Month: January 2023

Deconstructive Cycloaromatization Strategy toward N,O-Bidentate Ligands from Indolizines and Cyclopropenones was written by Zhou, Jinlei;Shi, Xiaotian;Zheng, Huitao;Chen, Guangxian;Zhang, Chen;Liu, Xiang;Cao, Hua. And the article was included in Organic Letters in 2022.Recommanded Product: 24103-75-1 This article mentions the following:

Here, an unprecedented approach for the construction of polyaryl N,O-bidentate derivatives via the merging of ring deconstruction with cycloaromatization of indolizines and cyclopropenones was reported. Without any catalysts, this method could deliver a series of polyaryl 2-(pyridin-2-yl)phenols I [R¹ = H, 4-Me, 5-Et, etc.; R² = Me, cyclopropyl, Ph, etc.; Ar = Ph, 4-MeC₆H₄, 3-MeC₆H₄, 4-MeOC₆H₄, 2-thienyl] in excellent yields. In addition, N,O-bidentate organic BF₂ complexes, e.g., II, could also be constructed via this one-pot protocol. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Recommanded Product: 24103-75-1).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 24103-75-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones was written by Wang, Hua;Liu, Jie;Qu, Jian-Ping;Kang, Yan-Biao. And the article was included in Journal of Organic Chemistry in 2020.Synthetic Route of C12H9NO This article mentions the following:

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Synthetic Route of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The influence of surfactants on separation processes involving membranes was written by Simion, Demetra;Niculescu, Olga;Gaidau, Carmen;Simion, Marius;Popescu, Georgeta;Chelaru, Ciprian. And the article was included in Revista de Pielarie Incaltaminte in 2011.Name: 1-Dodecylpyridin-1-ium bromide This article mentions the following:

The influence of surfactants upon the wettability of some hydrophobic microporous membranes of polysulfone was studied by determining the contact angle and the ultrafiltration rates. The water-membrane contact angle increases with roughness and changes in presence of the surfactant in aqueous solution to an extent which depends on its nature and concentration The variations of contact angle of surfactant in aqueous solution are in good agreement with the variation of the rate of ultrafiltration solutions through membranes and with the adsorption of surfactants on polysulfone surface. The method of measuring the contact angle is simple and rapid; it may be employed in characterization of polysulfone membrane, hydrophobicity in spite of the scattering of values obtained of microporous surfaces. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Name: 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Crystal structures of two substituted 2,5-diaryl-1,3,4-oxadiazoles was written by Stockhause, S.;Wickleder, M. S.;Meyer, G.;Orgzall, I.;Schulz, B.. And the article was included in Journal of Molecular Structure in 2001.Formula: C12H8N4O This article mentions the following:

The crystal structures of 2,5-di(4-pyridyl)-1,3,4-oxadiazole (I) and 2-(4-cyanophenyl)-5-(4-dimethylaminophenyl)-1,3,4-oxadiazole (II) were determined from single crystal data. I is monoclinic, space group C2/c, a 5.3129(9), b 12.142(3), c 16.771(3) Å, β 93.41(2)°, R_all = 0.0774. II is triclinic, space group P1̅, a 7.3908(12), b 8.7992(15), c 12.036(2) Å, α 77.04(2), β 89.29(2), γ 87.58(2)°, R_all = 0.0552. At. coordinates are given. In both structures the formation of stacks of the almost planar mols. is observed as known for other oxadiazoles. These compounds exhibit differences to other substituted 2,5-diaryl-1,3,4-oxadiazoles in the crystalline structure. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Single-Crystal Mesostructured Semiconductors with Cubic Ia3d Symmetry and Ion-Exchange Properties was written by Trikalitis, Pantelis N.;Rangan, Krishnaswamy K.;Bakas, Thomas;Kanatzidis, Mercouri G.. And the article was included in Journal of the American Chemical Society in 2002.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

If the full scientific and technol. potential of mesostructured materials is to be achieved, systems with continuous domains in the form of single crystals or films must be prepared Here we report a reliable and facile system for making large single-crystal particles of chalcogenido mesostructured materials with a highly organized cubic structure, accessible pore structure, and semiconducting properties. Building blocks with square planar bonding topol., Pt²⁺ and [Sn₂Se₆]^4-, in combination with long-chain pyridinium surfactants (C_nPyBr, n = 18, 20) favor faceted single-crystal particles with the highest possible space group symmetry Ia3̅d. This is an important step toward developing large single-domain crystalline mesostructured semiconductors and usable natural self-assembled antidot array systems. The tendency toward cubic symmetry is so strong that the materials assemble readily under exptl. conditions that can tolerate considerable variation and form micrometer-sized rhombic dodecahedral cubosome particles. The c-C_nPyPtSnSe materials are the first to exhibit reversible ion-exchange properties. The surfactant mols. can be ion-exchanged reversibly and without loss of the cubic structure and particle morphol. The cubosomes possess a three-dimensional open Pt-Sn-Se framework with a low-energy band gap of âˆ?.7 eV. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application In Synthesis of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, experimental and theoretical studies of two cocrystals in 1:1 stoichiometric ratio from 4,4′-bithiazole-2,2′-diamine with two hydrogen acceptor molecules was written by Ranjbar, Zohreh Rashidi;Morsali, Ali. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2015.Reference of 15420-02-7 This article mentions the following:

This paper reports synthesis, characterization and theor. studies of two 1:1 stoichiometric ratio cocrystals of 4,4′-bithiazole-2,2′-diamine (DABTZ) with 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (bpo) and 1,3-bis(4-pyridyl)ethane (bpa). These cocrystal compounds have been prepared by slow evaporation method and characterized by elemental and thermal anal., FTIR, ¹H and ¹³C-NMR spectroscopies and X-ray crystallog. X-ray crystal analyses show that these structures [(DABTZ) (bpo)] and [(DABTZ) (bpa)] have crystallized in monoclinic forms with space groups of P2₁/n and C _2/c, resp. These structures were studied theor. and the results are in good agreement with the exptl. data. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Reference of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fragment screening of N-acetylmannosamine kinase reveals noncarbohydrate inhibitors was written by Aretz, Jonas;Wratil, Paul Robin;Wamhoff, Eike-Christian;Nguyen, Hoang Giang;Reutter, Werner;Rademacher, Christoph. And the article was included in Canadian Journal of Chemistry in 2016.Application of 122637-39-2 This article mentions the following:

Many biol. processes from infection to tumor immune evasion are controlled by cell surface sialylation. To gather further insight into these processes, methods to alter cell surface sialylation are required. One way to achieve this is inhibiting the key enzyme of sialic acid de novo biosynthesis, the intracellular bifunctional UDP-N-acetylglucosamine epimerase/N-acetylmannosamine kinase (GNE/MNK). Here, the authors present low-mol.-weight inhibitors of MNK activity based on picolinic acid derivatives They were identified in a fragment screening using ¹⁹F NMR and validated in a biochem. inhibition assay followed by a structure-activity relation anal. and docking. The optimized compound, 6-carbamoylpicolinic acid, inhibited MNK with a double-digit micromolar affinity. Its low mol. weight (166 Da) rendered this picolinic acid derivative an exquisite starting point for the development of high-affinity MNK inhibitors, which may serve as mol. probes or lead candidates in future. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Application of 122637-39-2).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 122637-39-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,5-bis(n-pyridyl)-1,3,4-oxadiazoles as corrosion inhibitors for mild steel in acidic media was written by Bentiss, F.;Lagrenee, M.;Traisnel, M.. And the article was included in Corrosion (Houston) in 2000.COA of Formula: C12H8N4O This article mentions the following:

The effect of new corrosion inhibitors-namely, 2,5-bis(n-pyridyl)-1,3,4-oxadiazoles (n-POX)-on the corrosion of mild steel in 1 M hydrochloric acid (HCl) and 0.5 M sulfuric acid (H₂SO₄) was investigated using weight loss measurements and electrochem. techniques such as polarization curves and electrochem. impedance spectroscopy. Results obtained revealed that these compounds were good inhibitors and behaved better in 1 M HCl than in 0.5 M H₂SO₄. Potentiodynamic polarization studies showed that n-POX are mixed-type inhibitors in 1 M HCl and anodic-type inhibitors in 0.5 M H₂SO₄. N-POX acted on the cathodic reaction without changing the mechanism of the hydrogen evolution reaction. The ability of the n-POX to inhibit the corrosion of mild steel was dependent on the position of the nitrogen atom on the pyridyl substituent. Surface anal. also were carried out to establish the mechanism of corrosion inhibition of mild steel in acidic solutions The adsorption of n-POX on the mild steel surface in both acidic media followed a Langmuir adsorption isotherm. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7COA of Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of âˆ?8.7 × 10âˆ? cm3·molâˆ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâˆ? in the liquid phase and 140.4 kJ·molâˆ? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties was written by Kuduk, Scott D.;Skudlarek, Jason W.;DiMarco, Christina N.;Bruno, Joseph G.;Pausch, Mark H.;O’Brien, Julie A.;Cabalu, Tamara D.;Stevens, Joanne;Brunner, Joseph;Tannenbaum, Pamela L.;Garson, Susan L.;Savitz, Alan T.;Harrell, Charles M.;Gotter, Anthony L.;Winrow, Christopher J.;Renger, John J.;Coleman, Paul J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Quality Control of 2-Fluoroisonicotinonitrile This article mentions the following:

Antagonism of orexin receptors has shown clin. efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, mols. related to the dual orexin receptor antagonist filorexant were transformed into compounds that were selective for the OX₂R subtype. Judicious selection of the substituents on the pyridine ring and benzamide groups led to I; which was highly potent, OX₂R selective, and exhibited excellent development properties. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Quality Control of 2-Fluoroisonicotinonitrile).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of 2-Fluoroisonicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Propeller Chirality of Boron Heptaaryldipyrromethene: Unprecedented Supramolecular Dimerization and Chiroptical Properties was written by Toyoda, Masataka;Imai, Yoshitane;Mori, Tadashi. And the article was included in Journal of Physical Chemistry Letters in 2017.COA of Formula: C5H6ClN This article mentions the following:

Chiral boron dipyrromethenes (BPs) enjoy high fluorescence efficiency at visible to near-IR wavelength regions with a reasonable range of dissymmetry factors. Here, the (quasi)propeller chirality, similarly to hexagonal propeller in hexaarylbenzene, can be effectively induced in heptaarylated BP. Supramol. dimer was formed at low temperatures in nonpolar solvent, which exhibits strong bisignate Cotton effects at BP transitions (the couplet amplitude A = 193 M^-1 cm^-1) in the CD. Due to the bulky substituents on the propeller blades, but with void space around boron atoms, BP chromophores in the dimer are aligned in a head-to-tail manner with a small torsion (φ â‰?15°), to avoid fluorescence quenching usually observed in H-type dimer of BPs, exhibiting strong circularly polarized luminescence (CPL) signals (g_lum = 2.0 × 10^-3, Φ_lum = 0.45). Such supramol. dimer formation would be viewed as an alternative approach for designing and developing novel chiroptical materials. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7COA of Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem