Day: January 5, 2023

Molecular spectra and molecular structure of heterocyclic compounds. Infrared and near ultraviolet absorption spectra of pyridine N-oxide derivatives was written by Ghersetti, Sergio;Maccagnani, Gaetano;Mangini, Angelo;Montanari, F.. And the article was included in Journal of Heterocyclic Chemistry in 1969.Formula: C7H9NO This article mentions the following:

The IR and UV spectra of many pyridine N-oxide derivatives (I) have been studied. The UV spectra show a strong solvent effect in going from aprotic to hydroxylic solvents due to strong H bonding. Values of ΔH° for several systems MeOH-I in tetrachloroethylene solution were evaluated by IR techniques and a linear correlation ΔH° vs.Δ MeOH was found. Features of the IR and UV characteristic absorption bands were also investigated. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability was written by Chino, Ayaka;Masuda, Naoyuki;Amano, Yasushi;Honbou, Kazuya;Mihara, Takuma;Yamazaki, Mayako;Tomishima, Masaki. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine This article mentions the following:

In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening hit compound from an inhouse library. Next, optimization of the imidazopyridine moiety to improve inhibitory activity gave imidazopyridinone 10b. Following further structure-activity relationship development by reducing lipophilicity and introducing substituents, we acquired 35, which exhibited both improved metabolic stability and reduced CYP3A4 time-dependent inhibition. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine).

2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Chloro-4-methoxy-3-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recyclable Pd(II)complex catalyzed oxidative sp² C-H bond acylation of 2-aryl pyridines with toluene derivatives was written by Perumgani, Pullaiah C.;Parvathaneni, Sai Prathima;Keesara, Srinivas;Mandapati, Mohan Rao. And the article was included in Journal of Organometallic Chemistry in 2016.COA of Formula: C12H11N This article mentions the following:

A recyclable polymer-anchored Pd(II) complex C was synthesized and characterized using different spectroscopic techniques. In addition the catalytic efficiency of the Pd (II) complex C was evaluated for ortho-acylation of 2-aryl pyridines with toluene derivatives to form aryl ketones via cross dehydrogenative coupling. In this catalytic process toluene acts as an effective coupling partner upon sp³ C-H bond oxidation for sp² C-H bond acylation of 2-aryl pyridines in the presence of Pd(II)/TBHP system on water. Furthermore, the catalyst C was highly stable and could be easily recovered and reused for four cycles with no significant decrease in its activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of meta-substituted [¹⁸F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N-oxides was written by Brugarolas, P.;Freifelder, R.;Cheng, S.-H.;DeJesus, O.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Related Products of 116922-60-2 This article mentions the following:

A methodol. for the preparation of 3-fluoro-4-aminopyridine was developed via two-step procedure involving fluorination of 3-bromo-4-nitropyridine N-oxide to yield 3-fluoro-4-nitropyridine N-oxide as an intermediate in first step and its reduction via catalytic hydrogenation in second step. Furthermore, this approach was successfully applied for the preparation of [¹⁸F]3-fluoro-4-aminopyridine. The use of pyridine N-oxides for the preparation of fluoropyridines was unprecedented in chem. literature and had potential to offer a new way for the synthesis of these important structures in pharmaceuticals and radiopharmaceuticals. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluoropyridine (cas: 116922-60-2Related Products of 116922-60-2).

3-Bromo-4-fluoropyridine (cas: 116922-60-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 116922-60-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of alkylpyridine structure on the reaction of diphenylphosphinic acid hydrazide with phenyl isothiocyanate was written by Yanchuk, N. I.;Bodrov, V. P.;Tsareva, N. V.. And the article was included in Zhurnal Obshchei Khimii in 1986.SDS of cas: 644-98-4 This article mentions the following:

The catalytic effect of 2-, 3- or 4-methyl-, 2-ethyl-, 2-isopropyl-, 2,4- or 2,6-dimethyl-, and 2,4,6-trimethylpyridine on the rate of Ph₂P(O)NHNH₂ addition with PhNCS to give Ph₂P(O)NHNHCSNHPh was studied. The reaction proceeds via 2 parallel mechanisms, catalytic and noncatalytic. The pyridines with the N atom shielded by alkyl radicals have very low catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermal stability of some organic compounds was written by Johns, I. B.;McElhill, E. A.;Smith, J. O.. And the article was included in Journal of Chemical and Engineering Data in 1962.Safety of 2-Phenoxypyridine This article mentions the following:

Decomposition temps, as defined previously (Ind. Eng. Chem., Prod. Res. Develop. 1, 2-6(1962)) are given for approx. 90 compds, in the classes: aromatic, substituted aromatic, heterocyclic, s-triazine, Si, B, P, and F compounds Decomposition products of 42 of the compounds are identified. Vapor pressure data for 16 of the compounds are given as constants in the equation log P_mm = b – a/T. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Safety of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and dissolving power of 1-Alkyl-3-methylpyridinium-based ionic liquids was written by Sashina, E. S.;Kashirskii, D. A.;Zaborski, M.;Jankowski, S.. And the article was included in Russian Journal of General Chemistry in 2012.Name: 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

1-Alkyl-3-methylpyridinium-based ionic liquids with substituents from C₂ to C₁₀ and anions Cl^– and Br^– were synthesized, and their dissolving power toward the cellulose was investigated. The results of quantum-chem. calculations of mols. of ionic liquids are presented. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Name: 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper (I) coordination polymers with extended π···π interactions: syntheses, structures, characterization and luminescent properties was written by Huang, Ting-hong;Yan, Jie;Yang, Hu;Zeng, Xian-guang;Yang, Yan. And the article was included in Wuji Huaxue Xuebao in 2015.Synthetic Route of C12H8N4O This article mentions the following:

Two copper(I) coordination polymers, {[Cu₂(4-bpo)₂(MeCN)₂(PPh₃)₂](BF₄)₂}_n (1), {[Cu(4-bpo)(MeCN)(dppe)_0.5]BF₄}_n (2) (PPh₃ = triphenylphosphine, dppe = 1,2-bis(di-Ph phosphino)ethane, 4-bpo = 2,5-bis(4-pyridyl)-1,3,4-oxadiazole), were synthesized and characterized by IR, ¹H NMR, ¹⁹F NMR, ¹¹B NMR, elemental anal. and x-ray crystal structure anal. The structural anal. showed that complexes 1 and 2 consisted of diverse and interesting 2D supramol. structures formed by inter-chain interactions. For 1, π-stacking interactions result in the construction of 1D bilayer chain and 2D supramol. network. Compound 2 exhibits a 1D ladder-like chain and a 1D+1D→2D/3D supramol. structure formed by π-stacking interactions. Solid-state emission spectra of complexes 1 and 2 were studied, displaying the existence of ILCT/MLCT excited states. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Synthetic Route of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature was written by Jung, Seo-Hee;Sung, Dan-Bi;Park, Cho-Hee;Kim, Won-Suk. And the article was included in Journal of Organic Chemistry in 2016.Name: 3,5-Dibromo-2-hydroxypyridine This article mentions the following:

A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Name: 3,5-Dibromo-2-hydroxypyridine).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 3,5-Dibromo-2-hydroxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation and characterization of organo-bentonites modified by different surfactants was written by Zhou, Xiaojian;Wang, Xiaozhi;Jin, Cuili;Zhao, Bin;Yan, Feng;Feng, Ke. And the article was included in Asian Journal of Chemistry in 2012.Safety of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

Clay minerals with 2:1 type structure possess prodigious area of inner-surface in silicate interlayers. Inserting surfactants into the interlayers will change the characteristics of inner-surface from hydrophilic to hydrophobic ones, which significantly enlarges the capacity of clay minerals to adsorb organic pollutants. Surfactants on the inner-surface of silicates can affect the phys. and chem. properties of the inner-surface and the dimension of interspace. The array forms of the surfactant mols. on the inner-surface of minerals may also influence adsorption capacity to a special organic pollutant. In the present study four surfactants, cetyltrimethylammonium bromide (CTMAB), cetylpyridinium bromide (CPB), dodecyltrimethylammonium bromide (DTMAB) and dodecylpyridiniumbromide (DPB) were selected for production of organo-bentonite. With burning and X-radial diffraction (XRD) the amount of surfactants adsorbed on the inner-surface of bentonite were measured and the mol. array forms of surfactants on the inner-surface of bentonite were discussed. The results were as follows: (1) all surfactants tested could be adsorbed onto the inner-surface of bentonite, which increased the distance between layers of elemental cells; (2) for surfactants with same length of carbon chain, one with pyridinium head is more easily adsorbed on the inner-surface of bentonite than that with trimethylammonium; for surfactants with same head but different length of carbon chains, the one with greater length is more easily adsorbed onto inner-surface of bentonite; (3) The possible mol. array forms of cetyltrimethylammonium bromide and cetylpyridinium bromide, which possess carbon chain with 16 carbon atoms, was assumed to be a pseudo-trilayer lying on the inner-surface of bentonite and those for dodecyltrimethylammonium bromide and dodecylpyridiniumbromide, which possess carbon chain with 12 carbon atoms, were assumed to be a tightly-combined lateral bilayer; (4) with increasing concentration of surfactants the mol. array forms of surfactants on the inner-surface of bentonite became complex: monolayer → lateral bilayer → paraffin-type monolayer → pseudo-trilayer. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Safety of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem