Month: January 2023

Lanthanide post-functionalized UiO-67 type metal-organic frameworks for tunable light-emission and stable multi-sensors in aqueous media was written by Guo, Huadong;Wang, Fengyuan;Ma, Ruidan;Zhang, Min;Fu, Lianshe;Zhou, Ting;Liu, Shuang;Guo, Xianmin. And the article was included in Inorganica Chimica Acta in 2021.Application In Synthesis of Pyridin-4-ol This article mentions the following:

As well known, Zr-based UiO-type MOFs exhibit extraordinary high thermal and chem. stability, making them excellent candidates for new kinds of host materials. In this work, A UiO-67 type MOF (UiO-67-PO) has been successfully synthesized based on a lanthanide-affinity pyridin-4(1H)-one decorated dicarboxylate ligand. Post-functionalization with Tb³⁺ and Eu³⁺ (Tb_1-x/Eu_x@UiO-67-PO, x = 0 to 1.0) afforded tunable green ↔ yellow ↔ red light-emitting materials. Tb@UiO-67-PO shows strong luminescence and water stability, which can be served as an efficient multi-sensor for detection of aniline, Cr₂O^2-₇ and Fe³⁺ ions in aqueous solution with low detection limit of 60.11, 0.33 and 12.69 μM, resp. This study displays the advantages of combining luminescent lanthanide ions with robust UiO-type MOFs in tuning the fluorescence and sensing performance. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alkylation of 4-cyanopyridine and pyridine was written by Wang, Cheng-Hsia;Horng, Jhy-Ming;Hwang, Fang-Yu. And the article was included in Bulletin of the Institute of Chemistry, Academia Sinica in 1979.Recommanded Product: 644-98-4 This article mentions the following:

Pyridine and 4-cyanopyridine were alkylated with RCO₂H (R = Me, Et, Pr, CHMe₂, Bu) in the presence of (NH₄)₂S₂O₈ and AgNO₃ in aqueous H₂SO₄ at 70-80° to give 51-95% 2- and 4-alkylpyridines and 2-alkyl- and 2,6-dialkyl-4-cyanopyridines. Aromatic compounds were not alkylated under these conditions. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dihydropyrrole[2,3-d]pyridine Derivatives as Novel Corticotropin-Releasing Factor-1 Antagonists: Mapping of the Receptor Binding Pocket by in Silico Docking Studies was written by Di Fabio, Romano;Arban, Roberto;Bernasconi, Giovanni;Braggio, Simone;Blaney, Frank E.;Capelli, Anna M.;Castiglioni, Emiliano;Donati, Daniele;Fazzolari, Elettra;Ratti, Emiliangelo;Feriani, Aldo;Contini, Stefania;Gentile, Gabriella;Ghirlanda, Damiano;Sabbatini, Fabio M.;Andreotti, Daniele;Spada, Simone;Marchioro, Carla;Worby, Angela;St-Denis, Yves. And the article was included in Journal of Medicinal Chemistry in 2008.Application In Synthesis of 3-Amino-2,6-dimethoxypyridine This article mentions the following:

In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochem. properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent Ph ring and the nature of the heterocyclic moieties present in the upper region of the mol. Selective and potent compounds have been discovered endowed with reduced ClogP with respect to compounds known in the literature. Of particular relevance was the finding that the in vitro affinity of the series was maintained by reducing the overall lipophilicity. The results achieved by this exploration enabled the formulation of a novel hypothesis on the nature of the receptor binding pocket of this class of CRF-1 receptor antagonists, making use of in silico docking studies of the putative nonpeptidic antagonist binding site set up in house by homol. modeling techniques. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application In Synthesis of 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mono- and dimethylbenzyls as new protecting groups for no-carrier-added nucleophilic aromatic radiofluorination was written by Malik, Noeen;Zlatopolskiy, Boris D.;Solbach, Christoph;Voelter, Wolfgang;Reske, Sven N.;Machulla, Hans-Juergen. And the article was included in Journal of Radioanalytical and Nuclear Chemistry in 2011.Related Products of 15128-90-2 This article mentions the following:

In this work, we tested the applicability of several Me substituted benzyl groups as an alternative to the Me group for the protection of the hydroxyl groups in the nucleophilic aromatic radiofluorination. As a model synthesis, the no-carrier-added (n.c.a.) preparation of 2-[¹⁸F]fluoro-3-hydroxy-6-methylpyridine from O-protected 3-hydroxy-6-methyl-2-nitropyridine was chosen. Conditions for acidolytic and hydrogenolytic cleavage of heteroaryl esters were studied. Among various protecting groups tested, 4-methylbenzyl and 2,4-dimethylbenzyl groups proved to be the best by resulting in about 70% yields of [¹⁸F]-labeled product after hydrolysis with 32% HCl at 120 °C for 10 min. Furthermore, 4-methylbenzyl ester cleaved readily under catalytic transfer hydrogenation condition using ammonium formate and 10% Pd/C in boiling methanol to give 2-[¹⁸F]fluoro-3-hydroxy-6-methylpyridine in radiochem. yield of 75% within a reaction time of 10 min. Conditions for the cleavage of both 4-methylbenzyl and 2,4-dimethylbenzyl esters are well suited for the implementation into an automated synthesis module. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Related Products of 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phosphination of Phenol Derivatives and Applications to Divergent Synthesis of Phosphine Ligands was written by Li, Chenchen;Zhang, Kezhuo;Zhang, Minghao;Zhang, Wu;Zhao, Wanxiang. And the article was included in Organic Letters in 2021.HPLC of Formula: 4783-68-0 This article mentions the following:

The authors describe a general and efficient protocol for the synthesis of organophosphine compounds from phenols and phosphines (R₂PH) via a metal-free C-O bond cleavage and C-P bond formation process. This approach exhibits broad substrate scope and excellent functional group tolerance. The synthetic utilities of this protocol were demonstrated by the synthesis of chiral ligands via the various transformations of cyano groups and their applications in asym. catalysis. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions was written by Zhang, Xitao;Feng, Xiujuan;Zhou, Chuancheng;Yu, Xiaoqiang;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Organic Letters in 2018.Recommanded Product: 4373-61-9 This article mentions the following:

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

γ-Bromination of quinoline and pyridine N-oxides was written by Saito, Hirohisa;Hamana, Masatomo. And the article was included in Heterocycles in 1979.Formula: C7H9NO This article mentions the following:

Treatment of quinoline 1-oxide with Br (2 equiv) and Tl(OAc)₃ in HOAc at 50° for 29 h gave 65.8% 4-bromoquinoline 1-oxide. Similarly, quinaldine and 3-bromoquinoline 1-oxide gave the corresponding γ-bromo derivatives in good yields. From 2-cyanoquinoline 1-oxide, 2-cyano-4-bromoquinoline 1-oxide and 2-carbamoyl-4-bromoquinoline 1-oxide were obtained. The reactivity of N-oxides of pyridine series was somewhat lower and pyridine and 2-picoline 1-oxides resist bromination under similar conditions, but 2,6-lutidine, 3-picoline and 3,5-lutidine 1-oxides afforded the corresponding γ-bromo derivatives In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A one-pot synthesis of substituted pyrido[2,3-b]indolizines was written by Proenca, Fernanda;Costa, Marta. And the article was included in Tetrahedron in 2011.Reference of 17281-59-3 This article mentions the following:

An efficient and novel approach to the synthesis of substituted pyrido[2,3-b]indolizine-10-carbonitriles (I; R¹, R² = Me, aryl) was developed. These structures are practically unavailable through previously described methods. The cascade transformation involves the reaction of α,β-unsaturated carbonyl compounds with a stable dimer prepared from 1-(cyanomethyl)pyridinium chloride. The reaction was performed under reflux conditions in ethanol/water and in the presence of sodium acetate. This procedure represents a eco-friendly regioselective approach to the pyrido[2,3-b]indolizine core structure. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Reference of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer′s disease and depression was written by Zhang, Chao;Wang, Lan;Xu, Yixiang;Huang, Yunyuan;Huang, Junyang;Zhu, Jin;Wang, Wei;Li, Wangsheng;Sun, Annan;Li, Xiaokang;Zhang, Haiyan;Li, Jian. And the article was included in European Journal of Medicinal Chemistry in 2022.Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:

Depression is identified as one of the most common psychiatric symptoms in Alzheimer′s disease (AD). The comorbidity of AD and depression increases the burden of clin. treatment and care in elderly patients. In order to find new treatment options, we first proposed the dual RAGE/SERT inhibitors by fusing the key pharmacophore of vilazodone and azeliragon for the potential treatment of AD with comorbid depression. After a series of structural modifications, 34 dual-target directed ligands were designed and synthesized, and their RAGE and SERT inhibitory activities were systematically evaluated. Among them, compound 12 showed good dual-target bioactivities against RAGE (IC50 = 8.26 ± 1.12 μM) and SERT (IC50 = 31.09 ± 5.15 nM) in vitro, better safety profile than azeliragon, good liver microsomal stability, weak CYP inhibition, and acceptable pharmacokinetic properties. Moreover, 12 ameliorated Aβ25-35-induced neurotoxicity in SH-SY5Y cells and alleviated the depressive symptom in tail suspension test. In brief, these results indicated that 12 is a prospective prototype for the potential treatment of AD with comorbid depression. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of tert-Butyl 4-carbamothioylpiperidine-1-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemoselective Demethylation of Methoxypyridine was written by Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo. And the article was included in Synlett in 2019.Related Products of 626-64-2 This article mentions the following:

A chemoselective demethylation method for various methoxypyridine derivatives I (R = 3-OMe, 4-CH₂=CHCH₂O, 4-C₆H₅CH₂O, etc.; X = H, 5-Cl, 4-Me, etc.; Y = CH, N) has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; and no reaction to anisole is occurred. The utility of this method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Related Products of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem