Month: December 2022

Qiu, Pei published the artcileAn efficient water-soluble surfactant-type palladium catalyst for Suzuki cross-coupling reactions in pure water at room temperature, COA of Formula: C5H6BNO2, the publication is New Journal of Chemistry (2016), 40(8), 6568-6572, database is CAplus.

A palladium catalyst based on a bidentate phosphine-type zwitterionic surfactant as a ligand exhibited an excellent catalytic activity in the Suzuki-Miyaura cross coupling reactions. This novel method allowed the reaction of aryl halides RX (R = 2-HOC₆H₄, benzofuran-2-yl, benzothiazol-2-yl, etc.; X = Br, I) with arylboronic acids R¹B(OH)₂ [R¹ = Ph, benzo[1,3]dioxol-5-yl, thiophen-2-yl, etc.] to occur in pure water at room temperature, forming a variety of biaryls RR¹ in good to high yields. Heterobiaryls were also efficiently assembled even in the presence of water-insoluble heteroaryl halides as substrates. In addition, such a coupling protocol was successfully used in the iterative diarylation of 2,5-dibromopyridine in one-pot.

New Journal of Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Yaxin published the artcileTunable System for Electrochemical Reduction of Ketones and Phthalimides, Application of Phenyl(pyridin-2-yl)methanone, the publication is Chinese Journal of Chemistry (2021), 39(12), 3297-3302, database is CAplus.

An efficient, tunable system for electrochem. reduction of ketones R¹C(O)R² (R¹ = Ph, pyridin-2-yl, 4-chlorophenyl, etc.; R² = H, t-Bu, thiophen-2-yl, 3-bromophenyl, etc.) and phthalimides I (R³ = prop-2-en-1-yl, phenoxymethyl, Bn, etc.) at room temperature without the need for stoichiometric external reductants was reported. By utilizing NaN₃ as the electrolyte and graphite felt as both the cathode and the anode, it was able to selectively reduce the carbonyl groups of the substrates to alcs. R¹C(OH)R², pinacols (R¹C(OH)R²)₂, or methylene groups e.g., 13-chloro-4-azatricyclo[9.4.0.0 (3,8)]pentadeca-1(11),3,5,7,12,14-hexaene by judiciously choosing the solvent and an acidic additive. The reaction conditions were compatible with a diverse array of functional groups, and phthalimides I could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds e.g., 10-azatetracyclo[8.7.0.0(2,7).0(12,17)]heptadeca-2,4,6,12(17),13,15-hexaen-11-one. Mechanistic studies showed that the reactions involved electron, proton, and hydrogen atom transfers. Importantly, an N₃/HN₃ cycle operated as a hydrogen atom shuttle, which was critical for reduction of the carbonyl groups to methylene groups e.g., 13-chloro-4-azatricyclo[9.4.0.0 (3,8)]pentadeca-1(11),3,5,7,12,14-hexaene.

Chinese Journal of Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C9H13NO2, Application of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cao, Liang published the artcilePractical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H₂O-mediated H₂ evolution, Formula: C5H6BNO2, the publication is Nature Communications (2021), 12(1), 4206, database is CAplus and MEDLINE.

Despite the widespread applications of 2-(hetero)aryl N-heteroarenes in numerous fields of science and technol., universal access to such compounds is hampered due to the lack of a general method for their synthesis. Herein, by a H₂O-mediated H₂-evolution cross-coupling strategy, an iridium(III)-catalyzed facile method to direct α-arylation of N-heteroarenes with both aryl and heteroaryl boronic acids, proceeding with broad substrate scope and excellent functional compatibility, oxidant and reductant-free conditions, operational simplicity, easy scalability, and no need for prefunctionalization of N-heteroarenes is reported. This method is applicable for structural modification of biomedical mols., and offers a practical route for direct access to 2-(hetero)aryl N-heteroarenes, a class of potential cyclometalated CN̂ ligands and NN̂ bidentate ligands that are difficult to prepare with the existing α-C-H arylation methods, thus filling an important gap in the capabilities of synthetic organic chem.

Nature Communications published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Shuzheng published the artcileVoltammetric study on some electron relays and ligands, Related Products of pyridine-derivatives, the publication is Taiyangneng Xuebao (1983), 4(3), 269-75, database is CAplus.

The voltammetric behavior is described of 2,2′-bipyridine; 4,4′-bipyridine and their derivative of small mols. and macromols. at pH 2-10. From the viewpoint of selecting an electron relay, these results are discussed, including the generation of H in the photoreduction system of H₂O with Ru (bipy)₃²⁺ as sensitizer. Finally, the voltammetric behavior and redox potentials of these compounds are explained.

Taiyangneng Xuebao published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Limin published the artcileLow-frequency vibrational modes of DL-homocysteic acid and related compounds, Synthetic Route of 636-73-7, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2009), 73A(5), 884-891, database is CAplus and MEDLINE.

Several polycrystalline mols. with sulfonate groups and some of their metal complexes, including DL-homocysteic acid (DLH) and its Sr- and Cu-complexes, pyridine-3-sulfonic acid and its Co- and Ni-complexes, sulfanilic acid and -cysteic acid were studied using THz time-domain methods at room temperature The results of THz absorption spectra show that the mols. have characteristic bands at 0.2-2.7 THz (6-90 cm^-1). THz technique can be used to distinguish different mols. with sulfonate groups and to determine the bonding of metal ions and the changes of H bond networks. In the THz region DLH has three bands: 1.61, 1.93 and 2.02 THz; and 0.85, 1.23 and 1.73 THz for Sr-DLH complex, 1.94 THz for Cu-DLH complex, resp. The absorption bands of pyridine-3-sulfonic acid are located at 0.81, 1.66 and 2.34 THz; the bands at 0.96, 1.70 and 2.38 THz for its Co-complex, 0.76, 1.26 and 1.87 THz for its Ni-complex. Sulfanilic acid has three bands: 0.97, 1.46 and 2.05 THz; and the absorption bands of -cysteic acid are at 0.82, 1.62, 1.87 and 2.07 THz, resp. The THz absorption spectra after complexation are different from the ligands, which indicate the bonding of metal ions and the changes of H bond networks. M-O and other vibrations appear in the FIR region for those metal-ligand complexes. The bands in the THz region were assigned to the rocking, torsion, rotation, wagging and other modes of different groups in the mols. Preliminary assignments of the bands were carried out using Gaussian program calculation

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C11H21BF4N2O2, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Jianbing published the artcileMarine environmental risk assessment method for active substances used in antifouling systems on ships in China, Category: pyridine-derivatives, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2014), 962-972, database is CAplus.

A Chinese risk assessment procedure was developed to address active substances used in biol. active (biocidal) antifouling paints. The priority was to promote the use of environmentally friendly, tech. and economically viable alternatives to DDT/TBT (dichlorodiphenyltrichloroethane/tributyltin) in the control of marine fouling organisms. The procedure was based upon European Union Biocide Product Directive (EU-BPD) and International Standard Organization (ISO) method for the Environmental risk assessment of antifouling systems. In order to focus on Chinese national conditions, international templates were adapted to address regional differences. In the Chinese method, persistence, bioaccumulation and toxicity information is assessed on a step by step basis, allowing an antifouling substance to be defined as either “Risk of high concern” or “Relatively low risk” at the end of the decision making process. 4,5-Dichloro-2-n-Octyl-3-Isothiazolinone (DCOIT, Sea-nine), triphenylborane pyridine (TPBP), 8-methyl-N-vanillyl-6-nonenamide (Capsaicin) and Zinc ethylene(bis) dithiocarbamate (Zineb), popularly used in China as active substance of antifouling paints, were reviewed according to the developed procedure. The preliminary results indicate that Sea-nine use in antifouling products can be considered low risk, whereas TPBP, Capsaicin and Zineb failed the screening procedure on the basis of bioaccumulation potential, persistence and an unacceptable risk ratio, resp. Data availability was determined to be a critical factor in the assessments due to the application of Safety Factors for data-poor substances.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C17H14F3N3O2S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cheng, Kai published the artcileSilver-catalyzed decarboxylative acylation of arylglyoxylic acids with arylboronic acids, Quality Control of 197958-29-5, the publication is RSC Advances (2014), 4(89), 48698-48702, database is CAplus.

The silver-catalyzed coupling of arylboronic acids with arylglyoxylic acids was found to be an extremely efficient route for the synthesis of unsym. diaryl ketones. It was conducted on a gram scale under mild and open-flask conditions with good functional group compatibility, avoiding the addition of expensive and/or toxic metals.

RSC Advances published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Quality Control of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liao, Jun published the artcileEfficacy of vestibular rehabilitation training combined with medication in treatment of vestibular neuritis, Computed Properties of 54856-23-4, the publication is Sichuan Yixue (2017), 38(3), 332-334, database is CAplus.

Objective: To observe and evaluate the clin. effect of vestibular rehabilitation training combined with drug therapy in the treatment of vestibular neuritis. Methods: 30 cases of vestibular neuritis diagnosed during hospital stay between Sept. 2014 and Sept. 2015 in our department were included. 15 patients in exptl. group received vestibular rehabilitation training combined with drug therapy and 15 patients in control group only received drug therapy. Dizziness Handicap Inventory (DHI) scores on admission and 4 wk after onset of exptl. group and control group were compared. Results: Difference of DHI scores on admission between the two groups was not statistically significant (P>0.05). Both in two groups, differences of DHI scores before and after treatment were statistically significant (P<0.05). After 1 mo of treatment, comparing the differences of DHI scores in the two groups, the difference being statistically significant (P<0.05). Conclusion: Vestibular rehabilitation training combined with drug therapy can improve the prognosis of patients with vestibular neuritis.

Sichuan Yixue published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Computed Properties of 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhibin published the artcileSelective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Science China: Chemistry (2021), 64(12), 2134-2141, database is CAplus.

A selective electrochem. oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochem. oxidation The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcs. and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochem. oxidation performance.

Science China: Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhao, Bing published the artcileDiscovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates, Formula: C12H9NO, the publication is Acta Pharmaceutica Sinica B (2021), 11(1), 203-221, database is CAplus and MEDLINE.

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R¹C(S)NHN=C(R²)(R³) (I) (R¹ = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R² = H, Me; R³ = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R¹ = piperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (II); R¹ = 4-methylpiperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug.

Acta Pharmaceutica Sinica B published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C4H3Cl2N3, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem