Month: December 2022

Umemoto, Teruo published the artcileα-Fluorination of sulfides with N-fluoropyridinium triflates, HPLC of Formula: 107263-95-6, the publication is Bulletin of the Chemical Society of Japan (1986), 59(11), 3625-9, database is CAplus.

The reaction of RSCH₂R¹ [I R = Ph, PhCH₂, C₆H₄Cl-4, Me, dodecyl; R¹ = H, CO₂Et, CO₂Me, CH₂CH(CO₂Me)NHCOCF₃] with N-fluoropyridium salts II (X = CF₃SO₃, BF₄), III, and IV was examined While the fluorinating power increased in the order of II (X = CF₃SO₃) < III < IV, the yield of α-fluoro sulfide decreased in the order of II > III, and IV no longer produced the α-fluoro sulfide. II (X = CF₃SO₃) was more reactive than II (X = BF₄). Thus, RSCHFR¹ were prepared by α-fluorination of I with II (X = CF₃SO₃) under mild conditions. RS(O)_nCHFR¹ (n = 1, 2) were easily prepared by α-fluorination of I with II, followed by oxidation

Bulletin of the Chemical Society of Japan published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C8H15ClN2, HPLC of Formula: 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Umemoto, Teruo published the artcileNovel base-initiated reactions of N-substituted pyridinium salts, COA of Formula: C6H5F4NO3S, the publication is Journal of Fluorine Chemistry (1996), 77(2), 161-168, database is CAplus.

Reaction of N-fluoropyridinium triflate with a base in dichloromethane gave 2-chloropyridine as the major product along with 2-pyridyl triflate and 2-fluoropyridine, regardless of the nature of the base. This base-initiated reaction was also shown to take place similarly in other halogenated alkanes, ethers, a nitrile, aromatics, a ketone, vinyl ethers, alcs. and trimethylsilyl acetate as solvents to give pyridine derivatives substituted with a solvent mol.(s) at the 2-position. N-(Trifluoromethanesulfonyloxy)- and (benzenesulfonyloxy)pyridinium salts were found to undergo the same base-initiated reaction. These reactions may be explained by a postulated singlet carbene produced through proton abstraction of N-substituted pyridinium salts. A similar carbene reaction may thus likely occur in the thermal decomposition of thiatriazole. The ab initio MO calculations revealed the structure and properties of the labile deprotonated N-fluoropyridinium cation and supported the carbene intermediate reaction mechanism rather than a pyridynium or pyridyl cation mechanism. Quarroz’s reports on the reactions of picolinic acid N-oxide and the reported reactions of pyridines with F₂, CH₃COOF or CsSO₄F in solvents may be explained by this carbene mechanism.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C9H21NO3, COA of Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Umemoto, Teruo published the artcileN-Fluoropyridinium triflate: an electrophilic fluorinating agent, Safety of 1-Fluoropyridiniumtriflate, the publication is Organic Syntheses (1990), 129-43, database is CAplus.

The title compound (I) was prepared by fluorination of pyridine with F₂ in MeCN in the presence of CF₃SO₃Na. Treating methoxy(trimethylsiloxy)estratetraene II with I in CHCl₂ gave 66% the 16α-fluoroestrone III. A variety of examples of the use of I and its derivatives are also described.

Organic Syntheses published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C10H12F6N4O6PdS2, Safety of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Umemoto, Teruo published the artcileN-Fluoropyridinium triflate and its analogs. The first stable 1:1 salts of pyridine nucleus and halogen atom, Application In Synthesis of 107263-95-6, the publication is Tetrahedron Letters (1986), 27(28), 3271-4, database is CAplus.

N-Fluoropyridinium salts having non-nucleophilic counter-anions, e.g., I (R = F, R¹-R⁵ = H; R = F, R¹ = Me, R²-R⁵ = H; X = CF₃SO₃), and their derivatives were synthesized by treating pyridine-F₂ adducts with strong Broensted acids, their salts, or trimethylsilyl esters, or Lewis acids, or by allowing F₂ to react with N-trimethylsilylpyridinium salts I (R = SiMe₃).

Tetrahedron Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C7H7IN2O, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mimura, Kazuya published the artcileAtypical preeclampsia without underlying disease and elevated sFlt-1/ PlGF ratio, HPLC of Formula: 21829-25-4, the publication is Journal of Obstetrics and Gynaecology Research (2022), 48(2), 471-476, database is CAplus and MEDLINE.

Atypical preeclampsia before 20 wk of gestation without an underlying disease is very rare; however, the soluble Fms-like tyrosine kinase 1/placental growth factor (sFlt-1/PlGF) ratios remain unknown. Four pregnant women with no underlying disease, except for a history of childhood IgA vasculitis, developed preeclampsia at 13, 14, 17, and 18 wk of gestation with sFlt-1/PlGF ratios of 1589, 1183, 500, and 1460 pg/mL, resp. Their pregnancies were terminated, and they delivered within 2 wk. All previously abnormal clin. findings normalized within 3 mo. The sFlt-1/PlGF ratios were elevated in the four patients with atypical preeclampsia without underlying disease before 20 wk of gestation. A high sFlt-1/PlGF ratio may be indicative of preeclampsia when no underlying disease is present in pregnancies of less than 20 wk of gestation.

Journal of Obstetrics and Gynaecology Research published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, HPLC of Formula: 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oi, Norihito published the artcileDevelopment of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors, SDS of cas: 903899-13-8, the publication is Journal of Medicinal Chemistry (2015), 58(21), 8444-8462, database is CAplus and MEDLINE.

The authors document the development of PET probes for central AMPA receptors and their application to in vivo animal imaging. An initial screening of perampanel derivatives was performed to identify probe candidates. Despite the high autoradiog. contrast yielded by several radioligands, rat PET scans did not support their in vivo suitability. Further focused derivatization and a second screening by ex vivo LC-MS measurements led to the selection of 2-[1-(3-methylaminophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl]benzonitrile, 21a, and its analogs as candidates. [¹¹C]21a was shown by autoradiog. to specifically bind to the neocortex and hippocampus, consistent with AMPA receptor localization. PET imaging with [¹¹C]21a demonstrated moderate uptake of radioactivity in rat and monkey brains, with the retention of radiosignals being consistent with that from the autoradiogram data, and the uptake was blocked by pretreatment with unlabeled 21a in a dose-dependent manner. The current approach has facilitated the discovery of a PET probe potentially suitable for translational research and development focused on AMPA receptors.

Journal of Medicinal Chemistry published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C5H6BNO3, SDS of cas: 903899-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ueno, Tetsuya published the artcilesynthesis of 1-fluoro- and 1,3-difluoroazulenes, Recommanded Product: 1-Fluoropyridiniumtriflate, the publication is Chemistry Letters (1995), 169-70, database is CAplus.

Title compounds were synthesized by the reaction of azulene with N-fluoropyridinium salts in MeCN. Me azulene-1-carboxylates were also fluorinated to give the corresponding 3-fluoro derivatives On the basis of the UV-visible absorption spectra, the fluorine atom acts as an electron-donating group to the azulene π-system due to the +Iπ effect. A solution of azulene and N-fluoro-2,4,6-trimethylpyridinium triflate in MeCN were refluxed to give 1-fluoroazulene and 1,3-difluoroazulene. The yields of these 2 compounds decreased with more powerful fluorinating agents.

Chemistry Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C19H17N2NaO4S, Recommanded Product: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ueno, Tetsuya published the artcileSynthesis and properties of fluoroazulenes. II. Electrophilic fluorination of azulenes with N-fluoro reagents, Name: 1-Fluoropyridiniumtriflate, the publication is Bulletin of the Chemical Society of Japan (1996), 69(6), 1645-1656, database is CAplus.

1-Fluoro- and 1,3-difluoroazulenes were synthesized for the first time by the electrophilic fluorination of azulenes with N-fluoro reagents. Selective preparation of 1-fluoroazulenes were performed by the fluorination of Me azulene-1-carboxylates, followed by demethoxycarbonylation in 100% H₃PO₄. 2-Substituted azulenes were fluorinated in higher yields. In the ¹H NMR of 1-fluoroazulene, long-range J_FH values were not observed at H-2 and H-8, in contrast to those for 1-fluoronaphthalene. The 1-fluorine atom causes significant bathochromic shifts in the visible absorption of azulene, due to the so-called +Iπ effect.

Bulletin of the Chemical Society of Japan published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C13H14N2O, Name: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Stanovnik, B. published the artcileHeterocycles. CLVII. Oxidative transformations of some heterocyclic hydrazones with lead tetraacetate, Related Products of pyridine-derivatives, the publication is Croatica Chemica Acta (1977), 49(1), 135-40, database is CAplus.

2-Pyridinecarboxaldehyde phenylhydrazone (I) was treated with MeO2CCCCO2Me in presence of Pb(OAc)4 to give RCONHNPhCOMe (R = pyridyl). Without Pb(OAc)4 RCH:NNPhC(CO2Me):CHCO2Me (R = 2-pyridyl) was formed. I and H2C:CHCN in presence of Pb(OAc)4 gave the pyrazole II. 2-Pyridinecarboxaldehyde 2-pyridylhydrazone and H2C:CHCN in presence of Pb(OAc)4 gave the triazolopyridine III (R = 2-pyridyl, R1 = H). P-methoxybenzaldehyde 3-nitro-2-pyridylhydrazone similarly gave III (R = p-MeOC6H4, R1 = NO2).

Croatica Chemica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C12H10FeO4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Palmquist, Karl H. published the artcileReciprocal cell-ECM dynamics generate supracellular fluidity underlying spontaneous follicle patterning, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Cell (Cambridge, MA, United States) (2022), 185(11), 1960-1973.e11, database is CAplus and MEDLINE.

During vertebrate embryogenesis, cell collectives engage in coordinated behavior to form tissue structures of increasing complexity. In the avian skin, assembly into follicles depends on intrinsic mech. forces of the dermis, but how cell mechanics initiate pattern formation is not known. Here, we reconstitute the initiation of follicle patterning ex vivo using only freshly dissociated avian dermal cells and collagen. We find that contractile cells phys. rearrange the extracellular matrix (ECM) and that ECM rearrangement further aligns cells. This exchange transforms a mech. unlinked collective of dermal cells into a continuum, with coherent, long-range order. Combining theory with experiment, we show that this ordered cell-ECM layer behaves as an active contractile fluid that spontaneously forms regular patterns. Our study illustrates a role for mesenchymal dynamics in generating cell-level ordering and tissue-level patterning through a fluid instability-processes that may be at play across morphol. symmetry-breaking contexts.

Cell (Cambridge, MA, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem