Day: January 6, 2023

Subtype-selective Na_v1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives was written by Kort, Michael E.;Atkinson, Robert N.;Thomas, James B.;Drizin, Irene;Johnson, Matthew S.;Secrest, Matthew A.;Gregg, Robert J.;Scanio, Marc J. C.;Shi, Lei;Hakeem, Ahmed H.;Matulenko, Mark A.;Chapman, Mark L.;Krambis, Michael J.;Liu, Dong;Shieh, Char-Chang;Zhang, XuFeng;Simler, Gricelda;Mikusa, Joseph P.;Zhong, Chengmin;Joshi, Shailen;Honore, Prisca;Roeloffs, Rosemarie;Werness, Stephen;Antonio, Brett;Marsh, Kennan C.;Faltynek, Connie R.;Krafte, Douglas S.;Jarvis, Michael F.;Marron, Brian E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Electric Literature of C8H8BrNO2 This article mentions the following:

A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na_v1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1) provided potent, selective derivatives with improved aqueous solubility and oral bioavailability. Representative compounds from this series displayed efficacy in rat models of inflammatory and neuropathic pain. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Electric Literature of C8H8BrNO2).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C8H8BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Regulating force-resistance and acid-responsiveness of pure organics with persistent phosphorescence via simple isomerization was written by Liu, Yan;Ma, Zhimin;Cheng, Xin;Qian, Chen;Liu, Jianwei;Zhang, Xue;Chen, Mingxing;Jia, Xinru;Ma, Zhiyong. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021.Electric Literature of C6H3FN2 This article mentions the following:

Stimulus-responsive purely organic room-temperature phosphorescence materials have been drawing massive attention due to their wide applications. Pyridine rings are introduced to supply π orbitals and cyanogroups are incorporated to boost the ISC efficiency by promoting the spin-forbidden transition. These groups are anticipated to enable the target mol. with multi-responsiveness because of the protonation of pyridine and their good crystallinity, which are able to regulate the acid-responsiveness and force-responsiveness, resp. Based on the above design concept, four new D-A-A’ type mols. using carbazole as the donor and the pyridine ring and cyanogroup as acceptors were designed and synthesized. The D-A-A’ structure bestows these isomers with an evident intramol. charge transfer (ICT) feature, particularly for 2-CNPyCZ and 3-CNPyCZ. All the isomers show intense long-lived phosphorescence with a lifetime over 500 ms. Particularly, 4-CNPyCZ has a high phosphorescence quantum yield of 27.1% owing to the strong intermol. interactions that stabilize the T*₁ excitons. Interestingly, four isomers could retain their long-lived afterglow even after being heavily ground and the afterglow shows well resistance to external forces due to high crystallinity. 4-CNPyCZ manifests unique mechanochromism owing to the fluorescence shift and intensity change of phosphorescence. Moreover, the four isomers demonstrate distinctive acid-responsiveness and give out colorful emissions because the electron cloud dispersion of the nitrogen atom in the pyridine ring varied when altering the position of the cyanogroup. To the best of our knowledge, this is a limited work on room temperature phosphorescence about systematically regulating the responsiveness to external stimuli and proposing an effective mol. design strategy. In the experiment, the researchers used many compounds, for example, 6-Fluoropicolinonitrile (cas: 3939-15-9Electric Literature of C6H3FN2).

6-Fluoropicolinonitrile (cas: 3939-15-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1-(4-Methoxyphenyl)-2-(6-methyl-2-nitro-3-pyridyloxy)propan-1-one was written by Vencato, Ivo;Ferri, Pedro H.;Santos, Suzana C.;Pereira, Maristela;Lariucci, Carlito;Homar, Leon I. B.;Napolitano, Hamilton B.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2005.Formula: C6H6N2O3 This article mentions the following:

The title compound, C₁₆H₁₆N₂O₅, is a β-ketoether derivative closely related to natural 8,4′-oxyneolignans, which are of interest because of their moderate antifungal activity against systemic mycosis. Crystallog. data are given. The nitro group is not coplanar with the aromatic ring, as shown by a torsion angle of 47.2(4)°. The mols. are linked by two nonclassical intermol. C-H···O H bonds with distances between donors and acceptors of 3.441(5) and 3.539(5) Å, giving mol. stacking perpendicular to the bc plane. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Formula: C6H6N2O3).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C6H6N2O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Block-copolymer-like supramolecules confined in nanolamellae was written by Wang, Jui-Hsu;Cheng, Chih-Chia;Yen, Ying-Chieh;Miao, Chia-Chun;Chang, Feng-Chih. And the article was included in Soft Matter in 2012.Computed Properties of C7H9N3O This article mentions the following:

This paper describes the development of a new concept in supramol. assembly of existing functional polypeptides to form diblock-like mol. clusters through complementary hydrogen-bonding interactions, providing a potential route toward design and fabrication of block copolymer-like supramol. materials. The preparation of uracil-functionalized poly(benzyl glutamate) and (acetamidopyridinyl)azidoundecanamide-functionalized POSS mixture is described. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Computed Properties of C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design of Highly Enantioselective Organocatalysts Based on Molecular Recognition was written by Tang, Zhuo;Cun, Lin-Feng;Cui, Xin;Mi, Ai-Qiao;Jiang, Yao-Zhong;Gong, Liu-Zhu. And the article was included in Organic Letters in 2006.Quality Control of N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

Various organocatalysts have been designed based on mol. recognition to catalyze the asym. direct aldol reaction of ketones with aryl and alkyl α-keto acids, affording β-hydroxy carboxylic acids with a tertiary stereogenic center with excellent enantioselectivities of up to 98% ee. A linear effect was observed for the reaction, demonstrating a single mol. of the catalyst involved in the catalysis. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Quality Control of N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Blue phosphorescent bipyridine-based iridium(III) complex for vacuum-deposited organic light-emitting diodes was written by Jang, Jae-Ho;Park, Jeong Yong;Un Kim, Hee;Park, Hea Jung;Kang, In-Nam;Lee, Jun Yeob;Hwang, Do-Hoon. And the article was included in Journal of Nanoscience and Nanotechnology in 2018.Name: 4-Methylpicolinonitrile This article mentions the following:

We have synthesized and characterized a blue phosphorescent iridium(III) complex (dfpypy)₂Ir(tftamp), which contains 2′,6′-difluoro-2,3′-bipyridine (dfpypy) as the main ligand and 4-methyl-2-(3′-trifluoromethyl-1’H-1′,2′,4′-triazol-5′-yl)pyridine (tftamp) as the ancillary ligand. The photophys., electrochem., and electroluminescent (EL) properties of (dfpypy)₂Ir(tftamp) were investigated. Vacuum-deposited blue and white organic light-emitting diodes (OLEDs) were fabricated using (dfpypy)₂Ir(tftamp) in 1,3-bis(carbazol-9-yl)benzene (mCP) as the emitting layer. The EL spectrum of (dfpypy)₂Ir(tftamp) exhibited emission maximum at 472 nm with a full-width at half-maximum (FWHM) of 81 nm and Commission Internationale de L’Eclairage (CIE) coordinates of (0.17, 0.27) at 100 cd· m^-2. In addition, white-light-emitting devices were fabricated, which exhibited CIE coordinates of (0.42, 0.40) and a correlated color temperature (CCT) of 3,237 K at 1000 cd · m^-2, close to the standard warm-white light CIE coordinates of (0.44, 0.40) and CCT of 3,000 K. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Name: 4-Methylpicolinonitrile).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 4-Methylpicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification and optimization of novel partial agonists of Neuromedin B receptor using parallel synthesis was written by Shuttleworth, Stephen J.;Lizarzaburu, Mike E.;Chai, Anne;Coward, Peter. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Recommanded Product: 199296-39-4 This article mentions the following:

The design and parallel synthesis of potent, small mol. partial agonists of Neuromedin B receptor based on the 3-amino-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid amide core is described. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Recommanded Product: 199296-39-4).

2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 199296-39-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of alkyl chain length and halide ions on the corrosion inhibition potential of imidazolium and pyridinium based ionic liquids: Computational studies was written by Alrefaee, Salhah H.. And the article was included in Journal of Molecular Liquids in 2021.Reference of 104-73-4 This article mentions the following:

In the present investigation, thirty imidazolium and pyridinium based ionic liquids are undertaken for DFT based computational study to demonstrate the anticorrosive potential. Results showed that imidazolium and pyridinium based ionic liquids act as effective anticorrosive materials and their corrosion inhibition performance depends on the nature of alkyl groups and halide ions. Among the studied imidazolium based ionic liquids, 3-octyl-1H-imidazol-3-ium chloride (IM-C8-Cl), 3-hexadecyl-1H-imidazol-3-ium bromide (IM-C16-Br) and 3-butyl-1H-imidazol-3-ium iodide (IM-C4-I) behave as the best among the chloro, bromo and iodide substituted imidazolium based ionic liquids, resp. In the pyridinium based ionic liquids, 1-hexadecylpyridin-1-ium chloride (Pyr-C16-Cl), 1-dodecylpyridin-1-ium bromide (Pyr-C12-Br) and 1-octylpyridin-1-ium iodide (Pyr-C8-I) act as the best corrosion inhibitors among the chloro, bromo and iodide substituted pyridinium based ionic liquids, resp. Adsorption behavior of pyridinium and imidazolium based ionic liquids and corrosion inhibition using them has also been proposed in the present study. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Reference of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Organometallic Osmium(II) Arene Anticancer Complexes Containing Picolinate Derivatives was written by van Rijt, Sabine H.;Peacock, Anna F. A.;Johnstone, Russell D. L.;Parsons, Simon;Sadler, Peter J.. And the article was included in Inorganic Chemistry in 2009.Quality Control of 4-Methylpicolinonitrile This article mentions the following:

Chlorido Os(II) arene [(η⁶-biphenyl)Os^II(X-pico)Cl] complexes containing X = Br (1), OH (2), and Me (3) as ortho, or X = Cl (4), CO₂H (5), and Me (6) as para substituents on the picolinate (pico) ring were synthesized and characterized. The x-ray crystal structures of 1 and 6 show typical piano-stool geometry with intermol. π-π stacking of the biphenyl outer rings of 6. At 288 K the hydrolysis rates follow the order 2 ≫ 6 > 4 > 3 > 5 ≫ 1 with half-lives ranging from minutes to 4.4 h illustrating the influence of both electronic and steric effects of the substituents. The pK_a values of the aqua adducts 3A, 4A, 5A, and 6A were all at 6.3-6.6. The para-substituted pico complexes 4–6 readily formed adducts with both 9-Et guanine (9EtG) and 9-Et adenine (9EtA), but these were less favored for the ortho-substituted complexes 1 and 3 showing little reaction with 9EtG and 9EtA, resp. D.-functional theory calculations confirmed the observed preferences for nucleobase binding for complex 1. In cytotoxicity assays with A2780, cisplatin-resistant A2780cis human ovarian, A549 human lung, and HCT116 colon cancer cells, only complexes 4 (p-Cl) and 6 (p-Me) exhibited significant activity (IC₅₀ values < 25 μM). Both of these complexes were as active as cisplatin in A2780 (ovarian) and HCT116 (colon) cell lines, and even overcome cisplatin resistance in the A2780cis (ovarian) cell line. The inactivity of 5 is attributed to the neg. charge on its para carboxylate substituent. These data illustrate how the chem. reactivity and cancer cell cytotoxicity of Os arene complexes can be controlled and fine-tuned using steric and electronic effects of substituents on a chelating ligand to give Os(II) arene complexes which are as active as cisplatin but have a different mechanism of action. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Quality Control of 4-Methylpicolinonitrile).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 4-Methylpicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Operationally Simple Regioselective 5′-Phosphorylation of Unprotected 5-Ethynyl-2′-deoxyuridine Analogues was written by Hilko, David H.;Bornaghi, Laurent F.;Poulsen, Sally-Ann. And the article was included in Australian Journal of Chemistry in 2020.Reference of 628-13-7 This article mentions the following:

Here, we present the development of a straightforward methodol. to regioselectively phosphorylate the 5′-OH group of unprotected nucleosides. We employ cyclosaligenyl phosphoramidite reagents together with pyridinium trifluoroacetate as activator, followed by in-situ oxidation to prepare a panel of novel nucleoside-based chem. probes, Pro-Label compounds Alternative procedures for this transformation are available, but are limited in number and scope. Furthermore, the benefits of the new methodol. include milder reaction conditions, wider solvent applicability, and, by avoiding sensitive reagents, a more straightforward handling of reagents, reactions, and workup processes. The panel of novel cyclosaligenyl phosphotriester uridine Pro-Labels have variable 2′ substituents (H, F, Cl, Br, I) as well as four different cyclosaligenyl groups that would span a range of half-lives for in-vitro applications. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Reference of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Reference of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem