Day: January 6, 2023

Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles was written by Rabal, Obdulia;Sanchez-Arias, Juan A.;Cuadrado-Tejedor, Mar;de Miguel, Irene;Perez-Gonzalez, Marta;Garcia-Barroso, Carolina;Ugarte, Ana;Estella-Hermoso de Mendoza, Ander;Saez, Elena;Espelosin, Maria;Ursua, Susana;Tan, Haizhong;Wu, Wei;Xu, Musheng;Pineda-Lucena, Antonio;Garcia-Osta, Ana;Oyarzabal, Julen. And the article was included in ACS Chemical Neuroscience in 2019.Electric Literature of C5H5NO This article mentions the following:

Here, we present a series of dual-target phosphodiesterase 9 (PDE9) and histone deacetylase (HDAC) inhibitors devised as pharmacol. tool compounds for assessing the implications of these two targets in Alzheimer’s disease (AD). These novel inhibitors were designed taking into account the key pharmacophoric features of known selective PDE9 inhibitors as well as privileged chem. structures, bearing zinc binding groups (hydroxamic acids and ortho-amino anilides) that hit HDAC targets. These substituents were selected according to rational criteria and previous knowledge from our group to explore diverse HDAC selectivity profiles (pan-HDAC, HDAC6 selective, and class I selective) that were confirmed in biochem. screens. Their functional response in inducing acetylation of histone and tubulin and phosphorylation of cAMP response element binding (CREB) was measured as a requisite for further progression into complete in vitro absorption, distribution, metabolism and excretion (ADME) and in vivo brain penetration profiling. Compound 31b, a selective HDAC6 inhibitor with acceptable brain permeability, was chosen for assessing in vivo efficacy of these first-in-class inhibitors, as well as studying their mode of action (MoA). In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dual aminoquinolate diarylboron and nickel catalyzed metallaphotoredox platform for carbon-oxygen bond construction was written by Zu, Weisai;Day, Craig;Wei, Lanfeng;Jia, Xin;Xu, Liang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.COA of Formula: C7H9NO This article mentions the following:

Aminoquinolate diarylboron complexes were prepared and utilized as photocatalysts in dual Ni/photoredox catalyzed carbon-oxygen construction reactions. Via this unified metallaphotoredox platform, diverse aryl halides could be conveniently coupled with acids, water and alcs. to afford aryl esters R¹C(O)OR² [R¹ = H, 2-MeC₆H₄, 4-ClC₆H₄, etc.; R² = 4-CNC₆H₄], phenols R³OH [R³ = Ph, 4-CO₂EtPh, 4-BrC₆H₄, etc.], aryl ethers R⁴OR⁵ [R⁴ = 4-CNC₆H₄, 4-C(O)MeC₆H₄, 4-C(O)EtC₆H₄, etc.; R⁵ = Me, Et] resp. This method featured operational simplicity, broad substrate scope and good compatibility with functional groups. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1COA of Formula: C7H9NO).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors was written by Kono, Mitsunori;Matsumoto, Takahiro;Kawamura, Toru;Nishimura, Atsushi;Kiyota, Yoshihiro;Oki, Hideyuki;Miyazaki, Junichi;Igaki, Shigeru;Behnke, Craig A.;Shimojo, Masato;Kori, Masakuni. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Synthetic Route of C11H20N2O2S This article mentions the following:

A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain. We carried out an optimization study of the lead compound to improve its DMPK profile as well as in vitro potency. We identified the thiazole compound I with potent inhibitory activity, high brain permeability, and good bioavailability. Compound I showed a potent and dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test in mice. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Synthetic Route of C11H20N2O2S).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C11H20N2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Utilizing surfactants to control the sorption, desorption, and biodegradation of phenanthrene in soil-water system was written by Jin, Haiwei;Zhou, Wenjun;Zhu, Lizhong. And the article was included in Journal of Environmental Sciences (Beijing, China) in 2013.Reference of 104-73-4 This article mentions the following:

An integrative technol. including the surfactant enhanced sorption and subsequent desorption and biodegradation of phenanthrene in the soil-water system was introduced and tested. For slightly contaminated agricultural soils, cationic-nonionic mixed surfactantenhanced sorption of organic contaminants onto soils could reduce their transfer to plants, therefore safe-guarding agricultural production After planting, residual surfactants combined with added nonionic surfactant could also promote the desorption and biodegradation of residual phenanthrene, thus providing a cost-effective pollution remediation technol. Our results showed that the cationic-nonionic mixed surfactants dodecylpyridinium bromide (DDPB) and Triton X-100 (TX100) significantly enhanced soil retention of phenanthrene. The maximum sorption coefficient K_d* of phenanthrene for contaminated soils treated by mixed surfactants was about 24.5 times that of soils without surfactant (K_d) and higher than the combined effects of DDPB and TX100 individually, which was about 16.7 and 1.5 times K_d, resp. On the other hand, TX100 could effectively remove phenanthrene from contaminated soils treated by mixed surfactants, improving the bioavailability of organic pollutants. The desorption rates of phenanthrene from these treated soils were greater than 85% with TX100 concentration above 2000 mg/L and approached 100% with increasing TX100 concentration The biodegradation rates of phenanthrene in the presence of surfactants reached over 95% in 30 days. The mixed surfactants promoted the biodegradation of phenanthrene to some extent in 10-22 days, and had no obvious impact on phenanthrene biodegradation at the end of the experiment Results obtained from this study provide some insight for the production of safe agricultural products and a remediation scheme for soils slightly contaminated with organic pollutants. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Reference of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aggregation, adsorption, counterion binding, thermal and scattering behavior of metallosurfactant cis-[Co(en)₂(C₁₂H₂₅NH₂)Cl](NO₃)₂ was written by Wagay, T. A.;Dey, J.;Kumar, S.;Aswal, V. K.;Ismail, K.. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2016.Recommanded Product: 104-73-4 This article mentions the following:

Amphiphilic metal complexes, better known as metallosurfactants, are the emerging class of materials with a range of properties inherent to both metal complexes and surfactants. Studying the fundamental aspects of the adsorption and aggregation of these novel surfactants is necessary by looking at their potential applications. Cis-Chlorobis(ethylenediamine)dodecylaminecobalt(III) nitrate (CDCN) was synthesized and its critical micelle concentration (cmc) values were determined in aqueous medium as a function of sodium nitrate concentration by using surface tension, conductivity and spectrophotometric methods. The cmc of CDCN is equal to 1.4 mmol kg^-1 and compared to conventional ionic surfactants with same hydrocarbon chain length, CDCN has properties of a better surfactant. The counterion binding constant of CDCN is found to be nearly 0.8. Dynamic light scattering and small angle neutron scattering data showed that the size of the metallomicelle is strongly dependent on the added salt concentration, but not above 0.04 mol kg^-1 NaNO₃. The aggregates of CDCN have large size and from SANS data anal. they appear to exist as micellar clusters. The surface excess and area per mol. of CDCN at the cmc are equal to 2.59 × 10^-6 mol m^-2 and 0.64 nm², resp. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Recommanded Product: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Organic dye-photocatalyzed fluoroalkylation of heteroarene-N-oxide derivatives was written by Lantano, Beatriz;Barata-Vallejo, Sebastian;Postigo, Al. And the article was included in Organic & Biomolecular Chemistry in 2018.COA of Formula: C7H9NO This article mentions the following:

The first direct C_Het-H perfluoroalkylation reaction of heteroaromatic N-oxides to synthesize perfluoroalkylated heteroaryl N-oxides, e.g. I (R = C₃F₇, C₄F₉, C₆F₁₃), was achieved through a visible light-photocatalyzed reaction in the presence of com. available perfluoroalkyl iodides and a base in DMF using Rose Bengal as organic photocatalyst. The reactions proceeded in the absence of transition metals and could be scaled up. Through an acid-catalyzed transformation of the perfluoroalkylated N-oxides I thus obtained, the first direct synthesis of 2-(perfluoroalkyl)benzo[f][1,3]oxazepines II was achieved. De-oxygenation of the resulting perfluoroalkylated heteroaromatic N-oxides led to high yielding and regioselective radical perfluoroalkylation protocols of heteroaromatic compounds In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8COA of Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sulfonyl Fluoride Synthesis through Electrochemical Oxidative Coupling of Thiols and Potassium Fluoride was written by Laudadio, Gabriele;Bartolomeu, Aloisio de A.;Verwijlen, Lucas M. H. M.;Cao, Yiran;de Oliveira, Kleber T.;Noel, Timothy. And the article was included in Journal of the American Chemical Society in 2019.Category: pyridine-derivatives This article mentions the following:

Sulfonyl fluorides are valuable synthetic motifs for a variety of applications, among which sulfur(VI) fluoride exchange-based “click chem.” is currently the most prominent. Consequently, the development of novel and efficient synthetic methods to access these functional groups is of great interest. Herein, the authors report a mild and environmentally benign electrochem. approach to prepare sulfonyl fluorides using thiols or disulfides, as widely available starting materials, in combination with KF, as an inexpensive, abundant and safe fluoride source. No addnl. oxidants nor addnl. catalysts are required and, due to mild reaction conditions, the reaction displays a broad substrate scope, including a variety of alkyl, benzyl, aryl and heteroaryl thiols or disulfides. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Category: pyridine-derivatives).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duplex strand formation using alternating copolymers was written by Nakade, Hiroshi;Ilker, M. Firat;Jordan, Brian J.;Uzun, Oktay;LaPointe, Nicholas L.;Coughlin, E. Bryan;Rotello, Vincent M.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2005.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

The regular arrangement of complementary diaminopyridine-thymine (DAP-THY) on alternating diaminopyridine-thymine functionalized 7-oxanorbornene-cyclooctene copolymers permits cooperative binding events and the effective formation of well-controlled micrometer-scale aggregates. The formation of duplex supramol.-copolymer complex relative to stoichiometry and the binding affinity between complementary functionalized alternating copolymers was determined The alternating copolymers were prepared using ring opening metathesis polymerization (ROMP) giving between 92 and 98% alternating units. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic cocyclization of acetylene with nitriles in the presence of bis(η²-ethene)(η⁶-toluene)iron as catalyst was written by Schmidt, U.;Zenneck, U.. And the article was included in Journal of Organometallic Chemistry in 1992.Application of 644-98-4 This article mentions the following:

The reactive arene complex bis(η²-ethene)(η⁶-toluene)iron co-cyclotrimerizes acetylene and nitriles RCN (R = CH₃, C₂H₅, n-C₃H₇, i-C₃H₇, C₆H₅) catalytically to give pyridine derivatives In the case of acrylonitrile the reaction fails. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adsorption modification of metalized materials was written by Baranova, N. V.;Kareeva, V. M.;Temnikova, S. A.;Voronchikhina, L. I.. And the article was included in Tsvetnye Metally (Moscow, Russian Federation) in 2005.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

Feasibility of using quaternary salts of pyridine was studied for adsorption modification of aluminized glass fibers in order to create a hydrophobic protective layer to decrease contact resistance between fibers. All studied pyridine salts can be used for these purposes in a form of aqueous solutions with concentrations not exceeding the critical concentration of micellization. Presence of nanofilms of surface-active substance on the surface of fiber decreases friction and slipping forces and increases dispersing capacity. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application In Synthesis of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem