Day: January 6, 2023

Palladium catalyzed ortho-C-H-acylation of 2-arylpyridines using phenylacetylenes and styrene epoxide was written by Zhang, Qian;Wang, Yang;Yang, Tingting;Li, Li;Li, Dong. And the article was included in Tetrahedron Letters in 2016.Category: pyridine-derivatives This article mentions the following:

A palladium-catalyzed ortho-C-H-acylation of 2-arylpyridine using phenylacetylenes and styrene epoxide as the acylated reagents was developed. With the employment of tert-Bu hydroperoxide (TBHP) as the oxidant and a phosphorous ligand, the protocol generates corresponding aryl ketones in moderated to good yields with high regioselectivity and good functional group compatibility. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope was written by Robin, Aelig;Kohler, Valentin;Jones, Alison;Ali, Afruja;Kelly, Paul P.;O’Reilly, Elaine;Turner, Nicholas J.;Flitsch, Sabine L.. And the article was included in Beilstein Journal of Organic Chemistry in 2011.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

A high-throughput screening protocol for evaluating chimeric, self-sufficient P 450 biocatalysts and their mutants against a panel of substrates was developed, leading to the identification of a number of novel biooxidation activities. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure-activity relationship toward electrocatalytic nitrogen reduction of MoS₂ growing on polypyrrole/graphene oxide affected by pyridinium-type ionic liquids was written by Mao, Hui;Fu, Yuanlin;Yang, Haoran;Zhang, Shuai;Liu, Jinchi;Wu, Shuyao;Wu, Qiong;Ma, Tianyi;Song, Xi-Ming. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2021.Quality Control of Pyridin-4-ol This article mentions the following:

MoS₂ with different crystal structures and phase compositions have in-situ grown on the surface of pyridinium-type ionic liquids functionalized polypyrrole/graphene oxide (pyridinium-ILs/PPy/GO) and exhibited different electocatalytic performance towards Nitrogen reduction reaction (NRR), affected by the difference of crystal structure and phase compositions of MoS₂ resulting from the induction of substituent groups in pyridinium. Combining the results of NRR performance tests with material characterizations determined by XRD, XPS and Raman spectra to explore the structure-activity relationship toward NRR of MoS₂/pyridinium-ILs/PPy/GO, pyridinium-ILs with a group containing amino in the para- or ortho-position can be beneficial to induce 1T-MoS₂ with good crystallinity, resulting in the satisfying NH₃ yield, but poor stability, while the hydroxyl group at the para-position in pyridinium-ILs only induce 2H-MoS₂ indexed to JCPDS file number 75-1539, not conducive to nitrogen fixation. Surprisingly, the most excellent NRR electroactivity is achieved by MoS₂/pyridinium-ILs/PPy/GO synthesized using 2-amino-3-hydroxypyridine with the excellent lamellar hierarchical inorganic/organic micro-/nanostructures. It may be attributed to the confinement effect caused by the stereo hindrance composed of amino group at the ortho-position and hydroxyl group at the meta-position in pyridinium-ILs, resulting in 1T/2H-MoS₂ nanoplates with rich defects indexed to JCPDS file number 37-1492 growing on pyridinium-ILs/PPy/GO. Therefore, the kind and position of substituent groups in pyridinium played an essential role for the crystal structure and phase compositions of MoS₂ growing on pyridinium-ILs/PPy/GO, and further affected the NRR performance, which would provide a new thought and method for the reasonable design and performance optimization of electrocatalysts based on transition metal dichalcogenides for electrocatalysis. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd(II)-catalyzed oxidative alkoxycarbonylation of 2-phenoxypyridine derivatives with CO and alcohols was written by Liu, Bin;Jiang, Huai-Zhi;Shi, Bing-Feng. And the article was included in Organic & Biomolecular Chemistry in 2014.Recommanded Product: 2-Phenoxypyridine This article mentions the following:

A Pd(II)-catalyzed oxidative alkoxycarbonylation of phenol derivatives with atm. pressure of CO-O₂ and alcs. was achieved. The reaction provided an efficient strategy for the synthesis of carboxylic esters and can be applied to the late-stage modification of complex mols. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solubilization of a water-insoluble dye in aqueous NaBr solutions of alkylpyridinium bromides and its relation to micellar size and shape was written by Fujio, Katsuhiko;Mitsui, Tsunehiro;Kurumizawa, Hiroshi;Tanaka, Yoshikazu;Uzu, Yuhei. And the article was included in Colloid and Polymer Science in 2004.COA of Formula: C17H30BrN This article mentions the following:

To investigate the effect of added salt on micelle size, shape, and structure the solubilization of Orange OT in aqueous NaBr solutions of decylpyridinium bromide (DePB), dodecylpyridinium bromide (DPB), tetradecylpyridinium bromide (TPB), and hexadecylpyridinium bromide (CPB) was examined The solubilization powers of DePB and DPB micelles increase with increasing NaBr concentration up to 2.86 and 3.07 mol dm^-3, resp., but above these concentrations remain unaltered. This suggests that spherical micelles of DePB and DPB can have a maximum and constant size at NaBr concentrations higher than these threshold concentrations On the other hand, the solubilization powers of TPB and CPB micelles increase in the whole range of NaBr concentration studied. The dependencies of the solubilization powers of their micelles on the counterion concentration change at 0.10 and 0.03 mol dm^-3 NaBr, resp., as suggests that TPB and CPB micelles undergo the sphere-rod transition at those concentrations Orange OT is a more suitable probe for detecting the presence of the maximum- and constant-size spherical micelle than Sudan Red B. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4COA of Formula: C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.COA of Formula: C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO₄ nanoparticles was written by Abinaya, R.;Mani Rahulan, K.;Srinath, S.;Rahman, Abdul;Divya, P.;Balasubramaniam, K. K.;Sridhar, R.;Baskar, B.. And the article was included in Green Chemistry in 2021.Safety of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Visible light-mediated selective and efficient oxidation of various primary benzyl alcs. RCH₂OH (R = Ph, 2-bromophenyl, pyridin-2-yl, etc.)/secondary benzyl alcs. such as 1-(phenyl)-ethanol, diphenylmethanol, 1-phenylethane-1,2-diol, etc. to aldehydes RCHO/ketones such as acetophenone, benzophenone, chalcone, etc. and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atm. while the ODH of partially saturated heterocycles under an oxygen atm. resulted in very good to excellent yields. The methodol. is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcs. and heteroaryl carbinols I (R¹ = H, C(O)OMe) followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines II in high isolated yields. This methodol. was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles e.g., III using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Safety of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of physicochemical parameters of pyridine and its derivatives on the kinetics of microbiological transformation was written by Pavlyuk, M. I.;Turovskii, A. A.;Kucher, R. V.. And the article was included in Doklady Akademii Nauk Ukrainskoi SSR, Seriya B: Geologicheskie, Khimicheskie i Biologicheskie Nauki in 1988.SDS of cas: 644-98-4 This article mentions the following:

Physicochem. properties of pyridine and its derivatives affect the kinetics of biodegradation of these compounds by Arthrobacter pascens. The biodegradation rate constants are dependent on the donor properties of substituted pyridines, steric effect, and hydrophobicity parameter. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam was written by Fan, Zhoulong;Lu, Heng;Cheng, Zhen;Zhang, Ao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Name: 2-(m-Tolyl)pyridine This article mentions the following:

A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening was written by Ferro, Stefania;Gitto, Rosaria;Buemi, Maria Rosa;Karamanou, Spyridoula;Stevaert, Annelies;Naesens, Lieve;De Luca, Laura. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Application of 34206-49-0 This article mentions the following:

Searching for new antiviral agents, we focused our interest on the influenza PA-Nter endonuclease. Therefore, we developed a three-dimensional pharmacophore model which contains the binding features addressed to the metal-chelating active site. The obtained hypothesis has been fruitfully employed to select three “hit compounds” through an in silico screening campaign on our inhouse database of small mols. We studied the binding poses of these hit compounds using mol. docking, and subjected them to an enzymic assay with recombinant PA-Nter endonuclease. Compound I proved the most active inhibitor of the endonucleolytic cleavage reaction, with an IC₅₀ value of 12 μM. In the experiment, the researchers used many compounds, for example, 5-Bromopyridine-2,3-diol (cas: 34206-49-0Application of 34206-49-0).

5-Bromopyridine-2,3-diol (cas: 34206-49-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 34206-49-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aziridination of olefins mediated by a [Cu^I(L1)₂]⁺ complex via nitrene transfer reaction was written by Kumar, Pardeep;Chikara, Ashwani;Sen, Asmita;Shanmugam, Maheswaran. And the article was included in Inorganica Chimica Acta in 2022.Related Products of 91-02-1 This article mentions the following:

Copper-catalyzed aziridination of alkenes is dominated in the literature compared to any other metal catalysts. This catalytic reaction is believed to be mediated by the elusive Cu-nitrene intermediate. However, anal. characterization of this intermediate is extremely scarce in the literature. In this article, we intend to shed the light on the electronic structure of the Cu-nitrene intermediate. The reaction of Cu(I) salt in the presence of the redox-active bidentate Schiff base ligand (C₂₁H₂₀N₂; L1) led us to isolate a monomeric copper(I) complex with the mol. formula of [Cu(L1)₂]ClO₄. 2C₆H₆ (1), which was structurally characterized. Complex 1 behaves as an excellent catalyst that promotes the nitrene group transfer to the variety of alkenes in the presence of (N-(p-tolylsulfonyl)imino)phenyliodinane (PhINTs). The intermediate generated from 1 by the addition of PhINTs shows an m/z peak at 832.3079 g/mol which corresponds to an M+ ion peak of the intermediate with the mol. formula of [(L1)₂Cu^II-NTs]⁺ (where Ts = Tosyl). Further, based on the detailed exptl. studies (in-situ UV-Vis measurement and X-band EPR measurements) we propose that the active catalyst that possesses the copper ion in its +2 oxidation state under our exptl. condition, whose electronic structure can be best described as [(L1)₂Cu^II-NTs]⁺ nitrene radicals. The optimized structure of the Cu-nitrene intermediate suggests that the triplet state was found to be the ground state. Besides, we propose a mechanism for this catalytic reaction. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Related Products of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem