-L2 led to a supramol. assembly comprising the 2:2 complex Eu^III₂(anti-L2)₂ consisting of a bimetallic double-stranded helicate which shows a pos. split Cotton effect. Thus, the sp³ stereogenic centers in the BPI manifolds play pivotal roles in controlling both metal-ligand equilibrium and chirality-switching of luminescent Eu^III complexes. This approach, which exploits diastereomeric natural product-based manifolds, provides a relatively unexplored means for diversifying metal coordination modes and for controlling the chiroptical properties of the resultant luminescent lanthanoid complexes. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2HPLC of Formula: 122637-39-2).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 122637-39-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 1,8-Naphthyridines and Their Application in the Development of Anionic Fluorogenic Chemosensors was written by Nicoleti, Celso R.;Garcia, Diogo N.;Silva, Luiz E.;Begnini, Ieda M.;Rebelo, Ricardo A.;Joussef, Antonio C.;Machado, Vanderlei G.. And the article was included in Journal of Fluorescence in 2012.Reference of 1075-62-3 This article mentions the following:

Two 1,8-naphthyridines were synthesized and are fluorescent in solution These compounds were studied in the presence of Cu⁺ and Cu²⁺ ions and it was verified that the metal causes the quenching of their fluorescence emission, due to the formation of complexes between the naphthyridine and the metal. A displacement assay was carried out in a DMSO-water mixture with the addition of various anions to the solutions of the complexes, and these systems have a high capacity to selectively detect cyanide. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Reference of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4-(substituted amino)phenylalkyl] ester derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Inoue, Yoshihisa;Morimoto, Satoshi;Eda, Masahiro;Uchida, Takeshi;Ohtaki, Yutaka;Fujino, Yoshiyuki;Kido, Hideaki. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Related Products of 116308-35-1 This article mentions the following:

Novel 1,4-dihydropyridine derivatives bearing 3-[4-(substituted amino)phenylalkyl] ester side chains were prepared by several routes and tested for antihypertensive activity in spontaneously hypertensive rats. Most compounds showed a more potent antihypertensive effect and a longer duration of action than nicardipine. The derivatives with a benzhydrylpiperazinyl and a benzhydrylpiperidinyl group were distinctive. [(Benzhydrylpiperazinyl)phenyl]alkyl and [(benzhydrylpiperidinyl)phenyl]alkyl dihydrodimethylpyridinedicarboxylates I (R = 3-O₂NC₆H₄, X = N, X¹ = NCHPh₂, n = 2; R = 4-cyano-2-pyridyl, X = N, X¹ = NCHPh₂, n = 2; R = 3-O₂NC₆H₄, X = N, X¹ = NCHPh₂, n = 3; R = 3-O₂NC₆H₄, X = N, X¹ = CHCHPh₂, X = CH, X¹ = NCHPh₂, n = 2) were selected as candidates for further pharmacol. investigations. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1Related Products of 116308-35-1).

2-(Trifluoromethyl)nicotinaldehyde (cas: 116308-35-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 116308-35-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic pyrolysis of liquorice (Glycyrrhiza glabra L.) in a fixed-bed reactor: Effects of pyrolysis parameters on product yields and character was written by Aysu, Tevfik;Durak, Halil. And the article was included in Journal of Analytical and Applied Pyrolysis in 2015.Recommanded Product: 28020-37-3 This article mentions the following:

Pyrolysis of liquorice (Glycyrrhiza glabra L.) stalks were performed in a fixed-bed tubular reactor with (ZnO, FeCl₃, K₂CO₃, Al₂O₃, Na₂B₄O₇·10H₂O) and without catalyst at three different temperatures (350, 450, 550 °C) with a constant heating rate of 40 °C/min. The amounts of bio-char, bio-oil and gas produced, as well as the compositions of the resulting bio-oils were determined by GC-MS. The effects of pyrolysis parameters on product yields were investigated. The results indicate that both temperature and catalysts effect the conversions of G. glabra L. into solid, liquid and gaseous products. The highest conversion of 74.50% and liquid yield of 34.35% were obtained with Na₂B₄O₇·10H₂O catalyst at 550 °C temperature when 0.224 > Dp > 0.150 mm particle sized samples and 100 mL/min of sweeping gas flow rate were used. Liquid products (bio-oils) obtained at 350 and 550 °C were analyzed by elemental anal. and gas chromatog./mass spectrometry (GC-MS). 133 and 148 different compounds were identified by GC-MS in the bio-oils obtained at 350 and 550 °C, resp. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Recommanded Product: 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of 1-unsubstituted tautomeric 2-pyridones with benzyne was written by Kuzuya, Masayuki;Noguchi, Akihiro;Kamiya, Shoji;Okuda, Takachiyo. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Recommanded Product: 4783-68-0 This article mentions the following:

2-Pyridones I [R = H, Me; R¹ = H, Me, Ph, Br; R² = H, Me, Ph; R³ = H, Me, Br, Cl; R⁴ = H; R²R³ = (CH₂)₃, CH₂CH₂O] reacted with benzyne, generated in situ from 2-H₂NC₆H₄CO₂H and Me₂CHCH₂CH₂ONO, to give benzoazabarrelenones II and large amounts of 2-phenoxypyridines. Under similar conditions I (R⁴ = Me) gave II only. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nucleobase-grafted supramolecular polymers for tuning the surface properties was written by Lin, I.-Hong;Cheng, Chih-Chia;Li, Ke-Fong;Chen, Jem-Kun;Chiu, Chih-Wei;Chang, Feng-Chih. And the article was included in Polymer Chemistry in 2014.Formula: C7H9N3O This article mentions the following:

Nucleobase-grafted polycaprolactone has been prepared which exhibits amorphous nature, rapid photoresponse and controlled surface properties in the solid state owing to the formation of uracil-diamidopyridine (U-DAP) pairs by induced phys. crosslinking. In addition, they can self-organize to alter material behavior with light, switching both optical and thermal properties. Remarkable changes in the surface morphol. and the contact angle with water were also observed In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Formula: C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem