Day: January 5, 2023

Thermal properties of 1-alkyl-3-methylpyridinium halide-based ionic liquids was written by Sashina, Elena S.;Kashirskii, Dmitrii A.;Janowska, Grazyna;Zaborski, Marian. And the article was included in Thermochimica Acta in 2013.Category: pyridine-derivatives This article mentions the following:

This study was carried out for the comparison of thermal properties that determine various conditions and methods, including the DSC, thermogravimetry (DTG), and the Boetius heated stage. Series of 1-alkyl-3-methylpyridinium chloride- and bromide-based ionic liquids having alkylic chain lengths ranging from C₂ to C₁₀ were synthesized, and their thermal characteristics were defined: glass transitions, melting and decomposition Detailed thermal properties of ionic liquids, obtained in this work, can be useful in a variety of chem. engineering processes that are related with their application. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Category: pyridine-derivatives).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides was written by Petchey, Mark;Cuetos, Anibal;Rowlinson, Benjamin;Dannevald, Stephanie;Frese, Amina;Sutton, Peter W.;Lovelock, Sarah;Lloyd, Richard C.;Fairlamb, Ian J. S.;Grogan, Gideon. And the article was included in Angewandte Chemie, International Edition in 2018.Application In Synthesis of 6-Acetylpicolinic acid This article mentions the following:

Amide bond formation is one of the most important reactions in pharmaceutical synthetic chem. The development of sustainable methods for amide bond formation, including those that are catalyzed by enzymes, is therefore of significant interest. The ATP-dependent amide bond synthetase (ABS) enzyme McbA, from Marinactinospora thermotolerans, catalyzes the formation of amides as part of the biosynthetic pathway towards the marinacarboline secondary metabolites. The reaction proceeds via an adenylate intermediate, with both adenylation and amidation steps catalyzed within one active site. In this study, McbA was applied to the synthesis of pharmaceutical-type amides from a range of aryl carboxylic acids with partner amines provided at 1-5 molar equivalents. The structure of McbA revealed the structural determinants of aryl acid substrate tolerance and differences in conformation associated with the two half reactions catalyzed. The catalytic performance of McbA, coupled with the structure, suggest that this and other ABS enzymes may be engineered for applications in the sustainable synthesis of pharmaceutically relevant (chiral) amides. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Application In Synthesis of 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors was written by Green, Jeremy;Cao, Jingrong;Bandarage, Upul K.;Gao, Huai;Court, John;Marhefka, Craig;Jacobs, Marc;Taslimi, Paul;Newsome, David;Nakayama, Tomoko;Shah, Sundeep;Rodems, Steve. And the article was included in Journal of Medicinal Chemistry in 2015.HPLC of Formula: 3939-14-8 This article mentions the following:

The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphol., and contraction and are of therapeutic interest in diseases associated with cellular migration and contraction, such as hypertension, glaucoma, and erectile dysfunction. Beginning with compound 4, an inhibitor of ROCK1 identified through high-throughput screening, systematic exploration of SAR, and application of structure-based design, led to potent and selective ROCK inhibitors. Compound 37 represents significant improvements in inhibition potency, kinase selectivity, and CYP inhibition and possesses pharmacokinetics suitable for in vivo experimentation. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8HPLC of Formula: 3939-14-8).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 3939-14-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Study on “Urea to Urea” Approach: Access to Unsymmetrical Ureas Bearing Pyridyl Substituents was written by Kasatkina, Svetlana O.;Geyl, Kirill K.;Baykov, Sergey V.;Novikov, Mikhail S.;Boyarskiy, Vadim P.. And the article was included in Advanced Synthesis & Catalysis in 2022.COA of Formula: C7H9NO This article mentions the following:

A protocol for the synthesis of unsym. ureas substituted by pyridyl/quinolinyl moiety was developed. This method concluded in metal- and base-free reamination of N,N-dimethyl-N’-hetaryl ureas with a wide range of aryl and alkyl amines. The isolated yields varied from 40 to 96% depending on the nucleophilicity of the amines. The scope of this method includes more than 50 examples. The reaction was not hindered by either donor or acceptor groups as well as diverse functionalities. The synthesis was easily scaled to gram quantities. Theor. calculations supported by exptl. data allowed to propose a plausible mechanism for the process. This reaction takes place through the intermediate formation of hetaryl isocyanate. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8COA of Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The thermal condensation of imidazoles with carbonyl compounds was written by Roe, A. M.. And the article was included in Journal of the Chemical Society in 1963.Electric Literature of C7H10N2 This article mentions the following:

1-Substituted 2-(1-hydroxy-1-alkyl-and aryl)imidazoles (I) are obtained by thermal condensation of 1-methyl-, 1-benzyl-, and 1-methoxy-methylimidazole with aldehydes. These and other alc. are also obtained from the Li derivativeof the imidazole. 2-Acetylimidazole has been preparedand characterized. 1,4-Diketones react with imidazole to give imidazo[1,2-a]pyridines (II). In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0Electric Literature of C7H10N2).

3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Multilayer thin films by layer-by-layer assembly of hole- and electron-transport polyelectrolytes: optical and electrochemical properties was written by Choi, Kyungsun;Zentel, Rudolf. And the article was included in Macromolecular Chemistry and Physics in 2006.Electric Literature of C12H8N4O This article mentions the following:

A series of p-type and n-type semiconducting polyelectrolytes with triarylamine, oxadiazole, thiadiazole, and triazine moieties were prepared by radical polymerization of triarylamine monomers with maleic anhydride, followed by ring opening of the anhydride and formation of amide bonds. The synthesized polymeric hole and electron transport materials were examined optically and electrochem. using UV/Vis spectroscopy, photoluminescence (PL) spectroscopy and CV (cyclic voltammetry). Based on the optical and electrochem. data, each of the energy levels were calculated and values suggest that the polyelectrolytes are promising hole- (p-type) or electron-transport (n-type) materials for devices. The synthesized ionic polymers were suitable for LBL (layer-by-layer) thin film deposition from dilute polymer solutions and the multilayers were fully characterized by UV/Vis, PL spectroscopy and CV. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Electric Literature of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Electric Literature of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Mediated One-Pot Synthesis of 2,2-Difluoro-1,3-benzoxathioles from o-Bromophenols and Trifluoromethanethiolate was written by Zhang, Mengjia;Chen, Shouxiong;Weng, Zhiqiang. And the article was included in Organic Letters in 2018.SDS of cas: 13472-81-6 This article mentions the following:

A Cu-mediated difluoromethylenation of o-bromophenols with trifluoromethanethiolate is described. This 1-pot protocol proceeds through an intermol. addition of S:CF₂ (resulting from the decomposition of trifluoromethanethiolate) to o-bromophenols followed by intramol. C-S coupling to form 2,2-difluoro-1,3-benzoxathioles. This method is compatible with a broad range of substrates and enables the late-stage difluoromethylenation of several functionally dense drug like o-bromophenols. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6SDS of cas: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Unprecedented trinodal four-connected FRL MOF based on mixed ligands was written by Li, Peng;Lou, Jiaying;Zhou, Yaming;Liu, Xiaofeng;Chen, Zhenxia;Weng, Linhong. And the article was included in Dalton Transactions in 2009.Related Products of 15420-02-7 This article mentions the following:

The hydrothermal reaction of Zn(OAc)₂·2H₂O, H₃btc (1,3,5-benzenetricarboxylic acid), and 4-bpo (N,N’-bis(4-picolinoyl)hydrazine) affords a novel trinodal four-connected frl topol. coordination polymer, [Zn₄(btc)₂(4-bph)(H₂O)₄]_n·2n(H₂O) (1, 4-bphH₂ is in situ synthesized from 2,5-bis(4-pyridyl)-1,3,4-oxadiazole), which was characterized by x-ray crystallog. and exhibits reversible two-step dehydration-rehydration. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Related Products of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Highly Fluorescent Pyrido[2,3-b]indolizine-10-Carbonitriles through Pseudo Three-Component Reactions of N-(Cyanomethyl)pyridinium Salts was written by Sokolova, Ekaterina A.;Festa, Alexey A.;Golantsov, Nikita E.;Lukonina, Natalia S.;Ioffe, Ilya N.;Varlamov, Alexey V.;Voskressensky, Leonid G.. And the article was included in European Journal of Organic Chemistry in 2019.Product Details of 17281-59-3 This article mentions the following:

An interaction of N-(cyanomethyl)pyridinium salts with vinamidinium perchlorates or enaminones proceeds as a pseudo-three component process and results in the formation of 3- or 2-substituted pyrido[2,3-b]indolizine-10-carbonitriles, resp. Optical properties of these compounds have been evaluated, revealing effective green light emission with fluorescence quantum yields of up to 0.81. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Product Details of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C-H Cyanation of 6-Ring N-Containing Heteroaromatics was written by Elbert, Bryony L.;Farley, Alistair J. M.;Gorman, Timothy W.;Johnson, Tarn C.;Genicot, Christophe;Lallemand, Benedicte;Pasau, Patrick;Flasz, Jakub;Castro, Jose L.;MacCoss, Malcolm;Paton, Robert S.;Schofield, Christopher J.;Smith, Martin D.;Willis, Michael C.;Dixon, Darren J.. And the article was included in Chemistry – A European Journal in 2017.COA of Formula: C8H6N2O2 This article mentions the following:

Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chem. and the biomedical sciences. Herein, we report an approach to heteroaromatic C-H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures. In the experiment, the researchers used many compounds, for example, Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4COA of Formula: C8H6N2O2).

Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C8H6N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem