Month: December 2022

Chiswell, B. published the artcilePlatinum complexes of some deprotonatable tridentate ligands, Related Products of pyridine-derivatives, the publication is Australian Journal of Chemistry (1968), 21(8), 1997-2001, database is CAplus.

Pt(II) and Pt(IV) complexes of 1,3-bis(2-pyridyl)-1,2-diazaprop-2-ene and ligands of similar structure, but with Me “blocking groups” adjacent to the pyridine N atoms, were studied. In neutral solution, these ligands lose a proton upon interaction with either Pt(II) or Pt(IV) salts to yield highly colored complexes soluble in organic solvents. Protonated compounds of both oxidation states can be obtained, but such compounds are unstable in neutral solution and readily yield deprotonated complexes.

Australian Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Hong-hua published the artcileEfficacy of manual reduction combined with betahistine mesylate in treatment of benign paroxysmal positional vertigo, SDS of cas: 54856-23-4, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(7), 1235-1236, database is CAplus.

To explore the efficacy of manual reduction combined with drugs in the treatment of 60 cases of benign paroxysmal positional vertigo. Patients who were diagnosed with benign paroxysmal positional vertigo in our hospital from Feb. 2013 to Jan. 2015 were collected and randomly divided into a study group and a control group. The basic treatment of the two groups was manual reduction, and the study group was treated with betahistine mesylate tablets. The therapeutic effects of the two groups were compared for benign paroxysmal positional vertigo. The two groups were scored by the Vertigo Disorder Rating Scale before and after treatment. The therapeutic effects of the study group and the control group for benign paroxysmal positional vertigo were 100% and 66.7%, resp., and there was a difference (P < 0.05). The study group and the control group had no difference in the scores of the Vertigo Disorder Rating Scale before treatment (P > 0.05). There was a difference in the scores of the vertigo disorder rating scale between the study group and the control group after treatment (P < 0.05). This article believes that manual reduction combined with drugs has a definite effect in the treatment of benign paroxysmal positional vertigo and can significantly improve the symptoms of patients.

Xiandai Zhenduan Yu Zhiliao published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, SDS of cas: 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asahara, Haruyasu published the artcileSubstituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation, Quality Control of 89076-64-2, the publication is Procedia Engineering (2017), 1046-1057, database is CAplus.

A novel method for synthesis of various kinds of nitroarenes by using a three-component ring transformation (TCRT) of dinitropyridone with ketones in the presence of ammonium acetate as nitrogen source is developed. This method requires only simple manipulations and mild reaction conditions. Furthermore, the modification of obtained nitropyridine or nitroaniline frameworks can be easily obtained only changing a com. available substrates.

Procedia Engineering published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anonymous published the artcilePreparation of new nitrogen-bridged heterocycles. 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine derivatives [Erratum to document cited in CA154:284193], Application In Synthesis of 17281-59-3, the publication is Chemical & Pharmaceutical Bulletin (2010), 58(12), 1672, database is CAplus.

On page 1502 the title contains an error; the correct title is given. On page 1509 in the right column, lines 3,8 and 7 and in the left column, lines 8 and 7, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510 in the left column, lines 3 and 17, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510, a reference should be added; the reference is given.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Application In Synthesis of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anderegg, Giorgio published the artcilePyridine derivatives as complexing agents. IX. Stability constants of complexes with 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, and 1-(α-pyridylmethylene)-2-(α’-pyridyl)hydrazine, COA of Formula: C11H10N4, the publication is Helvetica Chimica Acta (1971), 54(2), 509-12, database is CAplus.

The stability constants for the Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Hg(II), Cd(II), and Ag(I) complexes of 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, 1-(2-pyridylmethylene)-2-(2′-pyridyl)hydrazine are reported. In all cases logK1 > logK2.

Helvetica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Almutairi, Zainab M. published the artcileComparative genomics of HORMA domain-containing proteins in prokaryotes and eukaryotes, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Cell Cycle (2018), 17(23), 2531-2546, database is CAplus and MEDLINE.

In eukaryotes, critical regulation of cell cycle is required to ensure the integrity of cell division. HORMA-containing proteins include various proteins that contain HORMA domain and play important role in the regulation of cell cycle in eukaryotes. Many types of HORMA-containing proteins are found in eukaryotes, but their role in prokaryotes has not been proven. Therefore, we conduct an extensive search in GenBank for HORMA-containing proteins in prokaryotes to compare HORMA domain structure and architecture across eukaryotes and prokaryotes. Strikingly, genome sequencing for many prokaryotic organisms reveals that HORMA domain is present in many bacterial genomes and only two archaeal genomes. We perform sequence alignment and phylogenetic anal. to trace the evolutionary link between HORMA domain in prokaryotes and eukaryotes. HORMA domain in prokaryotes appears to vary in sequence and architecture. Interestingly, seven bacterial HORMA-containing proteins and the two archaeal HORMA-containing proteins showed close relationships with eukaryotic HORMA-containing proteins. Addnl., we uncovered remarkable close relationships between HORMA-containing protein from Chlamydia trachomatis and eukaryotic MAD2 proteins. Our results provide insights into evolutionary relationships between prokaryotic and eukaryotic systems, which facilitate our understanding of the evolution of cell cycle regulation mechanisms.

Cell Cycle published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Xing published the artcileNewly-generated Al(OH)₃-supported Pd nanoparticles-catalyzed Stille and Kumada coupling reactions of diazonium salts, (Het)aryl chlorides, Quality Control of 89076-64-2, the publication is Tetrahedron (2016), 72(1), 69-75, database is CAplus.

A ligand-free Pd/Al(OH)₃ nano-catalyst which is prepared by one-pot three-component method using Pd(PPh₃)₄, tetra (ethylene glycol), and aluminum tri-sec-butoxide exhibits excellent catalytic activity in Stille cross-couplings of (Het)aryl chlorides, arenediazonium tetrafluoroborate salts with phenyltributylstannane, resp., and Kumada couplings of (Het)aryl chlorides with various Grignard reagents. More importantly, these two processes show excellent functional group compatibility with moderate to good yields and they are also versatile with respect to not only (Het)aryl chlorides, but also diazonium salts, and heteroaryl Grignard reagents. The nano-catalyst could also be recycled and reused 5 times without loss of activity and decrease of yield.

Tetrahedron published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ren, Hailong published the artcileCobalt-Catalyzed Regioselective Borylation of Arenes: N-Heterocyclic Silylene as an Electron Donor in the Metal-Mediated Activation of C-H Bonds, Name: 2,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the publication is Chemistry – A European Journal (2017), 23(24), 5663-5667, database is CAplus and MEDLINE.

C-H Borylation of arenes has been a subject of great interest recently because of its atom-economy and the wide applicability of borylated products in value-added synthesis. A new bis(silylene)cobalt(II) complex bearing a bis(N-heterocyclic silylene)-pyridine pincer ligand (SiNSi) has been synthesized and structurally characterized. It enabled the regioselective catalytic C-H borylation of pyridines, furans, and fluorinated arenes. Notably, it exhibited complementary regioselectivity for the borylation of fluorinated arenes compared to previously known catalytic systems, demonstrating that N-heterocyclic silylene donors have enormous potential in metal-catalyzed catalytic applications.

Chemistry – A European Journal published new progress about 741709-65-9. 741709-65-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Pyridine,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, and the molecular formula is C13H20BNO2, Name: 2,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Wenqing published the artcileDesign, Synthesis, Antifungal and Antibacterial Activities of N-phenyl and N-pyridinyl-5-(trifluoromethyl)-pyrazole-4-carboxamide Derivatives, Recommanded Product: 4-Amino-2-picoline, the publication is Journal of Heterocyclic Chemistry (2018), 55(10), 2261-2269, database is CAplus.

A series of N-Ph and N-pyridinyl-5-(trifluoromethyl)-pyrazole carboxamides, compounds I [R = Ph, 2-pyridinyl, 2-fluoro-4-pyridinyl, etc.] were designed and synthesized. Bioassay results indicated that antifungal and antibacterial activities of title compounds could be obviously improved by placing trifluoromethyl on the 5-position of the pyrazole ring and substituted 4-pyridinyl at the amine side of the amide bond. The EC₅₀ values of compound I [R = 4-pyridinyl] against Gibberella zeae, Cytospora mandshurica, and Fusarium oxysporum were 14.7, 21.1, and 32.7 μg/mL, resp., better than hymexazol (30.2, 47.3, and 42.5 μg/mL) and carboxin (34.2, >200, and >200 μg/mL). And the EC₅₀ values of compounds I [R = 2-fluoro-4-pyridinyl, 2,6-dichloro-4-pyridinyl, 3,5-dichloro-4-pyridinyl, 6-methyl-2-pyridinyl, 2-methylphenyl, 2-fluorophenyl, 4-chlorophenyl and 4-methoxyphenyl] against rice bacterial leaf blight were 17.0, 21.8, 21.9, 18.6, 16.8, 25.9, 9.4, and 24.4 μg/mL, resp., much better than bismerthiazol (70.5 μg/mL).

Journal of Heterocyclic Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C9H21NO3, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Anwei published the artcileMn(III) active site in hydrotalcite efficiently catalyzes the oxidation of alkylarenes with molecular oxygen, Computed Properties of 91-02-1, the publication is Molecular Catalysis (2021), 111276, database is CAplus.

Developing efficient heterogeneous catalytic systems based on easily available materials and mol. oxygen for the selective oxidation of alkylarenes is highly desirable. In the present research, NiMn hydrotalcite (Ni₂Mn-LDH) was found as an efficient catalyst in the oxidation of alkylarenes using mol. oxygen as the sole oxidant without any additive. Impressive catalytic performance, excellent stability and recyclability, broad applicable scope and practical potential for the catalytic system were observed Mn³⁺ species is proposed to be the efficient active site, and Ni²⁺ played an important role in stabilizing the Mn³⁺ species in the hydrotalcite structure. The kinetic study showed that the aerobic oxidation of diphenylmethane is a first-order reaction over Ni₂Mn-LDH with the activation energy (E_a) and pre-exponential factor (A₀) being 85.7 kJ mol^-1 and 1.8 x 10⁹ min^-1, resp. The Gibbs free energy (ΔG^≠) is -10.4 kJ mol^-1 K^-1 for the oxidation based on Eyring-Polanyi equation, indicating the reaction is exergonic. The mechanism study indicated that the reaction proceeded through both radical and carbocation intermediates. The two species were then trapped by mol. oxygen and H₂O or hydroxyl species, resp., to yield the corresponding products. The present research might provide information for constructing highly efficient and stable active site for the catalytic aerobic oxidation based on available and economic material.

Molecular Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H17NO2, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem