Day: January 5, 2023

Doping engineering of single-walled carbon nanotubes by nitrogen compounds using basicity and alignment was written by Kumanek, Bogumila;Milowska, Karolina Z.;Przypis, Lukasz;Stando, Grzegorz;Matuszek, Karolina;MacFarlane, Douglas;Payne, Mike C.;Janas, Dawid. And the article was included in ACS Applied Materials & Interfaces in 2022.Safety of Pyridin-4-ol This article mentions the following:

Charge transport properties in single-walled carbon nanotubes (SWCNTs) can be significantly modified through doping, tuning their elec. and thermoelec. properties. In our study, we used more than 40 nitrogen-bearing compounds as dopants and determined their impact on the material’s elec. conductivity The application of nitrogen compounds of diverse structures and electronic configurations enabled us to determine how the dopant nature affects the SWCNTs. The results reveal that the impact of these dopants can often be anticipated by considering their Hammett’s constants and pK_a values. Furthermore, the empirical observations supported by first-principles calculations indicate that the doping level can be tuned not only by changing the type and the concentration of dopants but also by varying the orientation of nitrogen compounds around SWCNTs. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rh^III-Catalyzed Olefination of 2-Aryloxy-pyridines Using 2-Pyridyloxyl as the Removable Directing Group was written by Borah, Arun Jyoti;Yan, Guobing;Wang, Lianggui. And the article was included in European Journal of Organic Chemistry in 2015.Safety of 2-Phenoxypyridine This article mentions the following:

An efficient Rh^III-catalyzed trans selective ortho-olefination of 2-aryloxypyridines I (R = 2-FC₆H₄, 4-ClC₆H₄, 3-F₃CC₆H₄, 2-H₃CC₆H₄, etc.) has been developed. The catalytic system is very effective for olefination of differently substituted 2-aryloxypyridines with acrylates or acrylamide CH₂:CHCOR¹ [R¹ = OCH₂CH₃, OCH₃, N(CH₃)₂, etc.] and styrenes R²CH:CH₂ [R² = 2-ClC₆H₄, 4-(H₃C)₃CC₆H₄, naphthalen-1-yl, etc.] and exhibits broad compatibility with assorted olefinic coupling partners. Although acrylates and acrylamide give rise to trans-olefinated products II in MeOH, styrenes provided the trans products III under solvent-free reaction conditions. Interestingly, in olefinations with Et acrylate, the aryloxypyridine compound bearing keto functionality at the ortho position was found to undergo directing group cleavage to afford the olefinated phenol product 2-HO-3-H₃CC₆H₃CH:CHC₆H₅ directly. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Safety of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ag₁Pd₁-rGO nanocomposite as recyclable catalyst for CDC reactions of 2-arylpyridines with aldehydes was written by Hu, Qiyan;Liu, Xiaowang;Huang, Fei;Wang, Feifan;Li, Qian;Zhang, Wu. And the article was included in Catalysis Communications in 2018.Product Details of 4373-61-9 This article mentions the following:

Ag₁Pd₁ nanoparticle-reduced graphene oxide (Ag₁Pd₁-rGO) nanocomposite was used as an efficient catalyst for the synthesis of aromatic ketones via cross dehydrogenative coupling (CDC) reactions of 2-arylpyridines with aldehydes. The catalyst can be reused for 5 cycles without significantly losing its catalytic activity. On the basis of the obtained exptl. evidence, a possible mechanism for the heterogeneous catalysis is proposed. The supported catalysts exhibit a set of benefits, including extraordinarily catalytic activity, high reusability and remarkable tolerance of a variety of substrates. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Product Details of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug was written by Hayashi, Shigeo;Ueno, Naomi;Murase, Akio;Nakagawa, Yoko;Takada, Junji. And the article was included in European Journal of Medicinal Chemistry in 2012.Synthetic Route of C7H6N2 This article mentions the following:

Cyclooxygenase (COX) is a key rate-limiting enzyme for prostaglandin (PG) production cascades in the human body. The mechanisms of both the anti-inflammation effects and the side-effects of traditional COX inhibitors are associated with the existence of two COX isoforms. Thus while COX-1 is predominantly expressed ubiquitously and constitutively, and it serves a housekeeping role in processes such as gastrointestinal (GI) mucosa protection, COX-2 is absent or exhibits a low level of expression in most tissues, and is highly upregulated in response to endotoxin, virus, inflammatory or tissue-injury stimuli/signals, and tumor promoter in the various types of organs, tissues, and cells. Furthermore, COX-2 contribution to PGE₂ and PGI₂ production evokes and sustains systemic or peripheral inflammatory disease, but it is not involved in the COX-1-mediated GI tract events. Also, hypersensitivity of aspirin owing to its inhibitory action against COX-1 is a significant concern clin. Consequently, highly selective COX-2 inhibitors have been needed for the treatment of inflammatory- and inflammation related-diseases that include pyrexia, inflammation, pain, rheumatoid arthritis, osteoarthritis, and cancers. In this study, a series of novel [2-{[(4-substituted or 4,5-disubstituted)-pyridin-2-yl]carbonyl}-(5- or 6-substituted or 5,6-disubstituted)-1H-indol-3-yl]acetic acid analogs was designed, synthesized, and evaluated to identify potent and selective COX-2 inhibitors as potential agents against inflammatory diseases. As significant findings, the present study clarified unique structure-activity relationship of the analogs toward potent and selective COX-2 inhibition in vitro, and identified 2-{6-fluoro-2-[(4-methyl-2-pyridinyl)carbonyl]-1H-indol-3-yl}acetic acid as a potent and selective COX-2 inhibitor in vitro that demonstrated orally potent anti-inflammation efficacy against carrageenan-induced edema formation in the foot of SPF/VAF male SD rats as a peripheral inflammation model in vivo. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Synthetic Route of C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalysis by α-substituted pyridines in the hydrolysis of aryl acetates and acetic anhydride was written by Deady, Leslie W.;Finlayson, Wayne L.. And the article was included in Australian Journal of Chemistry in 1983.HPLC of Formula: 24103-75-1 This article mentions the following:

Rate constants for the hydrolyses of p-nitrophenyl acetate (I), 2,4-dinitrophenyl acetate (II) and, acetic anhydride in the presence of α-substituted pyridines were determined Broensted LFER plots for I and II were linear over 4 pKa units. The 2-Me and 2-NH₂ substituted pyridines catalyze the hydrolyses by a nucleophilic mechanism. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1HPLC of Formula: 24103-75-1).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.HPLC of Formula: 24103-75-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of germination on the physicochemical properties of peanut seeds and volatile components of roasted sprouted peanut was written by Jin, Lu;Zhang, Li-xia;Zhang, Dong-lin;Sun, Qiang;Sun, Xiao-jing;Wei, Song-li. And the article was included in Shipin Yanjiu Yu Kaifa in 2021.Recommanded Product: 823-61-0 This article mentions the following:

To investigate the effect of germination and peanut variety on the physicochem. properties of peanut seeds and volatile components of roasted sprouted peanuts, Yuhua 37, Yuhua 65, Yuanza 9102 and Yuhua 9326 were germinated to different degrees, and the main nutritional contents of peanut seeds and volatile components of roasted sprouted peanut were analyzed. Results showed that with the development of germination, there was no significant difference in the ash content. The crude fat content gradually decreased and the crude protein content decreased first and then increased. A total of 79 volatile compounds were identified in roasted sprouted peanuts, including pyrazines, aldehydes, ketones, furans, pyrroles, pyridines, hydrocarbons, etc., while pyrazines (57.91%-62.42%, Yuhua 9326 > Yuhua 37 > Yuhua 65 > Yuanza 9102) were detected with the highest relative content followed by aldehydes (19.48%-23.87%, Yuanza 9102 > Yuhua 65 > Yuhua 9326 > Yuhua 37). The content of pyrazines in roasted sprouted peanuts increased with the development of germination, while the content of aldehydes increased first and then decreased significantly with the development of germination. In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0Recommanded Product: 823-61-0).

3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 823-61-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ruthenium-catalyzed C-H bond arylations of arenes bearing removable directing groups via six-membered ruthenacycles was written by Ackermann, Lutz;Diers, Emelyne;Manvar, Atul. And the article was included in Organic Letters in 2012.Application of 4783-68-0 This article mentions the following:

Ruthenium-catalyzed direct arylations of phenols bearing removable directing groups were accomplished through carboxylate assistance via six-membered ruthenacycles as key intermediates. 2-Phenoxypyridine (I) underwent ruthenium-catalyzed arylation with 4-bromoanisole to give compound II. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Silicon-Enriched Nickel Nanoparticles for Hydrogenation of N-Heterocycles in Aqueous Media was written by Mao, Shuxin;Ryabchuk, Pavel;Dastgir, Sarim;Anwar, Muhammad;Junge, Kathrin;Beller, Matthias. And the article was included in ACS Applied Nano Materials in 2022.Application of 644-98-4 This article mentions the following:

Reported a heterogeneous intermetallic nickel silicide catalyst prepared by impregnation of nickel acetate/1,10-phenanthroline on fumed silica and subsequent pyrolysis. The optimal catalyst exhibited good activity and selectivity for hydrogenation of N-heterocycles including pyridines and quinolines under comparably mild conditions using water as solvent. It was the first reported efficient nickel based heterogeneous catalyst for catalytic pyridine hydrogenation. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Benzomorphan related compounds. V. Synthesis of thienomorphans was written by Alvarez, M.;Bosch, J.;Granados, R.;Lopez, F.. And the article was included in Journal of Heterocyclic Chemistry in 1978.Category: pyridine-derivatives This article mentions the following:

Thienomorphans, e.g. I, II, and III, were prepared via the Grewe synthesis and by the reaction of 2-cyanopyridines with 3-thienyllithium. Thieno[2,3-f]morphans were also prepared from 3-oxotetrahydrothiophene. Separation and assignment of the α- and β-diastereomeric structures by means of NMR data is reported. Some side products were isolated and their structures were confirmed on the basis of their spectral data. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Category: pyridine-derivatives).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Unprecedented orientation in the nitration of certain 3-pyridinols was written by De Selms, Roy C.. And the article was included in Journal of Organic Chemistry in 1968.SDS of cas: 15128-90-2 This article mentions the following:

2-(X-Substituted)-4-nitro-3-pyridinols (I) and 2-(X-substituted)-6-nitro-3-pyridinols (II) are prepared The nitration of 3-pyridinol gives 3-hydroxy-2-nitropyridine containing 5-hydroxy-2-nitropyridine when ether is used as the final extraction solvent. 2-Methyl- and chloro-3-pyridinols are nitrated to give I (X = Me and Cl) and II (X = Me and Cl) in a 4:1 I-II ratio. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2SDS of cas: 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem