Month: January 2023

Investigation of dynamic surface tension of aqueous solutions of cetyl- and dodecylpyridinium bromide by the oscillating jet method was written by Abdulin, N. G.;Kochurova, N. N.;Povysheva, N. I.;Temkin, A. S.. And the article was included in Vestnik Sankt-Peterburgskogo Universiteta, Seriya 4: Fizika, Khimiya in 2002.Reference of 104-73-4 This article mentions the following:

The dynamic surface tension of aqueous solutions of cetyl- and dodecylpyridinium bromide at different concentrations and temperatures 10-25°C has been measured. In these experiments a temperature inversion of the dynamic surface tension is observed for fresh surfaces. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Reference of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

3D-QSAR, Synthesis, and antimicrobial activity of 1-Alkylpyridinium Compounds as Potential Agents to Improve Food Safety was written by Rodriguez-Morales, Sergio;Compadre, R. Lilia;Castillo, Rafael;Breen, Philip J.;Compadre, Cesar M.. And the article was included in European Journal of Medicinal Chemistry in 2005.Category: pyridine-derivatives This article mentions the following:

Cetylpyridinium chloride (CPC), an alkylpyridinium compound has been recently approved by the US Food and Drug Administration to reduce bacterial contamination in poultry. Although CPC is very effective and has a very good safety record, its relatively high lipophilicity may limit its use in high fat containing foods such as beef. In this study, the CoMFA anal. (3D-QSAR) of the antimicrobial activity of 60 N-alkylpyridinium compounds against different bacteria was presented. CoMFA contours showed that the activity is highly influenced by the steric factor. Based in these contours, new candidates were designed, which were synthesized and characterized by spectroscopic data. MIC activity over Gram pos. and Gram neg. microorganisms validated the 3D-QSAR study. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Category: pyridine-derivatives).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Enabling Catalytic Arene C-H Amidomethylation via Bis(tosylamido)methane as a Sustainable Formaldimine Releaser was written by Li, Zhong-Yuan;Chaminda Lakmal, Hetti Handi;Cui, Xin. And the article was included in Organic Letters in 2019.Application In Synthesis of 2-(m-Tolyl)pyridine This article mentions the following:

2-Arylpyridines and aryl N-heterocycles such as 2-phenylpyridine underwent regioselective directed tosylaminomethylation with bis(tosylamino)methane as the formaldimine source in the presence of [Ru(p-cymene)Cl₂]₂, NaOAc, and Na₂CO₃ in 1,4-dioxane to yield mono(tosylaminomethyl)aryl pyridines such as I. Using the method, a dihydrobenzonaphthyridine and a dihydropyridobenzazepine were prepared In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application In Synthesis of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Imidazo[1,5-α]pyridine-based fluorescent probe with a large Stokes shift for specific recognition of sulfite was written by Chen, Song;Hou, Peng;Sun, Jingwen;Wang, Haijun;Liu, Lei. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

By taking advantage of the intramol. charge transfer (ICT) process, we presented a novel fluorescent probe IPY-SO₂ based on imidazo[1,5-α]pyridine derivative for detecting SO^2-₃ with a low detection limit (70 nM). Combining its favorable turn-on fluorescence feature (75-fold), rapid response (5 min), high selectivity, large Stokes shift (174 nm) and low cytotoxicity, IPY-SO₂ was successfully applied to imaging SO²₃ in living MCF-7 cells and zebrafish. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A convergent synthesis of the imidazopyridine scaffold of fluorescent alkaloid ageladine A was written by Mineno, Tomoko;Kansui, Hisao;Yoshimitsu, Hitoshi. And the article was included in Tetrahedron Letters in 2011.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester This article mentions the following:

A convergent synthesis of the imidazopyridine scaffold of fluorescent alkaloid ageladine A was achieved, employing 3-amino-2-chloropyridine as starting material. A carboxylate was introduced using BuLi and dry ice as the key reaction. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester).

(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ru-Catalyzed Selective C-H Functionalization of Pyridotriazoles with Acrylates was written by Joshi, Abhisek;Semwal, Rashmi;Adimurthy, Subbarayappa. And the article was included in SynOpen in 2021.Formula: C12H9NO This article mentions the following:

Ruthenium-catalyzed efficient and selective C-H alkenylation of pyridotriazoles with acrylates is described. The combination of metals (Ru and Fe) plays a crucial role in achieving quant. yields of the desired products. The reaction is proposed to involve the formation of a ruthenium cyclometalated intermediate. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Seven-membered ring compounds. XXXVIII. Reaction of troponoid with ylide. III. Reaction of tropone with pyridinium compounds was written by Sugimura, Yukio;Soma, Nobuo;Kishida, Yukichi. And the article was included in Bulletin of the Chemical Society of Japan in 1972.Formula: C7H7ClN2 This article mentions the following:

Phenacylpyridinium ylide (I, R = H, Br) reacted with tropone to afford 2-hydroxy-2-phenyl-3-phenacyl-2H-cyclohepta[b]furan (II) which was converted into 2-(1,2-dibenzoylethyl)tropone. The reactions of tropone with several kinds of pyridinium bromides yielded 2-substituted tropones in the presence of amines and 1-azaazulene derivatives including III in a one-step formation in the presence of NH4OAc. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of new nitrogen-bridged heterocycles. 60. Syntheses and conformational analyses of bis(indolizin-1-yl) disulfides was written by Kakehi, Akikazu;Suga, Hiroyuki;Okuno, Hiroko;Okuhara, Masaki;Ohta, Akira. And the article was included in Chemical & Pharmaceutical Bulletin in 2007.COA of Formula: C7H7ClN2 This article mentions the following:

Bis(indolizin-1-yl) disulfides I (R = cyano, CO₂Et, COPh, R¹ = Me, Et, CH₂Ph, etc., R² = H, Me), readily obtainable from the treatment of 1-(benzoylthio)indolizines II with piperidine, were prepared and their conformations were investigated. In comparison with those of 1-(benzoylthio)indolizines, the ¹H-NMR spectra of these disulfides showed considerable high field shifts (δ 0.13-0.82 ppm) on each pyridine ring proton and the UV spectra exhibited significant bathochromic and hyperchromic shifts. These results supported strongly the participation of an intramol. π-π interaction between two indolizine rings in these mols. and, hence, of a particular gauche (cis) conformation. However, the conformational considerations and mol. calculations (Mopac PM3) for some bis(indolizin-1-yl) disulfides showed the presence of four more stable gauche forms in which two are enantiomeric, resulting in three types of gauche structures. These three types of gauche structures were confirmed by X-ray analyses. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3COA of Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Multiple linear regression modeling of the critical micelle concentration of alkyltrimethylammonium and alkylpyridinium salts was written by Jalali-Heravi, M.;Konouz, E.. And the article was included in Journal of Surfactants and Detergents in 2003.Formula: C17H30BrN This article mentions the following:

The critical micelle concentration (CMC) of a set of 30 alkyltrimethylammonium [RN⁺(R’)₃X^–] and alkylpyridinium salts [RN⁺ϕX^–] was related to topol., electronic, and mol. structure parameters using a stepwise regression method. Among different models obtained, two equations were selected as the best and their specifications are given. The statistics for these models together with the cross-validation results indicate the capability of both models to predict the CMC of cationic surfactants. The results obtained for alkyltrimethylammonium salts indicate that geometric characteristics such as volume of the tail of the mol., maximum distance between the atoms, and surface area play a major role in micelle formation. However, the simultaneous modeling of the CMC of both alkyltrimethylammonium and alkylpyridinium salts indicates that the topol. descriptors of the Balaban and Randic indexes and also the electronic parameter of total energy of the mols. are important. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Formula: C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and study of anisotropic ammonium salts for production of liquid-crystalline materials and devices with variable surface anchoring was written by Kuz’menok, N. M.;Mikhalyonok, S. G.;Arol, A. S.;Bezborodov, V. S.;Krakhalev, M. N.;Sutormin, V. S.;Prishchepa, O. O.;Zyryano, V. Ya.. And the article was included in Zhidkie Kristally i Ikh Prakticheskoe Ispol’zovanie in 2018.HPLC of Formula: 104-73-4 This article mentions the following:

This paper describes the various anisotropic quaternary ammonium salts characterized by a specific interaction with the interface and capable to form various orientational structures of liquid crystal layer, have been prepared It has been shown that these salts are promising materials for creation of advanced liquid crystal compositions with surface anchoring caused by ionic surfactants. The obtained results are of undoubted interest for the developers of new liquid crystal materials and electro-optical devices based on them. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4HPLC of Formula: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem