Day: January 6, 2023

A unique nickel-base nitrogen-oxygen bidentate ligand catalyst for carbonylation of acetylene to acrylic acid was written by Cui, Long;Yang, Xiangui;Zeng, Yi;Chen, Yuntang;Wang, Gongying. And the article was included in Molecular Catalysis in 2019.Safety of Pyridin-4-ol This article mentions the following:

A nickel-base nitrogen-oxygen bidentate ligand catalyst was prepared in-situ via the complexation method. Our results show that the ligand with nickel can form a chelate catalyst possessing a ring structure, which exhibits good catalytic performance in the carbonylation reaction of acetylene to acrylic acid (AA). Furthermore, we discovered that, under our optimized conditions, when 8-hydroxyquinoline (HQ) is used as the ligand [c(Ni(OAc)₂·4H₂O) = 15 X 10-6 mol L^-1, n(HQ):n(Ni(OAc)₂·4H₂O) = 1:1, V(H₂O) = 7 mL], 70.1% conversion of acetylene and 92.4% the selectivity of AA is achieved at 200 °C with 8.0 MPa pressure for 30 min. Compared to traditional acetylene carbonylation catalysts and nickel-base phosphine ligand homogeneous complex catalysts, our catalytic system has unique advantages, including no copper, no halogen and no carbon deposition generated during the reaction process. It displays high selectivity and no corrosion of equipment, suggesting that this catalytic system possesses future industrial applications. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper(II) Catalyzed C-H Alkoxylation of 2-Phenylpyridines with Aliphatic Diols was written by Xiao, Yan;Li, Juan;Liu, Yajun;Wang, Shuo;Zhang, Hui;Ding, Huaiwei. And the article was included in European Journal of Organic Chemistry in 2018.Formula: C12H11N This article mentions the following:

A very simple copper(II) catalyzed C-O coupling reaction of 2-phenylpyridines and aliphatic diols was achieved by using a strategy of C-H functionalization. A series of aroxylethanols are easily obtained with the yields of 30-67 %. Various functional groups, as well as different length of aliphatic diols are well tolerated in the developed catalytic system. This protocol features a simple reaction system, economical catalyst and good regioselectivity. In addition, a “one-pot” synthesis of 2-phenylpyridines was developed. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vacuum-processed small molecule solar cells based on terminal acceptor-substituted low-band gap oligothiophenes was written by Steinberger, Simon;Mishra, Amaresh;Reinold, Egon;Levichkov, Jordan;Uhrich, Christian;Pfeiffer, Martin;Baeuerle, Peter. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Recommanded Product: 2-Bromopyridine-3,4-diamine This article mentions the following:

Novel acceptor-donor-acceptor (A-D-A) type oligothiophenes incorporating benzothiadiazole (BTDA) and thiadiazolopyridine (TDAPy) as terminal acceptor groups have been developed for small mol. organic solar cells. In vacuum-processed planar heterojunction solar cells the TDAPy-based oligomer showed a power conversion efficiency of 3.15% and a high fill factor of 0.67. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-3,4-diamine (cas: 189230-41-9Recommanded Product: 2-Bromopyridine-3,4-diamine).

2-Bromopyridine-3,4-diamine (cas: 189230-41-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 2-Bromopyridine-3,4-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Substituted 2-picolines derived from 6-amino-2-picoline was written by Parker, Edwin D.;Shive, Wm.. And the article was included in Journal of the American Chemical Society in 1947.Recommanded Product: 218770-02-6 This article mentions the following:

6-Amino-2-picoline (Zeide, C.A. 18, 1497) on nitration and rearrangement, with steam distillation, yields 58.4% 6-amino-3-nitro-2-picoline (I) and 25.3% 5-NO₂ isomer (II). II (1.56 g.), 0.77 g. NaNO₂, and 20 cc. concentrated HCl, allowed to stand in a sealed tube at 0° several hrs. and then heated at 80° 2 hrs., give 38% 6-chloro-5-nitro-2-picoline (III), pale yellow, m. 70-70.8° (separated by steam distillation), and 25-30% 6-hydroxy-5-nitro-2-picoline, m. 226-7° (decomposition). Catalytic reduction of III in EtOAc-EtOH with Pt oxide and Pd-BaSO₄ at room temperature gives 60% 5-amino-2-picoline (IV), m. 95-6.5° (Graf, C. A. 26, 1932); the diazo reaction gives 5-hydroxy-2-picoline, m. 166-7° (the β-hydroxy-α-picoline of Wulff, U.S. 1,880,645, C.A. 27, 513). Catalytic reduction of II in EtOAc-EtOH over Pt oxide at room temperature gives 65% 5-amino-6-chloro-2-picoline (V), m. 82-3°, and 20% IV; reduction of II with SnCl₂ in concentrated HCl gives 83% V. V (0.40 g.) in 75 cc. N H₂SO₄, treated slowly with 0.2 g. NaNO₂ in 10 cc. H₂O and the diazo solution heated, gives 40 mg. 6-chloro-5-hydroxy-2-picoline, m. 196-8°. I (0.92 g.) in 10 cc. concentrated HCl with 0.47 g. NaNO₂ gives 29% 6-chloro-3-nitro-2-picoline (VI), pale yellow, m. 54-5°, and 49% 6-hydroxy-3-nitro-2-picoline, light yellow, m. 234-6°. Reduction of 0.56 g. VI in 6 cc. concentrated HCl with 2.5 g. SnCl₄ gives 91% 3-amino-6-chloro-2-picoline (VIA), m. 93-4°; diazotization of 0.32 g. in 85 cc. N H₂SO₄ gives 22% 6-chloro-3-hydroxy-2-picoline, m. 208°. I with Cl in AcOH, allowed to stand overnight, gives 50% 3-amino-5-chloro-3-nitro-2-picoline, light yellow, m. 215.4-16°; 5-Br derivative (VII), yellow, m. 211.6-12.4°; in 1 experiment there resulted the perbromide of I which, with concentrated H₂SO₄, gives the Br derivative VII (2.112 g.), and 0.697 g. NaNO₂ in 15 cc. concentrated HCl give 32.1% 5-bromo-6-chloro-3-nitro-2-picoline (VIII), light yellow, m. 93°, and 26.8% of the 6-HO derivative, light yellow, m. 261° (decomposition). Reduction of VIII with SnCl₂ in concentrated HCl gives 96.4% 3-amino-5-bromo-6-chloro-2-picoline (IX), m. 162.5-4°. Catalytic reduction of IX in EtOH over Pd-C gives 38% unchanged IX and 39% 3-amino-2-picoline (X); reduction of VIA likewise gives 37% X. In the experiment, the researchers used many compounds, for example, 6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6Recommanded Product: 218770-02-6).

6-Chloro-2-methylpyridin-3-ol (cas: 218770-02-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 218770-02-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Influence of alkylpyridine additives in electrolyte solution on the performance of dye-sensitized solar cell was written by Kusama, Hitoshi;Konishi, Yoshinari;Sugihara, Hideki;Arakawa, Hironori. And the article was included in Solar Energy Materials and Solar Cells in 2003.Related Products of 644-98-4 This article mentions the following:

The influence of alkylpyridine additives to an I^–/I₃^– redox electrolyte in MeCN on the performance of a bis(Bu₄N)cis-bis(thiocyanato)bis(2,2′-bipyridine-4-carboxylic acid, 4′-carboxylate)ruthenium(II) dye-sensitized TiO₂ solar cell was studied. I-V measurements were performed using >30 different alkylpyridines. The alkylpyridine additive had a significant influence on the performance of the cell. All the additives decreased the short-circuit photocurrent (J_sc), but most of the alkylpyridines increased the open-circuit photovoltage (V_oc) and fill factor (ff) of the solar cell. The results of MO calculations suggest that the dipole moment of the alkylpyridine mols. correlate with the J_sc of the cell. The size and ionization energy of the pyridines also correlate with the V_oc of a cell. Under AM 1.5 (100 mW/cm²), the highest solar energy conversion efficiency (η) of 7.6% was achieved by using 2-propylpyridine as an additive, which was more effective than the previously reported additive, 4-t-butylpyridine. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Manganese-catalyzed C-H cyanation of arenes with N-cyano-N-(4-methoxy)phenyl-p-toluenesulfonamide was written by Yu, Xiaoqiang;Tang, Jingjing;Jin, Xinxin;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Asian Journal of Organic Chemistry in 2018.Category: pyridine-derivatives This article mentions the following:

A manganese-catalyzed C-H cyanation reaction of arenes was developed using N-cyano-N-(4-methoxy)phenyl-p-toluenesulfonamide as the cyanating agent. The reaction proceeded smoothly with high regioselectivity to provide monocyanated products in satisfactory yields. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ru-Catalyzed Meta-C-H Benzylation of Arenes with Toluene Derivatives was written by Li, Bo;Fang, Sheng-Long;Huang, Dan-Ying;Shi, Bing-Feng. And the article was included in Organic Letters in 2017.Electric Literature of C12H11N This article mentions the following:

2-Arylpyridines such as 2-phenylpyridine, 2-arylpyrimidines, and N-phenylpyrazole underwent regioselective meta-benzylation with toluene, ethylbenzene, o-xylene, m-xylene, 2-chlorotoluene, and 3-chlorotoluene in the presence of [RuCl₂(p-cymene)]₂ and 4-chlorobenzaldehyde using perfluoropropyl iodide as an oxidant and radical initiator to yield diarylmethanes such as I (Ar = Ph, 2-MeC₆H₄, 2-ClC₆H₄, 3-MeC₆H₄, 3-ClC₆H₄; R = H, Me) and a diarylethane in 35-74% yields (in some cases as 1.5:1-4:1 mixtures with di-meta-benzylated byproducts). The mechanism of the reaction was studied with radical inhibitor, isotope labeling, and kinetic isotope effect studies. The structure of a (chlorobenzyl)methoxyphenylpyrimidine was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Electric Literature of C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Evaluation of a Pyridinium-Based Ionic Liquid-Type Surfactant as a New Low-Dosage Methane Hydrate Inhibitor was written by Romero-Martinez, Ascencion;Hernandez-Guerrero, Erika;Ramirez-Jaramillo, Edgar;Martinez-Palou, Rafael. And the article was included in Energy & Fuels in 2020.Application of 104-73-4 This article mentions the following:

This work reports the synthesis of a new low-dosage kinetic hydrate inhibitor (KHI) based on the ionic liquid C12PyBr (N-dodecyl pyridinium bromide), which was characterized and evaluated in order to determine its inhibition performance. By means of a microwave-assisted reaction scheme, a high-purity product was obtained and the com. product Inhibex 101 (IC) was employed as a comparison reference at 0.1, 0.5,, and 1.0 wt % in aqueous solution to test the inhibition of methane hydrate formation. In this sense, it was discovered that, by using C12PyBr at 0.1 wt %, the formation of methane hydrates was inhibited at a subcooling of 11.2 K and at a concentration one order of magnitude lower than that used with Inhibex 101 to reach the same performance as KHI. This fact could be used as an attractive factor when establishing gas hydrate inhibition plans for offshore and deep-water scenarios. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new method of synthesis of 1,3,4-oxadiazoles from aromatic acids and semicarbazide with polyphosphoric acid was written by Ren, Zhong-Jiao;Jiang, E.;Zhou, Hong-Bin. And the article was included in Youji Huaxue in 1995.Application of 15420-02-7 This article mentions the following:

Oxadiazoles I (R = Ph, substituted Ph, 3-pyridyl, 4-pyridyl) were prepared in 41-95% yield by stirring RCO₂H with semicarbazide hydrochloride and polyphosphoric acid at 150-160° for 1 h. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Quantum Chemistry Approach of Breast Cancer Drugs Bound to Human Serum Albumin was written by Tavares, Ana Beatriz M. L. A.;Albuquerque, Eudenilson L.. And the article was included in Advanced Theory and Simulations in 2022.Application of 91-02-1 This article mentions the following:

The bindings of three different anticancer drugs, Cu(BpT)Br (2-benzoylpyridine thiosemicarbazone copper), NAMI-A (imidazolium trans-imidazoledimethylsulfoxide-tetrachlorido ruthenate), and DOX (doxorubicin), widely used in the breast cancer treatment, to human serum albumin (HSA) are investigated using a quantum chem. approach based on the d. functional theory calculations employing a dispersion corrected exchange-correlation functional within a fragmentation strategy. As a consequence, it is possible to identify the magnitude of the most relevant quantum binding interactions of these supramol. complexes, and thus guide their mol. modification process. The data obtained in this work highlight the power of quantum calculations as an important tool for the drug design process, and pave the way for the use of HSA-ligand interactions during the rational design of new anticancer compounds More important, the results show that HSA/multi-drug complex, formed by the combination of the three individual anticancer drugs [Cu(BpT)Br]-(NAMI-A)-(DOX), increases the targeting ability compared with each single drugs interaction with HSA, in agreement with in vivo predictions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem