Month: December 2022

Yang, Feng V. published the artcileParallel synthesis of N-biaryl quinolone carboxylic acids as selective M₁ positive allosteric modulators, Product Details of C6H9BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(2), 531-536, database is CAplus and MEDLINE.

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M₁ pos. allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about 774170-15-9. 774170-15-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amine,Boronic Acids, name is (6-(Methylamino)pyridin-3-yl)boronic acid, and the molecular formula is C38H24F4O4P2, Product Details of C6H9BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yamada, Makito published the artcileLigand-free Suzuki-Miyaura coupling reaction of aryl chlorides using a continuous irradiation type microwave and a palladium nanoparticle catalyst: effect of a co-existing solid, Category: pyridine-derivatives, the publication is Green Chemistry (2019), 21(16), 4541-4549, database is CAplus.

The effect of a co-existing metal in the ligand-free Suzuki-Miyaura coupling reaction of aryl chlorides ArCl (Ar = Ph, pyridin-2-yl, naphthalen-1-yl, etc.) is promoted by a ”continuous irradiation type microwave” and a ”palladium nanoparticle catalyst”, and it is found that the co-existing metal affects this reaction due to its absorption ability of microwave energy in the reaction system. It is also observed that spiking occurred more frequently in the presence of a co-existing metal.

Green Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C17H19N3O7S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dabholkar, Vijay V. published the artcileChemistry of novel biphenyl cyclic 3,5-disubstituted 1,2,4-oxadiazole derivatives – their synthesis and microbial evaluation, COA of Formula: C6H8N2, the publication is Heterocyclic Letters (2013), 3(4), 525-531, database is CAplus.

2′-Cyano-4-bromomethyl biphenyl was reacted with hydroxylamine hydrochloride in the presence of sodium carbonate and on further treatment with 2-methyl-4-aminopyridine yielded 3,5-disubstituted 1,2,4-oxadiazole I. 3,5-Di(4-bromomethyl-biphenyl-6′,6”-yl)-1,2,4-oxadiazole was condensed with L-valine Me ester and further cyclized with aliphatic dibromo alkanes Br₂(CH₂)_n to yield the resp. cyclic 3,5-disubstituted 1,2,4-oxadiazoles II [n = 2, 3, 4]. Compounds I and II were evaluated for their antimicrobial activity against Gram pos. and Gram neg. bacteria.

Heterocyclic Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chae, Eunhee published the artcileDiscovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators, Application In Synthesis of 18437-58-6, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(7), 2134-2139, database is CAplus and MEDLINE.

Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor neg. allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Anal. of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 neg. allosteric modulators with anti-depressant activities.

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Application In Synthesis of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deng, Tianning published the artcileI(III)-Catalyzed Oxidative Cyclization-Migration Tandem Reactions of Unactivated Anilines, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Organic Letters (2020), 22(22), 9102-9106, database is CAplus and MEDLINE.

An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochem. determining C-N bond forming step.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gohil, Vishal M. published the artcileNutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Nature Biotechnology (2010), 28(3), 249-255, database is CAplus and MEDLINE.

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative metabolism, and studies in model systems have shown that targeting such shifts may be useful in treating or preventing a variety of diseases ranging from cancer to ischemic injury. However, we currently have a limited number of mechanistically distinct classes of drugs that alter the relative activities of these two pathways. We screen for such compounds by scoring the ability of >3500 small mols. to selectively impair growth and viability of human fibroblasts in media containing either galactose or glucose as the sole sugar source. We identify several clin. used drugs never linked to energy metabolism, including the antiemetic meclizine, which attenuates mitochondrial respiration through a mechanism distinct from that of canonical inhibitors. We further show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models. Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism

Nature Biotechnology published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Recommanded Product: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gong, Xinchi published the artcileHeterogeneous copper-catalyzed synthesis of diaryl sulfones, Category: pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2021), 19(48), 10662-10668, database is CAplus and MEDLINE.

A carbon-supported copper nanoparticle with high catalytic activity for the synthesis of diaryl sulfones is reported. For the first time, this Cu-NP is proved to be able to effectively promote the reaction of arylboronic acids and arylsulfonyl hydrazides to generate diaryl sulfones at room temperature The reaction shows excellent substrate universality, and substrates with different substituents can undergo the reaction smoothly, leading to the desired products in good yields. The Cu-NP is found to be made of low valence Cu based on XRD. Hence, the reaction catalyzed by the Cu-NP is believed to involve a Cu-mediated organometallic cycle.

Organic & Biomolecular Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hajjami, Maryam published the artcileSynthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions, Quality Control of 91-02-1, the publication is Catalysis Letters (2021), 151(8), 2420-2435, database is CAplus.

Two magnetic nano catalysts of nickel and copper, Fe₃O₄@SiO₂@DOP-BenPyr-M(II), (M=Ni and Cu) have been synthesized. These catalysts were applied as recoverable, efficient and new heterogeneous catalysts for the high yielding and room temperature one-pot procedure of selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides. In addition, the catalytic activity of Fe₃O₄@SiO₂@DOP-BenPyr-Ni(II) was investigated as heterogeneous nanocatalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-ones, 5-substituted 1H-tetrazoles and polyhydroquinolines. The synthesized catalysts were characterized by FT-IR, TGA, XRD, VSM, EDX, ICP and SEM techniques. These catalysts were recovered by an external magnet and reused several times without significant loss of catalytic efficiency.

Catalysis Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jun published the artcileConstruction and regulation of imidazo[1,5-a]pyridines with AIE characteristics via iodine mediated Csp²-H or Csp-H amination, Related Products of pyridine-derivatives, the publication is Chinese Chemical Letters (2021), 32(10), 3083-3086, database is CAplus.

The widespread applications of aggregation-induced emission luminogens (AIEgens) inspire the creation of AIEgens with novel structures and functionalities. In this work, we focused on the direct and efficient synthesis of a new type of AIEgens, imidazo[1,5-a]pyridine derivatives, via iodine mediated cascade oxidative Csp²-H or Csp-H amination route from phenylacetylene or styrenes under mild conditions. The resulted compounds showed excellent AIE characteristics with tunable maximum emissions, attractive bioimaging performance, and potential anti-inflammatory activity, which exert broad application prospects in material, biol., medicine, and other relevant areas.

Chinese Chemical Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C10H10O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jun published the artcileSelective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate, Application In Synthesis of 39856-58-1, the publication is Organic Letters (2021), 23(21), 8396-8401, database is CAplus and MEDLINE.

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C8H11NO, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem