Day: January 4, 2023

Efficient absorption of low partial pressure SO₂ by deep eutectic solvents based on pyridine derivatives was written by Wang, Qiang;Wu, Hongwei;Zhang, Tao;Fan, Yunchang;Zhang, Wencheng;He, Kang. And the article was included in Chemical Engineering Research and Design in 2022.Category: pyridine-derivatives This article mentions the following:

Efficient and reversible absorption of SO₂ by deep eutectic solvents (DESs) has drawn much attention in recent years. In this work, a new type of deep eutectic solvents (DESs) were synthesized via pyridine derivatives, nicotinamide, aminopyridines and hydroxypyridines, as the hydrogen bond donors (HBDs) with common quaternary ammonium salt ionic liquids (ILs) as hydrogen bond acceptors (HBAs). The studied DESs exhibited an attractive absorption behavior for SO₂, especially for low concentration SO₂. The 1-allyl-3-methylimidazolium chloride (AmimCl)/2-aminopyridine (2-NH2Py) (2:1) and 1-butyl-3-methylimidazolium chloride (BmimCl)/3-aminopyridine (3-NH2Py) (2:1) could capture 0.273 and 0.223 g SO₂/g DES at 293 K and 1.0 kPa, resp., surpassing that of most DESs and ILs in the present literature. The influence of DES composition, temperature and pressure on SO₂ absorption performance was systematically investigated. Moreover, the absorption mechanism studied by NMR (NMR) and Fourier transform IR (FT-IR) spectroscopies indicated that the efficient absorption of SO₂ was ascribed to the chem. interaction between the pyridine nitrogen atom and SO₂. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Category: pyridine-derivatives).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâˆ? in pyridine vs. 150 kJ·molâˆ? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of pyridine 1-oxides with benzyne. β-Hydroxyarylation of pyridines via {σ2s + π2a + π4s rearrangements was written by Abramovitch, Rudolph A.;Shinkai, Ichiro. And the article was included in Journal of the American Chemical Society in 1974.Synthetic Route of C7H9NO This article mentions the following:

Pyridine 1-oxides react with benzyne to give mainly the corresponding 3-(ο-hydroxyphenyl)-pyridines via a novel [σ2s + π2a + π4s] rearrangement. If the pyridine β-positions are blocked 3,5-disubstituted 2-(ο-hydroxyphenyl) pyridines are formed. Unusual dihydropyridine intermediates leading to the latter compounds were isolated and characterized. Addnl. evidence for a 2,3-dihydropyridine intermediate I (R = R1 = Me) was adduced from the reaction of 3,5-dichloropyridine 1-oxide with benzyne which led to 3-chloropyrido[3,2-b]benzofurn I (R = H, R1 = Me) in good yield. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Synthetic Route of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scale-Up Synthesis of IID572: A New β-Lactamase Inhibitor was written by Furegati, Markus;Nocito, Sandro;Reck, Folkert;Casarez, Anthony;Simmons, Robert;Schuetz, Heiner;Koch, Guido. And the article was included in Organic Process Research & Development in 2020.Reference of 59718-84-2 This article mentions the following:

The new potentially best-in-class β-lactamase inhibitor IID572 (I) was discovered by a late stage functionalization approach. An alternative synthesis was developed to satisfy the short-term material need for toxicol. studies in animals. The new synthetic strategy was built on two key features, an intramol. azomethine ylide [3+2] cycloaddition that allowed the efficient formation of mol. complexity from readily available starting materials and an enzymic resolution that resulted in high optical purity of a key intermediate. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Reference of 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Comparative study of palladium(II) complexes bearing tridentate ONS and NNS Schiff base ligands: Synthesis, characterization, DFT calculation, DNA binding, bioactivities, catalytic activity, and molecular docking was written by Singh, Anmol;Priya Gogoi, Himadri;Barman, Pranjit. And the article was included in Polyhedron in 2022.HPLC of Formula: 91-02-1 This article mentions the following:

Two palladium (II) Schiff base complexes were prepared by using equivalent molar of Schiff base ligand [L¹ = (E)-2-(((2-(benzylthio)phenyl)imino)methyl)naphthalen-1-ol and L² = (E)-N-(2-(benzylthio)phenyl)-1-phenyl-1-(pyridin-2-yl)methanimine] and sodium tetrachloropalladate. The structure of ligands and complexes were characterized by physicochem. and spectroscopic analyses. The results suggested that the Pd(II) complexes have a distorted square planar geometry when coordinated to the tridentate ONS from L¹ and the NNS donor ligand from L². Electronic absorption and spectrofluorometric measurements were employed to investigate the DNA binding of ligands and their associated complexes with CT-DNA. DFT calculations were used to optimize the geometric structures and calculate the electronic and structural properties of the synthesized compounds NBO anal. was also performed in combination with the TD-DFT method. Moreover, to study the reactivity and bioactivity, the synthesized compounds were tested for in-vitro antioxidant activity by utilizing the DPPH method, in-vitro anti-inflammatory activity using protein denaturation method, and in-vitro anti-diabetic activity employing α-glucosidase and α-amylase enzymes. The results reflect that PdL¹ is more biol. potent than PdL² or other related palladium complexes, as discussed in the literature. The binding mechanism of the synthesized compounds with CT-DNA, α-glucosidase, and α-amylase, was investigated using mol. docking experiments In addition to these, the catalytic activity of palladium metal complexes (PdL¹ and PdL²) was evaluated for the Suzuki-Miyaura reaction for comparisons. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1HPLC of Formula: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological activity of thiazolidine piperidine nicotinamide compounds was written by Ding, Chengrong;Pan, Yayun;Yin, Xu;Tan, Chengxia. And the article was included in Youji Huaxue in 2019.Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:

The structure of thiazolidine piperidine could affect the metabolic activities of cholesterol compounds in vivo, and it is the key pharmacophore of oxythiazolidine to inhibit the oxygen cholesterol-binding protein (OSBP) of pathogenic bacteria. 14 Novel thiazolidine piperidine nicotinamide derivatives were designed and synthesized in search of new bioactive compounds containing thiazolidine piperidine structure. The structures of target compounds were characterized by ¹H NMR, ¹³C NMR and HRMS spectra. The preliminary bioassay showed that the target compounds generally had antibacterial activities. At the concentration of 100μg/mL, the antibacterial activity of one compound against Fusarium graminearum was 60%, the antibacterial activities of three compounds against Botrytis cinerea were 60%, the bacteriostatical activities of six compounds against Diplocarpon mali were 70%, and the antibacterial activity of(4-(5-(2,3-dichlorophenyl)-4-methylthiazol-2-yl)piperidin-1-yl)(5,6-dichloropyridin-3-yl)methanone (6k) against Phytophthora infestans (Mont.) de Bary was 75%. Therefore it was worth for further research about structural optimization. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Oxidation of Benzylic C-H Bonds of Six-Membered N-Heteroaromatic Compounds was written by Gao, Xianying;Han, Shuaijun;Zheng, Maolin;Liang, Apeng;Li, Jingya;Zou, Dapeng;Wu, Yusheng;Wu, Yangjie. And the article was included in Journal of Organic Chemistry in 2019.Application In Synthesis of 4-Methylpicolinonitrile This article mentions the following:

A novel oxidation of benzylic C-H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones was developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application In Synthesis of 4-Methylpicolinonitrile).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 4-Methylpicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Germanium Hydride Catalyzed Selective Hydroboration and Cyanosilylation of Ketones was written by Khuntia, Anwesh Prasad;Sarkar, Nabin;Patro, A. Ganesh;Sahoo, Rajata Kumar;Nembenna, Sharanappa. And the article was included in European Journal of Inorganic Chemistry in 2022.Application In Synthesis of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Two new examples of β-diketiminate or NacNac analogs, i. e., conjugated bis-guanidinate (CBG) stabilized low valent germanium chloride (1) and germanium hydride (2) complexes, are reported. Deprotonation of LH upon treatment with n-BuLi and an in situ generated LLi further treated with GeCl₂·dioxane afforded LGeCl in 79% yield. Compound 1 reacted with hydride source NaHBEt₃ in toluene, afforded Ge (II) hydride (2) in 76% yield. Both compounds 1 and 2 were characterized by NMR and mass spectroscopic methods. Further, germanium hydride catalyzed hydroboration and cyanosilylation of a wide range of ketones have been investigated. Control reactions suggest hydroboration reactions occurred via insertion and Ge-O/B-H bond metathesis pathways. It is worthy of mentioning that, in the case of hydroboration of ketones, reducible groups such as alkene, alkyne, halide, ester, nitro, and heterocycles were untouched. Furthermore, compound 2 was employed for the reduction of carbonate, formate, and anhydride substrates via the hydroboration technique. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application In Synthesis of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermal parameters associated to micellization of dodecylpyridinium bromide and chloride in aqueous solution was written by Galan, J. J.;Gonzales-Perez, A.;Del Cactillo, J. L.;Rodriguez, J. R.. And the article was included in Journal of Thermal Analysis and Calorimetry in 2002.Recommanded Product: 104-73-4 This article mentions the following:

Elec. conductivity of aqueous solutions of dodecylpyridinium chloride and bromide have been determined From these data the critical micelle concentration (cmc) was determined The thermal properties as standard Gibbs free energy, enthalpy and entropy of micellization was estimated from a uncharged-phase separation model and enables to obtain another properties like heat capacity of micellization and the relevant parameters in the min. of temperature dependence of cmc. The enthalpy-entropy compensation was shown for the studied compounds In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Recommanded Product: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Highly Regio-, Diastereo-, and Enantioselective C-H Insertions of Methyl Aryldiazoacetates into Cyclic N-Boc-Protected Amines. Asymmetric Synthesis of Novel C₂-Symmetric Amines and threo-Methylphenidate was written by Davies, Huw M. L.;Hansen, Tore;Hopper, Darrin W.;Panaro, Stephen A.. And the article was included in Journal of the American Chemical Society in 1999.Product Details of 85838-94-4 This article mentions the following:

The reaction of cyclic N-Boc-protected amines (e.g., N-Boc-pyrrolidine, -piperidine, and -1,2,3,6-tetrahydropyridine) with aryldiazoacetates R¹C(:N₂)CO₂Me (R¹ = Ph, p-ClC₆H₄, p-MeC₆H₄, 2-naphthyl, p-MeOC₆H₄) catalyzed by Rh₂(S-DOSP)₄ or Rh₂(S-biDOSP)₂ [DOSP = N-[(4-dodecylphenyl)sulfonyl]prolinate] is proposed as a method for the asym. synthesis of chiral amines I and II and threo-methylphenidate (Ritalin). Thus C-H insertions with the above aryldiazoacetates can be achieved with high regio-, diastereo-, and enantioselectivity. These carbenoids are particularly selective toward C-H insertions into methylene groups adjacent to an amide nitrogen. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Product Details of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reversible and Sensitive Hg²⁺ Detection by a Cell-Permeable Ytterbium Complex was written by Bao, Guochen;Zha, Shuai;Liu, Zhenyu;Fung, Yan-Ho;Chan, Chi-Fai;Li, Hongguang;Chu, Pak-Ho;Jin, Dayong;Tanner, Peter A.;Wong, Ka-Leung. And the article was included in Inorganic Chemistry in 2018.Product Details of 131747-45-0 This article mentions the following:

A cell-permeable ytterbium complex shows reversible binding with Hg²⁺ in aqueous solution and in vitro by off-on visible and NIR emission. The fast response and 150 nM sensitivity of Hg²⁺ detection is based upon FRET and the lanthanide antenna effect. The reversible Hg²⁺ detection can be performed in vitro, and the binding mechanism is suggested by NMR employing the motif structure in a La complex and by DFT calculations In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Product Details of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem