Month: December 2022

Pellerano, C. published the artcileQuinolylhydrazones of acetylpyridines: synthesis and biological activity. Part VII, Quality Control of 2215-33-0, the publication is Bollettino Chimico Farmaceutico (1978), 117(12), 721-30, database is CAplus and MEDLINE.

The condensation of acetylpyridine isomers with hydrazinoquinoline isomers yielded hydrazones I (R = H, Me, OMe, Cl; R¹ = H, Me), which exhibited bactericidal and tuberculostatic activity.

Bollettino Chimico Farmaceutico published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pellerano, C. published the artcileTridentate N-N-N chelating systems as potential antitumoral agents, Computed Properties of 2215-33-0, the publication is Farmaco, Edizione Scientifica (1985), 40(9), 645-54, database is CAplus and MEDLINE.

Tridentate chelating agents were prepared as derivatives of 2-quinolylhydrazine (I; R = H, Me; R¹ = H, Me, MeO; R² = H, Me; R³ = H, Me), 2-pyridylhydrazine (II; R² = H, Me, Ph; R³ = H, Me), and 2-benzothiazolylhydrazine (III; R² = H, Me, Ph; R³ = H, Me) and tested for antitumor activity in mice bearing lymphocytic leukemia P388. Several of the compounds, including 1-(4‘-methyl-2‘-quinolyl)-3-(2‘-pyridyl)-1,2-diaza-2-propene  [71508-71-9], showed some activity against lymphocytic leukemia P388 in mice; the latter compound, however, was inactive when tested against other tumors.

Farmaco, Edizione Scientifica published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tamura, Masazumi published the artcileCeO₂-catalyzed nitrile hydration to amide: reaction mechanism and active sites, Formula: C6H3FN2, the publication is Catalysis Science & Technology (2013), 3(5), 1386-1393, database is CAplus.

CeO₂ acted as a reusable and effective catalyst for the hydration of various nitriles to amides in water, under neutral conditions at low temperature (30-100 °C). To identify the active site, we examined the relationship between activity and the amount of the pair site of a low-coordinated Ce site (Ce_LC) (oxygen defect site) and adjacent Lewis base (exposed oxygen), determined by methanol adsorption on FTIR. It is revealed that the Ce_LC-O site is the active site for the reaction. To clarify the reaction mechanism, we carried out in situ FTIR studies on the reaction of acetonitrile with surface Ce-OH groups and kinetic studies such as H₂O/D₂O kinetic isotope effect and Hammett plot. The results give the following catalytic cycle: (1) dissociation of H₂O on the Ce_LC-O site (oxygen defect site) to give OH^δ- and H^δ+ species on the site, (2) formation of an adsorption complex between nitrile and CeO₂, (3) addition of OH^δ- to the carbon atom of the cyano group of the complex and (4) desorption of the amide from the CeO₂ surface, accompanying a regeneration of the Ce_LC-O site. On the basis of the above fundamental information, we found a simple method for activity increase; preheating of CeO₂ at 600 °C resulted in desorption of surface carbonate, and the exposed Ce_LC-O site thus prepared showed one order of magnitude higher activity for the hydration of various nitriles than untreated CeO₂.

Catalysis Science & Technology published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C9H5ClO2, Formula: C6H3FN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ito, Satoru published the artcileDiscovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist, Synthetic Route of 107263-95-6, the publication is Bioorganic & Medicinal Chemistry (2008), 16(22), 9817-9829, database is CAplus and MEDLINE.

We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryltriazol-4-yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chem. modification of the lead compound successfully led to fluoropyridine analogs with improved in vivo antagonistic activities. Among the evaluated compounds, a chem. stable urea analog showed oral antagonistic activity at dose ranges of 10-30 mg/kg in an animal model.

Bioorganic & Medicinal Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Synthetic Route of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sekimata, Katsuhiko published the artcileBis-heteroaryl pyrazoles: identification of orally bioavailable inhibitors of activin receptor-like kinase-2 (R206H), Safety of 2-Pyridinylboronic acid, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(3), 224-235, database is CAplus and MEDLINE.

Mutant activin receptor-like kinase-2 (ALK2) was reported to be closely associated with the pathogenesis of fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG), and therefore presents an attractive target for therapeutic intervention. Through in silico virtual screenings and structure-activity relationship studies assisted by X-ray crystallog. analyses, a novel series of bis-heteroaryl pyrazole was identified as potent inhibitors of ALK2 (R206H). Derived from in silico hit compound RK-59638 (6a), compound 18p was identified as a potent inhibitor of ALK2 (R206H) with good aqueous solubility, liver microsomal stability, and oral bioavailability.

Chemical & Pharmaceutical Bulletin published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C6H13BO3, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kamogawa, Hiroyoshi published the artcileRedox photochromism of arylviologen crystals, Synthetic Route of 47369-00-6, the publication is Bulletin of the Chemical Society of Japan (1991), 64(1), 321-3, database is CAplus.

Reversible color development induced by near-UV light (photochromism) was observed for some crystalline powder of 1,1′-diaryl-4,4′-bipyridinium bis(p-toluenesulfonate). Redox mechanism by the electron transfer from the sulfonate anion to viologen dication is claimed.

Bulletin of the Chemical Society of Japan published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Synthetic Route of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kamogawa, Hiroyoshi published the artcileOrganic solid photochromism by photoreduction mechanism: aryl viologens embedded in poly(N-vinyl-2-pyrrolidone), SDS of cas: 47369-00-6, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1988), 26(2), 653-6, database is CAplus.

The reversible photocolor development (photochromism) is reported of N,N‘-diaryl-γ,γ’-dipyridylium dichlorides (aryl viologens) in a poly(N-vinyl-2-pyrrolidone) matrix. Green colors appeared in this case because of the extension of delocalization of electrons of the cation radical caused by the conjugation of aryl groups. Sensitivities to UV light were generally higher than those of conventional benzyl-type viologens.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, SDS of cas: 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mizugaki, Michinao published the artcileExtra-weak chemiluminescence of drugs. I. Extra-weak chemiluminescence of tablets and capsules, Name: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, the publication is Yakugaku Zasshi (1985), 105(4), 401-6, database is CAplus and MEDLINE.

The measurement of extra-weak chemiluminescence of 139 tablets and capsules was carried out with single photoelectron counting apparatus The tablets and capsules tested showed chemiluminescence values of 0 to 1380 counts/10 s, 0 to 10,800 counts/10 s and 37 to 245,000 counts/10 s, at 20, 50 and 80°, resp. Among the drugs tested in this report, imipramine, indole, and phenothiazine derivatives showed high chemiluminescence values.

Yakugaku Zasshi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Name: N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cheng, Ivy published the artcileEffects of pharmacological agents for neurogenic oropharyngeal dysphagia: A systematic review and meta-analysis, Related Products of pyridine-derivatives, the publication is Neurogastroenterology & Motility (2022), 34(3), e14220, database is CAplus and MEDLINE.

This systematic review and meta-anal. aimed to evaluate the effects of pharmacol. agents for neurogenic oropharyngeal dysphagia based on evidence from randomized controlled trials (RCTs). Electronic databases were systematically searched between Jan. 1970 and March 2021. Two reviewers independently extracted and synthesized the data. The outcome measure was changed in (any) relevant clin. swallowing-related characteristics. Data from 2186 dysphagic patients were collected from 14 RCT studies across a range of pharmacotherapies. The pooled effect size of transient receptor potential (TRP) channel agonists was large compared to placebo interventions (SMD[95%CI] =1.27[0.74,1.80], p < 0.001; I2 = 79%). Data were limited for other pharmacol. agents and the overall pooled effect size of these agents was non-significant (SMD [95% CI] =0.25 [-0.24, 0.73]; p = 0.31; I2 = 85%). When analyzed sep., large effect sizes were observed with Nifedipine (SMD[95%CI] =1.13[0.09,2.18]; p = 0.03) and Metoclopramide (SMD[95%CI] =1.68[1.08,2.27]; p < 0.001). By contrast, the effects of angiotensin-converting enzyme (ACE) inhibitors (SMD[95%CI] = -0.67[-2.32,0.99]; p = 0.43; I2 = 61%), Physostigmine (SMD[95%CI] = -0.05[-1.03,0.93]; p = 0.92) and Glyceryl Trinitrate (GTN) (SMD [95% CI] = -0.01 [-0.11, 0.08]; p = 0.78) were non-significant. Within stroke patients, subgroup anal. showed that TRP channel agonists had a moderate pooled effect size (SMD[95%CI] =0.74[0.10,1.39]; p = 0.02; I2 = 82%) whereas the effects of other agents were non-significant (SMD[95%CI] =0.40[-0.04,0.84]; p = 0.07; I2 = 87%). Our results showed that TRP channel agonists, Nifedipine and Metoclopromide may be beneficial for neurogenic dysphagic patients. Large scale, multicenter clin. trials are warranted to fully explore their therapeutic effects on swallowing.

Neurogastroenterology & Motility published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arashiba, Kazuya published the artcileSynthesis and Protonation of Molybdenum- and Tungsten-Dinitrogen Complexes Bearing PNP-Type Pincer Ligands, Safety of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Organometallics (2012), 31(5), 2035-2041, database is CAplus.

Novel molybdenum- and tungsten-dinitrogen complexes bearing PNP-type pincer ligands are prepared and characterized by x-ray anal. Reactions of these molybdenum- and tungsten-dinitrogen complexes with an excess amount of sulfuric acid in THF at room temperature afford ammonia and hydrazine in good yields.

Organometallics published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Safety of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem