Month: December 2022

Makida, Yusuke published the artcileAsymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes, COA of Formula: C5H5BrN2, the publication is Angewandte Chemie, International Edition (2016), 55(39), 11859-11862, database is CAplus and MEDLINE.

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η³-methallyl)₂(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Munshi, Sadeka J. published the artcileMetal(II) chloride complexes containing a tridentate N-donor Schiff base ligand: syntheses, structures and antimicrobial activity, Synthetic Route of 91-02-1, the publication is Journal of Coordination Chemistry (2021), 74(12), 2004-2016, database is CAplus.

One new tridentate N-coordinate ligand, N’-phenyl-N”-(phenyl(pyridin-2-yl)methylene)ethane-1,2-diamine (L), were synthesized and characterized. The tridentate N₃-coordinate ligand L were used in the synthesis of a series of three mononuclear complexes [M(L)Cl₂] [M = Cu(II), Co(II), and Zn(II)] and one polynuclear Cd(II) complex [Cd(L)Cl₂]_n and these complexes were characterized by spectroscopic techniques. The structure of all the complexes has been solved by single-crystal X-ray diffraction studies and the data reveal that all mononuclear complexes have distorted square pyramidal geometry and the polynuclear Cd(II) complex has distorted octahedral geometry. The antimicrobial activity of all complexes was investigated against Gram-pos. (Bacillus subtilis, Staphylococcus aureus) and Gram-neg. (Escherichia coli, Proteus vulgaris) bacteria by disk diffusion method. The compounds demonstrated significant antimicrobial activity while [Cu(L)Cl₂] exhibited the best antibacterial activity among all the synthesized complexes.

Journal of Coordination Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Smith, Ashleigh D. published the artcileSynthesis, characterization and reactivity of iron- and cobalt-pincer complexes, Related Products of pyridine-derivatives, the publication is Polyhedron (2016), 286-291, database is CAplus.

The ^tBuPONOP (2,6-bis(di-tert-butylphosphinito)pyridine) complexes of iron and cobalt, (^tBuPONOP)FeCl₂ (1) and (^tBuPONOP)CoCl₂ (2), were prepared Both complexes are paramagnetic and the solid-state structures of 1 and 2 were determined by single crystal x-ray diffraction studies. Analogous Fe and Co complexes of the ^tBuPNP (2,6-bis(di-tert-butyl-phosphinomethyl)pyridine) ligand (3 and 4, resp.) were prepared to allow comparison between the closely related pincer ligands in the hydrosilylation of carbonyl moieties. All four complexes are catalytically active when treated with NaBEt₃H, which was assumed to generate a metal-hydride species in-situ.

Polyhedron published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C5H10O, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sarkar, Nabin published the artcileAluminum-catalyzed selective hydroboration of carbonyls and dehydrocoupling of alcohols, phenols, amines, thiol, selenol, silanols with HBpin, Name: Phenyl(pyridin-2-yl)methanone, the publication is Polyhedron (2022), 115902, database is CAplus.

A popular N,N’-chelated NacNac analog, i.e., conjugated bis-guanidinate (CBG) stabilized aluminum dihydride LAlH₂ [1; L = ArNC(ArNH):NC:(NHAr)NAr, where Ar = 2,6-Et₂-C₆H₃], demonstrates excellent catalytic hydroboration of a wide array of carbonyls with pinacolborane (HBpin) under neat conditions with good tolerance of reducible functional groups such as alkyl, alkene, halide, nitrile, nitro, ester, amide, and heteroaryl. In addition, we investigated complex 1 catalyzed cross-dehydrocoupling (CDC) of alcs., phenols, amines, thiol, selenol, and silanols with HBpin under mild reaction conditions. Furthermore, several control experiments have been performed to understand the mechanisms in hydroboration and CDC reactions. All corresponding catalytic intermediates have been identified and characterized by ¹H and ¹³C{¹H} NMR spectroscopic methods. In contrast to several reports on metal-catalyzed hydroboration of carbonyls, this is the second report for the mol. aluminum catalyzed CDC of organic substrates with HBpin.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anant, Arjun published the artcileAn analytical review for the estimation of montelukast sodium, Related Products of pyridine-derivatives, the publication is Separation Science plus (2022), 5(5), 120-137, database is CAplus.

A review. Montelukast is a highly potent and selective receptor antagonist of cysteinyl leukotrienes (CysLT1) used in chronic asthma and vasoconstriction reduction and also used in allergies, swelling, hay fever, and shortness of breath. For the measurement of montelukast sodium in biol. and pharmaceutical samples, there are different asynchronous and concurrent anal. methods, such as high-performance thin layer chromatog., UV spectroscopy, capillary electrophoresis, high-performance liquid chromatog., and liquid chromatog.-mass spectrometry, have been developed. The pathogenesis of asthma, mechanism of action, and various anal. methods for the detection of montelukast sodium and its combination of dosage forms and biol. samples have been described in the present review. Ranjan et al. suggested the reverse phase high-performance liquid chromatog. approach for estimating montelukast in rabbit plasma and found the best limit of detection result of 1.0 ng/mL. Ezzeldin et al. developed a liquid chromatog. with tandem mass spectrometry system for the simultaneous detection of combinations of montelukast, gliclazide, and nifedipine. The authors conclude that the studies described in the present manuscript will assist researchers in choosing a simple, rapid, and responsive method for the anal. of montelukast sodium and its combinations.

Separation Science plus published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Das, Prasenjit published the artcileAerobic Direct C(sp2)-H Hydroxylation of 2-Arylpyridines by Palladium Catalysis Induced with Aldehyde Auto-Oxidation, COA of Formula: C11H8N2O2, the publication is ACS Catalysis (2016), 6(9), 6050-6054, database is CAplus.

Herein we present a Pd-catalyzed direct C-H hydroxylation of 2-arylpyridines using mol. oxygen (O₂) as the sole oxidant. The key aspects of the method include: (a) the activation of mol. oxygen with a nontoxic and inexpensive aldehyde; (b) an efficient association of the in situ-generated acyl peroxo radical with palladium catalysis; and (c) convenient operating conditions. On the basis of the results obtained in a series of control experiments, a Pd^II/Pd^IV catalytic cycle is implicated for the transformations. Furthermore, the method offers an easy access to a broad range of substituted 2-(pyridin-2-yl)phenols in good isolated yields.

ACS Catalysis published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, COA of Formula: C11H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pedroni, J. published the artcileEnantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system, Category: pyridine-derivatives, the publication is Chemical Science (2015), 6(9), 5164-5171, database is CAplus and MEDLINE.

Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range of synthetically attractive cyclopropyl containing dihydroquinolones and dihydroisoquinolones as well as allows for an efficient enantioselective construction of the 7-membered ring of the cyclopropyl indolobenzazepine core of BMS-791325.

Chemical Science published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Higashi, Tomohiro published the artcileDiphenyl Viologen on an HOPG Electrode Surface: Less Sharp Redox Wave than Dibenzyl Viologen, Safety of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Langmuir (2013), 29(36), 11516-11524, database is CAplus and MEDLINE.

Redox behavior of di-Ph viologen (dPhV) on a basal plane of a highly oriented pyrolytic graphite (HOPG) electrode was described using the results of voltammetric and electroreflectance measurements. Its characteristics were compared to those of dibenzyl viologen (dBV), which undergoes the 1st-order faradaic phase transition. Unlike dBV, dPhV-dication (dPhV²⁺) was found to take a strongly adsorbed state on an HOPG surface. This is due to much stronger π-π interaction between Ph rings of dPhV²⁺ and HOPG surface than between benzyl groups of dBV²⁺ and the surface. The participation of this strongly adsorbed dPhV²⁺ in the redox process can be avoided by (1) a shorter than âˆ? min time period elapsing from touching a freshly cleaved HOPG surface to dPhV solution until the start of potential scan, (2) complete equilibration at the electrode potentials at which superficial dPhV mols. are fully reduced, or (3) multiple cyclic potential scanning to repeat oxidation-reduction of adsorbed species. Even in such conditions, although voltammograms of thin-layer electrochem. for the surface-confined dPhV^â€?/dPhV²⁺ couple were obtained with peak widths being as narrow as those of dBV, it is not the 1st-order phase transition. The participation of strongly adsorbed dPhV²⁺ mols. results in another new voltammetric feature with a broader peak. The film formed by strongly adsorbed dPhV²⁺ was hydrophilic, whereas dBV²⁺ does not form such a film but only a gas-like layer. Measurements using XPS confirmed that the film consists of dPhV²⁺ with coexistent H₂O. These results reveal a typical case that delicate interaction balance among V²⁺, V^â€?, and electrode surface determines whether the two-dimensional 1st-order transition takes place or not.

Langmuir published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Safety of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schmuelling, Michael published the artcileTo what extent can the Pt-C bond of a metallacycle labilize the trans position? A temperature- and pressure-dependent mechanistic study, Product Details of C5H5NO3S, the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) (1994), 1257-63, database is CAplus.

The orthoplatinated complexes [Pt{C₆H₃X(CH₂NMe₂)}(NC₅H₄SO₃-3)(H₂O)] (X = H 1a or 3-MeO 1b) were designed for mechanistic studies in H₂O. The aqua ligand is located trans to the Pt-C bond of the Ph group which lies in the Pt(II) coordination plane. The rates of substitution of the aqua ligand by nucleophiles (Nu) (Cl^–, Br^–, I^–, N₃^–, SCN^–, thiourea, N,N’-dimethylthiourea or N,N,N’,N’-tetramethylthiourea) were studied as a function of concentration, pH, temperature, and pressure by using a stopped-flow technique. The pK_a value of the aqua ligand in 1a is 9.75 ± 0.505 and the observed pseudo-first-order rate constants for the substitution reaction are given by k_obs = k₁[Nu] + k_-1. The k_-1 term arises from the reverse solvolysis reaction and is insignificant for stronger, S-donor nucleophiles. The values of k₁ are âˆ? orders of magnitude higher than the corresponding rate constants for anation reactions of [Pt(dien)(H₂O)]²⁺ (dien = diethylenetriamine) and close to the rate constants for anation of [Pd(dien)(H₂O)]²⁺. The effect is largely due to a strong decrease in ΔH^{â§?/sup>, ΔSâ§?/sup> and ΔVâ§?/sup>, clearly shows that the substantial rate increase is not associated with a changeover in mechanism and that the substitution process is still associative.}

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schmuelling, M. published the artcileSteric and electronic tuning of the lability of square planar d⁸ metal complexes: platinum(II) â‰?palladium(II), Computed Properties of 636-73-7, the publication is Journal of the Chemical Society, Chemical Communications (1992), 1609-11, database is CAplus.

Electronic tuning of Pt^II complexes via cyclometalation, i.e. the introduction of a Pt-C bond trans to the leaving ligand, can increase their lability to that of related Pd^II complexes.

Journal of the Chemical Society, Chemical Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem