Month: January 2023

Electronic absorption spectra and effect of solvents on electronic transitions of 3-hydroxy-6-methyl-2-nitropyridine was written by Yadav, B. S.;Kumaryadav, Amit;Chand, Subhash;Seema;Siddiqui, I. A.. And the article was included in Oriental Journal of Chemistry in 2006.Name: 3-Hydroxy-6-methyl-2-nitropyridine This article mentions the following:

UV spectra have been recorded in different polar solvents in the region 400-200 nm. The solvent effect on the electronic transitions of 3-hydroxy-6-methyl-2-nitropyridine is discussed. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Name: 3-Hydroxy-6-methyl-2-nitropyridine).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 3-Hydroxy-6-methyl-2-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of some streoregular polydiacetylenes and the slow release of drug using some linear polymers was written by Al-Ajely, Mohammad S.;Sharif, A. Y.;Qasim, A. A.. And the article was included in Pakistan Journal of Chemistry in 2012.Related Products of 104-73-4 This article mentions the following:

Some polydiacetylenes have been synthesized using UV light in topochem. polymerization technique. Some diacetylene compounds were reacted with benzocaine and procaine in an attempt to be used as biosensors in topochem. polymerization process (In vivo). The linear (Amorphous) polymer was allowed to react with some com. antibiotics and were studied as slow drug release polymers. Externally treatment of the drug containing polymers to groups of infected rabbits revealed that these polymers are effective against certain types of micro organisms. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Related Products of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dissolution, regeneration and ion-gel formation of agarose in room-temperature ionic liquids was written by Singh, Tejwant;Trivedi, Tushar J.;Kumar, Arvind. And the article was included in Green Chemistry in 2010.Reference of 125652-55-3 This article mentions the following:

The suitability of several ionic liquids, containing imidazolium or pyridinium cations with different alkyl chains and anions ranging from small hydrogen-bond acceptors to those of a large and non-coordinating nature, has been tested for solubilization of a widely used biopolymer, agarose. The solubility of agarose was found to depend on both the nature of anion and amphiphilicity of the cation. Dissolved agarose was regenerated using methanol, and ionic liquids were recovered and recycled for different experiments Regenerated agarose largely maintained the features of native agarose in terms of mol. weight, polydispersity, thermal stability and crystallinity but varied slightly in conformation preferences. Subsequently, agarose-based highly conducting soft ion-gels having small thermal hysteresis were prepared and characterized. Such ion-gels have possible applications as electrochem. devices. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Reference of 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Azomethines containing electron-attracting substituents. V. (2 + 4) Cycloaddition of p-tosylisonitrosomalonodinitrile. Scope and mechanism of the reaction was written by Fleury, Jean Pierre;Desbois, Michel;See, Jacqueline. And the article was included in Bulletin de la Societe Chimique de France in 1978.COA of Formula: C7H6N2 This article mentions the following:

Tetrahydropyridines I (R = H; R¹ = H, Me, Ph; R²-R⁴ = H, Me) were obtained by treating 4-MeC₆H₄SO₃N:C(CN)₂ with R¹CH:CR²CR³:CHR⁴ under reflux; C₆H₆ thermolysis of I in EtOH gave the pyridines II. I (R = R¹ = R³ = Me, R² = R⁴ = H) was similarly prepared The azabicyclooctenes III (R⁵ = 4-MeC₆H₄SO₂, 4-O₂NC₆H₄CO, Bz) were similarly obtained from 1,3-cyclohexadiene and RON:C(CN)₂. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4COA of Formula: C7H6N2).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C7H6N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Indolizy Carbene Ligand. Evaluation of Electronic Properties and Applications in Asymmetric Gold(I) Catalysis was written by Martinez, Thibaut;Vanitcha, Avassaya;Troufflard, Claire;Vanthuyne, Nicolas;Forte, Jeremy;Gontard, Geoffrey;Lemiere, Gilles;Mouries-Mansuy, Virginie;Fensterbank, Louis. And the article was included in Angewandte Chemie, International Edition in 2021.Synthetic Route of C12H9NO This article mentions the following:

We report herein a new family of carbene ligands based on an indolizine-ylidene (Indolizy) moiety. The corresponding gold(I) complexes are easily obtained from the gold(I)-promoted cyclization of allenylpyridine precursors. Evaluation of the electronic properties by exptl. methods and also by DFT calculations confirms strong σ-donating and π-accepting properties of these ligands. Cationization of the gold(I) complexes generates catalytic species that trigger diverse reactions of (poly)unsaturated precursors. When armed with a methylene phosphine oxide moiety on the stereogenic center adjacent to the nitrogen atom, the corresponding bifunctional carbene ligands give rise to highly enantioselective heterocyclizations. DFT calculations brought some rationalization and highlighted the critical roles played by the phosphine oxide group and the tosylate anion in the asym. cyclization of γ-allenols. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Synthetic Route of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metal-Free Catalyzed Synthesis of Fluorescent Indolizine Derivatives was written by Yuan, Yu-Chang;Liu, Tian-Zhen;Zhao, Bao-Xiang. And the article was included in Journal of Organic Chemistry in 2021.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

A mild and high efficient method to prepare indolizines such as I [R = H, Me; R¹ = Me, Ph, CH₂CH₂CO₂Et; R² = H, Me, OEt; R³ = Me, Ph, 4-ClC₆H₄; R¹R² = (CH₂)₃] by two-component reaction with the acid as the catalyst was developed. In this reaction, a new ring efficiently formed in one-step reaction. A wide range of substrates could be applied and the desired products were obtained in 8-95% yields under metal-free conditions. Different indolizine derivatives I were synthesized by general conditions and microwave irradiation conditions, and compound I [R = H, R¹ = Me, R² = H, R³ = Ph] gave the best results with an isolated yield of 95% and 82%, resp. The structures of synthesized compounds I were characterized by spectral anal., and compound I [R = H, R¹R² = (CH₂)₃, R³ = 4-ClC₆H₄] was confirmed by single crystal X-ray anal. UV-vis absorption and fluorescence properties of these compounds I were correlated with substituent groups on indolizine rings. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ligand Control in Selective C-H Oxidative Functionalization Using Pd-PEPPSI-Type Complexes was written by Bolbat, Ekaterina;Wendt, Ola F.. And the article was included in European Journal of Organic Chemistry in 2016.Related Products of 644-98-4 This article mentions the following:

To achieve high selectivity in directed C-H activation, an NHC ligand was introduced to a palladium catalyst. A range of Pd-PEPPSI complexes were applied in the direct acetoxylation of 2-phenylpyridine. The best catalyst is the one based on a diisopropylphenyl-substituted NHC ligand, and this was successfully used for the functionalization of sp² as well as more challenging sp³ bonds for a broad variety of substrates. The explored method showed a highly improved selectivity compared to previously reported results with up to 96% yield for the monoacetoxylated product. Kinetic studies show that sterics of the catalyst is less important in dictating conversion and selectivity; despite an induction period, the catalyst is mol. in nature. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile was written by Tamura, Yuusuke;Hayashi, Kyouhei;Omori, Naoki;Nishiura, Yuji;Watanabe, Kana;Tanaka, Nobuyuki;Fujioka, Masahiko;Kouyama, Naoki;Yukimasa, Akira;Tanaka, Yukari;Chiba, Takeshi;Tanioka, Hideki;Nambu, Hirohide;Yukioka, Hideo;Sato, Hiroki;Okuno, Takayuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Computed Properties of C11H9NO This article mentions the following:

Optimization of HTS hit 1 (I) for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study. Among them, derivative 4i inhibited food intake induced by the NPY Y5 selective agonist, and chronic oral administration of 4i in DIO mice caused a dose-dependent reduction of body weight gain. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7Computed Properties of C11H9NO).

5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of Substituted Pyridines via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates was written by Renslo, Adam R.;Danheiser, Rick L.. And the article was included in Journal of Organic Chemistry in 1998.Quality Control of Methyl 3-methylpicolinate This article mentions the following:

Diels-Alder cycloadditions of 2,2-dimethyl-5-tosyloxyimino-1,3-dioxane-4,6-dione (I) with a variety of 1,3-dienes proceed with regiochem. opposite to that observed with conventional imino dienophiles, providing expeditious synthetic routes to substituted pyridines, tetrahydropyridines, and pyrrolines. I is prepared in one convenient synthetic operation from Meldrum’s acid and reacts with conjugated dienes at -78 °C in the presence of 2 equiv of dimethylaluminum chloride to afford [4 + 2] cycloadducts in good to excellent yield. Exposure of these cycloadducts to the action of NaOMe and N-chlorosuccinimide in methanol-THF at room temperature then produces substituted pyridines. The utility of this new two-step annulation protocol is demonstrated in total syntheses of the pyridine alkaloids fusaric acid and (S)-(+)-fusarinolic acid. Heating the [4 + 2] cycloadducts derived from I in a mixture of acetonitrile and pH 7 phosphate buffer induces an unusual Stieglitz-type rearrangement leading to the formation of interesting spirobicyclic pyrrolines. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Quality Control of Methyl 3-methylpicolinate).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of Methyl 3-methylpicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors was written by Cox, Jason M.;Harper, Bart;Mastracchio, Anthony;Leiting, Barbara;Roy, Ranabir Sinha;Patel, Reshma A.;Wu, Joseph K.;Lyons, Kathryn A.;He, Huaibing;Xu, Shiyao;Zhu, Bing;Thornberry, Nancy A.;Weber, Ann E.;Edmondson, Scott D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Name: 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:

Substituted 3-aminopiperidines were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassium channel, calcium channel, Cyp2D6, and pharmacokinetic profiles. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Name: 2-Bromo-3-(trifluoromethyl)pyridine).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 2-Bromo-3-(trifluoromethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem