Day: January 5, 2023

Photometric characteristics of de-sulfonated pyrocatechol violet and its application to the photometric determination of trace amounts of mercury was written by Chen, Zhaoguo;Chen, Xi. And the article was included in Lihua Jianyan, Huaxue Fence in 2001.Computed Properties of C17H30BrN This article mentions the following:

A method for the spectrophotometric determination of Hg was presented with de-sulfonated pyrocatechol violet (DSPV). In a slightly acidic medium of pH 4.5-6.5, a stable quaternary chelate was formed by DSPV, Hg(II), KBr and DPB. The absorption maximum of the chelate was at 586 nm, the apparent molar absorptivity 9.5 × 10⁵, the detection limit 0.8 ng mL^-1, and Beer’s law obeyed at 0.02-4.00 μg/25 mL. The interference of Cd²⁺ and Pb²⁺ can be masked by thiolactic acid, and that of Sn²⁺ eliminated by H₂O₂. The results obtained by this method agreed very well with those obtained by AAS method. The method was used in the determination of trace Hg in environmental water samples and foodstuff with the relative standard deviation 9.5-13.9% and the recovery 93-116%. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Computed Properties of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of pyridine 1-oxides with isocyanates: Structure of the intermediates. Rationalization of rearrangements of six-membered heteroaromatic N-oxide derivatives was written by Abramovitch, Rudolph A.;Shinkai, Ichiro;Van Dahm, Richard. And the article was included in Journal of Heterocyclic Chemistry in 1976.Recommanded Product: 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Structure I (R = H, Br) claimed by Hisano, Matsuoka, and Ichikawa (1974) to be obtained from the reaction of 3,5-lutidine 1-oxide with 4-RC6H4NCO was determined to be II obtained by a rearrangement supported by MINDO/2′ calculations on relative heats of formation of analogous compounds Reduction and NMR studies of II also confirmed this structure. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Recommanded Product: 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors was written by Zhang, Xiaoming;Yang, Zhaokai;Xu, Huan;Liu, Yuansheng;Yang, Xinling;Sun, Tengda;Lu, Xingxing;Shi, Fasheng;Yang, Qing;Chen, Wei;Duan, Hongxia;Ling, Yun. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Application In Synthesis of Pyridin-4-ol This article mentions the following:

The introduction of active groups of natural products into the framework of pesticide mols. is an effective approach for discovering active lead compounds, and thus has been widely used in the development of new agrochems. In this work, a novel series of 1,2,3,4-tetrahydroquinoline derivatives containing a pyrimidine ether scaffold were designed and synthesized by the active substructure splicing method. The new compounds showed good antifungal activities against several fungi. Especially, compound (I) displayed excellent in vitro activity against Valsa mali and Sclerotinia sclerotiorum with EC₅₀ values of 0.71 and 2.47 μg/mL, resp. I had slightly stronger inhibitory activity (68.08% at 50 μM) against chitin synthase (CHS) than that of polyoxin D (63.84% at 50 μM) and exhibited obvious curative and protective effects on S. sclerotiorumin vivo. Thus, I can be considered as a new candidate fungicide as a chitin synthase inhibitor. An accurate and reliable three-dimensional quant. structure-activity relationship (3D-QSAR) model presented a useful direction for the further excogitation of more highly active fungicides. Mol. docking revealed that the conventional hydrogen bond mainly affected the binding affinity of I with chitin synthase. The present results will provide a guidance to discover potential CHS-based fungicides for plant disease control in agriculture. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines was written by Dang, Zhao;Yang, Yushe;Ji, Ruyun;Zhang, Shuhua. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

The design and synthesis of new fluoroquinolone antibacterial agents, e.g., I, having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-pos. organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

3-Oxoisoindoline-1-carboxamides: Potent, State-Dependent Blockers of Voltage-Gated Sodium Channel Na_V1.7 with Efficacy in Rat Pain Models was written by Macsari, Istvan;Besidski, Yevgeni;Csjernyik, Gabor;Nilsson, Linda I.;Sandberg, Lars;Yngve, Ulrika;Aahlin, Kristofer;Bueters, Tjerk;Eriksson, Anders B.;Lund, Per-Eric;Venyike, Elisabet;Oerther, Sandra;Hygge Blakeman, Karin;Luo, Lei;Arvidsson, Per I.. And the article was included in Journal of Medicinal Chemistry in 2012.Reference of 199296-39-4 This article mentions the following:

The voltage-gated sodium channel Na_V1.7 is believed to be a critical mediator of pain sensation based on clin. genetic studies and pharmacol. results. Clin. utility of nonselective sodium channel blockers is limited due to serious adverse drug effects. Here, we present the optimization, structure-activity relationships, and in vitro and in vivo characterization of a novel series of Na_V1.7 inhibitors based on the oxoisoindoline core. Extensive studies with focus on optimization of Na_V1.7 potency, selectivity over Na_V1.5, and metabolic stability properties produced several interesting oxoisoindoline carboxamides (16A, 26B, 28, 51, 60, and 62) that were further characterized. The oxoisoindoline carboxamides interacted with the local anesthetics binding site. In spite of this, several compounds showed functional selectivity vs. Na_V1.5 of more than 100-fold. This appeared to be a combination of subtype and state-dependent selectivity. Compound 28 showed concentration-dependent inhibition of nerve injury-induced ectopic in an ex vivo DRG preparation from SNL rats. Compounds 16A and 26B demonstrated concentration-dependent efficacy in preclin. behavioral pain models. The oxoisoindoline carboxamides series described here may be valuable for further investigations for pain therapeutics. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Reference of 199296-39-4).

2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 199296-39-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dissolution of n-decane in aqueous solution of individual surfactants was written by Strel’tsova, O. O.;Volyuvach, O. V.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 2005.Computed Properties of C17H30BrN This article mentions the following:

The dissolution of n-decane in aqueous solutions of cationic and anionic surfactants was investigated over a broad range of their concentrations The applicability of a formal second-order reaction kinetics to the kinetics of dissolution of n-decane in aqueous solutions of surfactants was shown for pre-micellization conditions. The distribution constants of n-decane between micelles and water and the free energy of solubilization were calculated In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Computed Properties of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Computed Properties of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oil-water distribution of p-alkylpyridines was written by Yeh, Kuang C.;Higuchi, William I.. And the article was included in Journal of Pharmaceutical Sciences in 1976.HPLC of Formula: 27876-24-0 This article mentions the following:

The distribution of a homologous series of p-alkylpyridines between water and six organic solvents with varying degrees of polarity was investigated. The distribution coefficients were considered as reflections of the strength of net interactions involved in the solvents. The order was chloroform > octanol > carbon tetrachloride > butyl ether > hexadecane > octane. The effect of the methylene group on the distribution coefficients differed little among the six solvents. The relative constancy was attributed to the predominance of the dispersion forces in the incremental effect. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0HPLC of Formula: 27876-24-0).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 27876-24-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Auxiliary hydroxy-phenanthro [9, 10-d] imidazole supported NLOphoric triphenylamine based donor-pi-acceptor compounds: Synthesis, solvatochromism and computational aspects was written by Yadav, Sagar B.;Erande, Yogesh;Ghanvatkar, Chaitanya W.;Sekar, Nagaiyan. And the article was included in Journal of Luminescence in 2020.Related Products of 628-13-7 This article mentions the following:

To study the effect of addnl. hydroxy-imidazole unit on the solvatochromic linear, and non-linear optical properties, three donor-pi-acceptor NLOphoric triphenylamine-imidazole based compounds were synthesized, and characterized. The photophys. characteristics of the synthesized compounds were examined in series of solvents. The solvatochromism in the chromophores supported by the linear (i.e. Mac-Rae, and Lippert-Mataga equations) as well as by the multi-linear (i.e. Kamlet-Taft and Catalan parameters) anal. ‘Solvent polarizability’ and ‘solvent dipolarity’ are the major components influence the shift in absorption and emission spectra resp. These compounds exhibit aggregation induced emission. The charge transfer characteristics in the chromophores are examined with the Generalized Mulliken-Hush, mol. electrostatic potential, and Frontier MO plot anal. The NLO properties of the synthesized compounds were studied using solvatochromic as well as computational methods. With the increase in the addnl. acceptor imidazole substituent on triphenylamine unit the polarizability, hyperpolarizability, and their associated mol. hyperpolarizability parameters gets enhanced. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic hydration of pyridinecarbonitriles in the presence of bis(ethylenediamine)copper(II) chloride dihydrate and copper(II) chloride dihydrate was written by Watanabe, Kenichi;Murayama, Kiyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1974.SDS of cas: 1620-76-4 This article mentions the following:

Spectrophotometric studies on the catalytic hydration of 2-pyridine-carbonitrile derivatives in the presence of the title catalysts under nearly neutral conditions revealed that the products are the amides. The hydration of the nitrile group was influenced by electronic and steric effects. Selective hydration of the nitrile group in the α-position was observed with dinitriles. The selectivity was applied to hydrolysis of nitriles to carboxylic acids. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4SDS of cas: 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid was written by Yuan, Yizhi;Liang, Yujie;Shi, Shihui;Liang, Yu-Feng;Jiao, Ning. And the article was included in Chinese Journal of Chemistry in 2020.Safety of 2-(m-Tolyl)pyridine This article mentions the following:

An efficient synthesis of monobromo (hetero)arenes RR¹ (R = 4-methyl-2-bromophenyl, 4-phenyl-2-bromophenyl, 4-benzyloxy-2-bromophenyl, etc.; R¹ = pyridin-2-yl, 4-methylpyridin-2-yl, isoquinolin-3-yl, etc.), dibromo (hetero)arenes R²R¹ (R² = 2,6-dibromo-4-methylphenyl, 2,6-dibromo-4-methoxyphenyl, 4-benzyloxy-2,6-dibromophenyl, 4-methyloxycarbonyl-2,6-dibromophenyl, 2,6-dibromophenyl) and 10-bromobenzo[h]quinolone through Pd-catalyzed directed C-H bromination protocol, in which DMSO is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source was developed. The DMSO/HBr(aq) system, which is novel and efficiently utilized in transition-metal catalyzed C-H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials R³R¹ (R³ = 4-methylphenyl, 4-phenylphenyl, 4-benzyloxyphenyl, etc.), and high bromide-atom economy. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem