Month: December 2022

He, Dian published the artcileDesign, Synthesis and Activity Evaluation of N-(pyridin-4-yl) Salicylamides as Antimycobacterial Agents, Computed Properties of 18437-58-6, the publication is Asian Journal of Chemistry (2014), 26(21), 7269-7275, 7 pp., database is CAplus.

A series of N-(pyridin-4-yl) salicylamides derivatives I (R¹ = H, Cl, CH₃; R² = R⁴ = H, Cl; R³ = H, Cl, CF₃; R⁵ = H, OCH₃; R⁶ = H, Cl, Br, CF₃) were prepared through acylation of the corresponding acetylsalicyloyl chlorides with substituted 4-aminopyridines. The compounds I were evaluated in vitro for antimycobacterial activities against Mycobacterium tuberculosis (TB) and Mycobacterium avium (A) by the min. inhibitory concentrations (MIC) values. Eight of the compounds I exhibited lower MIC against Mycobacterium avium than the one of isoniazide, meanwhile, four of the compounds I exhibited good anti-TB activity compared to isoniazide. Antimycobacterial activities of compounds I were influenced by the balance between hydrophobicity and electron withdrawing substituent effects on the Ph and pyridine ring.

Asian Journal of Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Wan-jing published the artcileEffect of vestibular rehabilitation training combined with betahistine mesylate on elderly patients with benign paroxysmal positional vertigo, Category: pyridine-derivatives, the publication is Huanan Guofang Yixue Zazhi (2016), 30(1), 71-72, database is CAplus.

Objective To investigate the effect of vestibular rehabilitation training combined with betahistine mesylate on elderly patients with benign positional paroxysmal vertigo (BPPV). Methods 120 elderly patients with BPPV were randomized into three groups: group A was treated with vestibular rehabilitation training, group B was treated by oral administration of betahistine mesylate, and group C was treated by vestibular rehabilitation training combined with oral administration of betahistine mesylate. Results The total effective rate of group C was significantly higher than that of group A and group B (χ²=11.61, P<0.05), and the total effective rate of group B was significantly higher than that of group A (χ²=8.90, P<0.05). The incidence of adverse reactions of group C was significantly lower than that of group A and group B (χ²=4.50, P<0.05), and the incidence of adverse reactions of group B was significantly lower than that of group A (χ²=3.53, P<0.05). The recurrence rate of group C was significantly lower than that of group A and group B (χ²=6.13, P<0.05), and the recurrence rate of group B was significantly lower than that of group A (χ²=5.00, P<0.05). Conclusion Vestibular rehabilitation training combined with betahistine mesylate had obvious effect for treating elderly patients with BPPV, which could effectively shorten treatment period and decrease recurrence rate.

Huanan Guofang Yixue Zazhi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C18H23N3O4S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Appelhans, Dietmar published the artcileOligosaccharide-modified poly(propyleneimine) dendrimers: synthesis, structure determination, and Cu^II complexation, SDS of cas: 971-66-4, the publication is Macromolecular Bioscience (2007), 7(3), 373-383, database is CAplus and MEDLINE.

The multiple application of reductive amination on primary amino groups of first and second generation poly(propyleneimine) dendrimers is used as a one-pot approach to introduce twice the amount of the oligosaccharide units as surface groups, compared to initially present amino groups in the first and second generation dendrimers. This was proven by ¹H NMR, MALDI-TOF-MS, and LILBID-MS anal. The size of these dendrimers was determined by the hydrodynamic radius using pulsed field gradient NMR and dynamic light scattering. Mol. modeling confirmed the presence of dense-shell dendrimers. These dendrimers exhibit a generation dependent Cu^II/dendrimer ratio in an aqueous environment, highlighting these materials as possible metal-carrier systems with a well-defined oligosaccharide protection shell for application in a biol. environment.

Macromolecular Bioscience published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zheng, Wei-Xiang published the artcileSynthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent, Synthetic Route of 91-02-1, the publication is Synthesis, database is CAplus.

Carboxylic acids are an abundant and structurally diverse class of com. available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki-Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, authors report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄·7H₂O at 90 °C to give the corresponding aryl ketones.

Synthesis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H10F2Si, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liang, Ren-Xiao published the artcileEnantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives, Application of 2-Bromopyridin-3-amine, the publication is ACS Catalysis (2021), 11(3), 1827-1832, database is CAplus.

Palladium-catalyzed intramol. enantioselective β-arylation of tetrasubstituted endocyclic and exocyclic enamines was developed. A range of optically active medium-ring fused indolenines or 3,3′-spiroindolenines were achieved in enantiomeric ratios up to 98:2 with Cs₂CO₃ or K₃PO₄ as the base in the presence of chiral PHOX ligands. The use of Ag₃PO₄ as a base led to enantioenriched 1H-indoles in good enantiomeric ratios (up to 89:11) with (S)-DIFLUORPHOS as a chiral ligand, which proceeded via a possible domino enamine-isomerization/β-arylation sequence.

ACS Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Obdyakov, V. F. published the artcileStabilization of palladium in homogeneous chlorideless catalysts of oxidation of olefins C₂-C₄ by oxygen into carbonyl compounds, HPLC of Formula: 636-73-7, the publication is Kataliz v Promyshlennosti (2007), 19-25, database is CAplus.

The first step of homogeneous oxidation of olefins C₂-C₄ by oxygen in the presence of catalyst Pd + GPK-x, were GPK-x is phosphovanadomolybdic heteropoly acid H_3+xPV^V_x Mo_12-xO₄₀, consist in reduction of GPK-x with olefin in the presence Pd-complexes at 30-60° into H_mGPK-x where m=[V^IV]_∑/[GKP-x] – is excellent reduction catalyst. In this case the redox-system Pd¹₂/Pd⁰₂ works and with increasing of temperature in converts into system Pd²⁺/Pd_MET with higher redox-potential. During this transformation interval of values m is diminished where the catalyst remained as homogeneous and from reduced solution metallic Pd begins to precipitate To prevent the Pd precipitation it needs to introduce in catalyst the stabilizers stable from oxidation As stabilizers can be used 3-pyridinesulfonic acid of more cheaper 2,6-pyridinecarboxylic (dipicolinic) acid (I). In the presence of the stabilizers the activity of catalyst is diminished but the area of its homogeneity will extend. Complexes of Pd with I are stable at temperatures of regeneration of catalyst (150-160°). Therefore I is considered as rather perspective stabilizer of Pd in catalysts Pd + GPK-x and can be used in industrial homogeneous processes of oxidation of olefins C₂-C₄ with oxygen.

Kataliz v Promyshlennosti published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, De-Zhi published the artcileAn efficient method for the construction of 2-Aminothiazolo[5,4-c]pyridines via K₃[Fe(CN)₆] oxidized SP² C-H Functionalization, Computed Properties of 18437-58-6, the publication is Tetrahedron (2016), 72(52), 8610-8616, database is CAplus.

A practical approach to synthesize 2-aminothiazolo[5,4-c]pyridines from simple asym. pyridylthioureas was achieved by utilizing K₃[Fe(CN)₆] as the oxidant [e.g., I → II (97%)]. These reactions went through an intramol. oxidation and finally led to the formation of C-S bond. Furthermore, the possible oxidative cyclization mechanism was also explored by the addition of radical scavengers, which showed that the oxidative cyclization was promoted via a free radical mechanism.

Tetrahedron published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C7H16Cl2Si, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Benyettou, Farah published the artcileRedox-Responsive Viologen-Mediated Self-Assembly of CB[7]-Modified Patchy Particles, Formula: C22H18Cl2N2, the publication is Langmuir (2016), 32(28), 7144-7150, database is CAplus and MEDLINE.

Sulfonated surface patches of poly(styrene)-based colloidal particles (CPs) were functionalized with cucurbit[7]uril (CB[7]). The macrocycles served as recognition units for di-Ph viologen (DPV²⁺), a rigid bridging ligand. The addition of DPV²⁺ to aqueous suspensions of the particles triggered the self-assembly of short linear and branched chainlike structures. The self-assembly mechanism is based on hydrophobic/ion-charge interactions that are established between DPV²⁺ and surface-adsorbed CB[7]. DPV²⁺ guides the self-assembly of the CPs by forming a ternary DPV²⁺⊂(CB[7])₂ complex in which the two CB[7] macrocycles are attached to two different particles. Viologen-driven particle assembly was found to be both directional and reversible. Whereas sodium chloride triggers irreversible particle disassembly, the one-electron reduction of DPV²⁺ with sodium dithionite causes disassembly that can be reversed via air oxidation Thus, this bottom-up synthetic supramol. approach allowed for the reversible formation and directional alignment of a 2D colloidal material.

Langmuir published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Formula: C22H18Cl2N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, JiaoYang published the artcileComputational study on C-B homolytic bond dissociation enthalpies of organoboron compounds, Application of 2-Pyridinylboronic acid, the publication is New Journal of Chemistry (2017), 41(3), 1346-1362, database is CAplus.

Based on many transition-metal-catalyzed Suzuki-Miyaura cross-coupling reactions of organoboron compounds in which C-B cleavages are involved, it is meaningful to understand one of the thermodn. properties of the C-B bond, the strength of the C-B bond, which can be measured using homolytic bond dissociation enthalpies (BDEs). To this end, we first calculated 64 C-B BDEs of organoboron compounds by theor. methods including composite high-level ab initio methods of G3, G4, G3B3, CBS-Q, CBS-QB3, and CBS-4M and 34 d. functional theory (DFT) methods. The results show that it is reasonable and credible to regard the average values of six composite high-level methods as the standard C-B BDE values. By comparing the DFT methods, it is found that the M06-HF method provides the most accurate results and the root mean square error (RMSE) is the smallest of 6.4 kJ mol^-1. Therefore, the C-B BDEs including C(sp)-B, C(sp²)-B and C(sp³)-B of organoboron compounds such as boronic acids, trifluoroborate salts, boronate esters, etc. as well as the substituent effects were investigated by using the M06-HF method. The results indicated that the different substituents including electron-donating groups (EDGs), electron-withdrawing groups (EWGs) and conjugated effect groups (CEGs) exhibit different effects on different types of C-B BDEs. Moreover, the natural bond orbital (NBO) anal. was performed in order to further disclose the essence of BDE change patterns.

New Journal of Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C15H20O6, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuan, Chunling published the artcileCu(II)-catalyzed homocouplings of (hetero)arylboronic acids with the assistance of 2-O-methyl-D-glucopyranose, COA of Formula: C5H6BNO2, the publication is Molecules (2019), 24(20), 3678pp., database is CAplus and MEDLINE.

This is the first report of a natural ligand improving the copper-catalyzed homocouplings of (hetero)arylboronic acids. Various important synthetic biaryl intermediates in organic synthesis could be assembled via this method. To gain insight into this reaction, in-situ React IR technol. was used to confirm the effectivity of this catalyst system. This protocol provides important biaryl compounds in high yields within a short time.

Molecules published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C6H16OSi, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem