Month: December 2022

Chatterjea, J. N. published the artcileSynthesis in the 4-azafluorene group. Part III, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Journal of the Indian Chemical Society (1978), 55(2), 149-53, database is CAplus.

Cyclocondensation of benzylideneindandiones I (R = H, Me, MeO, NO₂) with NH₄OAc in the presence of 1-phenacylpyridinium bromide gave the diindenopyridines II. Hantzsch cyclization of 2-benzylidene-1-indanone with PhC(NH₂):CCN gave the dihydroazafluorenone III, which was aromatized by chromic acid, hydrolyzed, and decarboxylated to give the azafluorenone IV (Z = O). Wolff-Kishner reduction of IV (Z = O) gave IV (Z = H₂). Treatment of 2-benzylideneindan-1-one with NH₄OAc and 1-acetonylpyridinium bromide gave 3-methyl-1-phenyl-4-azafluorene, which was also obtained from Et 3-methyl-1-phenyl-4-azafluorenone-2-carboxylate by successive hydrolysis, decarboxylation, and Wolff-Kishner reduction 1-Benzylidene-2-indanone was prepared from Et 3-benzylidene-2-oxo-1-indancarboxylate by hydrolysis-decarboxylation.

Journal of the Indian Chemical Society published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Paone, Daniel V. published the artcilePotent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974), Recommanded Product: 2-Pyridinylboronic acid, the publication is Journal of Medicinal Chemistry (2007), 50(23), 5564-5567, database is CAplus and MEDLINE.

Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Herein we describe optimization of CGRP receptor antagonists based on an earlier lead structure containing a (3R)-amino-(6S)-phenylcaprolactam core. Replacement of the phenylimidazolinone with an azabenzimidazolone gave stable derivatives with lowered serum shifts. Extensive SAR studies of the C-6 aryl moiety revealed the potency-enhancing effect of the 2,3-difluorophenyl group, and trifluoroethylation of the N-1 amide position resulted in improved oral bioavailabilities, ultimately leading to clin. candidate 38 (MK-0974).

Journal of Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arora, Bhavya published the artcileFabrication of a recyclable magnetic halloysite-based cobalt nanocatalyst for the efficient degradation of bisphenol A and malachite green, Quality Control of 91-02-1, the publication is Materials Advances (2022), 3(15), 6373-6384, database is CAplus.

Worsening water quality has drawn considerable attention from the scientific fraternity owing to its serious impact on human health and environmental ecosystem. In this regard, magnetic halloysite-based organic-inorganic hybrid materials with a hollow nanotubular structure and surface tunable chem. have emerged as an excellent platform for the efficient removal of recalcitrant water contaminants. The fabrication of nanocatalyst involves a simple yet versatile covalent immobilization strategy, wherein a chelating ligand, 2-benzoylpyridine (2-BPy) was grafted onto silane-functionalized magnetic halloysite nanotubes with subsequent anchoring of cobalt ions. Various physico-chem. techniques such as FT-IR spectroscopy, P-XRD, VSM, FE-SEM, TEM and XPS provided valuable insights into the crystallinity, magnetic attributes and morphol. of the designed nanocomposites. The exptl. results indicated that a Co(II)@2-BPy@APTES@MHNTs/H₂O₂ catalytic system not only exhibits immense catalytic potential in accelerating the degradation process but also shows impressive features such as shorter reaction time and ambient reaction conditions. With the assistance of coumarin fluorescent probe technique and radical scavenging studies, the mechanistic pathway has been proposed, and it has been found that in situ generated highly reactive hydroxyl radicals play a crucial role in achieving outstanding degradation efficiency. The kinetic characteristics of the degradation profile demonstrate that pseudo-first-order kinetics is followed with an apparent rate constant of 0.1179 min^-1 for BPA and 0.1242 min^-1for MG. Fascinatingly, the splendid magnetic properties of the designed Co(II)@2-BPy@APTES@MHNTs furnished their facile recovery and reusability for nine subsequent runs. Remarkably, the new findings demonstrated here will deepen our understanding of the fabrication and utilization of heterogeneous catalysts for wastewater treatment via a greener approach.

Materials Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mahajan, Abhishek published the artcileInterplay mechanisms between progesterone and endocannabinoid receptors in regulating bull sperm capacitation and acrosome reaction, Synthetic Route of 21829-25-4, the publication is Journal of Cellular Physiology (2022), 237(7), 2888-2912, database is CAplus and MEDLINE.

After ejaculation, sperm show a limited capacity for transcription and translation. In the oviduct, most of the signalling in sperm is nongenomic and is mediated through membrane receptors. Studies have shown that the cation channel of sperm (CatSper), cAMP, cGMP, protein kinases, and tyrosine phosphorylation are involved in the nongenomic signalling of progesterone (P4) in sperm. However, it is not known whether there is an interplay between P4 and cannabinoid receptors 1 and 2 (CB1 and CB2), transient receptor potential vanilloid 1 (TRPV1), CatSper channels, cAMP, inositol trisphosphate receptor (IP3R), and mitogen-activated protein kinase (MAPK); these potential regulators are involved in the regulation of capacitation and the acrosome reaction. In the present study, selective blockers of CB1, CB2, TRPV1, CatSper channels, cAMP, protein kinase A (PKA), IP3R, and MAPK were used to identify their involvement in P4-mediated bull sperm capacitation and the acrosome reaction. Selective blocking of any one of the mols. caused a significant reduction in P4 signalling (p < 0.05). Interestingly, blocking these mols. in combination followed by treatment with P4 resulted in the complete absence of capacitation and the acrosome reaction. Blocking a single receptor was not able to eliminate the P4-induced capacitation and the acrosome reaction. In addition to the CB1 and CB2 receptors, there may be other signalling pathways that mediate P4 signalling. In conclusion, P4 signalling exhibited interplay with the cannabinoid receptors. The regulation of sperm capacitation and the acrosome reaction also involved cAMP, PKA, L-type and T-type calcium channels, TRPV1, inositol trisphosphate, and MAPK.

Journal of Cellular Physiology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Synthetic Route of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Makaravage, Katarina J. published the artcileCopper(II)-Mediated [¹¹C]Cyanation of Arylboronic Acids and Arylstannanes, Related Products of pyridine-derivatives, the publication is Organic Letters (2018), 20(6), 1530-1533, database is CAplus and MEDLINE.

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[¹¹C]-nitriles is reported. This method is operationally simple, uses com. available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [¹¹C]perampanel in 10% nondecay-corrected radiochem. yield (RCY).

Organic Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Abu Zuhri, Ali Z. published the artcilePolarography of pyridine-2-carboxaldehyde 2-pyridylhydrazone in solutions of varying pH at a dropping-mercury electrode: effect of surface-active substance, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1985), 499-502, database is CAplus.

The polarog. behavior of pyridine-2-carboxaldehyde 2-pyridylhydrazone (I) at a dropping-Hg electrode was studied in aqueous Britton-Robinson buffers containing 50% EtOH. The polarograms consist of one wave in the acidic and alk. medium. Two electrons are consumed in the splitting of the N-N bond to give 2-aminopyridine and pyridine-2-carboxaldehyde. The adsorption effects of cationic, anionic, and nonionic surfactants on the polarog. waves of I were investigated. The kinetic parameters for the electrode reaction at different pH values were calculated

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Emami, Marzieh published the artcileSynthesis, Study, and Application of Pd(II) Hydrazone Complexes as the Emissive Components of Single-Layer Light-Emitting Electrochemical Cells, Product Details of C12H9NO, the publication is Inorganic Chemistry (2021), 60(2), 982-994, database is CAplus and MEDLINE.

For the first time, square planar Pd(II) complexes of hydrazone ligands have been investigated as the emissive components of light-emitting electrochem. cells (LECs). The neutral transition metal complex, [Pd(L¹)₂]·2CH₃OH (1), (HL¹ = (E)-Nâ€?(phenyl(pyridin-2-yl)methylene)isonicotinhydrazide), was prepared and structurally characterized. Complex 1 displays quasireversible redox properties and is emissive at room temperature in solution with a λ_max of 590 nm. As a result, it was subsequently employed as the emissive material of a single-layer LEC with configuration FTO/1/Ga/In, where studies reveal that it has a yellow color with CIE(x, y) = (0.33, 0.55), a luminance of 134 cd cm^-2, and a turn-on voltage of 3.5 V. Protonation of the pendant pyridine nitrogen atoms of L¹ afforded a second ionic complex [Pd(L¹H)₂](ClO₄)₂ (2) which is also emissive at room temperature with a λ_max of 611 nm, resulting in an orange LEC with CIE(x, y) = (0.43, 0.53). The presence of mobile anions and cations in the second inorganic transition metal complex resulted in more efficient charge injection and transport which significantly improved the luminance and turn-on voltage of the device to 188.6 cd cm^-2 and 3 V, resp. This study establishes Pd(II) hydrazone complexes as a new class of materials whose emissive properties can be chem. tuned and provides proof-of-concept for their use in LECs, opening up exciting new avenues for potential applications in the field of solid state lighting. The emissive properties of two Pd(II) hydrazone complexes have been exploited for the fabrication of single-layer light-emitting electrochem. cells. We demonstrate that a neutral Pd(II) complex capable of undergoing proton transfer with the solvent can support a suitable ionic medium for LECs. Furthermore, selective protonation of the hydrazone ligands and the introduction of perchlorate counterions afford a second LEC device with increased c.d., a red-shifted emission, and significantly improved brightness.

Inorganic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Eisch, John J. published the artcileRearrangements of organometallic compounds. 26. Bora-aromatic systems. 15. Skeletal rearrangements of arylborane complexes mediated by redox reactions: thermal and photochemical oxidation by metal ions, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Organometallic Chemistry (1994), 464(1), 11-21, database is CAplus.

A variety of metal salts are reduced by thermal and photochem. interaction with tetraarylborate salts and with neutral alkyl- and aryl-borane complexes. In the cases of Cu²⁺, Cu⁺, Ni²⁺, Co²⁺, Pd²⁺, Pt²⁺, Ag⁺, Zn²⁺, Hg²⁺, Sn²⁺, Pb²⁺ and Rh³⁺ salts, such photochem. reductions with NaBPh₄ led to the deposition of the free metal, while a number of binary mixtures of metal salts led to the codeposition of both metals, sometimes as true alloys, under such photoreductions The arylborate reductants underwent oxidative coupling of the aryl groups to form biaryls in a strictly intra-ionic (for BAr₄^–) or intramol. (Ar₃B) manner, resp. Individual studies of the photochem. of the tetraarylborate anion itself, of cuprous tetraphenylborate and of the triphenylborane-pyridine complex adduced evidence for a gamut of reactive intermediates capable of serving as the photoreductant for metal ions, such as triarylborane radical anions, diarylborate(I) anions or arylborenes, 7-borabicycloheptadiene anions or neutral complexes and finally arylborohydride anions or arylboron hydrides. The role of these intermediates both in the photoinduced skeletal rearrangements of arylboranes and in the concomitant reduction of metal ions is discussed in critical detail.

Journal of Organometallic Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lee, Seoung Rak published the artcileInduction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Angewandte Chemie, International Edition (2022), 61(29), e202204519, database is CAplus and MEDLINE.

Fungi offer a deep source of natural products but remain underutilized. Most biosynthetic gene clusters (BGCs) that can be detected are silent or “cryptic” in standard lab cultures and their products are thus not interrogated in routine screens. As genetic alterations are difficult and some strains can only be grown on agar, we have herein applied an agar-based high-throughput chem. genetic screen to identify inducers of fungal BGCs. Using R. solani and S. sclerotiorum as test cases, we report 13 cryptic metabolites in four compound groups, including sclerocyclane, a natural product with a novel scaffold. Steroids were the best elicitors and follow-up studies showed that plant-steroids trigger sclerocyclane synthesis, which shows antibiotic activity against B. plantarii, an ecol. competitor of S. sclerotiorum. Our results open new paths to exploring the chem. ecol. of fungal-plant interactions and provide a genetics-free approach for uncovering cryptic fungal metabolites.

Angewandte Chemie, International Edition published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van der Born, Dion published the artcileA Universal Procedure for the [¹⁸F]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity, Synthetic Route of 197958-29-5, the publication is Angewandte Chemie, International Edition (2014), 53(41), 11046-11050, database is CAplus and MEDLINE.

Herein, we describe a valuable method for the introduction of the [¹⁸F]CF₃ group into arenes with highly improved specific activity by the reaction of [¹⁸F]trifluoromethane with aryl iodides or aryl boronic acids. This [¹⁸F]trifluoromethylation reaction is the first to be described in which the [¹⁸F]CF₃ products are generated in actual trace amounts and can therefore effectively be used as PET tracers. The method shows broad scope with respect to possible aryl iodide and aryl boronic acid substrates, as well as good to excellent conversion. In particular, the [¹⁸F]trifluoromethylation of boronic acids was found to outperform [¹⁸F]trifluoromethylation reactions of halogenated aryl precursors with regard to conversion, reaction conditions, and kinetics.

Angewandte Chemie, International Edition published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C21H26Br4S2, Synthetic Route of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem