Month: December 2022

Martinez, Thibaut published the artcileIndolizy Carbene Ligand. Evaluation of Electronic Properties and Applications in Asymmetric Gold(I) Catalysis, Synthetic Route of 91-02-1, the publication is Angewandte Chemie, International Edition (2021), 60(36), 19879-19888, database is CAplus and MEDLINE.

We report herein a new family of carbene ligands based on an indolizine-ylidene (Indolizy) moiety. The corresponding gold(I) complexes are easily obtained from the gold(I)-promoted cyclization of allenylpyridine precursors. Evaluation of the electronic properties by exptl. methods and also by DFT calculations confirms strong σ-donating and π-accepting properties of these ligands. Cationization of the gold(I) complexes generates catalytic species that trigger diverse reactions of (poly)unsaturated precursors. When armed with a methylene phosphine oxide moiety on the stereogenic center adjacent to the nitrogen atom, the corresponding bifunctional carbene ligands give rise to highly enantioselective heterocyclizations. DFT calculations brought some rationalization and highlighted the critical roles played by the phosphine oxide group and the tosylate anion in the asym. cyclization of γ-allenols.

Angewandte Chemie, International Edition published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lutz, Martin published the artcileA reversible solid-solid phase transition Z’=1 to Z’=6 in [Ni(OAc)(PNP^tBu)]OTf, COA of Formula: C23H43NP2, the publication is Polyhedron (2009), 28(12), 2341-2346, database is CAplus.

At ambient temperature, [Ni(OAc)(PNP^tBu)]OTf has one independent mol. in the asym. unit of the crystal structure with very large anisotropic displacement parameters. During cooling a fully reversible solid-solid phase transition occurs at a discrete temperature in the range 210-230 K The low-temperature phase has six independent, well ordered mols. in the asym. unit. The P2₁/a space group symmetry of the high-temperature phase changes to P2₁/n for the low-temperature phase and the c-axis increases by a factor of six. The acetate ligand is coordinated in a η ¹-fashion through one of the O atoms, with the sterically encumbered, tridentate PNP^tBu ligand completing the square planar geometry around the Ni^II ion. The synthesis and full characterization of the complex is reported. Crystallog. data are given.

Polyhedron published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, COA of Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Estevez, Veronica published the artcileSynthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion, Recommanded Product: 2-Bromopyridin-3-amine, the publication is ACS Catalysis (2014), 4(1), 40-43, database is CAplus.

A new synthetic approach to 4-aminopyrido-[2,3-d]-pyrimidines and 4-aminopyrido-[3,2-d]-pyrimidines based on palladium-catalyzed reaction of isocyanides with readily available N-(bromopyridyl)amidines is reported. The target heterocycles, e.g., I, were obtained in generally good to excellent yield. For the two regioisomeric pyrimidopyrimidines, the authors compared our approach involving oxidative addition with the analogous C-H activation protocol because both methods have been reported for the synthesis of 4-aminoquinazolines. It was found that the C-H activation protocol does not allow one to obtain the target pyridopyrimidines, but the imidoylative cross-coupling protocol provided a new entry to the synthesis of these medicinally important scaffolds.

ACS Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hanan, Emily J. published the artcileDiscovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10090-10107, database is CAplus and MEDLINE.

The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified the pyrazolo[1,5-a]pyrimidine scaffold as a potent inhibitor of Jak2. Optimization of lead compounds in this chem. series for activity against Jak2, selectivity against other Jak family kinases, and good in vivo pharmacokinetic properties led to the discovery of (I). In a SET2 xenograft model that is dependent on Jak2 for growth, I demonstrated a time-dependent knock-down of pSTAT5, a downstream target of Jak2.

Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Porter, William W. III published the artcileIsolation and Characterization of Phenyl Viologen as a Radical Cation and Neutral Molecule, HPLC of Formula: 47369-00-6, the publication is Journal of Organic Chemistry (2005), 70(13), 5028-5035, database is CAplus and MEDLINE.

The chem. synthesis, isolation, and characterization of Ph viologen (PV) as a dication, radical cation, and neutral species are described. Single-crystal X-ray diffraction of PV²⁺2Cl^–·2H₂O and PV^â€?PF₆^–·pyridine reveals the expected differences in bond lengths and also a structural change from two coplanar central rings in PV^â€? to a twist of 36° between the two central rings in PV²⁺. The Ph viologen radical cation exhibits behavior characteristic of many radical cations, including weak π-dimerization in the solid state and reversible π-dimerization in solution Elec. conductivity measurements of neutral Ph viologen, the first such measurements of a neutral viologen, reveal that it is a significantly better conductor than the radical cation. Differences in geometric relaxation during charge transfer offer a possible explanation for the higher conductivity of the neutral viologen.

Journal of Organic Chemistry published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, HPLC of Formula: 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Tao published the artcileDiscovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir, Synthetic Route of 197958-29-5, the publication is Journal of Medicinal Chemistry (2018), 61(14), 6308-6327, database is CAplus and MEDLINE.

The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs) that originated with 1 to deliver temsavir (3, BMS-626529) is described. The most beneficial increases in potency and pharmacokinetic (PK) properties were attained by incorporating N-linked, sp²-hybridized heteroaryl rings at the 7-position of the heterocyclic nucleus. Compounds that adhered to a coplanarity model afforded targeted antiviral potency, leading to the identification of 3 with characteristics that provided for targeted exposure and PK properties in three preclin. species. However, the phys. properties of 3 limited plasma exposure at higher doses, both in preclin. studies and in clin. trials as the result of dissolution- and/or solubility-limited absorption, a deficiency addressed by the preparation of the phosphonooxymethyl prodrug 4 (BMS-663068, fostemsavir). An extended-release formulation of 4 is currently in phase III clin. trials where it has shown promise as part of a drug combination therapy in highly treatment-experienced HIV-1 infected patients.

Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C11H15NO2, Synthetic Route of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Funada, Atsushi published the artcileConformational Transformations of (C₁₂H₂₅NH₃⁺)(Pyridinesulfonate) in the Solid State, Related Products of pyridine-derivatives, the publication is Chemistry – An Asian Journal (2016), 11(6), 915-925, database is CAplus and MEDLINE.

The phase-transition behaviors, crystal structures, and dielec. properties of four kinds of simple 1:1 organic salts of (C₁₂H₂₅NH₃⁺)(benzenesulfonate) and (C₁₂H₂₅NH₃⁺)(pyridine sulfonates) were examined from the viewpoint of intermol. hydrogen-bonding interactions and dynamic conformational transformation in mol. assemblies. Crystals of (C₁₂H₂₅NH₃⁺)(benzenesulfonate) and (C₁₂H₂₅NH₃⁺)(3-pyridinesulfonate) were isostructural and solid-solid and solid-liquid-crystal smectic A (SmA) phase transitions were observed These two crystals formed rodlike cation-anion assemblies. However, the two salts, (C₁₂H₂₅NH₃⁺)(2-pyridinesulfonate) and (C₁₂H₂₅NH₃⁺)(4-pyridinesulfonate), formed largely bent L-shaped cation-anion conformations. Interesting conformational transformations from rodlike to L-shaped assemblies were observed in (C₁₂H₂₅NH₃⁺)(2-pyridinesulfonate) and (C₁₂H₂₅NH₃⁺)(3-pyridinesulfonate).

Chemistry – An Asian Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Han, Fei published the artcileEffect of functional group position change of pyridinesulfonic acid as interface-modified layer on perovskite solar cell, Formula: C5H5NO3S, the publication is Applied Surface Science (2018), 517-525, database is CAplus.

There are fewer researches on the effect of functional group position change on device performance for highly efficient perovskite solar cell. In this work, we take pyridinesulfonic acid as an example, and study the effect of the isomeride: 2- and 3-pyridinesulfonic acid self-assembled monolayer on device performance for highly efficient perovskite solar cell. The efficiency of control device is 14.65% (Hysteresis Index = 0.31) under illumination of a simulated sunlight (AM 1.5G, 100 mW cm^-2). Through use of the 3-pyridinesulfonic acid self-assembled monolayer, the device exhibits striking improvements to reach the efficiency of 16.88% (Hysteresis Index = 0.02), which constitutes an enhancement compared to those of 2-pyridinesulfonic acid self-assembled monolayer modified device (16.54%, Hysteresis Index = 0.02). The enhanced photovoltaic performances can be attributed to the larger perovskite grain sizes, and easier passivation of electron transporting layer/perovskite interface, which promote the charge separation, transport and collection.

Applied Surface Science published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuasa, Makoto published the artcileSynergistic effect of organic additives and pulse-current plating in a gold electrodeposition acid bath and gold plating film corrosion resistance, Product Details of C5H5NO3S, the publication is Hyomen Gijutsu (1994), 45(8), 842-3, database is CAplus.

Effects of addition of pyridine derivatives such as aminopyridines and pyridinesulfonic acids into a citric acid-base Au electrodeposition solution were discussed. Using both pyridine additives and pulse current effectively lowered porosity and increased deposition efficiency compared to using only d.c. or pulse current and both d.c. and pyridine additives.

Hyomen Gijutsu published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C15H20N2O2, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuasa, Makoto published the artcileSynergistic effect of organic additives and pulse-current plating in gold electrodeposition from a citric acid bath and corrosion resistance of the gold electroplate film. Relationship between structures of additives and corrosion resistance of the film, Computed Properties of 636-73-7, the publication is Hyomen Gijutsu (1995), 46(12), 1150-6, database is CAplus.

The synergistic effect of organic additives and pulse-current plating in gold electrodeposition from a citric acid bath was investigated. Then the corrosion resistance of the gold plated film was evaluated by physicochem. methods. By the synergistic effect, the bath containing 2,3-diaminopyridine (23 DAmPy) produced both lower film porosity and higher gold deposition efficiency. These properties are due to the moderate phys. adsorption of 23-DAmPy, whose structure is susceptible to cation, under pulse-current plating. In any event, the synergistic effect appears in pulse-current plating in the bath containing organic additive.

Hyomen Gijutsu published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H8N2O, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem