Month: January 2023

7′-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors was written by Zhang, Lin;Fan, Junhua;Vu, Khang;Hong, Kevin;Le Brazidec, Jean-Yves;Shi, Jiandong;Biamonte, Marco;Busch, David J.;Lough, Rachel E.;Grecko, Roy;Ran, Yingqing;Sensintaffar, John L.;Kamal, Adeela;Lundgren, Karen;Burrows, Francis J.;Mansfield, Robert;Timony, Gregg A.;Ulm, Edgar H.;Kasibhatla, Srinivas R.;Boehm, Marcus F.. And the article was included in Journal of Medicinal Chemistry in 2006.Safety of 3,4-Dichloro-5-nitropyridine This article mentions the following:

We report on the discovery of benzo- and pyridino- thiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chlorobenzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl)-9H- purin-6-ylamine)(I). In the experiment, the researchers used many compounds, for example, 3,4-Dichloro-5-nitropyridine (cas: 56809-84-8Safety of 3,4-Dichloro-5-nitropyridine).

3,4-Dichloro-5-nitropyridine (cas: 56809-84-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,4-Dichloro-5-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and synthesis of non-symmetric phenylpyridine type ligands. Experimental and theoretical studies of their corresponding iridium complexes was written by Iturbe, C.;Loeb, B.;Barrera, M.;Brito, I.;Canete, A.. And the article was included in Polyhedron in 2016.Reference of 4373-61-9 This article mentions the following:

In this work three nonsym. phenylpyridine type ligands, L1, L2 and L3, were designed, and their corresponding Ir complexes, C1, C2 and C3, synthesized, to understand the effect of ligand asymmetry on the properties of the complexes, and to explore their potentiality in light emitting devices. The complexes were structurally characterized by NMR experiments and by x-ray Diffraction, and physicochem. by technics as UV/visible and cyclic voltammetry. Theor. DFT calculations of the energy and electronic d. of the frontier orbitals of the complexes under study were also performed. The energy of the HOMO and LUMO correlated well with the exptl. electrochem. data, and supported the understanding of the processes observed In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Reference of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Electronic Characterization of Iridium-Aluminum and Rhodium-Aluminum Heterobimetallic Complexes Bridged by 3-Oxypyridine and 4-Oxypyridine was written by Charles, R. Malcolm III;Tupkar, Hrishikesh;Helland, Sarah D.;Mercado, Angel A.;Eckenhoff, William T.;Schley, Nathan D.;DeYonker, Nathan J.;Brewster, Timothy P.. And the article was included in European Journal of Inorganic Chemistry in 2020.Recommanded Product: 626-64-2 This article mentions the following:

The authors demonstrate the synthesis and characterization of regioisomeric late transition metal-aluminum heterobimetallic complexes containing 3- and 4-oxypyridine ligands which bridge between the aluminum and transition metal center (Rh or Ir). Combined exptl. and theor. data allow for direct comparison of the electronic effect of the two different aluminum-containing ligands on the late transition metal center. In combination with electronic data regarding previously reported 2-oxypyridine bridged systems, the authors report a measurable decrease in ligand donor power as the regiosubstitution of the oxypyridine bridge is varied from 2- to 4- to 3-. In all cases, addition of aluminum is found have a minimal effect on the donor ability of the oxypyridine bridge in dichloromethane solution In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Recommanded Product: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The Mechanism of Orotidine 5′-Monophosphate Decarboxylase: Catalysis by Destabilization of the Substrate was written by Feng, Wan Yong;Austin, Travis J.;Chew, Frank;Gronert, Scott;Wu, Weiming. And the article was included in Biochemistry in 2000.Name: 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid This article mentions the following:

The mechanism of orotidine 5′-monophosphate decarboxylase (OMP decarboxylase, ODCase) was studied using the decarboxylation of orotic acid analogs as a model system. The rate of decarboxylation of 1,3-dimethylorotic acid and its analogs as well as the stability of their corresponding carbanion intermediates was determined The results have shown that the stability of the carbanion intermediate is not a critical factor in the rate of decarboxylation. On the other hand, the reaction rate is largely dependent on the equilibrium constant for the formation of a zwitterion. Based on these results, we have proposed a new mechanism in which ODCase catalyzes the decarboxylation of OMP by binding the substrate in a zwitterionic form and providing a destabilizing environment for the carboxylate group of OMP. In the experiment, the researchers used many compounds, for example, 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2Name: 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid).

1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (cas: 59864-31-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A simple coumarin based “fluorescent On” probe for the selective detection of Al³⁺ along with its application in live cell imaging via AGS cell line was written by Gharami, Saswati;Aich, Krishnendu;Ghosh, Paramita;Patra, Lakshman;Murmu, Nabendu;Mondal, Tapan Kumar. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Category: pyridine-derivatives This article mentions the following:

A new coumarin based fluorescent switch (HCBP) has been fabricated which displays high selective sensing towards Al³⁺ among other metal cations at physiol. pH. On gradual addition of Al³⁺ specifically, HCBP shows a brilliant “turn-on” emission enhancement of about âˆ?3-fold with about 50 nm red shift at 481 nm in MeOH/H₂O (1/1, volume/volume) solution The fluorescent switch is proven to be a reversible probe by addition of EDTA gradually into the HCBP-Al³⁺ solution Detection limit as well as Binding constant values have been calculated and found to be in the order of 10^-9 M and 10³ M^-1 resp. DFT and TDDFT studies are conducted with the probe to establish a similarity between theor. and exptl. outcomes. We can also use this new fluorescent switch as a biomarker kit as it has shown a brilliant potential in the application of live cell imaging using gastric cancer cell (AGS cell). In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Category: pyridine-derivatives).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, anti-tumour activity, and mechanism of benzoyl hydrazine Schiff base-copper complexes was written by Chen, Meixu;Chen, Xin;Huang, Guidong;Jiang, Yanlin;Gou, Yi;Deng, Jungang. And the article was included in Journal of Molecular Structure in 2022.COA of Formula: C12H9NO This article mentions the following:

Four new complexes of Cu(II) coordinated to a benzoyl hydrazine Schiff base-[Cu(L1)Cl] (C1), [Cu(L1)Py] (C2), [Cu(L2)NO₃] (C3), [Cu(L3)NO₃] (C4) were synthesized and characterized. X-ray crystallog. results indicated that all complexes had four-coordinated Cu centers. The mol. structures of the complexes were altered by linking the Ph or pyridyl group with the ligand branch or by attaching a 2nd ligand (Py, pyridine) to the Cu center. The IC₅₀ values of the four complexes acting on the selected tumor cells were 2.69-16.32μM. The C1 and C2 complexes could up-regulate the expression of p21 to down-regulate the expression of cyclin D1, cyclin E, and CDK2, which caused the cell cycle to be arrested in the G1 phase. Further studies revealed that the C2 complex was able to stabilize G-quadruplex (G4) DNA structure, including that of the proto-oncogene c-kit and the Pu27 sequence situating the promoter region of c-myc, which led to the significant inhibition the expression of c-myc and c-kit. This affected the expression of downstream proteins, such as hTERT and Bcl-2, ultimately inducing apoptosis. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1COA of Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ion speciation: a key for the understanding of the solution properties of ionic liquid mixtures was written by Kurnia, Kiki Adi;Fernandes, Ana M.;Pinho, Simao P.;Coutinho, Joao A. P.. And the article was included in Physical Chemistry Chemical Physics in 2019.Recommanded Product: 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Recently, combinations of two (or more) ionic liquids, known as ionic liquid mixtures, have become popular and have a broad range of applications. However, the fundamental knowledge on the mol. interactions that exist in ionic liquid mixtures is far from being understood. In this work, the exptl. measurement of the water activity coefficient and computational modeling using Conductor-like Screening Model for Real Solvent (COSMO-RS) were carried out to get an insight into the mol. interactions that are present in ionic liquid mixtures in aqueous solution The results show that the combination of two ionic liquids of different basicity in aqueous solution allows fine tuning of the water activities, covering a wide range of values that could replace several pure fluids. This is an important feature resulting from the unexpected ion speciation of the ionic liquid mixtures in aqueous solution In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Three-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives was written by Luan, Yu-Yong;Gou, Xue-Ya;Shi, Wei-Yu;Liu, Hong-Chao;Chen, Xi;Liang, Yong-Min. And the article was included in Organic Letters in 2022.SDS of cas: 4783-68-0 This article mentions the following:

Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R¹ = H, Me, Cl, etc.; R² = H, Me, F, etc; R³ = Me, F; R⁴ = Ph, 4-FC₆H₄, 4-BrC₆H₄, etc.; R² = R³ = Me, F; R⁵ = OEt, piperidin-1-yl, N(n-Bu)₂] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Microwave irradiation induced synthesis of 2-amino-4,6-diarylpyridines was written by Wu, Ping;Cai, Xi-Mei;Yan, Chao-Guo. And the article was included in Youji Huaxue in 2006.HPLC of Formula: 17281-59-3 This article mentions the following:

Under microwave irradiation, N-cyanomethylpyridinium chloride reacted with chalcones in the presence of ammonium acetate and acetic acid to give 2-amino-4,6-diarylpyridines in high yields. 2-Aminoduiarylpyridines can also be prepared from one-pot reactions of N-cyanomethylpyridinium chloride with aromatic aldehydes and substituted acetophones. The structures of the products were characterized with ¹H NMR, IR and HPLC-MS spectra. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3HPLC of Formula: 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâˆ? in pyridine vs. 150 kJ·molâˆ? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Self-assembled three-dimensional molecule-based magnet composed of a trinuclear manganese unit and octacyanidotungstate was written by Komine, Masaya;Nakabayashi, Koji;Stefanczyk, Olaf;Ohkoshi, Shin-ichi. And the article was included in Inorganica Chimica Acta in 2019.Quality Control of Pyridin-4-ol This article mentions the following:

The authors report a three-dimensional mol.-based magnet, [Mn^II₃(4-pyridone)₆][W^V(CN)₈]₂·2H₂O (1). This compound was synthesized in 1-pot by evaporation of an aqueous solution in which MnCl₂·4H₂O, 4-hydroxypyridine and Cs₃[W(CN)₈]·2H₂O were dissolved. The evaporation process causes self-assembly of the building blocks, forming a three-dimensional network structure with unique trimanganese units of [Mn₃(4-pyridone)₆]⁶⁺ bridged by [W(CN)₈]^3- anions. This compound has two types of short intermetallic bridges, which can exhibit two magnetic interaction pathways (Mn^II-O-Mn^II and Mn^II-NC-W^V). The magnetic interactions between W^V (S = 1/2) and Mn^II (S = 5/2) and between Mn^II and Mn^II are antiferromagnetic with exchange coupling constants of J_MnW = -3.9 cm^-1 and J_MnMn = -5.9 cm^-1, resp. The present compound exhibits ferrimagnetism with spontaneous magnetization <20 K. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem