Month: December 2022

Trezza, Alfonso published the artcileFunctional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is European Journal of Pharmacology (2022), 174778, database is CAplus and MEDLINE.

Quercetin, a flavonoid abundantly present in the Mediterranean diet, is considered a vasodilator despite its recognized capability to stimulate vascular CaV1.2 channel current (ICa1.2). The present study was undertaken to assess its possible vasocontractile activity. Functional and electrophysiol. experiments were performed in vitro on rat aorta rings and tail artery myocytes along with an in-depth mol. modeling anal. The CaV1.2 channel stimulator (S)-(-)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate (Bay K 8644) was used as reference compound Quercetin and Bay K 8644 caused a significant leftward shift of KCl concentration-response curve. Neither agent affected basal muscle tone, though in rings pre-treated with thapsigargin or 15 mM KCl they caused a strong, concentration-dependent contraction. Both quercetin and Bay K 8644 potentiated the response to Ca²⁺ in weakly depolarised rings. At high KCl concentrations, however, quercetin caused vasorelaxation. While Bay K 8644 stimulated ICa1.2, this effect being sustained with time, quercetin-induced stimulation was transient, although the mol. in solution underwent only marginal oxidation Quercetin transient stimulation was not affected by pre-treatment with isoprenaline, sodium nitroprusside, or dephostatin; however, it converted to a sustained one in myocytes pre-incubated with Go6976. Classical mol. dynamics simulations revealed that quercetin and Bay K 8644 formed hydrogen bonds with target sensing residues of CaV1.2 channel favoring the inactivated conformation. In conclusion, quercetin-induced stimulation of ICa1.2 promoted vasocontraction when Ca²⁺ buffering function of sarcoplasmic reticulum was impaired and/or smooth muscle cell membrane was moderately depolarised, as it may occur under certain pathol. conditions.

European Journal of Pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H28N2O7, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pickles, G. M. published the artcileThe reactions of diborane with aryl organotin compounds, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Organometallic Chemistry (1984), 260(1), 7-15, database is CAplus.

Treating R₄Sn (R = Ph, 2- and 4-tolyl, 4-ClC₆H₄) and Ph₃SnX (X = Cl, H, OH, OAc, O₂CCF₃) with BH₃ gave transmetalation, in which â‰? aryl group was transferred to B. The organoboron intermediates give phenols upon oxidation and boronic and borinic acids upon hydrolysis. Pyridine (L) complexes of organoboranes, Ph₂BHL and Ph₃BL were also isolated.

Journal of Organometallic Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hendricks, Robert T. published the artcile3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase, SDS of cas: 903899-13-8, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(2), 410-414, database is CAplus and MEDLINE.

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C5H6BNO3, SDS of cas: 903899-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ju, Zhao-Yang published the artcileSelective Aerobic Oxidation of C_sp³-H Bonds Catalyzed by Yeast-Derived Nitrogen, Phosphorus, and Oxygen Codoped Carbon Materials, COA of Formula: C12H9NO, the publication is Journal of Organic Chemistry (2022), 87(6), 3978-3988, database is CAplus and MEDLINE.

Nitrogen, phosphorus and oxygen codoped carbon catalysts were successfully synthesized using dried yeast powder as pyrolysis precursor. The yeast-derived heteroatom-doped carbon (yeast@C) catalysts exhibited outstanding performance in the oxidation of C_sp3-H bonds to ketones and esters giving excellent products yields (up to 98% yield) without organic solvents at low O₂ pressure (0.1 MPa). The catalytic oxidation protocol exhibited broad range of substrates (38 examples) with good functional group tolerance, excellent regioselectivity and synthetic utility. The yeast-derived heteroatom-doped carbon catalysts showed good reusability and stability after recycle six times without any significant loss of activity. Exptl. results and DFT calculations proved the important role of N-oxide (N⁺-O^–) on the surface of yeast@C and a reasonable carbon radical mechanism.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xuqing published the artcileOptimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors, HPLC of Formula: 844501-00-4, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(16), 4762-4767, database is CAplus and MEDLINE.

A series of indazoles, e.g. I–III, have been discovered as KHK inhibitors from a pyrazole hit identified through fragment-based drug discovery (FBDD). The optimization process guided by both X-ray crystallog. and solution activity resulted in lead-like compounds with good pharmaceutical properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C31H25F2N5O7S, HPLC of Formula: 844501-00-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pecak, Wiktoria H. published the artcileSynthesis of 1,4-Enamino Ketones by [3,3]-Rearrangements of Dialkenylhydroxylamines, Product Details of C10H18BNO4, the publication is Organic Letters (2014), 16(13), 3440-3443, database is CAplus and MEDLINE.

The synthesis of 1,4-enamino ketones has been achieved through the [3,3]-rearrangement of dialkenylhydroxylamines generated from the addition of N-alkenylnitrones to electron-deficient allenes. The mild conditions required for this reaction, and the simultaneous installation of a fluorenyl imine N-protecting group as a consequence of the rearrangement, avoid spontaneous cyclization of the 1,4-enamino ketones to form the corresponding pyrroles and allow for the isolation and controlled divergent functionalization of these reactive intermediates. The optimization, scope, and tolerance of the new method are discussed with demonstrations of the utility of the products for the synthesis of pyrroles, 1,4-diones, and furans.

Organic Letters published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C10H18BNO4, Product Details of C10H18BNO4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sugimura, Yukio published the artcileSeven-membered ring compounds. XXXVIII. Reaction of troponoid with ylide. III. Reaction of tropone with pyridinium compounds, Quality Control of 17281-59-3, the publication is Bulletin of the Chemical Society of Japan (1972), 45(10), 3174-8, database is CAplus.

Phenacylpyridinium ylide (I, R = H, Br) reacted with tropone to afford 2-hydroxy-2-phenyl-3-phenacyl-2H-cyclohepta[b]furan (II) which was converted into 2-(1,2-dibenzoylethyl)tropone. The reactions of tropone with several kinds of pyridinium bromides yielded 2-substituted tropones in the presence of amines and 1-azaazulene derivatives including III in a one-step formation in the presence of NH4OAc.

Bulletin of the Chemical Society of Japan published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C3H3Br2ClO, Quality Control of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bachurin, S. O. published the artcileRole of dopamine uptake system in the development of experimental parkinsonism induced by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine and its pyridine analogs, Application of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Doklady Akademii Nauk SSSR (1989), 307(3), 740-3 [Biochem.], database is CAplus.

The effects of the title drug (I), an agent inducing exptl. parkinsonism, and 8 of its pyridine and dipyridyl analogs on brain content of monoamines, behavior, and synaptosomal reuptake of dopamine were studied in mice. Two daily doses of the agents at 80-90% of their LD₅₀ did not affect (except I) the brain levels of noradrenaline, dopamine, and serotonin within 5-7 days and the behavior within 3 mo. In vitro, all the agents reversibly and competitively inhibited [¹⁴C]dopamine uptake by the brain synaptosomes. The tetradehydro-I was the strongest inhibitor which is also an in vivo metabolite of I. The inhibitory effects of the other agents were partially related to their structure and lipophilicity.

Doklady Akademii Nauk SSSR published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Application of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mohamed, Yasser M. A. published the artcileSynthesis, antibacterial evaluation, and docking studies of azaisoflavone analogues generated by palladium-catalyzed cross coupling, Application of 2-Pyridinylboronic acid, the publication is Monatshefte fuer Chemie (2018), 149(10), 1857-1864, database is CAplus.

Palladium-catalyzed, cross-coupling reaction of N-methyl-3-iodo-4-quinolone with boronic acids or N-methyliminodiacetic acid boronates to obtain azaisoflavone derivatives was investigated through conventional Suzuki-Miyuara coupling or by slow release strategy. It was observed that a slow release approach was a highly successful. In addition, a series of novel azaisoflavones containing alkynyl group were synthesized via Sonogashira reaction. The antibacterial activities of the all synthesized compounds were screened against series of bacterial strains. Furthermore, a mol. docking study was carried out for the most active compounds using Leadit 2.1.8 docking software, and the results were in good agreement with the exptl. data. The details of synthetic methods, spectroscopic data, and biol. results were reported.

Monatshefte fuer Chemie published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hameed P., Shahul published the artcileTriaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate, Product Details of C6H8N2, the publication is Nature Communications (2015), 6715, database is CAplus and MEDLINE.

The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The clin. candidate (compound 12) is efficacious in a mouse model of Pf malaria with an ED₉₉ <30 mg kg^-1 and displays good in vivo safety margins in guinea pigs and rats. With a predicted half-life of 36 h in humans, a single dose of 260 mg might be sufficient to maintain therapeutic blood concentration for 4-5 days. Whole-genome sequencing of resistant mutants implicates the vacuolar ATP synthase as a genetic determinant of resistance to TAPs. Our studies highlight the potential of TAPs for single-dose treatment of Pf malaria in combination with other agents in clin. development.

Nature Communications published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem